Article
Engineering, Environmental
Yang Song, Jianshan Peng, Ziquan Zhao, Wen Qin, Jin Jiang, Jun Ma
Summary: This study investigates the control of N-nitrosodimethylamine (NDMA) and bromate (BrO3(-)) formation during the ozonation process using different catalysts. The results show that the addition of O-3/Al2O3 catalyst can effectively reduce the formation of NDMA and BrO3(-) during ozonation, with better control efficiency observed in real water samples containing Br(-).
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Environmental Sciences
Manish Kumar, Shashank Shekhar, Rakesh Kumar, Pawan Kumar, Muthusamy Govarthanan, Tushara Chaminda
Summary: This article summarizes the formation of various disinfection by-products (DBPs) during wastewater treatment and their treatment methods, discusses permissible limits and concentrations of DBPs in water systems globally, and their consequences on humans. It also critically reviews various remediation approaches and highlights the need for further advancements in detection and removal of hazardous DBPs before commercial-scale implementation.
ENVIRONMENTAL POLLUTION
(2023)
Review
Environmental Sciences
Yang Song, Sha Feng, Wen Qin, Juan Li, Chaoting Guan, Yang Zhou, Yuan Gao, Zhong Zhang, Jin Jiang
Summary: This review summarizes the major findings regarding the formation of N-nitrosodimethylamine (NDMA) during ozonation, a highly toxic and carcinogenic disinfection by-product. It evaluates the reaction kinetics, chemical yields, and mechanisms of potential precursors, as well as proposes strategies for controlling NDMA formation through improved ozonation processes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Junlang Qiu, Yi Zhang, Caley Craven, Zhongshan Liu, Yanpeng Gao, Xing-Fang Li
Summary: This study identifies a natural product called MTCCA in source water, which can produce multiple nitrosamines through chloramination. The widespread presence of MTCCA in source water and wastewater, along with its resistance to degradation and removal, suggests that natural N-heterocyclic compounds may be a new source of nitrosamine precursors.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Joerg Schlingemann, Celine Boucley, Sebastian Hickert, Laura Bourasseau, Matt Walker, Caroline Celdran, Thibaut Chemarin, Celine Pegues, Matthias Fritzsche, Judith Keitel, Anja Goettsche, Maic Seegel, Stefan Leicht, Brunhilde Guessregen, Philipp Reifenberg, Stephanie Wetzel, Tim Mueller, Fanny Schooren, Tobias Schuster, Mike Liebhold, Annette Kirsch, Phillip Krueger, Christoph Saal, Bruno Mouton, Sandra Masanes
Summary: This study found that Metformin API is not a significant source of NDMA in Metformin pharmaceuticals, and that NDMA is primarily created during the drug product manufacturing process involving heat and nitrite. Reduction of nitrite in excipients and limiting residual dimethylamine in API were effective means to reduce NDMA in the drug product. Furthermore, although NDMA may increase during storage, it does not reach levels that limit the shelf-life of the products under study.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Environmental
Jiaqi Li, William A. Arnold, Raymond M. Hozalski
Summary: The temporal and spatial variations in N-nitrosodimethylamine (NDMA) precursor levels in the Crow River in Minnesota, USA, were investigated through monthly sampling at 12 locations over 18 months. The NDMA precursors were quantified using the NDMA formed under low chloramine dose uniform formation conditions (NDMA(UFC)) and occasionally the high dose formation potential (NDMA(FP)). The results showed that NDMA precursor levels exhibited temporal variation but relatively little spatial variation, with an increase observed after lime-softening treatment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yang Song, Jianshan Peng, Kai Li, Sha Feng, Wen Qin, Jin Jiang, Jun Ma
Summary: In this study, O-3/H2O2 and O-3/PMS methods were used to control the formation of NDMA, with O-3/PMS being more effective. SO4 center dot- significantly contributed to the control of NDMA formation, and injecting small quantities of ozone multiple times further minimized its concentration. Additionally, the effects of tannic acid, bromide, and bicarbonate on NDMA formation were investigated.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Xiaobin Liao, Linlu Shen, Zhibin Jiang, Menglan Gao, Yu Qiu, Huan Qi, Chao Chen
