Article
Environmental Sciences
Mousa O. Germoush, Maged M. A. Fouda, Mohamed Kamel, Mohamed M. Abdel-Daim
Summary: The study demonstrated the potential therapeutic effect of Spirulina platensis against MC-LR-induced toxic effects in male Wistar rats, by alleviating oxidative damage in liver and kidneys, cardiotoxicity, and neurotoxicity. Spirulina restored normal levels of serum markers and normalized tissue antioxidant biomarkers, mitigating organ toxicities induced by MC-LR.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
May N. Bin-Jumah, Arwa Abdulkreem AL-Huqail, Noha Abdelnaeim, Mohamed Kamel, Maged M. A. Fouda, Mahmoud M. A. Abulmeaty, Islam M. Saadeldin, Mohamed M. Abdel-Daim
Summary: The study found that rats given AA alone showed significantly increased levels of liver enzymes, kidney function parameters, DNA damage markers, and proinflammatory cytokines. Meanwhile, Spirulina was able to improve abnormal serum biochemistry, reduce MDA and NO levels, and enhance antioxidant biomarkers in AA-intoxicated rats in a dose-dependent manner.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Nema A. Mohamed, Mohamed A. M. Hashem, Abdullah M. Alzahrani, Ashraf M. Abdel-Moneim, Heba M. Abdou
Summary: The study demonstrated that Spirulina platensis (SP) has a protective effect against carbon tetrachloride-induced liver toxicity in rats by enhancing antioxidant defense mechanisms, inhibiting inflammatory cytokines, and anti-proliferative effects to prevent liver damage.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Samar Saber Ibrahim, Rasha Elsabagh, Ali Allam, Gehan Youssef, Sabreen Ezzat Fadl, Ehab Yahya Abdelhiee, Mohamed Alkafafy, Ahmed Soliman, Mohamed Aboubakr
Summary: The study showed that Spirulina platensis has protective effects against DM-induced hepatorenal injury in broiler chickens, reducing DM residues in meat, skin, and liver, improving meat composition, and growth performance.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Thabani Sibiya, Terisha Ghazi, Jivanka Mohan, Savania Nagiah, Anil A. Chuturgoon
Summary: Spirulina platensis has shown high potency in the treatment of oxidative stress, diabetes, immune disorder, inflammatory stress, and bacterial and viral-related diseases. This study found that Spirulina platensis can protect against ARV-induced oxidative stress in HepG2 cells. The activation of the antioxidant response by Spirulina platensis can mitigate the adverse drug reactions of HAART.
Article
Green & Sustainable Science & Technology
Gaetana Napolitano, Paola Venditti, Claudio Agnisola, Saverio Quartucci, Gianluca Fasciolo, Maria Teresa Muscari Tomajoli, Eugenio Geremia, Claudio Marcello Catone, Sergio Ulgiati
Summary: Spirulina can improve the growth and wellbeing of fish when used as a supplement in the diet, and growing spirulina in a circular economy context can reduce environmental impacts and enhance fish welfare.
JOURNAL OF CLEANER PRODUCTION
(2022)
Review
Nutrition & Dietetics
Thabani Sibiya, Terisha Ghazi, Anil Chuturgoon
Summary: This review highlights the biochemical mechanism of Spirulina platensis (SP) and its potential in inhibiting HIV, inflammation, and oxidative stress. SP has been shown to regulate oxidative and inflammatory pathways and exhibit various beneficial properties, making it a potential supplement for HIV-infected persons on lifelong HAART.
Article
Nutrition & Dietetics
Paula Benvindo Ferreira, Anderson Fellyp Avelino Diniz, Francisco Fernandes Lacerda Junior, Maria da Conceicao Correia Silva, Glebia Alexa Cardoso, Alexandre Sergio Silva, Bagnolia Araujo da Silva
Summary: The study showed that strength training increases contractile reactivity and decreases relaxing reactivity in rat uterus. It also revealed that supplementation with antioxidant algae can prevent oxidative stress induced by exercise and enhance antioxidant capacity.
