Article
Biology
Miki Okuno, Yoko Arimizu, Seina Miyahara, Yuki Wakabayashi, Yasuhiro Gotoh, Shuji Yoshino, Tetsuya Harada, Kazuko Seto, Takeshi Yamamoto, Keiji Nakamura, Tetsuya Hayashi, Yoshitoshi Ogura
Summary: A cryptic clade of Escherichia coli, known as C-I, has been identified as a potential human intestinal pathogen. It possesses virulence and antimicrobial resistance genes, including Stx toxin genes. Further surveillance and population studies of C-I strains are needed to better understand their characteristics and infections.
Article
Multidisciplinary Sciences
Nicolas Waisbord, Amin Dehkharghani, Jeffrey S. Guasto
Summary: Through microfluidic experiments, it was found that individual magnetotactic bacteria display three distinct regimes when directed upstream through pores, resembling the electrical conductivity of a diode. This diode-like behavior persists at the pore scale, impacting flow conductivity in higher dimensional geometries. The study has implications for magnetotactic bacteria survival strategies in sediments and potential drug delivery applications in vascular networks.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Josiah C. Kratz, Shiladitya Banerjee
Summary: A quantitative theory is developed to explain the relationship between bacterial growth and division rates and proteome allocation in time-varying nutrient environments. The theory shows that in such environments, cell size and growth are regulated by trade-offs between biomass accumulation and division. The study also finds that bacteria exhibit a transient memory of previous metabolic states, allowing for faster adaptation to previously encountered environments.
COMMUNICATIONS BIOLOGY
(2023)
Article
Microbiology
Jason T. Small, Alison Ann Weiss
Summary: Enterohemorrhagic Escherichia coli O157:H7 is a pathogen responsible for severe diseases. The difficulty in studying O157:H7 lies in its specificity for the human intestine and the lack of appropriate cell culture models. The recent development of human intestinal enteroids provides a suitable model for studying O157:H7 pathogenesis and potential treatments.
JOURNAL OF BACTERIOLOGY
(2022)
Article
Microbiology
Qingyuan Yi, Jiaxin Liu, Yufeng Zhang, Hanzhen Qiao, Fang Chen, Shihai Zhang, Wutai Guan
Summary: This study demonstrated that dietary supplementation of anethole can improve the growth performance of weaned piglets challenged with enterotoxigenic Escherichia coli K88 by attenuating intestinal barrier disruption and inflammation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
Qingqing Fang, Yu Feng, Alan McNally, Zhiyong Zong
Summary: Fang et al. identified two previously unidentified phages that can inhibit the growth and decrease the virulence of carbapenem-resistant Klebsiella pneumoniae (CRKP). They also found that CRKP can develop phage resistance but can still be eliminated in a mouse intestinal colonization model, highlighting the potential of phage therapy as a treatment against drug-resistant pathogens.
COMMUNICATIONS BIOLOGY
(2022)
Article
Infectious Diseases
Pei Yee Woh, May Pui Shan Yeung, William Bernard Goggins
Summary: This study aimed to determine the multiple antibiotic resistance index (MARI) of Salmonella isolated from children hospitalized for gastroenteritis in Hong Kong. The results showed that Salmonella had the highest resistance to ampicillin, ciprofloxacin, and tetracycline, while MDR strains had high resistance towards ampicillin, tetracycline, cotrimoxazole, chloramphenicol, and ciprofloxacin. MARI revealed that 80.2% of Salmonella, including all MDR strains, had indexes greater than 0.2.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Kai-Di Liu, Wen-Jie Jin, Run-Bo Li, Rong-Min Zhang, Jian Sun, Ya-Hong Liu, Min-Ge Wang, Xiao-Ping Liao
Summary: The prevalence and molecular characteristics of mcr-1-positive E. coli in duck farms and surrounding environments in China were investigated. The results showed a higher prevalence of mcr-1-positive E. coli in Guangdong province compared to other provinces. The study also revealed clonal spread of mcr-1-positive E. coli between duck farms and surrounding environments, and identified the presence of mcr-1 on IncI2 and IncHI2 plasmids.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Haixiu Wang, Eric Cox, Bert Devriendt
Summary: Enterotoxigenic Escherichia coli (ETEC) strains recognize and respond to factors secreted by gut epithelial cells, leading to transcriptional modulation of key ETEC virulence genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Sylvie Estrela, Alicia Sanchez-Gorostiaga, Jean C. C. Vila, Alvaro Sanchez
Summary: The study found that while the family-level community composition can generally be predicted using the null, naturally additive model, there are systematic deviations from the additive predictions that reflect generic patterns of nutrient dominance. Pairs of more similar nutrients tend to be more additive than pairs of dissimilar nutrients, and sugar-acid communities are generally more similar to sugar communities than acid communities, possibly due to family-level asymmetries in nutrient benefits. Overall, the study suggests that regularities in how nutrients interact may help predict community responses to dietary changes.
