Article
Environmental Sciences
Shiyu Chen, Zhenzhen Shi, Qiang Zhang
Summary: In this study, a human physiologically based pharmacokinetic (PBPK) model of diethyl phthalate (DEP) was developed to assess its toxicity. The model considers the distribution and metabolism of DEP and its active metabolite monoethyl phthalate (MEP) in different tissue compartments. Sensitivity analysis and Bayesian Markov chain Monte Carlo (MCMC) simulations were performed to evaluate the uncertainty and variability of the model parameters. The results suggest that dermal absorption is an important route of exposure to DEP in the environment.
ENVIRONMENTAL POLLUTION
(2024)
Article
Environmental Sciences
Alexandre N. N. Zerbini, Kimberly T. T. Goetz, Karin A. A. Forney, Charlotte Boyd
Summary: This study used distance sampling to estimate the abundance of harbor porpoises in the Southeast Alaska inland waters, and found that bycatch in the drift gillnet fishery may be unsustainable for the southern population. Monitoring the abundance and bycatch is therefore important for evaluating the potential impact of fisheries on this species in Southeast Alaska.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Fisheries
Dennis Brennecke, Ursula Siebert, Lotte Kindt-Larsen, Henrik Skov Midtiby, Henrik Dyrberg Egemose, Sara Torres Ortiz, Katrin Knickmeier, Magnus Wahlberg
Summary: This study demonstrates that harbor porpoises exhibit strong avoidance behavior and reduced surfacing frequency in response to pinger sounds, indicating the effectiveness of pingers in reducing bycatch. However, there is also a diversity in behavioral responses, with some porpoises not reacting to pinger sounds at all. This suggests that pinger use should be carefully considered and alternative mitigation measures may need to be explored.
FISHERIES RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Basile Amice, Harvey Ho, En Zhang, Chris Bullen
Summary: This research report presents a rare physiologically based pharmacokinetic (PBPK) model for the absorption, disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine in pregnant women. The model successfully reproduces the higher clearance rates of nicotine and cotinine in pregnant women compared to non-pregnant women, with simulation results showing temporal profiles for their disposition in organs such as the brain, including nicotine reaching its peak concentration within 2 minutes after intravenous injection. Further pharmacokinetic experiments are needed to refine clearance parameters for individual organs and the fetus.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Kiara Fairman, Miao Li, Baitang Ning, Annie Lumen
Summary: PBPK modeling is a powerful tool with potential applications in the development of RNAi therapeutics, a class of drugs with unique pharmacokinetic properties. While there is active research in this area, there are still challenges to fully evaluating the utility of PBPK models for RNAi therapeutics. The current computational modeling approaches can support efficient development and approval of RNAi therapeutics, but further exploration and standardization are needed to optimize their use.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Acoustics
Jakob Tougaard, Kristian Beedholm, Peter T. Madsen
Summary: This article reviews the evidence available after 2015 regarding the criteria for noise-induced hearing loss in marine mammals. It analyzes the thresholds for impulsive sounds and non-impulsive sounds in two functional hearing groups. The current thresholds have strong support for certain cetaceans and seals, but discrepancies exist in other frequency ranges, calling for further studies.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Environmental Sciences
Julika Voss, Armin Rose, Vladislav Kosarev, Raul Vilela, Ilse Catharina van Opzeeland, Ansgar Diederichs
Summary: Before piling, acoustic harassment devices (AHDs) are used to drive harbor porpoises away from the area. The use of seal scarers led to unintended decreased porpoise detection rates beyond the intended distances, causing the development of new devices specifically designed for mitigation purposes. The present study monitored harbor porpoise detection rates during piling using these new devices and found a significant decrease in detection rates near the devices, indicating the displacement of the animals from a small-scale area.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Keyur R. Parmar, Pradeep B. Lukka, Santosh Wagh, Zaid H. Temrikar, Jiuyu Liu, Richard E. Lee, Miriam Braunstein, Anthony J. Hickey, Gregory T. Robertson, Mercedes Gonzalez-Juarrero, Andrea Edginton, Bernd Meibohm
Summary: Spectinamides 1599 and 1810 are being developed as potential treatments for multidrug-resistant and extensively drug-resistant tuberculosis. A physiologically based pharmacokinetic (PBPK) model has been developed to predict the pharmacokinetics of these compounds in various tissues, including those relevant to tuberculosis infection. The model accurately predicts the drug exposure in mice and rats, and can be used to optimize the dosing regimens.