Article
Plant Sciences
Thabani Sibiya, Terisha Ghazi, Jivanka Mohan, Savania Nagiah, Anil A. Chuturgoon
Summary: This study investigates the mechanisms of microRNA expression in HepG2 cells in the presence of HAART and SP. The results show that miR-146a and miR-155 levels increased in SP-treated cells, while only miR-146a increased in HAART-SP treatment and miR-155 decreased. Furthermore, Cox-1 expression increased in HAART-SP-treated cells, while Cox-2 and mRNA expression decreased. These findings suggest that SP potentially controls inflammation by regulating microRNA expressions and exhibit a positive synergistic effect with HAART.
Article
Plant Sciences
Dechao Chen, Shuya Chen, Chenxi Zhao, Jin Yan, Zelong Ma, Xiaokai Zhao, Zhenfeng Wang, Xuedong Wang, Huili Wang
Summary: The study found that sRNAs in Spirulina platensis play a crucial role in oxidative stress responses, and high-throughput sequencing can reliably identify the differential expression of sRNAs. Bioinformatics prediction and structure identification showed that these sRNAs may participate in the defense mechanism of H2O2 by regulating multiple target genes.
FUNCTIONAL PLANT BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jian Li, Yaqi Zhang, Shen Yang, Zhenhua Lu, Guiling Li, Jingwen Liu, Bo Zhou, Daren Wu, Li Wang
Summary: Crude polysaccharides from Spirulina platensis were isolated and fractionated into two purified fractions PSP-1 and PSP-2, which were found to be branching dextran composed mainly of glucose. These glucans can enhance macrophages' phagocytic ability, iNOS activity, NO production, and IL-6 mRNA expression, indicating potential immunomodulatory activity.
Article
Agriculture, Dairy & Animal Science
Vincenzo Tufarelli, Payam Baghban-Kanani, Saba Azimi-Youvalari, Babak Hosseintabar-Ghasemabad, Marina Slozhenkina, Ivan Gorlov, Alireza Seidavi, Tugay Ayasan, Vito Laudadio
Summary: The study found that supplementing laying hens' diet with horsetail and spirulina did not have a detrimental effect on productive parameters. Spirulina was more effective in improving blood traits and oxidative status of the laying hens.
Article
Andrology
Hossein Moghanlo, Seyed Mohammad Ali Shariatzadeh
Summary: This study investigated the effects of Spirulina platensis (SP) on the reproductive toxicity of silver nanoparticles (AgNPs) in mouse testis. The results showed that AgNPs exposure had detrimental effects on spermatogenesis, sperm parameters, and testicular histopathology, while co-administration of SP alleviated these effects. SP also improved antioxidant capacity and reduced oxidative stress induced by AgNPs. These findings suggest that SP has a protective potential against AgNPs-induced reproductive toxicity.
Article
Multidisciplinary Sciences
Fatma Abd El Lateef Gharib, Eman Zakaria Ahmed
Summary: This study investigated the effects of foliar application of Spirulina platensis and soil irrigation with heavy metals on the growth and antioxidant activity of rosemary plants. Results showed that Spirulina platensis significantly improved plant growth, oil yield, photosynthetic pigments, and antioxidant enzyme activity. Conversely, heavy metal stress negatively affected growth and oil yield but increased antioxidant enzyme levels. Analysis of bioaccumulation and translocation factors revealed that Cd and Pb accumulated primarily in the roots. However, the addition of 0.1% Spirulina platensis mitigated the negative effects of heavy metals, improving growth parameters, antioxidant activity, and reducing lipid peroxidation and oxidative stress markers in rosemary plants.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Nicole Longtin, Daniela Oliveira, Aishwarya Mahadevan, Varun Gejji, Carmen Gomes, Sandun Fernando
Summary: In this study, a unique configuration of Spirulina-based microalgal fuel cell was tested, showing highest performance on day seven during the exponential growth phase. Additionally, the highest power density was achieved when three fuel cells were connected in parallel.
JOURNAL OF POWER SOURCES
(2021)
Review
Surgery
Magnus J. Chun, Yichi Zhang, Eman A. Toraih, Patrick R. McGrew
Summary: Mechanical chest compression has been associated with a higher risk of iatrogenic injuries compared to manual chest compression. Deeper compression depths in mechanical chest compression may contribute to the increased injuries.
