Article
Environmental Sciences
Rodrigo Alvarez-Ruiz, Yolanda Pico, Julian Campo
Summary: This study assessed the bioaccumulation of 20 chemical substances catalogued as ECs in Mytilus galloprovincialis, showing the accumulation of certain substances in the visceral mass and haemolymph of mussels, with MPs acting as a vector for the accumulation of PFASs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Qianqian Geng, Mengmeng Guo, Haiyan Wu, Jixing Peng, Guanchao Zheng, Xiaoyu Liu, Yuxiu Zhai, Zhijun Tan
Summary: The study investigated the combined effects of BDE-47 and PFOA on blue mussels, finding that the mussel had different accumulation and toxicity responses to the two compounds, with co-exposure resulting in increased toxicity mainly due to oxidative stress and tissue damage. This research provides insights into the combined behaviors and cumulative risks of BDE-47 and PFOA in marine ecosystems.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Magali Rey-Campos, Beatriz Novoa, Alberto Pallavicini, Marco Gerdol, Antonio Figueras
Summary: Mytimycins are cysteine-rich antimicrobial peptides with antifungal properties, part of the immune network of the Mediterranean mussel. Recent genetic studies have identified a total of 106 different mytimycin variants in individual mussel genomes, showing evolutionary trends that contribute to understanding the mussel immune system. Additionally, the distribution of mytimycins has been extended to other Mytilida species, highlighting the importance of these peptides in the defense mechanisms of molluscs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Marica Mezzelani, Alessandro Nardi, Ilaria Bernardini, Massimo Milan, Luca Peruzza, Giuseppe d'Errico, Daniele Fattorini, Stefania Gorbi, Tomaso Patarnello, Francesco Regoli
Summary: The study found that under simulated ocean acidification scenarios, the interaction between carbamazepine and acidification can increase cellular hazard in marine organisms.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Marine & Freshwater Biology
Hannah Mahoney, Jenna Cantin, Yuwei Xie, Markus Brinkmann, John P. Giesy
Summary: This study aimed to characterize the effects of PFECHS using in vitro systems, such as rainbow trout liver cells and lymphocytes. The results showed that exposure to PFECHS caused minor acute toxic effects and had a low bioconcentration factor. However, PFECHS was observed to affect mitochondrial membrane and key molecular receptors related to oxidative stress.
AQUATIC TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yvette N. Lamb
Summary: Ganaxolone is a synthetic neuroactive steroid that acts as a positive allosteric modulator of the GABA(A) receptor complex. It has received first approval in the USA for the treatment of seizures associated with CDKL5 deficiency disorder and is undergoing evaluation for other seizure disorders. This article provides a summary of the milestones in the development of ganaxolone leading to its first approval.
Article
Chemistry, Medicinal
Evane Thorel, Fanny Clergeaud, Alice M. S. Rodrigues, Philippe Lebaron, Didier Stien
Summary: This study investigates the effects of octocrylene on two coral species and reveals that it can cause mitochondrial dysfunction and cellular senescence. The impact on a second coral species suggests that environmental octocrylene pollution may affect various reef-building species. Additionally, the research demonstrates that octocrylene can be modified by organisms and its contamination levels in the food chain may have been underestimated.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Marine & Freshwater Biology
Qi Meng, Karen Yeung, King Ming Chan
Summary: Studies have shown that Octocrylene (OC) has toxic effects on zebrafish and zebrafish liver cells, inducing gene expression and affecting hormone synthesis and antioxidant pathways. The findings support banning the use of OC in cosmetics.
AQUATIC TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Margherita Bernardeschi, Patrizia Guidi, Mara Palumbo, Massimo Genovese, Michela Alfe, Valentina Gargiulo, Paolo Lucchesi, Vittoria Scarcelli, Alessandra Falleni, Elisa Bergami, Francesca S. Freyria, Barbara Bonelli, Ilaria Corsi, Giada Frenzilli
Summary: The study focused on using non-genotoxic nanoparticles to reduce the genetic and chromosomal damage associated with exposure to Benzo(a)pyrene (B(a)P). The results showed that pure Anatase n-TiO2 was the most suitable material, as it is cytotoxicity and genotoxicity free and able to reduce the genetic and chromosomal damage caused by B(a)P exposure.
