期刊
ENVIRONMENTAL POLLUTION
卷 159, 期 2, 页码 495-502出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2010.10.013
关键词
Danio rerio; Depleted uranium; Bioconcentration; Oxidative stress; Genotoxicity; Neurotoxicity
资金
- Institute of Radioprotection and Nuclear Safety
Because of its toxicity and its ubiquity within aquatic compartments, uranium (U) represents a significant hazard to aquatic species such as fish. In a previous study, we investigated some biological responses in zebrafish either exposed to depleted or to enriched U (i.e., to different radiological activities). However, results required further experiments to better understand biological responses. Moreover, we failed to clearly demonstrate a significant relationship between biological effects and U radiological activity. We therefore chose to herein examine U bioaccumulation and induced effects in zebrafish according to a chemical dose-response approach. Results showed that U is highly bioconcentrated in fish, according to a time- and concentration-dependent model. Additionally, hepatic antioxidant defenses, red blood cells DNA integrity and brain acetylcholinesterase activity were found to be significantly altered. Generally, the higher the U concentration, the sooner and/or the greater the effect, suggesting a close relationship between accumulation and effect. (C) 2010 Elsevier Ltd. All rights reserved.
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