Article
Environmental Sciences
Regiane Natumi, Sandro Marcotullio, Elisabeth M. -L. Janssen
Summary: The study examined the photochemical fate of various cyanopeptides extracted from different strains of cyanobacteria. It was found that cyanopeptides from Dolichospermum flos aquae and Planktothrix rubescens had higher removal rates after sunlight exposure compared to those from Microcystis aeruginosa strains. The more reactive cyanopeptides contained amino acids known to undergo phototransformation, and their photochemical half-lives were affected by pH levels.
ENVIRONMENTAL SCIENCES EUROPE
(2021)
Article
Environmental Sciences
Luca Carena, Andrea Scozzaro, Monica Romagnoli, Marco Pazzi, Luca Martone, Claudio Minero, Marco Minella, Davide Vione
Summary: The fungicide tebuconazole (TBCZ) can be degraded by indirect photochemistry in sunlit surface waters, with the potential to decrease its environmental impact.
Article
Engineering, Environmental
Regiane Natumi, Christoph Dieziger, Elisabeth M-L Janssen
Summary: This study investigated the reaction of 30 cyanopeptides with photochemically produced singlet oxygen, finding that 18 of them were easily degraded under the influence of pH. The study indicates that singlet oxygen plays a significant role in the indirect phototransformation of cyanopeptides and the presence of tyrosine moieties can affect the second-order rate constants.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Webber Wei-Po Lai, Chia-Hsun Tien, Zih-Syuan Tang
Summary: In this study, the efficiency of UV/peracetic acid (UV/PAA) treatment for the removal of 5-fluorouracil and cyclophosphamide was investigated. The results showed that UV/PAA could efficiently remove these two drugs within 20 min. The study also examined the influence of various factors on the removal process and proposed possible degradation pathways for the byproducts formed. The UV/PAA treatment demonstrated good applicability in the removal of these compounds from real water samples.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Cell Biology
Sophie M. Poznanski, Kanwaldeep Singh, Tyrah M. Ritchie, Jennifer A. Aguiar, Isabella Y. Fan, Ana L. Portillo, Eduardo A. Rojas, Fatemeh Vahedi, Abdullah El-Sayes, Sansi Xing, Martin Butcher, Yu Lu, Andrew C. Doxey, Jonathan D. Schertzer, Hal W. Hirte, Ali A. Ashkar
Summary: NK cells play a central role in anti-tumor immunity, but their dysfunction in the tumor microenvironment is a major barrier for cancer immunotherapies. Research showed that human NK cell dysfunction in the tumor microenvironment is caused by suppression of glucose metabolism, and activating the antioxidant pathway can restore NK cell function and enhance anti-tumor activity. Additionally, expanded NK cells with metabolic flexibility not only sustained metabolic fitness but also improved tumor killing in response to nutrient deprivation, showing the potential for exploiting metabolic flexibility in cancer immunotherapy.
Article
Biochemistry & Molecular Biology
Chow-Seng Kong, Alexandra Almansa Ordonez, Sarah Turner, Tina Tremaine, Joanne Muter, Emma S. Lucas, Emma Salisbury, Rita Vassena, Gustavo Tiscornia, Ali A. Fouladi-Nashta, Geraldine Hartshorne, Jan J. Brosens, Paul J. Brighton
Summary: The study found that uterine natural killer cells play a crucial role in embryo biosensing and implantation process, highlighting their importance in selectively eliminating senescent decidual cells.
Article
Multidisciplinary Sciences
Yi Luan, Seok-Yeong Yu, Amirhossein Abazarikia, Rosemary Dong, So-Youn Kim
Summary: Cyclophosphamide and doxorubicin cause premature ovarian insufficiency, and this study clarifies the mechanism behind it. Dormant oocytes are more sensitive to cyclophosphamide, and TAp63 plays a pivotal role in oocyte death induced by cyclophosphamide and doxorubicin, contrary to previous reports.