Article
Pharmacology & Pharmacy
Chaozhuang Shen, Dahu Liang, Xiaohu Wang, Wenxin Shao, Kuo Geng, Xingwen Wang, Hua Sun, Haitang Xie
Summary: A physiologically based pharmacokinetic (PBPK) model of PTU was developed to predict its pharmacokinetic characteristics in different populations. The study found that dose adjustments are necessary for pediatric patients to achieve the same plasma exposure levels, while elderly patients do not require dose adjustments. This study provides important information for individualized drug administration and evaluation in the clinical setting.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sara Peribanez-Dominguez, Zinnia P. Parra-Guillen, Tomoko Freshwater, Inaki F. Troconiz
Summary: A physiologically based pharmacokinetic model of OV V937 in non-tumor-bearing mice was developed, showing time- and dose-dependent distribution in various organs. This model provides a quantitative understanding of OV biodistribution and could be expanded to include a tumor compartment for further research on OVs' in vivo behavior.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tycho Heimbach, Yuan Chen, Jun Chen, Vaishali Dixit, Neil Parrott, Sheila Annie Peters, Italo Poggesi, Pradeep Sharma, Jan Snoeys, Mohamad Shebley, Guoying Tai, Susanna Tse, Vijay V. Upreti, Ying-Hong Wang, Alice Tsai, Binfeng Xia, Ming Zheng, Andy Z. X. Zhu, Stephen Hall
Summary: The predictive performance of physiologically-based pharmacokinetics (PBPK) models for pharmacokinetics (PK) in renal impairment (RI) and hepatic impairment (HI) populations was evaluated using clinical data from 29 compounds with 106 organ impairment study arms. The results showed high accuracy in predicting AUC ratios for RI, while inaccuracies were more likely to occur in moderate and severe HI cases. PBPK predictions can help determine the need and timing of organ impairment study.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Liang Zheng, Hongyi Yang, Andre Dallmann, Xuehua Jiang, Ling Wang, Wei Hu
Summary: A physiologically based pharmacokinetic (PBPK) model of olanzapine in pregnant women was developed and validated in this study. The model predicted that dose adjustment of olanzapine may not be necessary for pregnant women if effective treatment was achieved before pregnancy and fetal toxicity can be ruled out.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Acoustics
Ronald A. Kastelein, Lean Helder-Hoek, Jennifer Covi, John M. Terhune, Georg Klump
Summary: Acoustic masking reduces communication efficiency, prey detection, and predator avoidance in marine mammals. This study examined harbor porpoises' ability to detect sounds in amplitude-varying masking noise. Results show that SAM rate has a significant impact on masking release, while signal duration, masker bandwidth, and modulation depth have less effect.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Hinojal Zazo, Eduardo Lagarejos, Manuel Prado-Velasco, Sergio Sanchez-Herrero, Jenifer Serna, Almudena Rueda-Ferreiro, Ana Martin-Suarez, M. Victoria Calvo, Jonas Samuel Perez-Blanco, Jose M. Lanao
Summary: This study developed a physiologically-based pharmacokinetic (PBPK) model for gentamicin to explore dosing regimens in neonates. The model showed good predictive performance and demonstrated high efficacy and low toxicity in preterm and term neonates.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Hinke Siebinga, Berlinda J. de Wit-van der Veen, Marcel D. M. Stokkel, Alwin D. R. Huitema, Jeroen J. M. A. Hendrikx
Summary: Physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PK) modelling approaches are not widely used in radiopharmaceutical development. However, these methods have great potential for understanding the pharmacokinetics and whole-body distribution of radiopharmaceuticals.
Article
Environmental Sciences
Stephanie Chaousis, Frederic D. L. Leusch, Colin J. Limpus, Amanda Nouwens, Liesbeth J. Weijs, Antonia Weltmeyer, Adrian Covaci, Jason P. van de Merwe
Summary: All seven species of sea turtle are facing increasing pressures from human activities that are impacting their health. Changes in blood proteins can indicate adverse health outcomes. This study examines the protein abundance in sea turtle plasma, compares protein expression between different populations, and investigates markers of contaminant exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castano, Adrian Covaci, Radu Corneliu Duca, Sarah Faure, Karen S. Galea, Sean Hays, Nancy B. Hopf, Yuki Ito, Maryam Zare Jeddi, Marike Kolossa-Gehring, Eva Kumar, Judy S. LaKind, Marta Esteban Lopez, Henriqueta Louro, Kristin Macey, Konstantinos C. Makris, Lisa Melnyk, Aline Murawski, Josh Naiman, Julianne Nassif, Nolwenn Noisel, Devika Poddalgoda, Lesliam Quiros-Alcala, Ata Rafiee, Loic Rambaud, Maria Joao Silva, Jun Ueyama, Marc-Andre Verner, Maisarah Nasution Waras, Kate Werry
Summary: Human biomonitoring (HBM) data can be used to compare population exposures, but finding the relevant health-based biomonitoring guidance values can be time-consuming. To address this issue, an online repository called the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard has been created. This database provides a centralized location for researchers and decision makers to access and interpret HBM data.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Biochemical Research Methods
Siebe Lievens, Evelynn Vervoort, Giulia Poma, Adrian Covaci, Mik Van Der Borght
Summary: Concerns about microplastics in the environment have grown, leading scientists to conduct thorough studies. A cryogenic grinding and wet-sieving method was developed to efficiently produce and fractionate microplastics. With this method, polyvinyl chloride (PVC) microplastics could be produced with specific particle sizes and easily separated into different size ranges. The method has the potential to be applied to other types of plastics as well.
