Article
Multidisciplinary Sciences
Natalia Garcia-Reyero, Mark A. Arick, E. Alice Woolard, Mitchell Wilbanks, John E. Mylroie, Kathleen Jensen, Michael Kahl, David Feifarek, Shane Poole, Eric Randolph, Jenna Cavallin, Brett R. Blackwell, Daniel Villeneuve, Gerald T. Ankley, Edward J. Perkins
Summary: This dataset provides the full hepatic transcriptomes of laboratory-reared fathead minnows in the Milwaukee Estuary Area of Concern, as well as water contaminant data. Studying these data can help understand the impact of Contaminants of Emerging Concern (CECs) on gene expression in aquatic species.
Article
Environmental Sciences
Brett R. Blackwell, Gerald T. Ankley, Adam D. Biales, Jenna E. Cavallin, Alexander R. Cole, Timothy W. Collette, Drew R. Ekman, Rachel N. Hofer, Weichun Huang, Kathleen M. Jensen, Michael D. Kahl, Ashley R. Kittelson, Shannon N. Romano, Mary Jean See, Quincy Teng, Charlene B. Tilton, Daniel L. Villeneuve
Summary: Multiple experiments were conducted to investigate the reproductive toxicity of metformin and guanylurea to adult fathead minnows. The results showed that both compounds did not have significant effects on steroidogenesis, gene transcription, hormone concentrations, or fecundity. The impacts on the hepatic transcriptome and metabolome were time-dependent, with the greatest effect observed after 23 days of exposure to 100 μg/L guanylurea.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Environmental Sciences
Hossein Mehdi, Markelle E. Morphet, Samantha C. Lau, Leslie M. Bragg, Mark R. Servos, Joanne L. Parrott, Graham R. Scott, Sigal Balshine
Summary: Municipal wastewater treatment plant effluent is a significant source of pollution in aquatic habitats and its impacts vary with seasons. This study investigated the effects of wastewater exposure on adult fathead minnow and found that it can cause metabolic and behavioral disruptions, which vary in magnitude and direction depending on temperature. The findings highlight the importance of studying interactions between stressors and the need for research during colder periods to enhance our understanding of wastewater contamination in aquatic ecosystems.
Article
Environmental Sciences
Mary Jean See, David C. Bencic, Robert W. Flick, Jim Lazorchak, Adam D. Biales
Summary: This study characterized the VTG protein in male fathead minnow mucus compared to plasma and liver mRNA. The results showed that the induction kinetics of VTG protein concentration in mucus and plasma were similar, with a significant increase detected after 2 days of exposure in the mucus-based assay and after 7 days in the plasma-based assay.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Leah Chibwe, Joanne L. Parrott, Kallie Shires, Hufsa Khan, Stacey Clarence, Christine Lavalle, Cheryl Sullivan, Anna M. O'Brien, Amila O. De Silva, Derek C. G. Muir, Chelsea M. Rochman
Summary: The study reveals that the ecological impact of tire wear particles in aquatic ecosystems is a growing environmental concern. Through toxicity testing on fathead minnow embryos and characterization of chemical mixtures, the research identifies the potential toxic effects caused by harmful chemicals in tire particle leachates.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Review
Nutrition & Dietetics
Lian Wang, Peijie Chen, Weihua Xiao
Summary: Beta-hydroxybutyrate (beta-HB) is an important ketone body that serves as both an energy source to maintain metabolic homeostasis and a signaling molecule with epigenetic regulatory functions to delay age-related diseases. Research supports the effectiveness of endogenous beta-HB administration or exogenous supplementation as strategies to induce nutritional ketosis.