Article
Environmental Sciences
Andrej Grobin, Robert Roskar, Jurij Trontelj
Summary: This study measured the concentrations of a group of hormonal compounds in water and evaluated the removal efficiency of wastewater treatment plants (WWTPs). The results showed that the concentrations of hormonal compounds in water were influenced by the removal efficiency of WWTPs, and there might be other sources of contamination. Most of the hormonal compounds were effectively removed, but improvement of removal techniques is still needed. The compounds E2 and EE2 contributed the most to the total endocrine disruptor risk. A comprehensive risk assessment determined high risk values for several compounds in water.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Review
Biochemistry & Molecular Biology
Christa Corley, Antino R. Allen
Summary: Inflammation is considered a potential mechanism behind long-term cognitive dysfunction after chemotherapy, with CMF chemotherapy being an early method for treating breast cancer. As interest in the relationship between inflammation, CMF, and cognitive dysfunction grows over time, terms related to inflammation and breast cancer were prevalent throughout the three decades.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Environmental Sciences
Xuan Jia, Lushi Lian, Shuwen Yan, Yue Song, Jianxin Nie, Xiangdong Zhu, Weihua Song
Summary: The study found that the triplet excited state of DOM played a crucial role in the photo-transformation of MLs, and LC-HRMS was used to identify the transformation products of MLs. Demethylation and hydroxylation were identified as the main reactions during the phototransformation of MLs.
Article
Engineering, Environmental
Xiaofan Li, Guochun Lv, Ning Wang, Xiaomin Sun, Xiang Li, Mei Li
Summary: This study investigates the mechanism and kinetics of the degradation of non-biodegradable 5-Fluorouracil (5-FU) in aquatic systems using computational chemistry methods. The results show that 5-FU can be rapidly degraded by oxidants O-3 and middotOH, forming various transformation products. The toxicity assessment reveals a decrease in toxic effects on aquatic organisms, but developmental toxicity and mutagenicity still exist in some products.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Medicine, Research & Experimental
Lamis I. Alotayk, Maha A. Aldubayan, Sattam K. Alenezi, Md Jamir Anwar, Ahmad H. Alhowail
Summary: Chemotherapeutic agents commonly used for treating various cancers often lead to chemobrain, which is characterized by difficulties in learning and memory processes that can persist for years. This study used a rat model of neuroinflammation to evaluate cognitive function after treatment with these agents and assess the possible involvement of thyroid toxicity in chemotherapy-induced cognitive dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Pyunggang Kim, Jinah Park, Dong-Joon Lee, Seiya Mizuno, Masahiro Shinohara, Chang Pyo Hong, Yealeen Jeong, Rebecca Yun, Hyeyeon Park, Sujin Park, Kyung-Min Yang, Min-Jung Lee, Seung Pil Jang, Hyun-Yi Kim, Seung-Jun Lee, Sun U. Song, Kyung-Soon Park, Mikako Tanaka, Hayato Ohshima, Jin Won Cho, Fumihiro Sugiyama, Satoru Takahashi, Han-Sung Jung, Seong-Jin Kim
Summary: This study reveals the important roles of TGF-beta and Wnt signaling pathways in regulating differentiation of MSC into cartilage and bone, respectively, and the essential involvement of Mast4 as a mediator in these processes. TGF-beta inhibits Mast4 to enhance chondrogenesis of MSC by stabilizing Sox9, while Wnt stabilizes Mast4 to promote osteogenesis of MSC by facilitating β-catenin nuclear localization and Runx2 activity.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
D. Scott Smith, R. Nasir, Wayne Parker, A. Peters, G. Merrington, R. van Egmond, S. Lofts
Summary: The study compared WHAM predictions with measured ionic silver in diverse DOM, capturing the variability within model uncertainty. WHAM significantly underestimated silver binding in sewage samples, proposing a revised empirical model to account for sewage-specific binding sites. It is suggested that as sewage organic matter degrades, WHAM may better model the form.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Davide Vione, Fernando L. Rosario-Ortiz
Summary: Cyanobacteria dominate water environments and can cause harmful algal blooms with toxic effects. Climate change is expected to increase the frequency of harmful algal blooms, impacting water quality and public health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Ming-Chi Hsieh, Webber Wei-Po Lai, Angela Yu-Chen Lin
