Article
Chemistry, Multidisciplinary
Tsutomu Ohtsuki, Aaditya Manjanath, Kaoru Ohno, Makoto Inagaki, Shun Sekimoto, Yoshiyuki Kawazoe
Summary: Through nuclear reactions, the formation of middle- and/or high-weight atom-incorporated fullerenes was investigated. Experimental results showed that radionuclides can be stably encapsulated by fullerenes, potentially playing a valuable role in diagnostic nuclear medicine.
Review
Biochemistry & Molecular Biology
Joanne Saldanha, Julie Rageul, Jinal A. Patel, Hyungjin Kim
Summary: DNA replication is a tightly controlled process that ensures the faithful duplication of the genome. DNA damage, both endogenous and exogenous, can cause replication stress, which needs to be protected and repaired to maintain genomic integrity and cell survival. The plasticity of the replication fork and the activation of the ATR kinase play crucial roles in overcoming replication obstacles and coordinating cellular responses to replication stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Erin Bonnell, Emeline Pasquier, Raymund J. Wellinger
Summary: Telomeres, crucial for maintaining genomic stability, pose challenges for replication due to their repetitive nature and the formation of secondary structures, leading to replication fork stalling. Multiple mechanisms are involved in overcoming these obstacles to ensure efficient telomeric DNA duplication and preserve genome integrity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Bo Peng
Summary: Using first-principles calculations, it is found that the stability of quasi-tetragonal two-dimensional fullerene networks is not as expected, while the quasi-hexagonal phase exhibits relatively high stability. The high stability of the quasi-hexagonal phase is attributed to the strong covalent C-C bonds that tightly hold the linked C60 clusters together, allowing for a closely packed hexagonal network.
Editorial Material
Biochemistry & Molecular Biology
Jason A. Halliwell, Eva R. Hoffmann
Summary: The study reveals evolutionary conservation between replication timing and meiotic recombination in males through mapping replication origins directly in mammalian tissue for the first time. This provides new insights into understanding germ cell formation.
Review
Oncology
Jonathan J. Morgan, Lisa J. Crawford
Summary: This article examines the importance of genomic stability in tumour development and the role of ubiquitination in maintaining genome integrity. Faithful DNA replication during cell division is crucial for genome stability, and dysregulation of the UPS may contribute to cancer progression.
Article
Biochemistry & Molecular Biology
Sophie L. Williams, Corella S. Casas-Delucchi, Federica Raguseo, Dilek Guneri, Yunxuan Li, Masashi Minamino, Emma E. Fletcher, Joseph T. P. Yeeles, Ulrich F. Keyser, Zoe A. E. Waller, Marco Di Antonio, Gideon Coster
Summary: This study investigates the effects of physiological quadruplex secondary structures on genome stability by reconstituting eukaryotic DNA replication in vitro. G-quadruplexes (G4s) and intercalated Motifs (iMs) are found to form during replication and thereby induce replisome stalling, leading to helicase-polymerase uncoupling and nascent DNA breakage. A single physiological G4 or iM structure stalls the eukaryotic replisome by inhibiting leading strand synthesis. Helicase-polymerase uncoupling occurs following replication stalling at G4s. iMs can induce breakage on nascent DNA. Stalled forks at G4s or iMs can be rescued by the accessory helicase Pif1. In vitro reconstitution shows that a single physiological G4 or iM secondary structure stalls the eukaryotic replisome by inhibiting leading strand synthesis.
Article
Cell Biology
Rachel A. Hoffman, Heather K. MacAlpine, David M. MacAlpine
Summary: This study provides insights into helicase activation within origin chromatin and its regulation in the absence of DNA replication. Activation of the helicase disrupts and disorganizes chromatin, extending up to 1 kb from early replication origins. The local sequence context plays a role in regulating helicase progression when uncoupled from replication.
GENES & DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Barbara Ben Yamin, Sana Ahmed-Seghir, Junya Tomida, Emmanuelle Despras, Caroline Pouvelle, Andrey Yurchenko, Jordane Goulas, Raphael Corre, Quentin Delacour, Nathalie Droin, Philippe Dessen, Didier Goidin, Sabine S. Lange, Sarita Bhetawal, Maria Teresa Mitjavila-Garcia, Giuseppe Baldacci, Sergey Nikolaev, Jean Charles Cadoret, Richard D. Wood, Patricia L. Kannouche
Summary: The study highlights the crucial role of DNA polymerase zeta in bypassing DNA damage and cell proliferation, as well as the significance of REV3L's interactions with heterochromatin components in maintaining chromosome stability.
