Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Thanakorn Pungsrinont, Julia Kallenbach, Aria Baniahmad
Summary: Androgen deprivation therapy and androgen receptor-targeted therapy are effective in treating prostate cancer initially, but tumors may develop resistance mechanisms through alternative pathways, such as the PI3K-AKT-mTOR pathway. This resistance leads to a decrease in the efficacy of ADT and AR antagonists over time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Qin Wu, Jiajun Dong, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Yahong Cheng, Gaofeng Jiang
Summary: This study explores the effects of propionate on neurological deficits, cerebral blood flow, and oxidative stress in diabetic mice. It found that propionate can improve neurological function by stimulating NO production, increasing cerebral microcirculation, suppressing oxidative stress, and reducing neuron loss. The brain-protective function of propionate is related to the PI3K/Akt/eNOS signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Mi Wang, Bo Wang, Shuaishuai Zhou, Jiayan Liu, Han Lu, Hao Wu, Manyi Ding, Yao Li
Summary: Quercetin improves chicken meat quality by regulating the PI3K/PKB/AMPK(alpha 1) signaling pathway, protecting it against lipid oxidation and deposition.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Iksen, Sutthaorn Pothongsrisit, Varisa Pongrakhananon
Summary: Lung cancer is a common and highly lethal cancer, posing a major clinical challenge. The PI3K/AKT/mTOR pathway has been linked to lung cancer, making it a significant therapeutic target. Interest in targeting these pathways with medications has grown, showing promise in various types of studies.
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Biochemistry & Molecular Biology
Hualin Chen, Lin Ma, Wenjie Yang, Yingjie Li, Zhigang Ji
Summary: POLR3G is highly expressed in bladder cancer and is associated with poor prognosis. Its deficiency inhibits migration and invasion of bladder cancer cells and reduces the expression of EMT-related markers. Mechanistically, POLR3G can promote EMT in bladder cancer by activating the PI3K/AKT signaling pathway.
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Plant Sciences
Xiao-chen Li, Shuai Wang, Xin-xin Yang, Tian-jiao Li, Jia-xing Gu, Lin Zhao, Yong-rui Bao, Xian-sheng Meng
Summary: This study aimed to investigate the treatment of colorectal cancer (CRC) using Patrinia villosa Juss. (P.V) and clarify its underlying mechanism. The results from animal models showed that P.V can reduce tumor number and diameter, improve colon cell injury, and decrease levels of CRC biomarkers. Metabolomics analysis revealed changes in endogenous metabolites, indicating that P.V modulates the glycerol phospholipid metabolites closely related to the PI3K target and PI3K/Akt signaling pathway for CRC treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Amin Iranpanah, Leila Kooshki, Seyed Zachariah Moradi, Luciano Saso, Sajad Fakhri, Haroon Khan
Summary: As a major public health concern, neurological diseases and neurodegenerative diseases significantly impact the growing aging population, leading to disability and mortality. Apoptosis, inflammation, and oxidative stress play crucial roles in the development of neurodegenerative diseases, with the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway being a key player. The blood-brain barrier poses challenges for drug delivery, but exosomes have emerged as potential nano-sized vehicles for central nervous system drug delivery due to their ability to cross the blood-brain barrier and their unique characteristics such as low immunogenicity and great tissue/cell penetration capabilities. This systematic review highlights the therapeutic potential of exosomes targeting the PI3K/Akt/mTOR signaling pathway in the context of neurodegenerative diseases and neurological diseases.
