Article
Environmental Sciences
L. M. Iribarne-Duran, I. Castillero-Rosales, F. M. Peinado, F. Artacho-Cordon, J. M. Molina-Molina, E. Medianero, S. I. Nicolas-Delgado, L. Sanchez-Pinzon, V. Nunez-Samudio, F. Vela-Soria, N. Olea, N. E. Alvarado-Gonzalez
Summary: This study provides the first evidence of the presence of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in placentas of Latin-American women, and highlights their potential interference with the hormonal system of unborn babies. The findings raise concerns about the consequences of prenatal exposure to these compounds on children's health and emphasize the need for preventive measures.
ENVIRONMENTAL RESEARCH
(2024)
Article
Neurosciences
Shiyu Wang, Anna I. Neel, Kristen L. Adams, Haiguo Sun, Sara R. Jones, Allyn C. Howlett, Rong Chen
Summary: It has been found that long-term use of atorvastatin reduces the function of dopamine transporter (DAT) in neuroblastoma 2A cells, possibly due to the drug lowering brain cholesterol levels. However, atorvastatin does not have a significant effect on dopamine efflux. This study has important implications for understanding the neurological side effects associated with BBB penetrant statins.
Article
Pharmacology & Pharmacy
Jose A. Pino, Gabriel Nunez-Vivanco, Gabriela Hidalgo, Miguel Reyes Parada, Habibeh Khoshbouei, Gonzalo E. Torres
Summary: This study reveals that G protein beta gamma subunits can bind to the dopamine transporter (DAT) and activate DAT-mediated dopamine efflux, similar to the mechanism of action of psychostimulants like amphetamine (AMPH). Through a combination of computational biology, mutagenesis, biochemical, and functional assays, the amino acid residues within the 582-596 sequence of the DAT carboxy terminus involved in the DAT-G beta gamma interaction and G beta gamma-induced dopamine efflux were identified. Residues like R588 and F587 within the carboxy terminus of DAT play critical roles in the physical interaction between DAT and G beta gamma, influencing dopamine efflux.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Marine & Freshwater Biology
Naima Hamid, Muhammad Junaid, Rakia Manzoor, Jin-Jing Duan, Ming Lv, Nan Xu, De-Sheng Pei
Summary: Chronic exposure to PPCP mixtures at environmentally relevant concentrations resulted in high accumulation in liver and gonadal tissues of adult zebrafish, leading to perturbed genetic responses and disruption of the HPG axis pathway. In silico molecular docking revealed specific amino acid residues of PPCPs binding with estrogen receptors, confirming their xenoestrogenic behavior. Strict environmental regulations for the disposal of PPCPs are crucial to protect ecological and public health.
AQUATIC TOXICOLOGY
(2022)
Article
Microbiology
Fernando Sanz-Garcia, Sara Hernando-Amado, Carla Lopez-Causape, Antonio Oliver, Jose Luis Martinez
Summary: Low antibiotic concentrations in natural environments pose a serious and often overlooked threat to public health by selecting for antibiotic-resistant pathogens. The sub-MIC selective windows of ciprofloxacin are strain specific and resistome dependent, with clinically relevant multidrug-resistant mutants emerging at low concentrations. This emphasizes the importance of low drug concentrations in aggravating the antibiotic resistance crisis, particularly in environmental pathogens like P. aeruginosa.
MICROBIOLOGY SPECTRUM
(2022)
Review
Nutrition & Dietetics
Michal A. Zmijewski
Summary: Vitamin D exhibits a variety of activities, including both classic pathway- and vitamin D receptor-dependent transcriptional modulation, as well as rapid and nongenomic responses. It has cell-protective effects, triggers calcium influx, modulates intracellular processes, and influences mitochondrial function. The mechanisms of these nongenomic responses are still not fully understood, but their impact on physiology, pathology, and potential clinical applications are discussed in this review.
