Editorial Material
Psychiatry
Julia Jiyeon Woo, Emma van Reekum, Sagnik Bhattacharyya, Zainab Samaan
Summary: Despite limited evidence, cannabinoids are commonly perceived as safe and effective for improving mental health. This article discusses the reasons why patients find cannabinoids compelling and provides strategies for psychiatrists to counsel and educate patients on the available evidence.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Amy M. Inkster, Iciar Fernandez-Boyano, Wendy P. Robinson
Summary: Sex differences in perinatal complications, influenced by gene expression and gonadal steroid hormones, play a significant role in placental function and pregnancy outcomes. Consideration of sex differences is important when developing diagnostic or risk prediction tools for such complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Oncology
Christopher J. Bergin, Amanda Mendes da Silva, Yannick D. Benoit
Summary: The incidence of colorectal cancer has been increasing in young adults, suggesting the involvement of environmental risk factors. Recent research has found that there is an increase in the transposition frequency of LINE1 in colonic epithelium, which is important for understanding the transposition mechanism and potential therapeutic avenues for colorectal cancer.
Editorial Material
Biochemistry & Molecular Biology
Hagar F. Moussa, James F. Angstman, Ahmad S. Khalil
Summary: In this issue of Cell, Nunez et al. introduce CRISPRoff, a programmable epigenetic memory writer that establishes specific gene silencing programs stably maintained across cell division and differentiation. The singular dCas9 fusion provides a simple, reliable, and general tool for genome-wide screens, multiplexed editing, and potential therapeutics.
News Item
Multidisciplinary Sciences
Nicky Phillips
Summary: Scientists expect the virus that causes COVID-19 to become endemic and pose less danger over time, according to a Nature survey.
Article
Social Issues
Henrik Skaug Saetra
Summary: Generative AI has significantly influenced society and it is important to consider the potential harms and effects on different levels of society.
TECHNOLOGY IN SOCIETY
(2023)
Review
Environmental Sciences
Yue Zhang, Junhong Xie, Yixin Ouyang, Shuang Li, Yulin Sun, Weilun Tan, Lihua Ren, Xianqing Zhou
Summary: This review summarizes the research status of PBDEs-induced male reproductive toxicity and its mechanisms at various levels. The study found that reactive oxygen species production, disruptions of estrogen receptor-alpha and antagonism of androgen receptor were defined as critical molecular initiating events, leading to a series of adverse outcomes at the molecular and cellular levels and then affecting the tissue or organ levels, ultimately impacting male reproductive functions.
ENVIRONMENTAL RESEARCH
(2024)
Review
Gastroenterology & Hepatology
Claudio Fiocchi, Dimitrios Iliopoulos
Summary: Systems biology is a rapidly advancing field that offers new insights into disease mechanisms, patient diagnosis, and drug development. By integrating omics-derived big data to identify biological networks and develop specific blockers, systems biology has the potential to revolutionize therapeutic strategies for complex diseases like IBD. Although still in its early stages, the implementation of systems biology in IBD research holds great promise for advancing our understanding and improving patient outcomes.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Environmental Sciences
Xiaoqing Wang, Fei Li, Yuefa Teng, Chenglong Ji, Huifeng Wu
Summary: Data-driven analysis and pathway-based approaches are important for efficient toxicity research of organophosphate esters (OPEs). The widespread usage of OPEs poses potential risks to the environment and human health, but their adverse effects and toxicity mechanisms have not been fully assessed. By analyzing and evaluating the toxicity pathways and effects of different OPEs, better risk assessment and management can be achieved.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Kevin Brix, Gudrun De Boeck, Stijn Baken, Douglas J. Fort
Summary: This review synthesized information on chronic copper toxicity, identifying disruption of sodium homeostasis, effects on bioenergetics, and oxidative stress as primary pathways. Oxidative stress is likely the main driver of chronic Cu toxicity in aquatic vertebrates.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Engineering, Environmental
Lanpeng Yang, Jing Zeng, Ning Gao, Lin Zhu, Jianfeng Feng
Summary: The study demonstrates that the strong bioaccumulation of Cu compared to Cd leads to faster accumulation of Cu in zebrafish larvae, resulting in higher toxicity. The parameter C-IT/BCF is proposed to help understand toxicity differences by combining bioaccumulation and internal threshold information. The research highlights the importance of qAOP as an effective quantitative tool for understanding metal toxicity mechanisms.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Dragica Bozic, Katarina Zivancevic, Katarina Baralic, Evica Antonijevic Miljakovic, Aleksandra Buha Djordjevic, Marijana Curcic, Zorica Bulat, Biljana Antonijevic, Danijela Dukic-Cosic
Summary: This study aimed to generate SFN-triggered adverse outcome pathway (AOP) by examining the relationship between SFN chemical structure and its toxicity, as well as SFN-gene interactions. The study found that SFN may cause chromosomal damage, skin sensitization, and bacterial mutagenicity. Gene interaction analysis revealed connections between SFN and chromosomal damage and skin diseases. Network analysis showed the involvement of these genes in broader networks. Overall, SFN is implicated in adverse outcomes, particularly chromosomal damage and skin diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Engineering, Environmental
Rebecca A. L. Roe, Richard Man Kit Yu, Mohammad Mahmudur Rahman, Geoff R. MacFarlane
Summary: Anthropogenic metal pollution poses a significant threat to saltmarsh ecosystems, impacting halophytes at transcriptomic, proteomic, and metabolomic levels. Developing reliable adverse outcome pathways (AOPs) based on molecular and biological markers is crucial to predicting the broader ecological effects of metal pollution.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Multidisciplinary Sciences
Laura Aliisa Saarimaki, Michele Fratello, Alisa Pavel, Seela Korpilahde, Jenni Leppanen, Angela Serra, Dario Greco
Summary: Adverse outcome pathways (AOPs) serve as a central framework in modern toxicology and biomedicine, depicting biological mechanisms as causally linked sequences of key events (KEs). AOPs guide the development of new approaches and reduction in animal experimentation, and integrating them with toxicogenomics enables better interpretation of molecular mechanisms. Through rigorous curation, we have established a link between AOPs and molecular data interpretation, paving the way for new knowledge in biomedicine.
Article
Environmental Sciences
Yiling Ge, Sheng Yang, Tianyi Zhang, Xin Wan, Yuxin Zhu, Fei Yang, Lihong Yin, Yuepu Pu, Geyu Liang
Summary: Plastic pollution has become a global problem, leading to the accumulation of micro/nanoplastics in the environment and human exposure to these particles. This study reviewed the literature on the hepatotoxicity of micro/nanoplastics and developed an Adverse Outcome Pathway (AOP) framework to understand the mechanism and potential health risks. Additionally, the study discussed the application of emerging toxicological models such as liver organoids and liver-on-chips for toxicity testing and risk assessment of micro/nanoplastics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)