4.7 Article

Persistent organic pollutants and liver dysfunction biomarkers in a population-based human sample of men and women

期刊

ENVIRONMENTAL RESEARCH
卷 134, 期 -, 页码 251-256

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2014.07.023

关键词

Cross-sectional study; Human population; Liver dysfunction markers; Persistent organic pollutants

资金

  1. Swedish Research Council (VR) [2012-2407]
  2. Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS) [2007-2047]
  3. Swedish Heart-Lung Foundation

向作者/读者索取更多资源

Background and objective: Persistent organic pollutants (POPs) are stable organic compounds generated through different industrial activities. Liver is involved in the metabolism of POPs, and hence exposure to POPs may interfere with liver function. Although a few studies have shown adverse effects of POPs on liver function, large-scale studies involving humans are lacking. We performed this large population-based cross-sectional study to assess the associations between different POPs and liver dysfunction biomarkers. Methods: A total of 992 individuals (all aged 70 years, 50% males) were recruited as part of Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. The total toxic equivalency (TEQ) value was calculated for seven mono-ortho and two non-ortho substituted polychlorinated biphenyls (PCBs) and octachloro-p-dibenzodioxin (OCDD) to assess their toxicological effects. The association of TEQ values, summary measures of 16 PCBs (sum of PCBs) and three organochlorine pesticides (sum of OC pesticides) with liver dysfunction biomarkers (bilirubin; alkaline phosphatase, ALP; alanine amino-transferase, ALT; and gamma-glutamyltransferase, GGT) was analyzed utilizing linear regression analysis. Results: The mono-ortho PCB TEQ values were found to be significantly positively associated with bilirubin (beta=0.71, P=0.008), while sum of OC pesticide concentrations was negatively associated with ALP (beta= -0.02, P=0.002) after adjusting for various potential confounders. When analyzed individually, a number of different POPs were associated with ALP, ALT and bilirubin. No such association with GGT was observed. Conclusion: Various POPs including PCBs, OCDD and pesticides were associated with the liver dysfunction biomarkers bilirubin, ALT and ALP, suggesting adverse effects on liver function from these environmental pollutants. (C) 2014 Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Environmental Sciences

Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances

Samira Salihovic, Tove Fall, Andrea Ganna, Corey D. Broeckling, Jessica E. Prenni, Tuulia Hyotylainen, Anna Karrman, P. Monica Lind, Erik Ingelsson, Lars Lind

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY (2019)

Editorial Material Environmental Sciences

DDT and its metabolites could contribute to the aetiology of chronic kidney disease of unknown aetiology (CKDu) and more studies are a priority

Saroj Jayasinghe, Lars Lind, Samira Salihovic, Anders Larsson, P. Monica Lind

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Review Environmental Studies

Climate and society in long-term perspective: Opportunities and pitfalls in the use of historical datasets

Bas J. P. van Bavel, Daniel R. Curtis, Matthew J. Hannaford, Michail Moatsos, Joris Roosen, Tim Soens

WILEY INTERDISCIPLINARY REVIEWS-CLIMATE CHANGE (2019)

Article Cardiac & Cardiovascular Systems

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, N. William Rayner, Neil R. Robertson, Anubha Mahajan, Efthymia Vlachopoulou, Anuj Goel, Marcus E. Kleber, Christopher P. Nelson, Lydia Coulter Kwee, Tonu Esko, Evelin Mihailov, Reedik Magi, Lili Milani, Krista Fischer, Stavroula Kanoni, Jitender Kumar, Ci Song, Jaana A. Hartiala, Nancy L. Pedersen, Markus Perola, Christian Gieger, Annette Peters, Liming Qu, Sara M. Willems, Alex S. F. Doney, Andrew D. Morris, Yan Zheng, Giorgio Sesti, Frank B. Hu, Lu Qi, Markku Laakso, Unnur Thorsteinsdottir, Harald Grallert, Cornelia van Duijn, Muredach P. Reilly, Erik Ingelsson, Panos Deloukas, Sek Kathiresan, Andres Metspalu, Svati H. Shah, Juha Sinisalo, Veikko Salomaa, Anders Hamsten, Nilesh J. Samani, Winfried Maerz, Stanley L. Hazen, Hugh Watkins, Danish Saleheen, Andrew P. Morris, Helen M. Colhoun, Leif Groop, Mark I. McCarthy, Colin N. A. Palmer

