Article
Environmental Sciences
Jiangfei Chen, Jiani Li, Hao Jiang, Jiajian Yu, Hongzhu Wang, Nengzhuang Wang, Shan Chen, Wen Mo, Ping Wang, Robyn L. Tanguay, Qiaoxiang Dong, Changjiang Huang
Summary: The study examined the neurotoxicity of TBBPA/TiO2 NP mixtures on zebrafish and found that exposure to the mixtures led to changes in behavior, cell apoptosis, and oxidative stress. The findings suggest that TiO2 NP may act as carriers for increased accumulation of TBBPA, leading to heightened responses in zebrafish. This study highlights the importance of assessing toxicity using chemical mixtures.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Mahsa Aeeni, Mazdak Razi, Alireza Alizadeh, Arash Alizadeh
Summary: The study demonstrated that insulin treatment enhances testicular antioxidant capacity, improves the expression of Hsp70-2a, TP-1, and TP-2, and boosts the Hsp90-mediated DNA repair process, thereby maintaining DNA integrity induced by hyperglycemia.
Article
Agriculture, Dairy & Animal Science
Meijin Yu, Chunyu Jiang, Jiatian Liang, Hui Zhang, Xiaohua Teng, Lu Kang
Summary: This study investigates the effects of lead on oxidative damage and proteotoxicity in chicken bursa of Fabricius (BF), as well as the potential protective role of selenium. The results show that lead causes damage to BF and induces oxidative damage and proteotoxicity through the HSP27-HSP40-HSP70-HSP90 pathway. Furthermore, selenium alleviates lead-induced damage and up-regulation of heat shock proteins in chicken BF.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Qirui Zhang, Shengchen Wang, Fuhan Wang, Mengyao Guo, Shiwen Xu
Summary: TBBPA is a widely used substance that accumulates in the environment and causes extensive damage to organisms. It induces oxidative stress, tissue damage, and cell death, affecting the physiological function of tissues. In this study, mouse skeletal muscle models and mouse myoblast cell models were used to demonstrate that TBBPA treatment increases reactive oxygen species and Malondialdehyde levels while decreasing antioxidant enzyme activities. TBBPA inhibits Nrf2 entry into the nucleus, leading to increased expression of inflammatory factors and decreased expression of anti-apoptotic factors. Programmed necrosis-related factors are also elevated. TBBPA induces oxidative stress, inflammation, apoptosis, and necrosis in mouse skeletal muscle through the Nrf2/ROS/TNF-alpha signaling pathway.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Zhuozhen Qian, Cuiya Xu, Xiaoyi Dong, Shuifen Tang, Shaohong Wei
Summary: The concentration and spatial distribution of brominated flame retardants (BFRs) in bivalves from Fujian southern coastal areas show variations influenced by bay geographical location, seasonal patterns, and proximity to local industries. Higher levels of BFRs contamination were found in Xiamen and Quanzhou marine environments compared to Zhangzhou and Putian, suggesting an association with industrial activities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xue Han, Xiaowen Xu, Tingting Yu, Meifeng Li, Yulong Liu, Jingli Lai, Huiling Mao, Chengyu Hu, Shanghong Wang
Summary: Exposure to Diflubenzuron resulted in cardiac developmental damage in zebrafish embryos, increased apoptotic cells and promoted the expression of apoptosis-related genes, while inhibiting the expression of some heart-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Caren Weinhouse
Summary: Redox-active environmental pollutants can disrupt cellular redox status and induce specific and general stress responses in cells. Exposure to these pollutants can affect chromatin modifications and lead to transcriptional memory, predisposing cells to stronger transcriptional responses upon secondary challenge.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Taeyeon Hong, Hahyun Park, Garam An, Gwonhwa Song, Whasun Lim
Summary: This study investigated the effects of ethalfluralin on the development of zebrafish embryos. The results showed that ethalfluralin decreased the survival rate, hatching ratio, and heartbeat of zebrafish embryos. It also caused edema, apoptosis, and changes in gene expression related to apoptosis, inflammation, and angiogenesis. The study suggests that ethalfluralin can induce oxidative stress and have toxic effects on the development of zebrafish embryos.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Simeng Chen, Jie Zhou, Chidimma Juliet Igbokwe, Yuqing Duan, Meihong Cai, Yuanqing He, Haihui Zhang
Summary: This study investigated the effect and potential mechanism of RDPEER, an antioxidant oligopeptide derived from watermelon seeds, on heat stress-induced liver injury and cell damage. The results showed that supplementation with RDPEER attenuated hepatocyte injury by increasing cell viability, reducing ROS production, improving antioxidant enzyme activity, and decreasing MDA content. RDPEER also inhibited HPA axis hyperactivity, transaminase activity, and inflammatory factor levels, while activating the endogenous antioxidant pathway and reducing inflammatory factor transcription and heat shock protein expression. Overall, RDPEER supplementation enhanced antioxidant capacity and alleviated liver damage caused by heat stress, suggesting its potential use in nutritional interventions.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Sciences
Lina Bai, Peng Shi, Kun Jia, Hua Yin, Jilin Xu, Xiaojun Yan, Kai Liao
Summary: The toxicity of triflumizole (TFZ) was investigated in zebrafish to understand its potential risks in the aquatic environment. The study found that TFZ exposure affected the development of zebrafish and resulted in disturbances in oxidative stress, heat shock response, inflammation, and lipid synthesis. These findings provide important insights into the potential risks of TFZ to the aquatic ecosystem.