Summary: This study revealed that metformin can directly form NDMA during ozonation, with the addition of ·OH scavenger enhancing its formation significantly. The impacts of bromide and HCO3- on NDMA formation by O3 and ·OH were different, the increase in pH promoted NDMA production.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Ru-Qiang Lu, Weize Yuan, Robert G. Croy, John M. Essigmann, Timothy M. Swager
Summary: N-Nitrosamines are commonly found in various sources such as food, drugs, air, water, and soil, posing a significant risk to human health due to their carcinogenicity. This study synthesized two polymers containing calix[4]arene or 4-tert-butylcalix[4]arene tungsten-imido complexes as receptors for N-nitrosodimethylamine (NDMA), providing a sensitive sensor for its detection. The interaction between metallocalix[4]arene monomers/polymers and NDMA was confirmed, and the sensor exhibited high selectivity and low theoretical limit of detection for NDMA.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Environmental Sciences
Decai Liu, La Rao, Xiaoyang Shi, Jiayu Du, Chen Chen, Wenjie Sun, Ming-Lai Fu, Baoling Yuan
Summary: This study evaluates the formation of N-nitrosodimethylamine (NDMA) from different types of algal organic matter (AOM) during disinfection processes and investigates the factors influencing NDMA formation. The results reveal that NDMA formation is influenced by disinfection method, reaction time, disinfectant dosage, and pH. Additionally, the study confirms that soluble microbial by-product-like substances in AOM are the main precursors contributing to NDMA formation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Josep Sanchis, Mira Petrovic, Maria Jose Farre
Summary: The study focused on predicting the NDMA formation potential in water samples using non-target HRMS data. The results showed that non-target data, combined with predictive analytics, have the potential to estimate the NDMA formation potential of actual environmental samples accurately.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Yangtao Wu, Shumin Zhu, Jue Wang, Lingjun Bu, Jing Deng, Shiqing Zhou
Summary: The UV/chloramine process can effectively degrade RAN, with HO· being the main radical involved in degradation and RNS also contributing to the process. However, the degradation of RAN in the UV/chloramine process can be inhibited by increasing concentrations of HCO3-, Cl-, and NO3-, chloramine dosage, solution pH, and natural organic matter.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Yangtao Wu, Weiqiu Zhang, Lingjun Bu, Shumin Zhu, Jue Wang, Shiqing Zhou
Summary: UV photolysis of CDMA activated HO center dot to degrade BPA, with inhibitive effects from pH, HCO3-/CO32-, Cl-, and natural organic matter. UV photolysis reduced NDMA formation at pH 8.0 but increased TCNM formation at pH 7.0 and 8.0, highlighting concerns about the formation of organic chloramines.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Rehin Sulay, Jintumol Mathew, Anandhu Krishnan, Vibin Ipe Thomas
Summary: N-Nitrosodimethyl amine (NDMA), a member of N-Nitrosamine family, is a well-known carcinogenic and mutagenic agent. The formation of NDMA and its transformation products from the ozonation of hydrazines, such as unsymmetrical dimethylhydrazine (UDMH) and monomethylhydrazine (MMH), has been investigated in this study. It has been found that the reactions proceed via initial H abstraction from the -NH2 group of the hydrazine, followed by oxidation of the generated N-radical species. Various transformation products, such as acetaldehyde dimethyl hydrazine (ADMH) and tetramethyl tetra azene (TMT), are formed through subsequent reactions. The preferred attack of ozone on the N=C bond of ADMH generates DMAN intermediate, which is further oxidized to form NDMA. However, TMT formation occurs through the dimerization of DMAN.
Article
Environmental Sciences
Menglan Gao, Zhibin Jiang, Xiaobin Liao, Huan Qi, Lei Zhao, Chao Chen, Danielle Westerman
Summary: This study investigated the characteristics, kinetic rates, reaction pathways, and influencing factors of the formation of N-Nitrosodimethylamine (NDMA) during ozonation, using 3-(Dimethylamino)-1-propylamine (DMAPA) as a representative. The results showed that NDMA was generated directly from DMAPA during ozonation, and its yields increased with ozone dosages. The pH, hydroxyl radical (•OH), bromide ion (Br-), NO2-, NH4+, NO3-, and co-existing components in actual lake water all affected the formation of NDMA. The primary pathway for NDMA formation was found to be radical recombination.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