Article
Microbiology
Fernando Sanz-Garcia, Sara Hernando-Amado, Jose Luis Martinez
Summary: Antibiotic pollution in non-clinical environments may have an impact on human health by selecting for resistant pathogens. Research has shown that antibiotic resistant bacteria can be selected even at sub-MIC concentrations, highlighting the importance of understanding the implications of antibiotic resistance and the need for accurate information on sub-MIC selective windows.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Baohai Shao, Farsad Afshinnia, Anna V. Mathew, Graziella E. Ronsein, Carissa Thornock, Angela D. Irwin, Mayank Kansal, Panduranga S. Rao, Mirela Dobre, Sadeer Al-Kindi, Matthew R. Weir, Alan Go, Jiang He, Jing Chen, Harold Feldman, Karin E. Bornfeldt, Subramaniam Pennathur
Summary: Patients with chronic kidney disease (CKD) are at high risk for cardiovascular disease (CVD), but traditional risk factors cannot fully explain the increased risk. In CKD patients, altered HDL proteome is linked with incident CVD, but the association of other HDL metrics with incident CVD in this population remains unclear.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Neurosciences
Lola Welsch, Esther Colantonio, Mathilde Frison, Desiree A. Johnson, Shannan P. Mcclain, Victor Mathis, Matthew R. Banghart, Sami Ben Hamida, Emmanuel Darcq, Brigitte L. Kieffer
Summary: This study found that μ opioid receptor neurons in the dorsal raphe nucleus (DRN) participate in reward and emotional responses. These neurons respond to rewarding stimuli and their optoactivation has reinforcing effects and promotes positive emotional responses. Furthermore, their effects are partially mediated by their projections to the lateral hypothalamus.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Sara C. Staubo, Ole Martin Fuskevag, Mathias Toft, Ingeborg H. Lie, Kirsti M. J. Alvik, Pal Jostad, Stein H. Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Storset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
Summary: The study suggests that the occurrence of impulse control disorders (ICDs) among patients using ropinirole is dependent on serum concentration and drug exposure, while the use of pramipexole may inherently increase ICD risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Phillip M. Mackie, Adithya Gopinath, Dominic M. Montas, Alyssa Nielsen, Aidan Smith, Rachel A. Nolan, Kaitlyn Runner, Stephanie M. Matt, John McNamee, Joshua E. Riklan, Kengo Adachi, Andria Doty, Adolfo Ramirez-Zamora, Long Yan, Peter J. Gaskill, Wolfgang J. Streit, Michael S. Okun, Habibeh Khoshbouei
Summary: Monocyte-derived macrophages play crucial roles in tissue homeostasis and diseases, regulated by various signaling molecules. Recent studies have shown the ability of biogenic amines to control macrophage functions, with a focus on the mechanisms surrounding immune cells remaining unclear. Investigating the functions of norepinephrine transporter (NET) and dopamine transporter (DAT) on human MDMs, researchers found that DAT may play a potential role in regulating innate immunity through an immunomodulatory mechanism mediated by LPS-induced dopamine reverse transport.
Article
Microbiology
Sonia Prieto Martin Gil, Ana Tajuelo, Mireia Lopez-Siles, Michael J. McConnell
Summary: This study revealed that subinhibitory concentrations of clinically-relevant antibiotics and disinfectants have variable effects on the promoter activity of RND family members in Acinetobacter baumannii, depending on the strain, compound tested, and growth phase. These findings suggest important implications for the treatment of A. baumannii infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Physiology
Paul J. Davis, Shaker A. Mousa, Hung-Yun Lin
Summary: The integrin alpha v beta 3 receptor for thyroid hormone plays a crucial role in cancer and endothelial cells by regulating cell division, tumor defense mechanisms, angiogenesis, and supporting metastasis, radioresistance, and chemoresistance. T4 and tetrac are the main regulators, involved in signaling pathways and gene expression related to these cell processes.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Julian Gerson, Murat Kaan Erdal, Matthew H. McDonough, Kyle L. Ploense, Philippe Dauphin-Ducharme, Kevin M. Honeywell, Kaylyn K. Leung, Netzahualcoyotl Arroyo-Curras, Jenny M. Gibson, Nicole A. Emmons, Wendy Meiring, Joao P. Hespanha, Kevin W. Plaxco, Tod E. Kippin
Summary: In this study, electrochemical aptamer-based sensors were used to achieve real-time measurement of drug concentrations in the brains of freely moving rats. The results showed that the sensors can provide high-resolution, seconds-resolved neuropharmacokinetics and concentration-response relations of individual subjects. Additionally, a closed-loop feedback-controlled drug delivery system was employed to maintain stable intracranial drug levels.
Review
Environmental Sciences
Katarzyna Goralczyk
Summary: The study aims to review the impact of anthropogenic chemicals on various diseases, highlighting the importance of biomonitoring xenoestrogens for assessing health risks from environmental pollution. Special attention is given to BPA, benzo-alpha-pyrene, and phthalates in relation to their endocrine activity and common presence in daily life, suggesting a potential link to diseases of civilization.