Article
Psychology
Arthur Prat-Carrabin, Robert C. Wilson, Jonathan D. Cohen, Rava Azeredo da Silveira
Summary: Studies have shown that humans adapt their inference processes to the temporal structure in the statistics of stimuli, deviating away from optimality quantitatively. Despite behaving qualitatively in a Bayesian fashion, human responses are variable and influenced by the temporal statistics of stimuli. Human behavior is best described by sampling-based inference models, which involve a compressed approximation of the posterior represented through a modest set of random samples.
PSYCHOLOGICAL REVIEW
(2021)
Article
Multidisciplinary Sciences
Wen Sun, Ke Yang, Risheng Li, Tianqing Chen, Longfei Xia, Zhao Wang, Xubo Sun
Summary: This research analyzed the structure of a microorganism group in sediment and the absolute abundance of two typical pathogenic bacteria in Shahe Reservoir, China. The results show a positive correlation between the abundance of pathogenic bacteria and water eutrophication in the reservoir sediment. Additionally, the distribution of the pathogenic bacteria varies with depth and location in the sediment.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Yitong Zeng, Rui Li, Yi Dong, Dan Yi, Tao Wu, Lei Wang, Di Zhao, Yanyan Zhang, Yongqing Hou
Summary: The aim of this study was to investigate the effect of puerarin supplementation on the growth performance and intestinal function of piglets challenged with enterotoxigenic Escherichia coli (ETEC) K88. Dietary supplementation with 5 mg/kg puerarin alleviated intestinal injury and improved the intestinal function of piglets challenged with ETEC K88 by increasing the number of beneficial intestinal bacteria and reducing the number of harmful bacteria, as well as reducing oxidative stress and inflammation in the intestines.
Article
Biochemistry & Molecular Biology
Baylee J. Russell, Steven D. Brown, Nicole Siguenza, Irene Mai, Anand R. Saran, Amulya Lingaraju, Erica S. Maissy, Ana C. Dantas Machado, Antonio F. M. Pinto, Concepcion Sanchez, Leigh-Ana Rossitto, Yukiko Miyamoto, R. Alexander Richter, Samuel B. Ho, Lars Eckmann, Jeff Hasty, David J. Gonzalez, Alan Saghatelian, Rob Knight, Amir Zarrinpar
Summary: This study demonstrates the potential of using native bacteria as chassis for transgene delivery to manipulate the gut microbiome and reverse pathology in conventionally raised hosts.
Article
Medicine, Research & Experimental
Stefan Toth, Zuzana Fagova, Monika Holodova, Dema Zeidan, Patrick Hartel, Kristina Curgali, Eva Mechirova, Milan Maretta, Radomira Nemcova, Sona Gancarcikova, Marianna Dankova
Summary: This study aimed to investigate the influence of Escherichia coli (E. coli) on the intestinal barrier. The results showed that the colon of germ-free piglets was more resistant to coliform bacterial infection compared to the jejunum. Additionally, the intestinal barrier exhibited a rapid response and better preparation for possible pathological attacks.
