Article
Biochemistry & Molecular Biology
Xuan Liu, Xianyi Xie, Hongling Liu
Summary: Exposure to environmental estrogen during the critical gonadal differentiation period not only affects the development of zebrafish, but also influences the population development, leading to a biased sex ratio in the fish population.
Article
Andrology
Lottie Phillips, Cecilia Lundholm, Lisa Ortqvist, Catarina Almqvist, Agneta Nordenskjold, Anna Skarin Nordenvall
Summary: Using dizygotic twinning rates as an epidemiological indicator, this study found no significant difference in semen quality between men with hypospadias and controls. Although the sample size was limited, impaired semen quality in severe hypospadias could not be excluded. Men treated for cryptorchidism were more likely to use assisted reproductive technology for conception compared to controls.
Article
Pharmacology & Pharmacy
Sen He, Xin Li, Jie-Zhi Ma, Yuan Yang, Shuang Luo, Xian-De Xie, Bing-Hua Yan, Jian Yang, Lin Luo, Lin-Ying Cao
Summary: This study revealed the potential endocrine disruption mechanism of Niclosamide by activating estrogen receptors (ERs) and estrogen-related receptors (ERRs) at environmentally-related nanomolar levels. By fluorescence competitive binding assays and luciferase reporter gene assays, it was found that NIC showed higher binding affinity with ERR gamma than other receptors. Additionally, molecular docking simulations indicated that NIC could bind to ERR gamma with the highest binding energy.
Article
Environmental Sciences
Jiefeng Liang, Qian S. Liu, Zhihua Ren, Ke Min, Xiaoxi Yang, Fang Hao, Qing Zhang, Qian Liu, Qunfang Zhou, Guibin Jiang
Summary: This study systematically investigated the potential endocrine disrupting activities of four common parabens. The results showed that parabens exhibited typical estrogenic effects and could disrupt the endocrine system by activating estrogen receptors and disturbing steroid hormone synthesis and secretion, posing potential risks to the environment and human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Endocrinology & Metabolism
Nicolas Chevalier, Charlotte Hinault, Stephan Clavel, Rachel Paul-Bellon, Patrick Fenichel
Summary: GPER/GPR30, a novel estrogen-binding protein structurally distinct from classic estrogen receptors, is involved in male germ cell proliferation in testicular germ cell cancers. Overexpression of GPER/GPR30 in seminomas, potentially linked to genetic variations, suggests it as a therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Health Care Sciences & Services
Soyeon Kang, Hagyeong Jo, Mee-Ran Kim
Summary: This study aims to evaluate the effects and safety of menopausal functional health ingredients and medicines as endocrine disruptors on the human body through the literature review and OECD guidelines.
Article
Environmental Sciences
Steve U. Ayobahan, Julia Alvincz, Hannes Reinwald, Jannis Strompen, Gabriela Salinas, Christoph Schaefers, Elke Eilebrecht, Sebastian Eilebrecht
Summary: Endocrine disruptors (EDs) have long-lasting negative effects on reproduction in humans and the environment, making them unsuitable for approval for marketing. However, regulatory testing for endocrine disruption is time-consuming, expensive, and requires animal testing. This study combines sublethal zebrafish embryo assays with transcriptomics and proteomics to identify predictive biomarkers for sexual endocrine disruption. Evaluation of these biomarkers in zebrafish embryo-based bioassays can help identify endocrine disrupting hazards and reduce animal testing.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Developmental Biology
Pushpa Singh, Deepa Bhartiya
Summary: Incidence of uteropathies has increased in recent times, possibly due to exposure to endocrine-disrupting chemicals during early development. The present study shows that various uteropathies like endometrial cancer, adenomyosis, and endometriosis are interlinked and occur due to the dysfunction of tissue-resident, very small embryonic-like stem cells (VSELs).