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2020)

Article Environmental Sciences

Plasma perfluoroalkyls are associated with decreased levels of proteomic inflammatory markers in a cross-sectional study of an elderly population

S. Salihovic, L. Lind, A. Larsson, P. M. Lind

ENVIRONMENT INTERNATIONAL (2020)

Article Cardiac & Cardiovascular Systems

Multicohort Metabolomics Analysis Discloses 9-Decenoylcarnitine to Be Associated With Incident Atrial Fibrillation

Lars Lind, Samira Salihovic, Johan Sundstrom, Corey D. Broeckling, Patrik K. Magnusson, Jessica Prenni, Tove Fall, Johan Arnlov

Summary: Using plasma metabolomics, a novel biomarker for atrial fibrillation, 9-decenoylcarnitine, was identified. However, it is likely not causally related to atrial fibrillation.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Chemistry, Multidisciplinary

Polymer Type Identification of Marine Plastic Litter Using a Miniature Near-Infrared Spectrometer (MicroNIR)

Svetlana Pakhomova, Igor Zhdanov, Bert van Bavel

APPLIED SCIENCES-BASEL (2020)

Article Plant Sciences

NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform

Yagut Allahverdiyeva, Eva-Mari Aro, Bert van Bavel, Carlos Escudero, Christiane Funk, Jarna Heinonen, Lars Herfindal, Peter Lindblad, Sari Makinen, Merja Penttila, Kaarina Sivonen, Matilde Skogen Chauton, Hanne Skomedal, Jorunn Skjermo

Summary: NordAqua is a Nordic Center of Excellence focused on promoting Blue Bioeconomy and reforming the use of natural resources sustainably. Their key research includes improving photosynthesis, developing novel photosynthetic cell factories, promoting diversity of Nordic cyanobacteria and algae, and improving bio-based wastewater purification technologies.

PHYSIOLOGIA PLANTARUM (2021)

Article Medicine, Research & Experimental

Efficacy of two siddha polyherbal decoctions, Nilavembu Kudineer and Kaba Sura Kudineer, along with standard allopathy treatment in the management of mild to moderate symptomatic COVID-19 patients-a double-blind, placebo-controlled, clinical trial

Anurag Srivastava, Manickavasagam Rengaraju, Saurabh Srivastava, Vimal Narayanan, Vivek Gupta, Rashmi Upadhayay, Jitender Kumar, Sathiyarajeswaran Parameswaran, Kanakavalli Kadarkarai, Aarthi Velmurugan

Summary: The study found that patients treated with NVK and KSK showed a statistically significant reduction in hospital stay time, reduction in viral load of SARS-CoV-2, and time taken to transition from asymptomatic to symptomatic, compared to those in the placebo group. These traditional medicines demonstrated significant improvements in viral symptoms and hospitalization time.

TRIALS (2021)

Article Economics

Wealth inequality in pre-industrial Europe: What role did associational organizations have?

Bas van Bavel

Summary: This article highlights the role of associational organizations in the context of wealth inequality in pre-industrial Europe, which has been less systematically discussed in existing literature. These organizations developed less regressive forms of taxation and redistribution, controlled accumulation, and sometimes imposed maximums of wealth ownership. The article argues that in societies where associations of middling groups held strong positions, wealth inequality was notably reduced.

ECONOMIC HISTORY REVIEW (2022)

Article Environmental Sciences

Serum levels of perfluoroalkyl substances (PFAS) and body composition - A cross-sectional study in a middle-aged population

P. Monica Lind, Lars Lind, Samira Salihovic, Hakan Ahlstrom, Karl Michaelsson, Joel Kullberg, Robin Strand

Summary: According to this study, some PFAS are inversely related to fat mass, but not all PFAS show this relationship, and it mainly occurs in women.