Article
Immunology
Francois Angoulvant, Naim Ouldali, David Dawei Yang, Mathilde Filser, Vincent Gajdos, Alexis Rybak, Romain Guedj, Valerie Soussan-Banini, Romain Basmaci, Alain Lefevre-Utile, Dominique Brun-Ney, Laure Beaujouan, David Skurnik
Summary: The study found that during the COVID-19 lockdown and school closures, there was a significant decrease in emergency visits for infectious diseases transmitted through airborne or fecal-oral routes, including common cold, gastroenteritis, bronchiolitis, and acute otitis. However, there was no change in urinary tract infections.
CLINICAL INFECTIOUS DISEASES
(2021)
Letter
Immunology
David Dawei Yang, Naim Ouldali, Vincent Gajdos, Roxane Thomas-Sertillanges, Loganayagi Vasante, David Skurnik, Francois Angoulvant
CLINICAL INFECTIOUS DISEASES
(2021)
Letter
Immunology
David Skurnik, Alexis Rybak, David Dawei Yang, Stephanie Pons, Romain Guedj, Corinne Levy, Robert Cohen, Vincent Gajdos, Loganayagi Vasante, Naim Ouldali, Francois Angoulvant
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Nutrition & Dietetics
Virginie Rigourd, Benali Mouadh, Joel Poupon, Jerome Langrand, Arnaud Goutard, Christine Droguet, Emmanuel Bille, Pierre Frange, Yasmina Bahri, David Pasquier, Alexandre Lapillonne, David Skurnik
Summary: Promoting breastfeeding and breast pumping is crucial for vulnerable infants, even during the current pandemic crisis, and requires stringent hygiene measures. The use of chlorine solution for decontamination effectively reduces microbial contamination, providing a guideline for safe use and defining situations where pump sterilization is necessary.
FRONTIERS IN NUTRITION
(2021)
Letter
Immunology
Guilhem Royer, Olivier Clermont, Benedicte Condamine, Melanie Mercier-Darty, Cedric Laouenan, Agnes Lefort, Erick Denamur, Victoire de lastours
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Guilhem Royer, Melanie Mercier Darty, Olivier Clermont, Benedicte Condamine, Cedric Laouenan, Jean-Winoc Decousser, David Vallenet, Agnes Lefort, Victoire de Lastours, Erick Denamur
Summary: This study found that some Escherichia coli clonal lineages in bloodstream infections remain stable while others undergo significant changes, such as the replacement of STc95 by the global pandemic STc131. A small number of clonal lineages are responsible for the majority of cases, dominated by five STcs, with highly dynamic genomic patterns observed within these STcs.
Review
Peripheral Vascular Disease
David M. Smadja, Steven J. Mentzer, Michaela Fontenay, Mike A. Laffan, Maximilian Ackermann, Julie Helms, Danny Jonigk, Richard Chocron, Gerald B. Pier, Nicolas Gendron, Stephanie Pons, Jean-Luc Diehl, Coert Margadant, Coralie Guerin, Elisabeth J. M. Huijbers, Aurelien Philippe, Nicolas Chapuis, Patrycja Nowak-Sliwinska, Christian Karagiannidis, Olivier Sanchez, Philipp Kuempers, David Skurnik, Anna M. Randi, Arjan W. Griffioen
Summary: COVID-19 caused by SARS-CoV-2 is a systemic disease associated with vascular inflammation and endothelial injury, which can lead to ARDS and hypercoagulation. Besides pro-inflammatory cytokines, endothelial dysfunction can also cause hypercoagulation, thrombosis and pathological angiogenesis.
Article
Infectious Diseases
Marion Opatowski, Christian Brun-Buisson, Mehdi Touat, Jerome Salomon, Didier Guillemot, Philippe Tuppin, Laurence Watier
Summary: This study highlights the critical 3-month window for antibiotic exposure, the significant impact of broad-spectrum antibiotic consumption on ARB, especially in relation to urological procedures and prolonged stays in the intensive care unit.