Review
Urology & Nephrology
Takahiko Mitsui
Summary: Cryptorchidism, the most common genital disorder in boys, is influenced by prenatal sex hormone environment and environmental endocrine disruptors. However, the significant association between exposure to environmental endocrine disruptors and the incidence of cryptorchidism remains unknown. Further studies are needed to examine these issues.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Scott J. Swartz, Libby M. Morimoto, Todd P. Whitehead, Mindy C. DeRouen, Xiaomei Ma, Rong Wang, Joseph L. Wiemels, Katherine A. McGlynn, Robert Gunier, Catherine Metayer
Summary: The incidence of testicular germ cell tumors (TGCT) is increasing in the United States, particularly among Latinos, and prenatal exposure to acephate and malathion was associated with TGCT risk among Latinos while carbaryl was associated with TGCT risk among non-Latinos in California. These findings suggest a potential link between exposure to these pesticides and the rise in TGCT risk among Latinos.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Gyeyoon Yim, Andrea Roberts, David Wypij, Marianthi-Anna Kioumourtzoglou, Marc G. Weisskopf
Summary: The study found an association between grandmother's use of DES during pregnancy and increased risk of LBW and PTB in grandchildren. Even after considering the birth outcomes of the previous generation, the results suggest that this effect is not due to confounding by indication.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Toxicology
Christopher J. Borgert
Summary: Styrene is not considered an endocrine disruptor based on a rigorous evaluation of its potential to disrupt EATS pathways. The responses to styrene were inconsistent with patterns expected for chemicals and hormones known to disrupt endocrine function. Further endocrine screening for styrene would not provide useful information and would be unjustified from an animal welfare perspective.
CRITICAL REVIEWS IN TOXICOLOGY
(2023)
Article
Toxicology
Sayed Aliul Hasan Abdi, Abuzer Ali, Shabihul Fatma Sayed, Amena Ali, Shaivad Shabee Hulhasan Abadi, Abu Tahir, Mohd Amir Afjal, Hina Rashid, Omar M. Aly, Sumathi Nagarajan
Summary: Widespread and irrational or long-term use of paracetamol may be harmful to human endocrine homeostasis, especially during pregnancy. Interactions with reproductive hormone receptors can disrupt stability and synthesis of reproductive hormones.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Environmental Sciences
Delnia Ahmadpour, Sakina Mhaouty-Kodja, Valerie Grange-Messent
Summary: Exposure to low doses of DEHP or an environmental phthalate mixture was found to increase BBB permeability, affect glial activation and neuroinflammation in specific brain regions. This suggests that exposure to endocrine disruptors like phthalates may pose a risk to cerebrovascular function.
Article
Urology & Nephrology
Tariq O. Abbas, Mansour Ali
Summary: This study introduced scrotal base distance (SBD) as a sensitive genital anthropometric biomarker in human infants with cryptorchidism and hypospadias. The results showed that patients with these conditions had lower SBD, AGD, and penile length compared to healthy subjects, emphasizing the use of SBD as an objective measurement and biomarker for assessing the effects of fetal endocrine imbalance on male external genitalia development.
Article
Sociology
Neil Stephens, Photini Vrikki, Hauke Riesch, Olwenn Martin
Summary: This study reported an observational study of the March for Science in London in 2017, analyzing marchers' motives and collective understanding of science and its threats. Drawing upon Interaction Ritual Theory and civic epistemology, the notion of populist knowledge practices was developed to capture the 'other' that marchers defined themselves against. The study detailed how marchers performed and articulated a specific vision for science-society relations in Britain in the post-Brexit referendum context.
CULTURAL SOCIOLOGY
(2022)
Article
Environmental Sciences
David Domingues Pavanelli, Daniel Ferreira Domingues, Paulo Gustavo Hoch, Caio Tadao Joko, Marcus Vinicius de Oliveira Andrade, Marcelo Carvalho Lasmar, Alexandre Bacellar Raupp, Nikolaos Voulvoulis
Summary: Pollution incidents can cause temporary changes in water quality, impacting streamwater ecosystem services. This study proposes two Habitat Equivalency Analysis frameworks to assess and compensate for interim losses in streamwaters due to pollution events.