ENVIRONMENTAL RESEARCH (2022)

Article Environmental Sciences

Changes in plasma levels of per- and polyfluoroalkyl substances (PFAS) are associated with changes in plasma lipids-A longitudinal study over 10 years

Linda Dunder, P. Monica Lind, Samira Salihovic, Jordan Stubleski, Anna Karrman, Lars Lind

Summary: This study investigated the associations between multiple PFAS and blood lipids in a longitudinal manner. The results showed that changes in six out of the eight investigated PFAS were positively associated with changes in plasma lipids, providing further evidence for the role of PFAS exposure in human lipid metabolism.

ENVIRONMENTAL RESEARCH (2022)

Article Environmental Sciences

Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles

Marianne Haug, Linda Dunder, P. Monica Lind, Lars Lind, Samira Salihovic

Summary: This study found associations between plasma PFAS concentrations and cholesterol, lipoproteins, and fatty acids, suggesting a potential role of PFAS in lipid metabolism.

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY (2023)

Article Environmental Sciences

Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis

Linda Dunder, Samira Salihovic, Georgios Varotsis, Monica Lind, Solve Elmstahl, Lars Lind

Summary: This study conducted in Sweden using data from two population-based cohort studies found that moderately elevated levels of PFAS do not increase the risk of cardiovascular disease. The meta-analysis results indicated a modest inverse association between PFOA levels and incident CVD, further supporting that increasing PFAS levels are not linked to an increased risk of CVD.

ENVIRONMENT INTERNATIONAL (2023)

Article Medicine, General & Internal

Association of Exposure to Persistent Organic Pollutants With Mortality Risk An Analysis of Data From the Prospective Investigation of Vasculature in Uppsala Seniors (PIVUS) Study

P. Monica Lind, Samira Salihovic, Jordan Stubleski, Anna Karrman, Lars Lind

JAMA NETWORK OPEN (2019)

Article Environmental Sciences

Metals recovery from polymetallic sulfide tailings by bioleaching functional bacteria isolated with the improved 9K agar: Comparison between one-step and two-step processes

Muqiu Hu, Xin Zhao, Jinghan Gu, Lulu Qian, Zhiqing Wang, Yuanyuan Nie, Xiaoyu Han, Long An, Haiqiang Jiang

Summary: Due to its simple process, environmental friendliness, and low operating costs, biometallurgy has become a popular technology for metals recovering from low-grade ores and tailings. An optimized agar was used to isolate and grow functional bacteria, resulting in the successful isolation of six functional stains. These strains were further tested for their ability to leach metals from polymetallic sulfide tailings, with significant improvements observed when the strains were mixed together. The selection of leaching process should be based on tailings composition and target metals.

ENVIRONMENTAL RESEARCH (2024)

Review Environmental Sciences

Endocrine disruptors: Unravelling the link between chemical exposure and Women's reproductive health

Saqib Hassan, Aswin Thacharodi, Anshu Priya, R. Meenatchi, Thanushree A. Hegde, R. Thangamani, Ht Nguyen, Arivalagan Pugazhendhi

Summary: An Endocrine Disrupting Chemical (EDC) is a compound that disrupts the function of the endocrine system and is found in the environment. EDCs, such as Bisphenol A and pesticides, have been shown to have negative effects on the female reproductive system. Understanding the relationship between EDCs and women's health is crucial for developing strategies to protect reproductive health and informing public policy decisions.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Long-term effects of thiosulfate on the competition between sulfur-mediated bacteria and glycogen accumulating organisms in sulfate-rich carbon-deficient wastewater

Lichang Zhou, Zhaoling Li, Boyi Cheng, Jinqi Jiang, Xinqi Bi, Zongping Wang, Guanghao Chen, Gang Guo

Summary: Thiosulfate can promote sulfur-mediated bacterial activity, inhibit glycogen accumulating organisms, and enhance denitrification efficiency. After the carbon source is reduced, the competitive ability of glycogen accumulating organisms increases, resulting in reduced sulfate reduction.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Air pollution and age-dependent changes in emotional behavior across early adolescence in the US

