Article
Chemistry, Inorganic & Nuclear
Johannes Karges, Kai Xiong, Olivier Blacque, Hui Chao, Gilles Gasser
Summary: The study found that copper (II) polypyridine complexes have significant cytotoxic effects on human adenocarcinomic alveolar basal epithelial cells, and are equally effective against cisplatin-resistant cells, potentially serving as a treatment option for drug-resistant tumors.
INORGANICA CHIMICA ACTA
(2021)
Article
Oncology
Boonyakorn Boonsri, Kiren Yacqub-Usman, Pakpoom Thintharua, Kyaw Zwar Myint, Thannicha Sae-Lao, Pam Collier, Chinnawut Suriyonplengsaeng, Noppadol Larbcharoensub, Brinda Balasubramanian, Simran Venkatraman, Isioma U. Egbuniwe, Dhanwant Gomez, Abhik Mukherjee, Supeecha Kumkate, Tavan Janvilisri, Abed M. Zaitoun, Thiti Kuakpaetoon, Rutaiwan Tohtong, Anna M. Grabowska, David O. Bates, Kanokpan Wongprasert
Summary: The study found that CCA tumors had higher expression of ErbB receptors compared to resection margins. CCA cell lines showed decreased cell viability when treated with chemotherapeutic drugs and ErbB inhibitors, particularly afatinib. Co-culture of CCA primary cells with cancer-associated fibroblasts decreased sensitivity to chemotherapies, but sensitized to afatinib.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
A. Laura Nijstad, Shelby Barnett, Arief Lalmohamed, Inez M. Berenos, Elizabeth Parke, Vickyanne Carruthers, Deborah A. Tweddle, Jordon Kong, C. Michel Zwaan, Alwin D. R. Huitema, Gareth J. Veal
Summary: Cancer treatment in neonates and infants is complex, and dose optimization plays a crucial role in improving outcomes. This review provides clinically relevant pharmacological evidence-based dosing guidance for a wide range of cytotoxic drugs in this population.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Environmental Sciences
S. Domingo-Echaburu, A. Lopez de Torre-Querejazu, Y. Valcarcel, G. Orive, U. Lertxundi
Summary: Healthcare workers may be exposed to dangerous drugs, and the global consumption of anticancer drugs is expected to increase. This study reviewed the presence of hazardous drugs in the environment and their potential impact, finding evidence of 19 drugs in the environment. The absence of environmental risk data for certain hazardous drugs can help prioritize future research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Jian-Lu Duan, Jing-Ya Ma, Xiao-Dong Sun, Xiao-Yu Liu, Yue Wang, Lin Du, Peng-Fei Xia, Xian-Zheng Yuan
Summary: Antibiotic resistance is a global health challenge. This study reveals how bubbles can spread antibiotic resistance genes and interact with the extracellular matrix in the aquatic environment, providing new insights into the dissemination of antibiotic resistance.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Engineering, Environmental
Ahmed M. Elgarahy, Abdullah Akhdhar, Khalid Z. Elwakeel
Summary: Microplastics are considered a major water contaminant with potential adverse health effects on humans and animals, especially their accumulation in aquatic plant tissues. Interactions between MPs and various pollutants can enhance toxicity, emphasizing the importance of understanding their occurrence and prevalence in the aquatic environment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Engineering, Environmental
Ziqing Huang, Chengyu Chen, Yanjun Liu, Sijia Liu, Dehua Zeng, Chen Yang, Weilin Huang, Zhi Dang
Summary: The aggregation kinetics of nanoplastics in aquatic environments are influenced by their interactions with proteins of different structures and properties. The study found that the electrostatic properties, protein structures, and solution chemistries played a crucial role in the interactions between proteins and nanoplastics. The protein concentration and solution pH affected the stability of the nanoplastics.