ENVIRONMENTAL MANAGEMENT
(2022)
Review
Food Science & Technology
Birgit Geueke, Ksenia J. Groh, Maricel V. Maffini, Olwenn V. Martin, Justin M. Boucher, Yu-Ting Chiang, Frank Gwosdz, Phoenix Jieh, Christopher D. Kassotis, Paulina Lanska, John Peterson Myers, Alex Odermatt, Lindsey V. Parkinson, Verena N. Schreier, Vanessa Srebny, Lisa Zimmermann, Martin Scheringer, Jane Muncke
Summary: Food packaging plays a crucial role in today's globalized food system, but it can also contribute to the migration of hazardous chemicals into food. In order to assess the impact of food contact materials (FCMs) on human health, it is necessary to identify the chemicals they contain, known as food contact chemicals (FCCs). This study compiled a comprehensive database of migrating and extractable FCCs (FCCmigex) based on information from 1210 studies. The findings reveal that 2881 FCCs have been detected in six FCM groups, with 65% of these being previously unknown. Plastic, with 1975 detected FCCs, is the most extensively studied FCM. This knowledge expands our understanding of FCCs to 14,153 chemicals and can contribute to the development of non-hazardous FCMs, promoting safer food production and supporting a circular economy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Sibylle Ermler, Asma Baig, Martin Scholze
Summary: Through a systematic review of animal and epidemiological studies, we found convincing evidence of declines in semen quality after gestational bisphenol A (BPA) exposures. Many negative findings can be attributed to deficiencies in study sensitivity and insufficient control of background contamination. Divergent findings in epidemiological studies can be explained by differences in exposure conditions. We chose a BPA reference dose that balances caution and the weight of evidence to estimate BPA exposures that are unlikely to affect semen quality. Current BPA exposures experienced by European populations and beyond exceed this reference dose, and some epidemiological studies have observed effects on semen quality as a result of adult BPA exposures.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Green & Sustainable Science & Technology
Spyridoula Gerassimidou, Elena Lovat, Norman Ebner, Weimu You, Theodoros Giakoumis, Olwenn Martin, Eleni Iacovidou
Summary: This study aims to assess the role of stakeholders in improving the plastics recycling rate and circularity in the UK using PET drinks bottles as a case study. The findings reveal that internal stakeholders, driven by lobbying power and financial support, have a strong influence on the production and consumption processes, while waste management processes lack foresight. Collaboration between internal and external stakeholders is crucial to achieve a sustainable circular plastics economy.
SUSTAINABLE PRODUCTION AND CONSUMPTION
(2022)
Article
Toxicology
John E. Doe, Alan R. Boobis, Samuel M. Cohen, Vicki L. Dellarco, Penelope A. Fenner-Crisp, Angelo Moretto, Timothy P. Pastoor, Rita S. Schoeny, Jennifer G. Seed, Douglas C. Wolf
Summary: Concerns over potentially carcinogenic substances have led to various classification schemes, but binary choices are not effective in managing these substances. Hence, we propose a new classification scheme that categorizes carcinogens based on their mode of action and potency, providing better guidance in their regulation and management.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
N. Voulvoulis, T. Giakoumis, V. Kioupi, I. Souliotis, C. Vaghela, WIH. binti Wan Rosely
Summary: The Sustainable Development Goals serve as a reference and universal guidepost for transitioning to sustainable development. They require holistic, integrated, and interdisciplinary thinking to address sustainability challenges and drive system transformations.
