Article
Fisheries
Fasheng Liu, Hongmei Hu, Guilan Chen, Yanqi Lin, Wei Li, Ziyi Liu, Chao Chen, Xue Li, Sujie Sun, Li Zhang, Dou Yang, Kangyu Liu, Guanghua Xiong, Xinjun Liao, Huiqiang Lu, Zigang Cao, Jianjun Chen
Summary: This study investigated the effects of pexidartinib on embryonic development and immunotoxicity in zebrafish, and found that pexidartinib caused developmental defects and reduced immune cell numbers, possibly through hyperactivation of the Wnt signaling pathway. These findings provide new insights into the mechanisms of pexidartinib.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nikos Stratakis, Lucy Golden-Mason, Katerina Margetaki, Yinqi Zhao, Damaskini Valvi, Erika Garcia, Lea Maitre, Sandra Andrusaityte, Xavier Basagana, Eva Borras, Mariona Bustamante, Maribel Casas, Serena Fossati, Regina Grazuleviciene, Line Smastuen Haug, Barbara Heude, Rosemary R. C. McEachan, Helle Margrete Meltzer, Eleni Papadopoulou, Theano Roumeliotaki, Oliver Robinson, Eduard Sabido, Jose Urquiza, Marina Vafeiadi, Nerea Varo, John Wright, Miriam B. Vos, Howard Hu, Martine Vrijheid, Kiros T. Berhane, David Conti, Rob McConnell, Hugo R. Rosen, Lida Chatzi
Summary: The study suggests that developmental exposure to mercury may contribute to liver injury and increased risk of NAFLD in early life.
Article
Neurosciences
Vincent Migneron-Foisy, Gina Muckle, Joseph L. Jacobson, Pierre Ayotte, Sandra W. Jacobson, Dave Saint-Amour
Summary: This study provides neuroimaging evidence that exposure to mercury and polychlorinated biphenyls alters the posterior microstructure of the corpus callosum, impairing brain function and behavior in late adolescence.
Review
Environmental Sciences
Minghan Zhu, Yibo Yuan, Hua Yin, Zhanyu Guo, Xipeng Wei, Xin Qi, Hang Liu, Zhi Dang
Summary: PCB contamination in China shows regional disparities, with higher levels in East China and in areas with intensive industrial activities or e-waste disassembling. The unplanned UP-PCBs from industrial processes are becoming increasingly significant. There is a need for further studies on the accumulation and migration of PCBs in food webs, and for more investigations to assess human health risks accurately.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Kamila Sredlova, Tomas Cajthaml
Summary: PCBs, despite being restricted in the 1970s, remain hazardous contaminants due to their bioaccumulative and persistent nature. Remediation of historically contaminated matrices is challenging and requires a combination of different techniques and approaches.
Article
Environmental Sciences
Luze Yang, Peixuan Sun, Wenjin Zhao, Miao Liu
Summary: In this study, the developmental toxicity characteristics of pollutants, such as PBBs, were investigated using various methods. Key structural parameters affecting human development were identified, and supplementary food factors that can alleviate developmental toxicity were screened. The results provide important theoretical support for the regulation strategy of developmental toxicity caused by pollutants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Can Wang, Ruina Cui, Congying Niu, Xiali Zhong, Qicheng Zhu, Di Ji, Xianjie Li, Hongxia Zhang, Chunqiao Liu, Lina Zhou, Yanli Li, Guowang Xu, Yanhong Wei
Summary: The study reveals that low-dose exposure to PCB126 disrupts cardiac metabolism, affecting lipid metabolism, amino acid metabolism, and the tricarboxylic acid cycle. The hearts exposed to PCB126 showed increased collagen synthesis, cardiac fibrosis, and perturbed expression of genes related to the TGFβ/PPARγ/MMP-2 signaling pathway.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Lili Long, Xinghua Tang
Summary: This study investigated the association between exposure to organochlorine pesticides and hearing loss in adults, finding a positive correlation between exposure to certain organochlorine pesticides and hearing loss.