Article
Multidisciplinary Sciences
Xingxuan Wu, Shibin Xu, Peipei Wang, Zhao-Qi Wang, Hongxiang Chen, Xingzhi Xu, Bin Peng
Summary: ASPM plays a dispensable role in DNA replication but is enriched at stalled replication forks under replication stress. It promotes the loading of RAD9 and TopBP1 onto chromatin, facilitating ATR-CHK1 activation and ensuring genome stability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Valentina Rossio, Joao A. Paulo, Joel Chick, Bradley Brasher, Steven P. Gygi, Randall W. King
Summary: This study involves chemically inhibiting multiple DUBs to identify DUB substrates and characterize their specificity, overcoming challenges posed by DUB redundancy. USP7 is found to have a unique ability to broadly antagonize degradation.
CELL CHEMICAL BIOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Ilona Faustova, Mart Loog
Summary: Study by Hossain et al. (2021) reveals that ORC1 and CDC6 interact during pre-replicative complex formation in G1, mediated by SLiMs in IDRs and regulated by CDKs.
Article
Pharmacology & Pharmacy
Yasaman Najibzade, Enayatollah Sheikhhosseini, Mohammad Reza Akhgar, Sayed Ali Ahmadi
Summary: This study focuses on the reactivity characteristics of Tranylcypramine in gas and water phases and its adoption on C60 (ih). DFT B3LYP/6-311+G(d, p) calculations were conducted to determine the chemical structure (dipole momentum), thermodynamic features (Gibbs free energy, enthalpy, entropy, thermal capacity) and electronic parameters (sigma, mu, omega, chi, eta) of Tranylcypramine. Based on the calculations of HOMO and LUMO energy, Tranylcypramine exhibits stability and reactivity. Tranylcypramine has two active sites, both of which show thermodynamic stability.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Cell Biology
Marina A. Bellani, Althaf Shaik, Ishani Majumdar, Chen Ling, Michael M. Seidman
Summary: The replication apparatus faces challenges in duplicating the genome, particularly when encountering covalent DNA adducts on the leading template strand. The helicase, a key component of the replication machinery, is responsible for unwinding DNA and coming into contact with the adducts. Recent studies have shown that the helicase is able to tolerate larger adducts than previously believed.
Article
Substance Abuse
Karen O. Brandon, Christine Vinci, Marloes Kleinjan, Laura M. Hernandez, Leslie E. Sawyer, Steven K. Sutton, Thomas H. Brandon
Summary: The study showed that smoking-related cues presented through AR technology can effectively elicit smoking urges, demonstrating the potential use of AR in exposure therapy.
NICOTINE & TOBACCO RESEARCH
(2021)
Article
Engineering, Environmental
Renwu Zhou, Rusen Zhou, David Alam, Tianqi Zhang, Wenshao Li, Yang Xia, Anne Mai-Prochnow, Hongjie An, Emma C. Lovell, Hassan Masood, Rose Amal, Kostya Ken Ostrikov, Patrick J. Cullen
Summary: The study developed a Plasma Catalytic Bubble Column Reactor to efficiently treat water by delivering oxidative reactive species produced by plasma to the liquid phase. The addition of CeO2 catalysts enhanced the degradation of water contaminants, with improved performance and durability through plasma pre-activation. The integrated system demonstrated superior removal efficiency and kinetic constant compared to individual components, showing potential for water purification.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Pradip Singha, Nhat-Khuong Nguyen, Kamalalayam Rajan Sreejith, Hongjie An, Nam-Trung Nguyen, Chin Hong Ooi
Summary: Liquid marble is a non-wetting droplet coated with micro- or nanometer sized particles, showing potential applications in gas sensing, cell culture, and drug delivery. The thickness of the shell decreases significantly with the surface tension, while the mass remains almost constant. However, with further decrease in surface tension, both the thickness and the mass of the shell increase due to interfacial jamming.
ADVANCED MATERIALS INTERFACES
(2021)
Review
Chemistry, Physical
Beng Hau Tan, Hongjie An, Claus-Dieter Ohl
Summary: The existence and stability of nanoscopic gaseous domains in liquids, known as nanobubbles, have been debated due to classical theory predictions. However, through critical review and experiments, it has been proven that these gaseous domains not only exist but can also survive in liquid environments. Future research directions and unanswered questions remain for further exploration in this field.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Review
Chemistry, Physical
Beng Hau Tan, Hongjie An, Claus-Dieter Ohl
Summary: The passage discusses the characteristics of surface-attached nanobubbles, which are spherical cap-shaped gas bubbles that remain stable in size in saturated liquids. It also summarizes experimental techniques for recording their topography, softness, and chemical composition, as well as how to distinguish them from non-gaseous objects commonly found on surfaces in contact with liquids.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Fariba Malekpour Galogahi, Yong Zhu, Hongjie An, Nam-Trung Nguyen
Summary: This paper reports experimental investigation of flow-focusing microfluidic devices capable of producing size-tuneable and monodisperse core-shell droplets, showing that the microchannel geometry is more significant than flow rates in controlling the droplet size.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Physics, Multidisciplinary
Beng Hau Tan, Claus-Dieter Ohl, Hongjie An
Summary: By studying water and ethanol as solvents and nitrogen as the target species, researchers found that transient solubility gradients play a decisive role in the position of nitrogen on the substrate during solvent exchange.