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS
(2022)
Review
Environmental Sciences
Wan Lzar Haizan, Wan Roselya, Nikolaos Voulvoulis
Summary: Despite the development of frameworks, concepts, and indicators to improve the sustainability of urban water systems, progress has been slow. Water-related challenges, such as lack of access to safe water and sanitation, are expected to worsen due to population growth and decreasing availability. The concept of systemic solutions to address these challenges remains ambiguous in current urban water literature. This study explores the potential of systems thinking in addressing urban water challenges and identifies the shortcomings of conventional paradigms and management practices. Systems thinking allows for understanding the interrelations that create these challenges and rethinking assumptions about change. It has the potential to empower policymakers, water managers, urban planners, and stakeholders to address the root causes of urban water challenges and promote sustainable practices for the transformation of urban water systems.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Green & Sustainable Science & Technology
Spyridoula Gerassimidou, Olwenn V. Martin, Gilenny Yamily Feliz Diaz, Chaoying Wan, Dimitrios Komilis, Eleni Iacovidou
Summary: The production of FLW-derived bioplastics has the potential to revolutionize the plastics economy as an attractive alternative to first-generation bioplastics, but a clear understanding of their sustainability performance is lacking. This systematic evidence mapping fills the gap by assessing the complex and uncertain life cycle sustainability of FLW-derived bioplastics from multiple perspectives. Progress is being made, but innovation in both the food and plastics value chains is urgently needed to overcome challenges and mitigate pollution.
Article
Engineering, Environmental
T. Giakoumis, N. Voulvoulis
Summary: Water pollution caused by the frequent use of combined sewer overflows (CSOs) is a growing concern in England and worldwide. Analysis of event duration monitoring (EDM) data for 2021 and 2020 reveals that CSO spills are a systemic issue related to the under capacity of the English wastewater systems. The reliance on CSOs for peak dry weather flow conditions poses risks to the environment and water users.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2023)
Article
Agricultural Economics & Policy
Ellen Dyson, Rachel Helbig, Tessa Avermaete, Kate Halliwell, Philip C. Calder, Lynn R. Brown, John Ingram, Bert Popping, Hans Verhagen, Alan R. Boobis, Isabelle Guelinckx, Louise Dye, Neil Boyle
Summary: The reverberations of the Ukraine-Russia conflict have had a profound global impact in 2022, exacerbating existing pressures on global systems. The vulnerabilities of the global food system have been exposed, resulting in disruptions to food supply chains and disproportionately affecting vulnerable populations in the Global South.
Article
Environmental Sciences
Jane Muncke, Anna-Maria Andersson, Thomas Backhaus, Scott M. Belcher, Justin M. Boucher, Bethanie Carney Almroth, Terrence J. Collins, Birgit Geueke, Ksenia J. Groh, Jerrold J. Heindel, Frank A. von Hippel, Juliette Legler, Maricel V. Maffini, Olwenn V. Martin, John Peterson Myers, Angel Nadal, Cristina Nerin, Ana M. Soto, Leonardo Trasande, Laura N. Vandenberg, Martin Wagner, Lisa Zimmermann, R. Thomas Zoeller, Martin Scheringer
Summary: Food contact materials and articles are widely used in the global food system, but current regulations do not adequately protect public health from harmful chemicals that migrate from these materials. To address this issue, we propose testing the migration of finished food contact articles and expanding toxicological testing to improve the safety of these materials.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Toxicology
Olwenn V. Martin
Summary: Chemical pollution is characterized by exposure to complex mixtures, and assessing their effects presents challenges. Current proposals for mixture assessment factors assume additive behavior, but studies have shown that synergistic interactions are common in mixtures. Further research is needed, but the importance of potential synergisms in protecting people and the environment from mixture effects should not be overlooked.
CURRENT OPINION IN TOXICOLOGY
(2023)
Article
Education & Educational Research
Vasiliki Kioupi, Nikolaos Voulvoulis
Summary: Universities can play a significant role in promoting sustainability and developing sustainability competences in students. This research proposes an assessment framework to evaluate the attainment of sustainability competences in university students, providing tools and methods for assessment.
EDUCATION SCIENCES
(2022)