Article
Biochemistry & Molecular Biology
Li-Li Zhu, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Zhao-Qing Meng, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: This study investigated the cardioprotective effect of Muscone on AMI rats and found that Muscone significantly reduced myocardial injury, improved cardiac function, and exerted protective effects by inhibiting oxidative stress and apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Cell Biology
Wuming Qin, Linghui Cao, Isaac Yaw Massey
Summary: Cardiac fibrosis is a common pathological change in heart failure and other cardiovascular diseases, with the PI3K/Akt signaling pathway playing a crucial role in regulating its occurrence, progression, and pathological formation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Qianxu Jin, Jiahui Zhao, Zijun Zhao, Shiyang Zhang, Zhimin Sun, Yunpeng Shi, Hongshan Yan, Yizheng Wang, Liping Liu, Zongmao Zhao
Summary: CAMK1D is expressed at lower levels in glioma tissues and is positively correlated with the WHO classification of gliomas. Knockdown of CAMK1D promotes the proliferation, migration, and invasion of glioma cells, while overexpression has the opposite effect. Mechanistically, CAMK1D regulates glioma cell function through the PI3K/AKT/mTOR pathway. These findings suggest that CAMK1D may serve as a prognostic predictor and a potential therapeutic target for glioma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Chemistry, Multidisciplinary
Bei-ni Wang, Cheng-biao Wu, Zi-miao Chen, Pei-pei Zheng, Ya-qian Liu, Jun Xiong, Jing-yu Xu, Pei-feng Li, Abdullah Al Mamun, Li-bing Ye, Zhi-long Zheng, Yan-qing Wu, Jian Xiao, Jian Wang
Summary: DL-3-n-Butylphthalide (DL-NBP), extracted from Chinese celery seeds, shows neuroprotective effects by improving cognitive decline associated with diabetes, including enhancing learning and memory function, reducing morphological changes, increasing neuronal survival, and restoring synaptic protein levels and dendritic density in the hippocampus. Additionally, DL-NBP decreases oxidative stress through Nrf2/HO-1 signaling and boosts brain-derived neurotrophic factor (BDNF) expression via PI3K/Akt/CREB signaling, suggesting its potential as a pharmacologic treatment for DACD.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Oncology
Arash Poursheikhani, Mohammad Reza Abbaszadegan, Mohammad Amin Kerachian
Summary: Colorectal cancer is a common global cancer, and long noncoding RNAs play important roles in its tumorigenesis by affecting processes like cell proliferation, apoptosis, and migration, potentially influencing the risk of CRC development.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Hami
Summary: BDNF shows significant gender differences and left-right asymmetries in the developing rat hippocampus, potentially influencing the gender and laterality differences in the development, structure, and function of the hippocampus.
METABOLIC BRAIN DISEASE
(2021)
Review
Medical Laboratory Technology
Majid Vatankhah, Amir Azizi, Anahita Sanajouyan Langeroudi, Sajad Ataei Azimi, Imaneh Khorsand, Mohammad Amin Kerachian, Jamshid Motaei
Summary: The outbreak of the emerging SARS-CoV-2 virus has shed light on the challenges of detecting viral infections in resource-limited settings. CRISPR-based diagnostic platforms offer a promising solution by reducing reliance on RT-PCR, providing fast and cost-effective testing options for rapid diagnosis and potential treatment of COVID-19.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2021)
Review
Oncology
Amin Talebi, Jean Paul Thiery, Mohammad Amin Kerachian
Summary: Chimeric transcripts are important for diagnosis and prognosis, but their identification from FFPE tissues is limited due to the reduced quality and quantity of RNA. Strategies need to be developed to overcome these limitations and maximize the potential of FFPE tissues as a source for fusion transcript identification.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Khadijeh Jamialahmadi, Marjan Azghandi, Ali Javadmanesh, Mahdi Zardadi, Ehsan Shams Davodly, Mohammad Amin Kerachian
Summary: The study focused on detecting methylated DNA markers (MDMs) in colorectal cancer cases and control groups, identifying a methylation panel with better diagnostic performance for CRC.