Claire E. Campbell, Devyn L. Cotter, Katherine L. Bottenhorn, Elisabeth Burnor, Hedyeh Ahmadi, W. James Gauderman, Carlos Cardenas-Iniguez, Daniel Hackman, Rob McConnell, Kiros Berhane, Joel Schwartz, Jiu-Chiuan Chen, Megan M. Herting

Summary: Recent studies have found a connection between air pollution and increased risk for behavioral problems during development. However, more longitudinal studies are needed to investigate how exposure during the transition to adolescence may affect emotional behaviors.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Urban green, blue spaces and their joint effect are associated with lower risk of emotional and behavior problem in children and adolescents, a large population-based study in Guangzhou, China

Jing-hong Liang, Ru-yu Yang, Mei-ling Liu, Ying-qi Pu, Wen-wen Bao, Yu Zhao, Li-xin Hu, Yu-shan Zhang, Shan Huang, Nan Jiang, Xue-ya Pu, Shao-yi Huang, Guang-hui Dong, Ya-jun Chen

Summary: This study examines the association between urban Green and blue spaces (GBS) exposure and Emotion and behavior problems (EBP) in youth populations. The findings suggest that higher exposure to GBS, particularly green spaces (GS) and blue spaces (BS), is associated with a decrease in the risk of developing total difficulties in young individuals. The joint effect of GS and BS may also contribute to the decrease in EBPs.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Neurodevelopmental consequences of gestational exposure to particulate matter 10: Ultrasonic vocalizations and gene expression analysis using a bayesian approach

Diego Ruiz-Sobremazas, Mario Ruiz Coca, Miguel Morales-Navas, Rocio Rodulfo-Cardenas, Caridad Lopez-Granero, Maria Teresa Colomina, Cristian Perez-Fernandez, Fernando Sanchez-Santed

Summary: Air pollution is associated with a range of health issues and gestational exposure to environmental pollutants may be linked to neurodevelopmental disorders. This study investigated the effects of oral gestational exposure to particulate matter (PM) on ultrasonic vocalizations (USV). The findings suggest that this exposure may lead to social deficits and abnormal gene expression related to neurotransmitter systems. Further research is needed to better understand the effects of air pollution on neurodevelopmental disorders and the neurotransmission systems involved.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Enhancement of methane production by electrohydrolysis pretreatment for anaerobic digestion of OFMSW

Yagmur Kabakci, Sadiye Kosar, Ozgur Dogan, Fehmi Gorkem Uctug, Osman Atilla Arikan

Summary: This study investigated the effect of electrohydrolysis pretreatment on municipal solid waste. The results showed that applying electrohydrolysis pretreatment increased methane production and reduced the time required for hydrolysis, suggesting it is a promising method to improve anaerobic digestion efficiency.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Quantifying the contribution of industrial zones to urban heat islands: Relevance and direct impact

Chuanwu Zhao, Yaozhong Pan, Hanyi Wu, Yu Zhu

Summary: This study analyzed the impact of industrial zones on urban heat islands using remote sensing images and a novel spectral index. The research found that the contraction or expansion of industrial zones has a significant effect on land surface temperature. The results are valuable for environmental assessment and fine management of industrial cities.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

New insights into syntrophic ethanol oxidation: Effects of operational modes and solids retention times

Bang Du, Zhongzhong Wang, Piet N. L. Lens, Xinmin Zhan, Guangxue Wu

Summary: This study investigated the performance, syntrophic relationships, microbial communities, and metabolic pathways of ethanol-fed reactors with different operational modes and solids retention times. The results showed that different microorganisms were enriched under different SRT conditions, and syntrophic bacteria related to methane production could be enriched under low SRT conditions.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Conversion of seaweed waste to biochar for the removal of heavy metal ions from aqueous solution: A sustainable method to address eutrophication problem in water bodies

Gokulan Ravindiran, Sivarethinamohan Rajamanickam, Muralikrishnan Ramalingam, Gasim Hayder, Balamurugan Karupaiya Sathaiah, Madhava Krishna Reddy Gaddam, Senthil Kumar Muniasamy, Priya Arunkumar

Summary: The present study investigated the sustainable approach for wastewater treatment using waste algal blooms. The biochar produced by the marine algae Ulva reticulata was used to remove chromium, nickel, and zinc from aqueous solutions. The study examined the adsorbents' properties and stability using SEM/EDX, FTIR, and XRD. The results showed that the biochar had high removal efficiency for the toxic metals, and the packed bed column effectively removed the heavy metal ions. The Thomas and Adams-Bohart models were found to best fit the regression values, and desorption studies were conducted to understand the sorption and elution processes.