SCIENTIFIC REPORTS
(2022)
Article
Marine & Freshwater Biology
Samreen, Xiaona Zhang, Jun Wang, Yuejiao Li, Xuan Li, Yuqi Zheng, Muhammad Arif, Shaoguo Ru
Summary: This study found that prometryn, a widely detected triazine herbicide, has significant toxic effects on marine medaka embryos, including yolk sac shrinkage, heart malformations, delayed hatching time, increased heart rate, and hatching failure rate. It also caused obvious malformations and decreased body length in newly hatched larvae. Transcriptome analysis revealed that prometryn exposure affected the expression levels of several cardiac development-related genes in the larvae.
AQUATIC TOXICOLOGY
(2022)
Review
Toxicology
Jens Rengelshausen, Isabella Randerath, Thomas Schettgen, Andre Esser, Andrea Kaifie, Jessica Lang, Thomas Kraus, Patrick Ziegler
Summary: After detecting high PCB exposure in a German recycling company, the HELPcB program was established to investigate potential health effects of PCB exposure through a longitudinal study. More than 300 individuals were enrolled and various assessments were conducted. The program yielded new data on adverse effects of PCB exposure in humans and potential mechanisms. Larger studies are needed to confirm the results and establish causality between PCB exposure and clinical effects in humans.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Engineering, Environmental
Hui Wang, Andrea Adamcakova-Dodd, Hans-Joachim Lehmler, Keri C. Hornbuckle, Peter S. Thorne
Summary: Indoor air in schools contaminated with PCBs may pose health risks to children, teachers, and staff. Our study found that long-term inhalation exposure to PCBs impaired memory, induced anxiety-like behavior, reduced white blood cell counts, and influenced metabolism and gene transcription.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Victoria Santos Chemelo, Leonardo Oliveira Bittencourt, Priscila Cunha Nascimento, Mayra Frasson Paiva, Alberto Carlos Botazzo Delbem, Juliano Pelim Pessan, Alexandre Ribeiro do Espirito Santo, Alan Rodrigo Leal Albuquerque, Romulo Simoes Angelica, Maria Elena Crespo-Lopez, Sofia Pessanha, Michael Aschner, Rafael Rodrigues Lima
Summary: This study evaluated the effects of maternal exposure to methylmercury on the physico-chemical, ultrastructural, and functional properties of mature tooth enamel. The results showed that exposure to methylmercury caused changes in the composition and structure of mature enamel, as well as a decrease in enamel strength.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Reproductive Biology
Karen E. Weis, Lindsay M. Thompson, Madeline Streifer, Isabella Guardado, Jodi A. Flaws, Andrea C. Gore, Lori T. Raetzman
Summary: Polychlorinated-biphenyls (PCBs) are industrial compounds that were widely used but are now banned due to health concerns. A specific type of PCB mixture, Aroclor 1221 (A1221), has been found to affect reproductive function in rodents. In this study, the effects of A1221 exposure during different developmental periods on hormone and receptor expression in female rats were investigated. The results showed that prenatal exposure to A1221 increased pituitary luteinizing hormone beta (Lhb) mRNA and gonadotrope cell number in neonates, while decreasing LH hormone concentration. Additionally, exposure to A1221 during postnatal development increased pituitary follicle stimulating hormone beta (Fshb) mRNA levels and estrogen receptor alpha (ER alpha) levels in mature rats. These findings suggest that exposure to A1221 during critical developmental periods can alter pituitary hormone and receptor expression, potentially impacting reproductive function.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Environmental Sciences
Kady Lyons, Katherine E. Wynne-Edwards
Summary: This study demonstrates that organic contaminants can have significant effects on the physiological processes of elasmobranchs, particularly during pregnancy and embryonic development. Pregnant females and adult males exposed to PCBs showed differences in metabolic processes and tissue quality, indicating potential negative impacts on males from contaminant exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Fisheries