Article
Oncology
Mahla Ghorbani, Marjan Azghandi, Mohammad Amin Kerachian
Summary: By utilizing bioinformatics analysis, this study identified aberrantly differentially methylated genes and pathways in Iranian CRC patients. A total of 320 common genes and 10 KEGG pathways were detected, and hub genes were suggested as potential diagnostic and therapeutic targets for CRC, particularly those involved in cellular processes and protein binding.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Reza Sardar, Javad Hami, Mansoureh Soleimani, Mohammad-Taghi Joghataei, Reza Shirazi, Fereshteh Golab, Zeinab Namjoo, Zahra Zandieh
Summary: Maternal diabetes during pregnancy affects the development of offspring's hippocampus, with insulin treatment improving the expression of BDNF and preventing alterations in developing hippocampus.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Correction
Endocrinology & Metabolism
Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Hami
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemical Research Methods
Amin Talebi, Parisa Rokni, Mohammad Amin Kerachian
Summary: This study provides insights into the underlying mechanisms of CRC-LM and offers potential new options for personalized medicine in terms of diagnosis, prognosis, and therapeutic molecular selection.
MOLECULAR AND CELLULAR PROBES
(2022)
Article
Biochemistry & Molecular Biology
Ali Javadmanesh, Afsaneh Mojtabanezhad Shariatpanahi, Ehsan Shams Davodly, Marjan Azghandi, Maryam Yassi, Mehdi Heidari, Matin Kerachian, Mohammad Amin Kerachian
Summary: DNA methylation is a crucial epigenetic process that plays a critical role in various biological processes. Next-generation sequencing (NGS)-based methods are widely used to study DNA methylation at a large scale. However, the generated methylome data obtained from DNA methylation next-generation sequencing (mNGS) always needs to be validated by other techniques, which can be costly. In this study, a low-cost approach using high resolution melting (MS-HRM) analysis was proposed to corroborate the mNGS data. The results showed that MS-HRM accurately validated the differentially methylated regions (DMRs) identified by mNGS, suggesting its potential as a simple and cost-effective method for confirming DNA methylation sequencing results.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Oncology
Amin Talebi, Soodabeh Shahidsales, Mohsen Aliakbarian, Masoud Pezeshki Rad, Mohammad Amin Kerachian
Summary: This study identifies a novel driver fusion transcript, ADAP1-NOC4L, which provides new insights into the mechanisms involved in the development and spread of metastatic colorectal carcinoma (mCRC). These findings suggest the potential of RNA-based alterations as novel targets for personalized medicine in clinical practice.
Review
Genetics & Heredity
Reza Khayami, David Goltzman, Shafaat A. Rabbani, Mohammad Amin Kerachian
Summary: This review discusses the role of vitamin D and epigenetic factors in colorectal cancer. Vitamin D exerts anticancer effects through interactions with genes, the tumor microenvironment, microbiota, and other factors. Epigenetic factors also play a significant role in regulating the actions of vitamin D.
Article
Oncology
Mohammad Amin Kerachian, Marjan Azghandi
Summary: This article introduces a novel method for discovering lncRNAs based on their intergenic location and the methylation level of a single CpG site, which represents epigenetic characteristics.
CANCER CELL INTERNATIONAL
(2022)
Article
Anatomy & Morphology
Hossein Haghir, Anika Kuckertz, Ling Zhao, Javad Hami, Nicola Palomero-Gallagher
Summary: Neurotransmitters and their receptors are important for communication between neurons. In this study, a multimodal atlas of the rat brain was created using cyto- and receptor architecture. The atlas includes detailed information on various brain regions and their M-2 receptor densities, providing valuable tools for future research.
BRAIN STRUCTURE & FUNCTION
(2023)
Review
Neurosciences
Joachim H. R. Luebke, Faezeh Idoon, Mina Mohasel-Roodi, Fatemeh Alipour, Javad Hami, Alireza Ehteshampour, Hamideh Mostafaee, Akram Sadeghi
Summary: Alzheimer's disease is a common neurodegenerative disease characterized by abnormal accumulations of amyloid-beta peptide and neurofibrillary tangles, potentially linked to deficiencies in neurotrophic factors. Changes in nerve growth factors and TrkA have been observed in AD brains, indicating potential therapeutic targets for the disease.
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2021)