Article
Environmental Sciences
Nikola Stojilkovic, Biljana Radovic, Dragana Vukelic, Marijana Curcic, Evica Antonijevic Miljakovic, Aleksandra Buha Dordevic, Katarina Baralic, Durdica Maric, Zorica Bulat, Danijela Dukic-Cosic, Biljana Antonijevic
Summary: Toxicological research usually focuses on the effects of individual substances, but in reality, people are exposed to many different chemical substances in low doses. This in silico toxicogenomic study examines the impact of selected environmental metals (lead, cadmium, methyl mercury) + polychlorinated biphenyls mixture on thyroid and male reproductive system function, and predicts the potential toxic mechanisms of this environmental cocktail.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Delnia Ahmadpour, Sakina Mhaouty-Kodja, Valerie Grange-Messent
Summary: This study found that exposure of adult male mice to low doses of di(2-ethylhexyl)phthalate (DEHP) can lead to loss of blood-brain barrier (BBB) integrity and damage in the medial preoptic area (mPOA) involved in male sexual behavior. The exposure to DEHP resulted in reduced androgen receptor (AR) levels and decreased components of the basement membrane and cell-matrix interaction, leading to neurodegeneration. The findings suggest that environmental exposure to endocrine disruptors like phthalates can disrupt glio-neurovascular coupling and alter sexual behavior.
ENVIRONMENTAL RESEARCH
(2022)
Article
Fisheries
Xiu-mei Chen, Abdallah Ghonimy, Qiu-ju Wang, Zhi-xin Guo, Ting Yu, Yue Ma, Gui-qin Wang, Mohammed Hamdy Farouk, Dong-ming Zhang
Summary: Thermal exposure increases metabolic rate and ROS level. Study on Fathead minnow (FHM) muscle cell line demonstrated that L-carnitine supplementation effectively mitigated metabolic stress at 37 degrees C. The results showed significant differences in oxidative parameters at higher temperatures, while L-carnitine inclusion at 0.5-1 mM concentrations was effective against metabolic stress.
AQUACULTURE NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Mona E. M. Younis, Fatima A. Jaber, Kamlah Ali Majrashi, Hanan A. Ghoneim, Mustafa Shukry, Manal E. Shafi, Najah M. Albaqami, Mohamed E. Abd El-Hack, Mahmoud M. Abo Ghanima
Summary: This experiment estimated the effects of synthetic androgen and estrogenic antagonists on body characteristics and immune response of male and female broilers, as well as the correlation between sex hormone levels. Androgen treatment group showed the highest feed intake, while TAM20 treatment group showed the lowest. Early androgen injection significantly increased breast percentage, while TAM20 treatment particularly decreased comb percentage.
Review
Pharmacology & Pharmacy
Kenneth K. Wu
Summary: Tissue fibrosis is a dynamic process associated with tissue inflammation, leading to debilitating human diseases. 5-methoxytryptophan (5-MTP) has shown significant efficacy in attenuating fibrosis in different organs and may serve as a promising lead compound for developing new anti-fibrotic drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jianyuan Zhao, Jing Wang, Xu Pang, Zhenlong Liu, Quanjie Li, Dongrong Yi, Yongxin Zhang, Xiaomei Fang, Tao Zhang, Rui Zhou, Zhe Guo, Wancang Liu, Xiaoyu Li, Chen Liang, Tao Deng, Fei Guo, Liyan Yu, Shan Ceri
Summary: Researchers have discovered a compound called APL-16-5 that exhibits antiviral effects against influenza A virus (IAV). APL-16-5 binds to TRIM25 and viral PA protein, leading to the degradation of PA through ubiquitination and proteasome-mediated pathways. This compound shows potent in vivo anti-IAV activity and has the potential to become a new therapeutic option for IAV.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Jamie G. G. Suski, Michael K. K. Chanov, Christopher G. G. Heron, Jennifer A. A. Field, Christopher J. J. Salice
Summary: This study aimed to fill data gaps on the toxicity of perfluorononanoic acid (PFNA) to freshwater fish. PFNA was found to have effects on the development and biomass of the tested fish generations. The study also established a screening-level threshold for PFNA to protect 95% of freshwater aquatic species.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dorota Kwiatkowska, Mariola Wicka, Krzysztof Grucza, Patryk Konarski, Aleksandra Drapala, Pawel Kaliszewski
Summary: This study presents a method for detecting and identifying Ligandrol and its metabolite using ultra performance liquid chromatography-tandem mass spectrometry. The method is suitable for monitoring Ligandrol and its metabolites, and can be applied by other anti-doping or toxicological laboratories.