BMC INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Rishma Amarsy, David Trystram, Emmanuelle Cambau, Catherine Monteil, Sandra Fournier, Juliette Oliary, Helga Junot, Pierre Sabatier, Raphael Porcher, Jerome Robert, Vincent Jarlier
Summary: This study measured the impact of the first wave of COVID-19 on the incidence of bloodstream infections at the largest multisite public healthcare institution in France. The results showed that the COVID-19 pandemic had a strong impact on hospital management and had unfavorable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biology
Anamaria Babosan, David Skurnik, Anaelle Muggeo, Gerald B. Pier, Zeynep Baharoglu, Thomas Jove, Marie-Cecile Ploy, Sophie Griveau, Fethi Bedioui, Sebastien Vergnolle, Sophie Moussalih, Christophe de Champs, Didier Mazel, Thomas Guillard
Summary: PMQR genes promote high-level bacterial resistance to fluoroquinolone antibiotics, and we found that aminoglycosides can induce the SOS response, leading to elevated transcription of qnrD. The induction of SOS response is due to nitric oxide accumulation caused by sub-MIC of aminoglycosides.
Article
Microbiology
Alexis Rybak, David Dawei Yang, Cecile Schrimpf, Romain Guedj, Corinne Levy, Robert Cohen, Vincent Gajdos, Julie Tort, David Skurnik, Naim Ouldali, Francois Angoulvant
Summary: Following the implementation of NPIs in France, there was a significant decrease in the number of visits and hospital admissions for community-acquired pneumonia (CAP) in children, with reductions of 79.7% and 71.3% respectively. Further studies are needed to assess the long-term impact of these measures.
Article
Infectious Diseases
Anamaria Babosan, Margaux Gaschet, Anaelle Muggeo, Thomas Jove, David Skurnik, Marie-Cecile Ploy, Christophe de Champs, Fany Reffuveille, Thomas Guillard
Summary: Bacteria within biofilms exposed to sub-MIC concentrations of antibiotics can develop antibiotic resistance. This study shows that sub-MIC levels of aminoglycosides induce the SOS response in E. coli carrying the qnrD gene, leading to genetic rearrangements and increased biofilm formation. The presence of the qnrD-plasmid promotes biofilm production and the acquisition and spread of resistance determinants for other antibiotics.
Article
Public, Environmental & Occupational Health
Rishma Amarsy, Sandra Fournier, David Trystram, Catherine Monteil, Xavier Raynaud, Vincent Jarlier, Jerome Robert
Summary: The impact of COVID-19 pandemic on bloodstream infections due to Streptococcus pneumoniae and Streptococcus pyogenes was assessed in 25 university hospitals in Paris. The incidence rates of BSIs, which had been stable in 2018 and 2019, decreased for the two pathogens during the two lockdown periods in 2020. Containment policies such as social distancing, masking, and hand hygiene strengthening in community and hospital settings are likely to reduce BSIs caused by these pathogens.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Medicine, General & Internal
Stephanie Pons, Eric Frapy, Youssouf Sereme, Charlotte Gaultier, Francois Lebreton, Andrea Kropec, Olga Danilchanka, Laura Schlemmer, Cecile Schrimpf, Margaux Allain, Francois Angoulvant, Herve Lecuyer, Stephane Bonacorsi, Hugues Aschard, Harry Sokol, Colette Cywes-Bentley, John J. Mekalanos, Thomas Guillard, Gerald B. Pier, Damien Roux, David Skurnik
Summary: The study identified PNAG as a potential vaccine candidate for neonatal bacterial meningitis caused by E. coli K1 and demonstrated its efficacy in preventing and treating the infection. Furthermore, it was found that PNAG could also protect against Group B Streptococcus, the main cause of neonatal meningitis in developed countries.
Article
Cell & Tissue Engineering
Stephanie Pons, Fabrice Uhel, Eric Frapy, Youssouf Sereme, Lara Zafrani, Hugues Aschard, David Skurnik
Summary: Since the outbreak of COVID-19 pandemic, SARS-CoV-2 has caused millions of infections and deaths worldwide. Achieving long-term herd immunity is crucial to overcome the pandemic. While antibodies provide partial protection, robust cellular immunity is important for immune memory and limiting disease severity against SARS-CoV-2.
STEM CELL REVIEWS AND REPORTS
(2023)