METHODS AND PROTOCOLS
(2023)
Article
Chemistry, Analytical
Chien-chia Chen, Karabi Mondal, Philippe Vervliet, Adrian Covaci, Evan P. O'Brien, Karl J. Rockne, James L. Drummond, Luke Hanley
Summary: Compound identification by database searching is commonly used in mass spectrometric data analysis. Machine learning was applied to statistically evaluate the identification results generated by software. Logistic regression was used to assign identification probabilities for each compound, providing more confidence in identification beyond database matching.
ANALYTICAL CHEMISTRY
(2023)
Article
Toxicology
Elias Iturrospe, Rani Robeyns, Katyeny Manuela da Silva, Maria van de Lavoir, Joost Boeckmans, Tamara Vanhaecke, Alexander L. N. van Nuijs, Adrian Covaci
Summary: Despite being common, alcoholic liver disease remains poorly understood, especially in its early stages. In this study, alcoholic steatohepatitis was simulated in vitro to investigate the metabolic alterations and identify affected pathways. The researchers discovered key findings, such as the influence of TNF-alpha on hepatic triglycerides and the detection of FAHFA-containing triglycerides in human hepatocytes, which may play an important role in the progression of alcoholic steatohepatitis. Additionally, ethoxylated phosphorylcholine was identified as a potential new biomarker of ethanol exposure.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Shanshan Yin, Thomas J. McGrath, Adam Cseresznye, Jasper Bombeke, Giulia Poma, Adrian Covaci
Summary: Chlorinated paraffins (CPs) are a major environmental concern and it is essential to have an effective tool for monitoring personal exposure to CPs. In this study, silicone wristbands (SWBs) were used as a personal passive sampler, and results showed that micro-environments were key contributors to dermal exposure to CPs.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Analytical
Katyeny Manuela da Silva, Michele Woelk, Palina Nepachalovich, Elias Iturrospe, Adrian Covaci, Alexander L. N. van Nuijs, Maria Fedorova
Summary: Epilipids, a subset of the lipidome, play a crucial role in regulating redox lipid metabolism and influencing cell fate decisions. Ion mobility spectrometry (IMS) combined with liquid chromatography-high-resolution mass spectrometry (LC-HRMS) can improve the peak capacity and separation ability for the analysis of oxidized complex lipids. This study demonstrates the advantages and limitations of implementing IMS in LC-HRMS workflows and provides insights into the annotation of oxidized complex lipids.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Lidia Belova, Giulia Poma, Maarten Roggeman, Yunsun Jeong, Da-Hye Kim, Patrick Berghmans, Jan Peters, Amina Salamova, Alexander L. N. van Nuijs, Adrian Covaci
Summary: Quaternary ammonium compounds (QACs) in European indoor dust were identified, characterized, and semi-quantified using ion-mobility high-resolution mass spectrometry. Targeted QACs (21) and suspect QACs (17) were detected with high detection frequencies. The concentrations of individual QACs were estimated and daily intakes for adults and toddlers were calculated. This study provides important insights into the potential human exposure to QACs.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Thomas J. McGrath, Giulia Poma, Sebastien Hutinet, Yukiko Fujii, Robin E. Dodson, Boris Johnson-Restrepo, Dudsadee Muenhor, Gaud Dervilly, Ronan Cariou, Adrian Covaci
Summary: In this study, dust samples from Japan, Australia, Colombia, and Thailand were analyzed for different chain lengths of chlorinated paraffins. The results showed that chlorinated paraffins were detected in all samples, with the highest concentrations found in samples from Colombia and Thailand. Based on current toxicological data, it was determined that short-chain and medium-chain chlorinated paraffins in indoor dust do not pose a health risk through ingestion.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Elisabeth Hansen, Jiachen Sun, Bjorn Helander, Jan Ove Bustnes, Igor Eulaers, Veerle L. B. Jaspers, Adrian Covaci, Marcel Eens, Sophie Bourgeon