PHYSICAL REVIEW LETTERS
(2021)
Article
Mechanics
Qingyun Zeng, Hongjie An, Claus-Dieter Ohl
Summary: The study systematically examines the cavitation-induced wall shear stress on rigid boundaries as a function of liquid viscosity and stand-off distance using axisymmetric VoF simulations. The simulations accurately predict the dynamics of bubbles and the liquid film thickness before collapse. The spatial and temporal wall shear stress is analyzed in detail, showing inward stress from shrinking bubbles and outward stress from expanding bubbles and jet spreading.
JOURNAL OF FLUID MECHANICS
(2021)
Review
Biochemical Research Methods
Haotian Cha, Hedieh Fallahi, Yuchen Dai, Dan Yuan, Hongjie An, Nam-Trung Nguyen, Jun Zhang
Summary: Multiphysics microfluidics, which integrates multiple physical processes in a microfluidics platform, aims to overcome the limitations of individual phenomena and offers high precision and real-time tunability for cell manipulation. Reviewing the current research progress can provide insights into the advantages and future directions of multiphysics microfluidics.
Review
Environmental Sciences
Shui Cheung Edgar Leung, Pradeep Shukla, Dechao Chen, Ehsan Eftekhari, Hongjie An, Firuz Zare, Negareh Ghasemi, Dongke Zhang, Nam-Trung Nguyen, Qin Li
Summary: This review article focuses on the degradation methods for perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Various technologies, such as bioremediation, electrocoagulation, foam fractionation, sonolysis, photocatalysis, mechanochemical, and electrochemical degradation, have been developed and studied in recent years to address the PFAS crisis. However, challenges remain in terms of large-scale operation complexity and the release of toxic byproducts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Yuchen Dai, Haotian Cha, Michael J. Simmonds, Hedieh Fallahi, Hongjie An, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang, Antony P. McNamee
Summary: This study investigates the effects of altering fluid viscoelasticity on blood plasma extraction. Poly (ethylene oxide) (PEO) was added to increase blood viscoelasticity, resulting in improved cell focusing performance. The optimal PEO concentration was found to be in the range of 100 to 200 ppm, and the optimal flow rate was determined to be between 1 and 15 mu L/min.
Editorial Material
Physics, Multidisciplinary
Beng Hau Tan, Hongjie An, Claus-Dieter Ohl
PHYSICAL REVIEW LETTERS
(2022)
Article
Chemistry, Analytical
Yuchen Dai, Haotian Cha, Nhat-Khuong Nguyen, Lingxi Ouyang, Fariba Galogahi, Ajeet Singh Yadav, Hongjie An, Jun Zhang, Chin Hong Ooi, Nam-Trung Nguyen
Summary: This study investigated the formation process of double emulsion under a dripping regime in a capillary device through experimental, analytical, and numerical methods. The results showed that mismatches between core and shell droplets can be captured experimentally and numerically. A semi-analytical model was proposed to describe the match ratio and the mismatch issue can be avoided if the ratio is lower than unity. The model with the wall effect predicted the size of the matched double emulsion and showed good agreement with experimental data under certain flow conditions.
Article
Physics, Multidisciplinary
Beng Hau Tan, Hongjie An, Claus -Dieter Ohl
Summary: This article investigates the role of line tension of a three-phase contact line in various interfacial phenomena and finds a significant discrepancy in existing measurements. The research suggests that the discrepancy is mainly caused by the failure of a commonly used estimation method to eliminate body forces, resulting in measured line tensions behaving like extensive quantities.
PHYSICAL REVIEW LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Nhat-Khuong Nguyen, Pradip Singha, Hongjie An, Hoang-Phuong Phan, Nam-Trung Nguyen, Chin Hong Ooi
Summary: This paper explores the use of electrostatic force to induce vibration and deformation in liquid marbles for improved mixing performance. Results demonstrate significant enhancement in mixing performance when they were actuated, with higher electric field strengths further promoting the mixing process. These findings highlight the potential of utilizing liquid marbles as high-performance micromixers through mechanisms of vibration and deformation.
REACTION CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Chin Hong Ooi, Pradip Singha, Nhat-Khuong Nguyen, Hongjie An, Van Thuong Nguyen, Anh Nguyen, Nam-Trung Nguyen
Summary: Liquid marble is a droplet coated with microparticles that isolate the liquid interior, making it non-wetting and able to perform useful tasks. A novel method using X-ray imaging and curve fitting procedures was introduced to measure the effective surface tension of floating liquid marbles, revealing that the surface tension is similar to that of its liquid content. This indicates that the particle coating does not significantly alter the behavior of the liquid interface.