Article
Environmental Sciences
Tian Zhang, Wenhua Yan, Cong Liu, Weixia Duan, Yu Duan, Yuanyuan Li, Qin Yu, Yapei Sun, Jiacheng Tian, Jie Zhou, Zhiqin Xia, Guixue Wang, Shangcheng Xu
Summary: Cadmium (Cd) exposure induces ferroptosis of vascular endothelial cells (ECs), resulting in endothelial dysfunction and cardiovascular disease. Cd accumulates in ECs, leading to increased lipid peroxidation and disrupted oxidoreductase system. Cd decreases Gpx4 expression and alters mitochondrial morphology, causing reduced ECs and caudal venous plexus in zebrafish embryos, as well as decreased survival rate of HUVECs. Inhibition of Hsp70 ameliorates Cd-induced ferroptosis by targeting multiple factors, including Gpx4, Fth1, Nrf2, and Acsl4. Regulation of Hsp70 is therefore a promising approach for alleviating Cd-induced endothelial damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Huanhuan Xiao, Hongying Wang, Qiuxia He, Jianfeng Zhou, Shaojun Du
Summary: The expression and function of Aha1 in zebrafish were characterized in this study. It was found that Aha1 showed distinct expression patterns during zebrafish embryonic development and was significantly upregulated in response to heat shock. Furthermore, Aha1 was found to be dispensable for zebrafish embryonic development, growth, and survival.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Veterinary Sciences
Giuseppe Caruso, Elena Maria Scalisi, Roberta Pecoraro, Vincenzo Cardaci, Anna Privitera, Emanuela Truglio, Fabiano Capparucci, Romana Jarosova, Antonio Salvaggio, Filippo Caraci, Maria Violetta Brundo
Summary: Oxidative stress is caused by an imbalance between pro-oxidants and antioxidants/antioxidant system. Excessive production of reactive oxygen species (ROS) and nitrogen species (RNS) has been linked to the development of diseases. Carnosine, a naturally occurring dipeptide, has shown the ability to scavenge ROS and inhibit protein oxidation. In this study, the effects of carnosine and titanium dioxide nanoparticles (TiO2-NPs) on zebrafish embryos/larvae were investigated, and it was found that carnosine could reduce TiO2-NPs-induced oxidative stress.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Amany Behairy, Wafaa A. M. Mohamed, Lamiaa L. M. Ebraheim, Mohamed Mohamed Soliman, Yasmina M. Abd-Elhakim, Nabela I. El-Sharkawy, Taghred M. Saber, Maha M. El Deib
Summary: Boldenone Undecylenate (BLD), a synthetic derivative of testosterone, is a widely used anabolic androgenic steroid. Vitamin C (VC) has been recognized for its hepatorenal protective effects. This study investigated the preventive activity of VC against BLD-induced hepatorenal damage and found that VC could mitigate the damage caused by BLD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Meifeng Li, Tingting Yu, Jingli Lai, Xue Han, Jihuan Hu, Zeyuan Deng, Dongming Li, Zuocheng Ye, Shanghong Wang, Chengyu Hu, Xiaowen Xu
Summary: The study revealed that ethoprophos exposure can cause cardiac defects in zebrafish embryos, such as low heart rate, pericardium edema, and long SV-BA distance, while not affecting vascular development. This indicates that oxidative stress and inhibition of the wnt signaling pathway are the molecular mechanisms underlying ethoprophos-induced injury in zebrafish.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Ecology
Jun Hu, Yong Liang, Minjie Chen, Xiaorong Wang
AQUATIC ECOSYSTEM HEALTH & MANAGEMENT
(2010)
Article
Environmental Sciences
Jun Hu, Ye Qiao, Lianfeng Zhou, Sixin Li
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2012)
Article
Environmental Sciences
Hu Jun, Liu Jiantong, Liu Yongding
ENVIRONMENTAL GEOLOGY
(2009)
Article
Environmental Sciences
Jun Hu, Shiyun Chi, Juxiang Hu
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2019)
Article
Ecology
Jun Hu, Juxiang Hu, Shiyun Chi
Summary: By using factor analysis, a method was developed to assess the ecological status of a reservoir by creating a phytoplankton index of biotic integrity. This method can reflect water quality status and provide a monitoring tool.
Article
Environmental Sciences
Jun Hu, Qiang Shen, Yongding Liu, Jiantong Liu
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2007)
Article
Environmental Sciences
Jun Hu, Yongding Liu, Jiantong Liu
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2006)