期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 46, 期 14, 页码 7746-7754出版社
AMER CHEMICAL SOC
DOI: 10.1021/es203490f
关键词
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资金
- Foundation of the State Key Laboratory of Pollution Control and Resource Reuse, China [PCRRK09003, PCRRY11003]
- National Natural Science Foundation of China [20977067, 201177092]
- New Century Excellent Talents in University [20100472]
- Specialized Research Fund for the Doctoral Program of Higher Education [20100072110034985]
- Fundamental Research Funds for the Central Universities [0400219181]
During the past two decades, the phenomenon of hormesis has gained increasing recognition in environmental and toxicological communities. However, the mechanistic understanding of hormesis, to date, is extremely limited. Herein is proposed a novel parametric model with a mechanistic basis and two model based parameters for hormesis that was successfully applied to the hormetic dose-response observed in the chronic toxicity of sulfonamides on Photobacterium phosphoreum On the basis of the methods of molecular docking and quantitative structure-activity relationships (QSARs), we proposed a mechanistic hypothesis for hormesis that introduces for the first time the concept of quorum sensing in toxicological studies and explains the mechanism at the level of the receptors. The mechanistic hypothesis stated that (1) specific target binding like interaction with LuxR may contribute to transcriptional activation leading to enhanced luciferase activity at low dose exposure of sulfonamides, and (2) as the dose of sulfonamides increases, more sulfonamides competitively bind to dihydropteroate synthase, which inhibit the biosynthesis of folic acid and thus provoke toxicity. This mechanistic hypothesis, which explains both the dose dependent and time-dependent features of hormesis, could give new insight into the mechanistic study of hormesis.
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