Yi Liu, Jing Guo, Wenjin Liu, Fengjie Yang, Yunyun Deng, Yunlong Meng, Bo Cheng, Jianping Fu, June Zhang, Xinjun Liao, Lili Wei, Huiqiang Lu
Summary: Pesticides, such as haloxyfop-p-methyl, are harmful to the aquatic ecosystem as they leave residues in soil, water, and agricultural products. This study investigated the toxic effects of haloxyfop-p-methyl on zebrafish and found developmental, neurotoxic, and immunotoxic effects. Zebrafish larvae exhibited spinal deformities, decreased body length, slow heart rate, and enlarged yolk sac area. Behavior analysis showed reduced activity, accompanied by higher AChE activity. Exposure to haloxyfop-p-methyl also induced oxidative stress and affected immune cell populations in the thymus. Furthermore, haloxyfop-p-methyl caused neutrophil apoptosis and increased expression of proinflammatory cytokine genes. These findings provide insights into the toxicological mechanisms of haloxyfop-p-methyl in teleosts.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Statistics & Probability
Brice Ozenne, Esben Budtz-Jorgensen, Sebastian Elgaard Ebert
Summary: This article introduces the use of the max-test procedure in latent variable models for multiple testing. The effectiveness of the procedure for Wald and Score tests in LVMs is evaluated through simulation studies. The procedure is then applied to quantify the neuroinflammatory response to mild traumatic brain injury in multiple brain regions.
COMPUTATIONAL STATISTICS
(2023)
Correction
Environmental Sciences
Annelise Blomberg, Jann Mortensen, Pal Weihe, Philippe Grandjean
ENVIRONMENTAL HEALTH
(2023)
Article
Pharmacology & Pharmacy
Ann-Cathrine Dalgard Dunvald, Flemming Nielsen, Dorte Aalund Olsen, Martin Thomsen Ernst, Louise Donnelly, Enrique Soto-Pedre, Maja Refshauge Kristiansen, Jens Steen Nielsen, Frederik Persson, Kurt Hojlund, Jonna Skov Madsen, Jens Sondergaard, Ewan Pearson, Anton Pottegard, Tore Bjerregaard Stage
Summary: The initiation of glucose-lowering drugs in patients with type 2 diabetes may reduce the efficacy of warfarin, but does not affect drug metabolism.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Environmental Sciences
Veronika Ehrlich, Wieneke Bil, Rob Vandebriel, Berit Granum, Mirjam Luijten, Birgitte Lindeman, Philippe Grandjean, Andreas-Marius Kaiser, Ingrid Hauzenberger, Christina Hartmann, Claudia Gundacker, Maria Uhl
Summary: PFAS are a public health concern due to their persistent occurrence and adverse effects on the immune system. The mechanisms underlying the impact on the immune system are not fully understood. Various PFAS affect multiple aspects of the immune system, with the developing immune system being particularly vulnerable to toxic insults.
ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Esben Budtz-Jorgensen, Philippe Grandjean
Summary: By analyzing two data sets using the BMD method, the study found that using different dose-response models can lead to more accurate results. The toxicity of different PFAS was compared, confirming differences in toxicity among them. It was concluded that EFSA's proposed tolerable exposure limit is too high, while the EPA's proposal is more in line with the research results.
ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Damaskini Valvi, David C. Christiani, Brent Coull, Kurt Hojlund, Flemming Nielsen, Karine Audouze, Li Su, Pal Weihe, Philippe Grandjean
Summary: This study evaluated the genetic heterogeneity as a modifier in the association between perfluoroalkyl substances (PFAS) and insulin sensitivity and pancreatic beta-cell function. The findings suggest that certain genetic variations play an important role in the association between PFAS and insulin sensitivity.
ENVIRONMENTAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Philippe Grandjean, Alessandra Meddis, Flemming Nielsen, Anders Sjodin, Mads F. F. Hjorth, Arne Astrup, Esben Budtz-Jorgensen
Summary: The objective of this study was to test the association between perfluorinated alkylate substance (PFAS) exposures and body weight increases in a dietary intervention study. The results showed that elevated plasma concentrations of PFOA and PFHxS were significantly associated with increased weight gain, exceeding the effects of different diet groups. The findings suggest that obesogenic PFASs may contribute to the obesity pandemic.
