期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 46, 期 3, 页码 1811-1818出版社
AMER CHEMICAL SOC
DOI: 10.1021/es202625r
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资金
- Major State Basic Research Development Program [2008CB418102]
- National Natural Science Foundation of P. R. China [20737001]
- Science Foundation in Jiangsu Province [BK2011032]
- Program for Postgraduates Research and Innovation in Jiangsu Province [CX10B_022Z]
- Shanghai Tongji Gao Tingyao Environmental Science & Technology Development Foundation
- Canada Research Chair program
- Department of Biology and Chemistry
- State Key Laboratory in Marine Pollution
- City University of Hong Kong
- Chinese Academy of Sciences
- King Saud University, Riyadh, Saudi Arabia
Thyroid hormone is essential for the development of humans. However, some synthetic chemicals with thyroid disrupting potentials are detectable in drinking water. This study investigated the presence of thyroid active chemicals and their toxicity potential in drinking water from five cities in eastern China by use of an in vitro CV-1 cell-based reporter gene assay. Waters were examined from several phases of drinking water processing, including source water, finished water from waterworks, tap water, and boiled tap water. To identify the responsible compounds, concentrations and toxic equivalents of a list of phthalate esters were quantitatively determined. None of the extracts exhibited thyroid receptor (TR) agonist activity. Most of the water samples exhibited TR antagonistic activities. None of the boiled water displayed the TR antagonistic activity. Dibutyl phthalate accounted for 84.0-98.1% of the antagonist equivalents in water sources, while diisobutyl phthalate, di-n-octyl phthalate and di-2-ethylhexyl phthalate also contributed. Approximately 90% of phthalate esters and TR antagonistic activities were removable by waterworks treatment processes, including filtration, coagulation, aerobic biodegradation, chlorination, and ozonation. Boiling water effectively removed phthalate esters from tap water. Thus, this process was recommended to local residents to reduce certain potential thyroid related risks through drinking water.
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