Article
Oncology
Mario L. de Lemos, Nadine Badry, James Conklin, Michelle Koberinski
Summary: Safe handling precautions are important to prevent occupational exposure to hazardous antineoplastic drugs. By establishing a list of antineoplastic drugs with cytotoxic or non-cytotoxic designations based on mechanistic criteria, this review provides a reference for developing safe handling policies.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Haitao Wang, Haitao Shi, Yan Wang, Na Wang, Youjia Li, Qianting Yang, Ya Li, Chenwei Liu, Ying Zan, Siping Feng, Jiao Xie
Summary: The prevalence of hazardous drug-drug interactions (DDIs) related to oral antineoplastic agents (OAAs) appears to be low in cancer patients. However, physicians and clinical pharmacologists should be aware of the potential hazardous DDIs when prescribing OAAs, especially certain pH-dependent molecular targeted agents and drugs that can prolong QTc interval.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Inorganic & Nuclear
Monireh Ghorbanpour, Ali Shayanfar, Behzad Soltani
Summary: This study explores the anticancer potential of pyrazole-based copper complexes and investigates their mechanism of action at the molecular level. The results suggest that these complexes have promising applications as effective anticancer agents with lower side effects compared to approved drugs. However, the inhibitory effects of these complexes can be influenced by various laboratory conditions.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Chemistry, Applied
Zekeriya Biyiklioglu, Huseyin Bas, Yasemin Altun, Can Ozgur Yalcin, Burak Barut
Summary: In this paper, water-soluble zinc (II) phthalocyanines with tetra and octa-peripherally substituted groups were synthesized. Their interactions with DNA and phototoxic properties were investigated. The results suggest that these compounds have the potential to be photosensitizing agents for photodynamic therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Eslam Dabbish, Stefano Scoditti, Mohammed N. I. Shehata, Ida Ritacco, Mahmoud A. A. Ibrahim, Tamer Shoeib, Emilia Sicilia
Summary: This paper presents a DFT investigation on the metabolic phases and cytotoxic mechanism of cyclophosphamide (CP). The computational analysis provides insights into the energy profiles and DNA alkylation mechanism, aiming to contribute to the design of a new generation of oxazaphosphorines.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Gratal, Maria-Selma Arias-Perez, Lourdes Gude
Summary: In this study, a novel family of carbohydrate conjugates based on the 2-aryl-imidazo[4,5-f][1,10]phenanthroline core modified with carbohydrates (carb-APIPs) were presented. The carb-APIPs exhibited high affinity and selectivity towards telomeric G-quadruplex DNA structure, and showed significant cytotoxic properties in cancer cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Oncology
Daniela Campos, Ines Silva, Mariana Rego, Patricia Correia, Fernando Moreira
Summary: Pharmacy professionals in Portugal who handle cytotoxic drugs have received some training, but there is a lack of regular post-admission training. Most technicians comply with safety measures such as wearing gloves and gowns, but the use of sterile gauze and closed-system transfer devices for syringe connections is not common.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Xiaoyuan Tao, Sujuan Li, Guang Chen, Jian Wang, Shengchun Xu
Summary: Long non-coding RNAs (lncRNAs) are transcripts that are longer than 200 nucleotides (nt) and do not code for proteins. It is crucial to use appropriate research methodologies when studying lncRNAs with biological importance. While previous reviews have focused on lncRNA biogenesis, localization, functions, and potential applications, there has been limited discussion on leading strategies for lncRNA research. This article presents a comprehensive mind map for lncRNA research and explores the mechanisms and application scenarios of up-to-date techniques in studying the molecular functions of lncRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Tim Aus der Beek, Frank-Andreas Weber, Axel Bergmann, Silke Hickmann, Ina Ebert, Arne Hein, Anette Kuester
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2016)
Article
Engineering, Environmental
J. Radjenovic, M. Godehardt, M. Petrovic, A. Hein, M. Farre, M. Jekel, D. Barcelo
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2009)
Article
Ecology
Tobias Vrede, Stina Drakare, Peter Eklov, Arne Hein, Antonia Liess, Jens Olsson, Jonas Persson, Mario Quevedo, Henrik Ragnarsson Stabo, Richard Svanback
Article
Engineering, Environmental
E. Sahar, M. Ernst, M. Godehardt, A. Hein, J. Herr, C. Kazner, T. Melin, H. Cikurel, A. Aharoni, R. Messalem, A. Brenner, M. Jekel
WATER SCIENCE AND TECHNOLOGY
(2011)
Review
Environmental Sciences
Simon Schwarz, Daniela Gildemeister, Arne Hein, Patrick Schroeder, Jean Bachmann
Summary: Human pharmaceuticals undergo extensive environmental risk assessment before marketing approval, based on EU and German guidelines. An internal agency database contains effect data on approximately 300 active pharmaceutical ingredients, indicating potential for improvement in current assessment methods.
ENVIRONMENTAL SCIENCES EUROPE
(2021)