Article
Oncology
Le Zhang, Sandrine Billet, Gabrielle Gonzales, Krizia Rohena-Rivera, Hayato Muranaka, Gina Chia-Yi Chu, Qian Yang, Hyung Kim, Neil A. Bhowmick, Bethany Smith
Summary: A high-fat diet is associated with prostate cancer progression, and cancer-associated fibroblasts (CAF) play an important role in this process. This study found that saturated fatty acids induce lineage plasticity reprogramming of prostate cancer through interaction with CAF via the Wnt5a and Hedgehog (Hh) signaling pathways. These findings provide relevant data to potentially improve the prognosis for patients with high fat intake.
Article
Environmental Sciences
Sanja Babic, Josip Barisic, Drazenka Stipanicev, Sinisa Repec, Mario Lovric, Olga Malev, Dalma Martinovic-Weigelt, Rozelindra Coz-Rakovac, Goran Klobucar
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Letter
Engineering, Environmental
David C. Podgorski, Phoebe Zito, Jennifer T. McGuire, Dalma Martinovic-Weigelt, Isabelle M. Cozzarelli, Barbara A. Bekins, Robert G. M. Spencer
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Chemistry, Organic
Nicholas C. Pflug, Christopher J. Knutson, Dalma Martinovic-Weigelt, Dale C. Swenson, Kristine H. Wammer, David M. Cwiertny, James B. Gloer
Article
Engineering, Environmental
Timothy W. Collette, Drew R. Ekman, Huajun Zhen, Ha Nguyen, Paul M. Bradley, Quincy Teng
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Chemistry, Organic
Nicholas C. Pflug, Eric V. Patterson, Dalma Martinovic-Weigelt, Edward P. Kolodziej, James B. Gloer, Kristopher McNeill, David M. Cwiertny, Kristine H. Wammer
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Engineering, Environmental
Barbara A. Bekins, Jennifer C. Brennan, Donald E. Tillitt, Isabelle M. Cozzarelli, Jennifer McGuire Illig, Dalma Martinovic-Weigelt
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Environmental Sciences
G. T. Ankley, J. P. Berninger, B. R. Blackwell, J. E. Cavallin, T. W. Collette, D. R. Ekman, K. A. Fay, D. J. Feifarek, K. M. Jensen, M. D. Kahl, J. D. Mosley, S. T. Poole, E. C. Randolph, D. Rearick, A. L. Schroeder, J. Swintek, D. L. Villeneuve
Summary: The study demonstrates the application of integrated measurements for understanding the effects of complex chemical mixtures in the environment. By using pathway-based chemical and biological approaches to assess risks in the Maumee River, the research reveals the potential perturbations of biological pathways by different compounds in the environment and the direct effects of chemicals on fish.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Engineering, Environmental
Huajun Zhen, Quincy Teng, Jonathan D. Mosley, Timothy W. Collette, Yang Yue, Paul M. Bradley, Drew R. Ekman
Summary: This study utilized a zebrafish liver cell-based lipidomics approach to assess the ecotoxicological effects of complex contaminant mixtures in impacted stream waters, revealing lipid changes as potential indicators for environmental monitoring and risk assessments.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Stefan Scholz, John W. Nichols, Beate Escher, Gerald T. Ankley, Rolf Altenburger, Brett Blackwell, Werner Brack, Lawrence Burkhard, Timothy W. Collette, Jon A. Doering, Drew Ekman, Kellie Fay, Fabian Fischer, Joerg Hackermueller, Joel C. Hoffman, Chih Lai, David Leuthold, Dalma Martinovic-Weigelt, Thorsten Reemtsma, Nathan Pollesch, Anthony Schroeder, Gerrit Schueuermann, Martin von Bergen