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Engineering, Environmental
Erich T. Hester, Angela Y-C Lin, Christina W. Tsai
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Engineering, Environmental
Ta-Chih Hsiao, Angela Yu-Chen Lin, Wan-Chien Lien, Yen-Ching Lin
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Engineering, Environmental
Yen-Ching Lin, Ta-Chih Hsiao, Angela Yu-Chen Lin
Article
Engineering, Environmental
Jheng-Sian Yang, Webber Wei-Po Lai, Sri Chandana Panchangam, Angela Yu-Chen Lin
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Environmental Sciences
Webber Wei-Po Lai, Kuen-Lin Chen, Angela Yu-Chen Lin
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Sung-Chuan Hsieh, Webber Wei-Po Lai, Angela Yu-Chen Lin
Summary: The combination of UV light and persulfate can significantly remove 4-MBC, with a pseudo-first-order rate constant. The persulfate dose and k(obs) exhibited a linear proportional relationship, and the degradation rate significantly decreased at pH 9.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Microbiology
Wei-Kai Wu, Suraphan Panyod, Po-Yu Liu, Chieh-Chang Chen, Hsien-Li Kao, Hsiao-Li Chuang, Ying-Hsien Chen, Hsin-Bai Zou, Han-Chun Kuo, Ching-Hua Kuo, Ben-Yang Liao, Tina H. T. Chiu, Ching-Hu Chung, Angela Yu-Chen Lin, Yi-Chia Lee, Sen-Lin Tang, Jin-Town Wang, Yu-Wei Wu, Cheng-Chih Hsu, Lee-Yan Sheen, Alexander N. Orekhov, Ming-Shiang Wu
Article
Environmental Sciences
Hsin-Yu Hsiao, Hank Hui-Hsiang Lin, Jheng-Sian Yang, Ming-Chi Hsieh, Pei-Hsun Wu, Chang-Ping Yu, Angela Yu-Chen Lin
Summary: Algal substances can accelerate the photodegradation of pharmaceuticals under sunlight irradiation, with different drugs exhibiting varying photodegradation mechanisms based on their chemical composition.
Article
Engineering, Environmental
Hank Hui-Hsiang Lin, Angela Yu-Chen Lin
Summary: Cytostatic drugs are commonly found in wastewater effluents due to their poor biodegradability, but the Fe(III)-EDDS complex has shown to efficiently degrade cyclophosphamide and 5-fluorouracil under solar light. The addition of EDDS widens the operational pH range of the solar photo-Fenton process, and a suitable Fe(III):EDDS ratio and initial dissolved oxygen level impact the degradation performance. Rapid degradation of the drugs was achieved within 1.5 minutes in the solar photo-Fenton process, with potential for total mineralization under relatively low Fe(III) concentration and H2O2 dosage.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Article
Engineering, Environmental
Jheng-Sian Yang, Webber Wei-Po Lai, Angela Yu-Chen Lin
Summary: This study successfully fabricated a GOTiO2 photoelectrode for PFOS degradation in a PEC system, demonstrating efficient removal of PFOS and identifying new degradation pathways and byproducts including PFSAs, PFALs, and HFCs. The study also showed that shorter-chain PFAAs exhibit lower degradation rates and stronger competitive inhibition in a mixture system.
Article
Environmental Sciences
Hui-Ju Wang, Hank Hui-Hsiang Lin, Ming-Chi Hsieh, Angela Yu-Chen Lin
Summary: This study investigated the effects of aged microplastics on the photodegradation of coexisting pharmaceuticals and found that aged polystyrene microplastics can enhance the photodegradation of cimetidine. The enhancement is related to the increase in chromophoric oxygenated groups and the formation of environmentally persistent free radicals.
Article
Environmental Sciences
Zhen-Shuen Choo, Ming-Chi Hsieh, Hank Hui-Hsiang Lin, Jheng-Sian Yang, Angela Yu-Chen Lin
Summary: This study investigates the enhanced degradation of BT and 5-MeBT during the sunlight/free chlorine process. The results show that sunlight/free chlorine treatment can enhance the degradation of BT and 5-MeBT, especially under alkaline conditions. The enhanced removal is attributed to the generation of HO • and reactive chlorine species (RCSs).
Article
Chemistry, Multidisciplinary
Kuan-Yu Chen, Webber Wei-Po Lai, Hui-Ju Wang, Cheng-Chieh Lin, Chun-Wei Chen, Angela Yu-Chen Lin
Summary: Solar distillation technology using an interfacial evaporation device with activated carbon, P25 TiO2, and polyethylene foam showed significant improvements in evaporation rate, stability, and efficiency for clean water generation. The device demonstrated the ability to effectively remove volatile organic compounds and desalinate water, making it a practical and feasible solution for clean water production.
Article
Chemistry, Analytical
Yu-Jung Tseng, Webber Wei-Po Lai, Hsin-hsin Tung, Angela Yu-Chen Lin
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2020)