Article
Pharmacology & Pharmacy
Haoya Chang, Jian Li, Chunhui Zhang, Weiping Qian
Summary: This study investigated the impacts of Octocrylene (OCL) on mouse oocyte maturation and quality. The results showed that OCL exposure disrupted oocyte meiotic maturation, reduced oocyte quality, damaged mitochondrial function, and led to overproduction of reactive oxygen species (ROS) and apoptosis.
Article
Chemistry, Multidisciplinary
Adam M. Cowden, Abigail L. Whittock, Emily L. Holt, Vasilios G. Stavros, Martin Wills
Summary: This study explores the stability of avobenzone and octocrylene in binary mixtures and synthesizes a novel composite sunscreen by covalently linking the two molecules. Spectroscopy experiments reveal the stability and UV-filtering potential of the fused molecules. Computational analysis of truncated versions of the molecules uncovers the underlying energy states during the absorption processes. The study demonstrates that combining the elements of the two sunscreen molecules into one creates a derivative with improved stability to UV light.
Article
Environmental Sciences
P. Rodriguez-Velarte, J. M. F. Babarro, A. Cobelo-Garcia
Summary: There were no significant differences in the bioaccumulation of trace elements between the native Mytilus galloprovincialis and invasive Xenostrobus securis species in Vigo Ria, except for zinc and silver. Mytilus galloprovincialis showed a 4-fold enrichment in zinc compared to Xenostrobus securis, while Xenostrobus securis exhibited approximately 40-fold higher concentrations of silver. This high bioaccumulation of silver by Xenostrobus securis can be utilized for silver biomonitoring in the area.
MARINE POLLUTION BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Cheng Peng, Shanqi Zhou, Yinjie Zhang, Hongchang Zhang, Wei Zhang, Siyuan Ling, Shuangqing Hu
Summary: In this study, the accumulation and elimination of nonylphenol (NP) in zebrafish were investigated. The results showed that the LC50 values of NP in zebrafish ranged from 474 to 238 μg/L. The depuration stage followed a first-order kinetic model, with a decreased depuration rate constant (K-2) with higher NP concentration. The half-life (t(1/2)) of NP was shorter in the trunk compared to the whole fish, indicating faster elimination from the trunk by preferential transfer and rapid diffusion in reverse. The bioconcentration factors (BCFSS) suggested that muscle tissue was the major site of NP storage.
Article
Environmental Sciences
M. Auguste, M. Leonessi, M. Bozzo, B. Risso, L. Cutroneo, S. Prandi, A. Jemec Kokalj, D. Drobne, L. Canesi
Summary: This study investigated the effects of polyester microfibers (MF) on mussels. The results showed that MF exposure can induce immune and antioxidant responses in mussels and lead to histopathological changes. MF accumulation was higher in the digestive gland and gills, with shorter MF being selectively accumulated. In conclusion, polyester MF at environmental exposure levels have a significant impact on mussel physiology.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Yuan Mei, Kaijun Wu
Summary: This paper constructs a complete framework for compound selection, including feature selection, relationship mapping, and multi-objective optimization problem solving. It proposes a feature selection method based on unsupervised spectral clustering to select more comprehensive features, uses the CatBoost algorithm for relationship mapping, and improves the AGE-MOEA algorithm for multi-objective optimization, achieving better prediction and search performance.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Elena Gomez, Clothilde Boillot, Maria Jesus Martinez Bueno, Dominique Munaron, Olivier Mathieu, Frederique Courant, Helene Fenet
Summary: This study evaluated the in vivo bioconcentration of the antidepressant venlafaxine (VLF) in marine mussels over a 7-day exposure period, showing significant accumulation, first-order kinetics process, and active metabolism and excretion. Results encourage further research on the metabolism and disturbances linked to VLF bioconcentration in bivalves.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Fatme Merhabi, Elena Gomez, Helmieh Amine, David Rosain, Jalal Halwani, Helene Fenet
Summary: The Kadicha river basin in Northern Lebanon is a small coastal river facing multiple pressures due to rapid urbanization, population growth, and poor wastewater treatment. The study found various contaminants accumulating in the sediment, with polycyclic aromatic hydrocarbons (PAHs) and polycyclic musks showing the highest concentrations. The upstream urbanized area and estuary were identified as the most contaminated areas, with an environmental risk assessment indicating potential risks to benthic species from both legacy and emerging compounds.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Thibaut Dumas, Frederique Courant, Christine Almunia, Julien Boccard, David Rosain, Geoffroy Duporte, Jean Armengaud, Helene Fenet, Elena Gomez
Summary: The study revealed the potential molecular mechanisms of carbamazepine toxicity on mussels, including metabolic rewiring, cellular stress, autophagy induction, programmed cell death, and modulation of apoptotic cognate proteins. Integrative metabolomics and proteogenomics approaches were highly relevant in identifying these regulatory processes.