Summary: The concept of the eco-exposome, analogous to the human exposome, aims to describe the totality of internal exposure over the lifetime of ecologically relevant organisms and explore linking exposure to adverse effects. The study discusses methods and technologies using targeted and nontargeted chemical analyses and bioassays to characterize eco-exposome exposure.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Environmental Sciences
Brett R. Blackwell, Gerald T. Ankley, Adam D. Biales, Jenna E. Cavallin, Alexander R. Cole, Timothy W. Collette, Drew R. Ekman, Rachel N. Hofer, Weichun Huang, Kathleen M. Jensen, Michael D. Kahl, Ashley R. Kittelson, Shannon N. Romano, Mary Jean See, Quincy Teng, Charlene B. Tilton, Daniel L. Villeneuve
Summary: Multiple experiments were conducted to investigate the reproductive toxicity of metformin and guanylurea to adult fathead minnows. The results showed that both compounds did not have significant effects on steroidogenesis, gene transcription, hormone concentrations, or fecundity. The impacts on the hepatic transcriptome and metabolome were time-dependent, with the greatest effect observed after 23 days of exposure to 100 μg/L guanylurea.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Fisheries
Drew R. Ekman, Marina G. Evich, Jonathan D. Mosley, Jon A. Doering, Kellie A. Fay, Gerald T. Ankley, Timothy W. Collette
Summary: There is a need for more comprehensive approaches to fisheries assessments and reducing the health impacts of sample collections. Metabolomic tools provide high-throughput, untargeted biochemical information without the need for a sequenced genome, making them ideal for monitoring fish species, especially those under protected status.
JOURNAL OF FISH BIOLOGY
(2023)
Article
Environmental Sciences
David W. Bertolatus, Larry B. Barber, Christopher J. Martyniuk, Huajun Zhen, Timothy W. Collette, Drew R. Ekman, Aaron Jastrow, Jennifer L. Rapp, Alan M. Vajda
Summary: In order to evaluate the relationships between anthropogenic impacts, contaminant occurrence, and fish health, fish exposures were conducted across different land use sites in the Shenandoah River watershed. The study found adverse reproductive outcomes and increased mortality in fish exposed to wastewater treatment plant effluent and agricultural impacts. Molecular biomarkers and hepatic metabolomic and transcriptomic profiles indicated variations in land use and contaminant profiles. This study demonstrated the linkages between human impacts, contaminant occurrence, and exposure effects, highlighting the increased risk of adverse outcomes in fish exposed to complex mixtures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Marina G. Evich, Jonathan D. Mosley, Ioanna Ntai, Jenna E. Cavallin, Daniel L. Villeneuve, Gerald T. Ankley, Timothy W. Collette, Drew R. Ekman
Summary: The complexity of contaminant mixtures in surface waters presents challenges to assessing risks to human health and the environment. Novel strategies are needed to identify non-targeted contaminants and prioritize detected compounds based on their biological relevance.
Article
Environmental Sciences
Olga Malev, Mario Lovric, Drazenka Stipanicev, Sinisa Repec, Dalma Martinovic-Weigelt, Davor Zanella, Tomislav Ivankovic, Valnea Sindicic Duretec, Josip Barisic, Mei Li, Goran Klobucar
ENVIRONMENTAL POLLUTION
(2020)
Proceedings Paper
Engineering, Industrial
Yuyu He, Chih Lai, Dalma Martinovic-Weigelt, Zezheng Long
2019 14TH ANNUAL CONFERENCE SYSTEM OF SYSTEMS ENGINEERING (SOSE)
(2019)