Article
Surgery
Ruhul Munshi, Nicholas Mankowski, Spenser Souza, Hosam Shalaby, Ahmed Elnahla, Mounika Akkera, Mohammad Hussein, Katherine Cox, Jeffrey Borchardt, Brian McClure, Mohamed Shama, Eman Toraih, Emad Kandil
Summary: This retrospective cohort study compared intraoperative neuromonitoring (IONM) signals between the transaxillary and transcervical approaches. The results showed that the transaxillary approach did not increase stress on the vagus nerve or recurrent laryngeal nerve (RLN), according to IONM data. The study highlights the importance of considering patient positioning and laterality when interpreting IONM data.
Article
Cardiac & Cardiovascular Systems
Yasser M. Sammour, Hassan Lak, Johnny Chahine, Abdelrahman Abushouk, Sanchit Chawla, Amer Kadri, Feras Alkhalaileh, Sachin Kumar, Bindesh Ghimire, Lars Svensson, Zoran Popovic, Khaldoun Tarakji, Oussama Wazni, Grant W. Reed, James Yun, Rishi Puri, Amar Krishnaswamy, Samir R. Kapadia
Summary: This study described the clinical and echocardiographic outcomes of new-onset left bundle branch block (LBBB) after transcatheter aortic valve replacement (TAVR). It found that new-onset LBBB was associated with longer hospital stay, higher requirement for permanent pacemaker (PPM), increased heart failure hospitalizations, lower left ventricular ejection fraction (LVEF), and higher left ventricular volumes. However, there was no difference in mortality between the groups.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Biotechnology & Applied Microbiology
Safir Ullah Khan, Muhammad Imran Khan, Munir Ullah Khan, Noor Muhammad Khan, Simona Bungau, Syed Shams ul Hassan
Summary: Diseases affecting the brain and spinal cord are classified as central nervous system diseases. Most medications used for these diseases are unable to cross the blood-brain barrier, limiting their effectiveness. However, exosomes, due to their small size, high delivery efficiency, and compatibility, can cross the blood-brain barrier and serve as transporters for targeted drug administration. Further research and bioengineering modifications can enhance the properties and targeting abilities of exosomes, making them promising vectors for central nervous system diseases.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Mehreen Ghufran, Mehran Ullah, Haider Ali Khan, Sabreen Ghufran, Muhammad Ayaz, Muhammad Siddiq, Syed Qamar Abbas, Syed Shams ul Hassan, Simona Bungau
Summary: During the SARS-CoV-2 outbreak, researchers extensively studied pharmacological strategies to decrease the viral load in severe patients. The M-pro protease, which is essential for viral replication, has been identified as a potential therapeutic target. To prevent further spread of the pandemic, scientists are actively searching for more efficient inhibitors against SARS-CoV-2.
BIOENGINEERING-BASEL
(2023)
Review
Cell Biology
Andrei-Flavius Radu, Simona Gabriela Bungau
Summary: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder characterized by bone and cartilage damage in the synovium, resulting in joint impairment and increased mortality rate. Despite recent improvements in RA treatment, only a small fraction of patients achieve clinical remission without ongoing immunosuppressive drugs. Research on RA nano therapies has increased due to their potential advantages over traditional systemic treatments. Nanotherapeutic techniques, specifically drug delivery nano systems, offer new approaches to overcome the limitations of existing treatments by precisely delivering therapeutic drugs to affected sites.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Partha Biswas, Shabana Bibi, Qudsia Yousafi, Asim Mehmood, Shahzad Saleem, Awais Ihsan, Dipta Dey, M. D. Nazmul Hasan Zilani, M. D. Nazmul Hasan, Rasha Saleem, Aeshah A. Awaji, Usama A. Fahmy, Mohamed M. Abdel-Daim
Summary: An onco-informatics-based evaluation was conducted to assess the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer. The study analyzed the differential expression of MDM2 and searched for mutations and copy number variations. Several transcriptome servers and bioinformatics tools were used to determine the survival rate and protein interactions related to the MDM2 gene in LGG cancer patients.