Article
Environmental Sciences
Nieves R. Colas-Ruiz, Gaelle Ramirez, Frederique Courant, Elena Gomez, Miriam Hampel, Pablo A. Lara-Martin
Summary: Sulisobenzone (BP-4) is a commonly detected UV filter in aquatic ecosystems with suspected endocrine disrupting effects. Exposure to environmentally relevant concentrations of BP-4 in gilt-head sea bream resulted in disruption of energy and lipid metabolism, oxidative stress, and impacts on enzymes involved in steroid and thyroid hormones biosynthesis. This integrated multiomic approach highlights additional modes of action of BP-4 that may have been overlooked by traditional single omic methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Thibaut Dumas, Frederique Courant, Helene Fenet, Elena Gomez
Summary: This article discusses the current state and challenges of using environmental metabolomics to address ecotoxicological issues. The authors highlight the potential of this approach in elucidating contaminant mechanisms of action and developing biomarkers, particularly when combined with other omics approaches. The importance of linking molecular effects to adverse outcomes and the construction of adverse outcome pathways is also emphasized. The article concludes with recommendations to fully harness the advantages of environmental metabolomics.
Article
Environmental Sciences
Lucie Bouly, Frederique Courant, Elsa Bonnafe, Jean-Luc Carayon, Jean-Michel Malgouyres, Caroline Vignet, Elena Gomez, Florence Geret, Helene Fenet
Summary: Pharmaceutical substances released into the environment are emerging contaminants in aquatic systems. This study focused on the long-term effects of diclofenac (DCF) on freshwater gastropods. The findings showed that DCF impaired shell growth and feeding behavior, and may disrupt the immune system, energy metabolism, osmoregulation, and redox balance. Additionally, DCF exposure could potentially inhibit prostaglandin synthesis. The use of multiple approaches provided comprehensive insights into the effects of DCF on freshwater organisms.
Article
Marine & Freshwater Biology
Elise Lacoste, Beatrice Bec, Patrik Le Gall, Fehmi Boufahja, Patrick Raimbault, Gregory Messiaen, Vincent Ouisse, Emmanuelle Roque d'Orbcastel, Dominique Munaron, Annie Fiandrino, Franck Lagarde, Sebastien Mas, Myriam Callier, Nabila Gaertner-Mazouni, Marion Richard
Summary: The study showed that juvenile oysters have an impact on the water column, but do not significantly affect the benthic interface in low water temperature conditions. A multivariate approach supported the influence of juvenile oysters on the water column and revealed distinct differences in benthic conditions between farming areas and reference sites.
ESTUARINE COASTAL AND SHELF SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Gaelle Ramirez, Elena Gomez, Thibaut Dumas, David Rosain, Olivier Mathieu, Helene Fenet, Frederique Courant
Summary: This study assessed the metabolome of Mediterranean mussels exposed to the antidepressant venlafaxine, and found that multiple metabolites were modulated, with serotonin showing a similar modulation pattern in both male and female mussels. The modulation pattern of impacted metabolites varied over time and was gender-specific.