ENVIRONMENTAL RESEARCH (2024)

Review Environmental Sciences

Recent developments on advanced oxidation processes for degradation of pollutants from wastewater with focus on antibiotics and organic dyes

Vignesh Vinayagam, Kavitha Nagarasampatti Palani, Sudha Ganesh, Siddharth Rajesh, Vedha Varshini Akula, Ramapriyan Avoodaiappan, Omkar Singh Kushwaha, Arivalagan Pugazhendhi

Summary: The presence of pollutants in water contributes to global pollution and poses significant threats to humans and wildlife. Finding effective wastewater treatment techniques is crucial for reducing pollutant accumulation in the environment. This paper highlights recent advances in the electrochemical advanced oxidation method and other processes for treating pharmaceuticals, dyes, and pesticide-polluted effluents.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Promotion of phosphate release from humic acid-iron hydroxide coprecipitates in the presence of citric acid

M. M. M. Ahmed, Kai-Yue Chen, Fang-Yu Tsao, Yi-Cheng Hsieh, Yu-Ting Liu, Min Tzou

Summary: This study investigated the sorption of citric acid onto humic acid-iron hydr(o)xide coprecipitate (HAFHCP) and the reciprocal effects of citric acid and P sorption on HAFHCP. The results showed that citric acid could increase P availability and have an impact on P sorption.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

A remote sensing-based strategy for mapping potentially toxic elements of soils: Temporal-spatial-spectral covariates combined with random forest

Xibo Xu, Zeqiang Wang, Xiaoning Song, Wenjie Zhan, Shuting Yang

Summary: The selection of predictor variables is crucial in building a digital mapping model for potentially toxic elements (PTEs) in soil. Traditionally, spatial and spectral parameters have been used as predictor variables, but the temporal dimension is often overlooked. This study demonstrates the value of incorporating temporal indices in the model, leading to significant performance improvements. The temporal-spatial-spectral covariate combinations used in a random forest (RF) algorithm achieve satisfactory mapping accuracy and outperform other methods.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Heteroatom-modulated NiCo2O4 apparent energy activation of PMS for tetracycline removal: Mechanism and toxicity analysis

Yan Pei, Xun Liu, Mengbo Cao, Zijun Wang, Hongbing Yang

Summary: Heteroatom doping can reconfigure the electronic structure of heterogeneous catalysts, leading to the development of advanced oxidation water purification materials with superior performance and stability. In this study, a series of catalysts with different elemental doping were prepared using a simple and environmentally friendly method. The S-doped NiCo2O4 catalyst showed excellent catalytic performance for the removal of Tetracycline, with significantly increased kinetic constant and high oxidation and mineralization efficiency in a wide pH range. The degradation process was dominated by non-radical oxidation pathway after S doping, and the overall process moved towards low toxicity.

ENVIRONMENTAL RESEARCH (2024)

Article Environmental Sciences

Biodegradation of naphthalene - Ecofriendly approach for soil pollution mitigation

Srivalli Thimmarayan, Harshavardhan Mohan, Gaddapara Manasa, Karthi Natesan, Shanmugam Mahendran, Pavithra Muthukumar Sathya, Byung-Taek Oh, R. Ravi Kumar, Rangasamy Sigamani Gandhimathi, Arul Jayaprakash, Kamala-Kannan Seralathan

Summary: This study investigated the bacterial degradation of naphthalene (NPT) isolated from crude oil-contaminated soil. Bacillus sp. GN 3.4, a potential bacteria for NPT biodegradation, was isolated and the optimal conditions for NPT degradation were determined. The study suggests that Bacillus sp. GN 3.4 could potentially aid in bioremediation by eliminating NPT from the soil.

ENVIRONMENTAL RESEARCH (2024)