Article
Multidisciplinary Sciences
Maha Alkhalaf, Nadia A. Mohamed, Safinaz E. El-Toukhy
Summary: In this study, the anti-inflammatory and antioxidant potential of sodium salicylate against cisplatin-induced hepatotoxicity was assessed. The results showed that sodium salicylate-loaded silica nanoemulsion significantly alleviated cisplatin-induced liver damage and restored normal biomarker levels.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Safir Ullah Khan, Munir Ullah Khan, Muhammad Azhar Ud Din, Ibrar Muhammad Khan, Muhammad Imran Khan, Simona Bungau, Syed Shams ul Hassan
Summary: Over the past decade, it has been increasingly recognized that tumor-infiltrating myeloid cells, including tumor-associated macrophages (TAMs), play a crucial role in promoting tumor development, invasion, and metastasis. TAMs are the most common type of immune cells in many malignancies and contribute to the establishment of an immune-suppressive tumor microenvironment (TME). The presence of pro-tumoral TAMs hinders the effectiveness of conventional therapies and even innovative immunotherapies based on immune-checkpoint suppression. Understanding the metabolic changes and functional plasticity of TAMs in the complex TME is important for developing targeted tumor immunotherapy and more effective treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Rashita Makkar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Ravi Rawat, Summya Rashid, Celia Vargas-De-La-Cruz, Shivam Yadav, Simona Gabriela Bungau, Tapan Behl
Summary: Rheumatoid arthritis is a chronic autoimmune disorder that mainly affects the joints and joint membrane, resulting in immune cell infiltration, synovium lining hyperplasia, pannus formation, and bone and cartilage destruction. It affects approximately 1% of the global population, with a higher prevalence in women. The aggressive phenotype of synovial fibroblasts in rheumatoid arthritis individuals leads to the upregulation of proto-oncogenes, adhesive compounds, inflammatory cytokines, and matrix-deteriorating enzymes. Current treatment options include non-steroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, and biologics targeting specific molecules. Understanding the pathogenesis and associated parameters would facilitate the development of advanced therapeutic approaches for managing this debilitating disease.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Raed Alserihi, Hameeda Ahmad, Heba Alkhatabi, Talal Qadah, Shahad W. Kattan, Elrashed B. Yasin, Haitham M. H. Qutob, Waleed M. Bawazir, Abeer Fakhr-Eldeen, Manal S. Fawzy, Ahmad S. Barefah
Summary: This study aimed to explore the mutation frequencies of NPM1 and FLT3 in patients with AML and their correlation with cytogenetic profiles. The study found different mutation types and cytogenetic abnormalities in the patients based on molecular analysis and chromosomal aberration testing. The frequency of NPM1/FLT3 mutations in this study cohort was lower and showed a distinct pattern compared to other studies. More extensive screening is required to evaluate their usefulness as prognostic indicators in this region.
INTERNATIONAL JOURNAL OF BIOMEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Abdelrahman I. Abushouk, Ahmed Sayed, Esraa Ghanem, Ahmed Hassanin, Amgad Mentias, Ahmed Bendary, Joanna Ghobrial, Samir Kapadia
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Editorial Material
Multidisciplinary Sciences
Nikita Maruti Gaikwad, Pravin Digambar Chaudhari, Karimunnisa Sameer Shaikh, Somdatta Yashwant Chaudhari, Rasha Mohammed Saleem, Mohammad Algahtani, Ahmed E. Altyar, Ghadeer M. Albadrani, Mohamed Kamel, Mohamed M. Abdel-Daim
Summary: Drug repurposing is the process of discovering new activity for existing drugs. This study investigates the interaction of Albendazole, a well-known antihelmintic drug, with the tyrosine kinase protein receptor VEGFR-2. The findings suggest that Albendazole has potential as a potent angiogenesis inhibitor and could aid in the development of anticancer therapies.
Correction
Environmental Sciences
Eman A. Alwaleed, Mostafa El-Sheekh, Mohamed M. Abdel-Daim, Hani Saber
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Surgery
Lauren E. Mueller, Peter P. Issa, Mohammad Hosny Hussein, Rami M. . Elshazli, Muhib Haidari, Youssef Errami, Mohamed Shama, Manal S. Fawzy, Emad Kandil, Eman Toraih
Summary: Radiofrequency ablation (RFA) is a minimally invasive technique used to ablate tumor cells, with potential applications in a variety of cancer types. Incomplete RFA may result in tumor recurrence. This study aims to investigate the cellular mechanisms and behavior of ablated cancer tissue.