Article
Environmental Sciences
Lucie Bouly, Helene Fenet, Jean-Luc Carayon, Elena Gomez, Florence Geret, Frederique Courant
Summary: This study investigated the metabolites formed in Lymnaea stagnalis freshwater snails exposed to diclofenac. The results revealed that hydroxylation and glucosidation were the main detoxification pathways for diclofenac in L. stagnalis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Nieves R. Colas-Ruiz, Frederique Courant, Elena Gomez, Pablo A. Lara-Martin, Miriam Hampel
Summary: In this study, an integrated metabolomic and transcriptomic approach was used to investigate the adverse effects of DEET exposure in marine fish. The results showed that DEET exposure led to energy depletion, oxidative stress, DNA damage, lipid peroxidation, cell membrane damage, apoptosis, as well as activation of xenobiotic pathway and immune-inflammatory reaction.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Lea James, Elena Gomez, Gaelle Ramirez, Thibaut Dumas, Frederique Courant
Summary: This study aimed to investigate the metabolites of different functional tissues of Mediterranean mussels and analyze the molecular effects of chemical exposure. Metabolic fingerprints were obtained through liquid chromatography high-resolution mass spectrometry and 110 metabolites were identified. Clear gender differences were observed in the gonads and digestive glands, highlighting the importance of selecting appropriate tissues and genders to study the impact of contamination on metabolism.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2023)
Article
Environmental Sciences
Dominique Munaron, Bastien Merigot, Valerie Derolez, Nathalie Tapie, Helene Budzinski, Annie Fiandrino
Summary: This study assessed the risk of pesticide mixtures in lagoon waters using integrative passive samplers and concentration addition toxicological models. The findings revealed varying compositions and concentrations of dissolved pesticides over the year, with certain substances and transformation products posing a chronic toxicity risk for phytoplankton, crustaceans, and fish. The study suggests a need to review the current EU Water Framework Directive's risk-assessment method.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Cristina Valhondo, Geoffroy Duporte, Gaelle Cabaret, David Rosain, Elena Gomez, Linda Luquot
Summary: We assessed the feasibility of using clay, zeolite, biochar, compost, and woodchips as sustainable materials in a reactive barrier for soil aquifer treatment (SAT) to remove pharmaceutical active compounds (PhACs). Batch experiments revealed that materials with high organic carbon content (biochar, compost, and woodchips) had greater sorption capacity for PhACs compared to materials with low organic carbon content (clay and zeolite). The ion speciation of the molecules played a crucial role in the fate and transport of PhACs during SAT, with anionic species being at higher risk of reaching the aquifer due to their lower sorption compared to cationic and neutral species. Factors such as contact time, solid:water ratio, and grain size had no significant impact on PhACs sorption in the studied materials. Incorporating biochar, compost, and/or woodchips into reactive barriers can enhance PhACs sorption and improve the quality of recharged water in the SAT system.
Article
Environmental Sciences
Stephane Pesce, Laure Mamy, Wilfried Sanchez, Marcel Amichot, Joan Artigas, Stephanie Aviron, Carole Barthelemy, Remy Beaudouin, Carole Bedos, Annette Berard, Philippe Berny, Cedric Bertrand, Colette Bertrand, Stephane Betoulle, Eve Bureau-Point, Sandrine Charles, Arnaud Chaumot, Bruno Chauvel, Michael Coeurdassier, Marie-France Corio-Costet, Marie-Agnes Coutellec, Olivier Crouzet, Isabelle Doussan, Juliette Fabure, Clementine Fritsch, Nicola Gallai, Patrice Gonzalez, Veronique Gouy, Mickael Hedde, Alexandra Langlais, Fabrice Le Bellec, Christophe Leboulanger, Christelle Margoum, Fabrice Martin-Laurent, Remi Mongruel, Soizic Morin, Christian Mougin, Dominique Munaron, Sylvie Nelieu, Celine Pelosi, Magali Rault, Sergi Sabater, Sabine Stachowski-Haberkorn, Elliott Sucre, Marielle Thomas, Julien Tournebize, Sophie Leenhardt
Summary: Preserving biodiversity and ecosystem services is crucial for sustainable development and human well-being. However, the use of plant protection products (PPP) has led to an alarming decline in biodiversity. A scientific assessment was conducted by a panel of experts, exploring the impacts of PPP on biodiversity and ecosystem services. The assessment revealed that PPP contaminates various environmental matrices and has clear ecotoxicological effects, causing the decline of certain biological groups and altering ecosystem functions and services. The study suggests local actions and regulatory improvements to mitigate PPP-driven pollution, but highlights the need for further research to understand its full impact.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Chan Li, Vincent Goetz, Serge Chiron
Summary: This study demonstrated the effective degradation of phenol and antibiotics in water using the CuO/PDS system, with Cu(III) and O·2- playing key roles in the process. The reduction and oxidation reactions involving copper in the system led to stable catalytic degradation of contaminants, with minimal leaching of copper from CuO observed in wastewater.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)