Article
Pediatrics
Philippe Grandjean, Yu-Hsuan Shih, Louise Helskov Jorgensen, Flemming Nielsen, Pal Weihe, Esben Budtz-Jorgensen
Summary: A study found that early exposure to perfluoroalkyl substances (PFASs) was associated with lower resistin concentrations at the age of 9, suggesting that infancy may be a vulnerable time window for metabolic programming affected by PFAS exposure.
PEDIATRIC RESEARCH
(2023)
Article
Environmental Sciences
Marzanna Marianna Sorensen, Ane Baerent Fisker, Christine Dalgard, Kristoffer Jarlov Jensen, Flemming Nielsen, Christine Stabell Benn, Philippe Grandjean, Amalie Timmermann
Summary: The aim of this study was to identify predictors of infant serum-PFAS concentrations. The study found that the location of residence was the most important determinant of serum-PFAS concentrations among Guinea-Bissau infants, indicating a potential role of diet as affected by the global spread of PFAS, but further research is needed to explore reasons for the regional differences in PFAS exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Brittney O. Baumert, Fabian C. Fischer, Flemming Nielsen, Philippe Grandjean, Scott Bartell, Nikos Stratakis, Douglas I. Walker, Damaskini Valvi, Rohit Kohli, Thomas Inge, Justin Ryder, Todd Jenkins, Stephanie Sisley, Stavra Xanthakos, Sarah Rock, Michele A. La Merrill, David Conti, Rob Mcconnell, Lida Chatzi
Summary: Animal studies have suggested that the liver is a major site for the accumulation and toxicity of per- and polyfluoroalkyl substances (PFAS), but these findings have not been replicated in human populations. In this study, concentrations of seven PFAS were measured in matched liver and plasma samples from 64 adolescents undergoing bariatric surgery. A multilinear regression model based on toxicokinetic descriptors perfectly explained the liver:plasma concentration ratios. Among the PFAS congeners examined, perfluoroheptanoic acid (PFHpA) had a considerably higher liver:plasma concentration ratio. Mechanistic modeling suggested that complex kinetic transport processes contribute to the high liver:plasma concentration ratio of PFHpA. This study demonstrates the potential of combining biomonitoring data with mechanistic modeling to understand the internal distribution and specific target organ toxicity of PFAS in humans.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ann-Cathrine Dalgard Dunvald, Kasper Soltoft, Ekta Sheetal, Soren Andreas Just, Ida Emilie Brejning Frederiksen, Flemming Nielsen, Dorte Aalund Olsen, Jonna Skov Madsen, Oliver Hendricks, Tore Bjerregaard Stage
Summary: Continuous anti-IL-6R therapy in patients with rheumatoid arthritis may cause an acute but transient increase in CYP3A4 activity, which could be attributed to the normalization of inflammation-suppressed CYP activity. Further research is needed to better understand this potential transient effect.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Philippe Grandjean, Alessandra Meddis, Flemming Nielsen, Iben H. Beck, Niels Bilenberg, Carly Goodman, Howard Hu, Christine Till, Esben Budtz-Jorgensen
Summary: By merging data from three birth cohort studies, the study found a statistically significant association between urine-fluoride concentrations and IQ, suggesting the need for protection against fluoride toxicity in pregnant women and children.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jack J. J. Xu, Lars Loenn, Esben Budtz-Jorgensen, Samir Jawad, Peter S. S. Ulriksen, Kristoffer L. L. Hansen
Summary: This study compared the noise, contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and image quality of deep-learning image reconstruction (DLIR) vs. adaptive statistical iterative reconstruction (ASIR-V) in gray scale 74 keV virtual monoenergetic (VM) abdominal dual-energy CT (DECT) with different slice thicknesses. The results showed that DLIR significantly reduced image noise, increased CNR and SNR, and improved image quality, especially in 0.625 mm slice images, compared to ASIR-V.
ABDOMINAL RADIOLOGY
(2023)