Summary: English Summary: Exposure to persistent organic pollutants (POPs), such as organochlorines (OCs) and polybrominated diphenyl ethers (PBDEs), can have adverse health effects on wildlife. White-tailed eagles in the Baltic ecosystem have suffered population declines due to severe exposure to DDT and PCB. In this study, feathers from breeding WTE pairs were analyzed to investigate the annual variations in feather corticosterone (fCORT), POPs, and dietary proxies. The results did not support fCORT as a relevant biomarker of contaminant-mediated effects in WTEs, but fCORT can be used as a non-destructive assessment of long-term stress physiology in wild raptors.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Paulien Cleys, Lucas Panneel, Jasper Bombeke, Catalina Dumitrascu, Govindan Malarvannan, Giulia Poma, Antonius Mulder, Philippe G. Jorens, Adrian Covaci
Summary: This study reports metabolites of phthalate and alternative plasticizers in neonatal hair samples as biomarkers for exposure to these plasticizers. Results showed that hair sampled from premature neonates after a NICU stay contained significantly higher metabolite concentrations of both phthalates and alternative plasticizers compared to healthy control neonates. Prolonged NICU exposure to respiratory support devices and gastric tubes was correlated with increased concentrations in hair samples.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Laura Rodriguez Martin, Liese Gilles, Emilie Helte, Agneta Akesson, Jonas Tagt, Adrian Covaci, Amrit K. Sakhi, An Van Nieuwenhuyse, Andromachi Katsonouri, Anna-Maria Andersson, Arno C. Gutleb, Beata Janasik, Brice Appenzeller, Catherine Gabriel, Cathrine Thomsen, Darja Mazej, Denis Sarigiannis, Elena Anastasi, Fabio Barbone, Hanna Tolonen, Hanne Frederiksen, Jana Klanova, Jani Koponen, Janja Snoj Tratnik, Kim Pack, Koppen Gudrun, Kristin Olafsdottir, Lisbeth E. Knudsen, Loic Rambaud, Loreta Strumylaite, Lubica Palkovicova Murinova, Lucia Fabelova, Margaux Riou, Marika Berglund, Mate Szabados, Medea Imboden, Michelle Laeremans, Milada Estokova, Natasa Janev Holcer, Nicole Probst-Hensch, Nicole Vodrazkova, Nina Vogel, Pavel Piler, Phillipp Schmidt, Rosa Lange, Sonia Namorado, Szilvia Kozepesy, Tamas Szigeti, Thorhallur I. Halldorsson, Till Weber, Tina Kold Jensen, Valentina Rosolen, Vladimira Puklova, Wojciech Wasowicz, Ovnair Sepai, Lorraine Stewart, Marike Kolossa-Gehring, Marta Esteban-Lopez, Argelia Castano, Jos Bessems, Greet Schoeters, Eva Govarts
Summary: This study evaluated the exposure levels of children and women in Europe over time. The results showed that exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. These findings are important for policy efficacy monitoring and highlight the role of HBM in supporting policies.
Article
Environmental Sciences
Valentina Rosolen, Elisa Giordani, Marika Mariuz, Maria Parpinel, Vicente Mustieles, Liese Gilles, Eva Govarts, Laura Rodriguez Martin, Kirsten Baken, Greet Schoeters, Ovnair Sepai, Eva Sovcikova, Lucia Fabelova, Jiri Kohoutek, Tina Kold Jensen, Adrian Covaci, Maarten Roggeman, Lisa Melymuk, Jana Klanova, Argelia Castano, Marta Esteban Lopez, Fabio Barbone
Summary: The knowledge about the effects of organophosphate flame retardants on children's neurodevelopment is limited. This research aimed to evaluate the association between exposure to these flame retardants and children's neurodevelopment. The study found a small, negative trend between neurodevelopment and exposure to BDCIPP and DPHP, but the evidence is limited. Further investigations are needed to explore the timing of exposure and the effect of other metabolites.
Article
Engineering, Environmental
Anran Cai, Sylvie Remy, Virissa Lenters, Bianca Cox, Greet Schoeters, Adrian Covaci, Roel Vermeulen, Lutzen Portengen
Summary: Childhood exposure to endocrine-disrupting chemicals (EDCs) may affect metabolic outcomes. Our study found associations between certain chemicals and body mass index, abdominal obesity, total cholesterol, and triglycerides. Further investigation is needed for sex-specific effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)