Article
Pharmacology & Pharmacy
Ching-Kai Shen, Bor-Ren Huang, Wei-Lan Yeh, Chao-Wei Chen, Yu-Shu Liu, Sheng-Wei Lai, Wen-Pei Tseng, Dah-Yuu Lu, Cheng-Fang Tsai
Summary: This study showed that IL-1 beta induces the expression of ICAM-1 and VCAM-1 in GBM cells, leading to increased adhesive interaction between monocytes and GBM cells. Additionally, IL-1 beta also triggers the production of soluble ICAM-1 and VCAM-1 in GBM, which plays a crucial role in regulating tumor-associated monocyte/macrophage polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medical Laboratory Technology
Varinder Singh, Rupinder Kaur, Pratima Kumari, Chirag Pasricha, Ravinder Singh
Summary: Leukocyte migration is vital for lymphocyte recirculation and immune response. ICAM-1 and VCAM-1 play a crucial role in leukocyte adherence to endothelial cells in various diseases. They contribute to inflammation, leukocyte migration, and have implications in multiple pathological states. Understanding their immunoregulatory role and pathophysiological effects helps in disease management.
CLINICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Weixuan Wang, Shuang Li, Xi Wang, Jianbo Wang, Yanshu Zhang
Summary: This study investigated the effect of nano-PbO exposure on lymphocyte cells infiltration and adhesion protein expression in the choroid plexus, as well as the role of reactive oxygen species (ROS) in the process. Results showed that nano-PbO exposure increased lymphocyte cell percentage and upregulated ICAM-1 and VCAM-1 expression. Additionally, nano-PbO treatment led to increased ROS production and decreased antioxidant activity. Inhibition of ROS significantly decreased ICAM-1 and VCAM-1 expression. In conclusion, nano-PbO exposure increases ICAM-1 and VCAM-1 expression through oxidative stress, facilitating lymphocyte infiltration into the brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biology
Sandra Marinovic Kulisic, Marta Takahashi, Marta Himelreich Peric, Vedrana Muzic Radovic, Ruzica Jurakic Toncic
Summary: This study evaluated the expression of E-selectin, ICAM-1, and VCAM-1 in skin biopsy specimens of patients with AD using a computer program. The results showed that the number of ICAM-1 and VCAM-1 positive cells decreased, while the E-selectin positive epidermal surface area increased in AD patients. The endothelial area positive for E-selectin and ICAM1 was significantly larger in AD-affected skin. In addition, strong signals of E-selectin were detected in skin macrophages and ICAM-1 in dermal vessel endothelium. VCAM-1 signal could not be found in the endothelial cells of AD-affected skin. The expression of E-selectin, ICAM-1, and VCAM-1 shows significant changes in AD-affected skin compared to control skin.
Article
Chemistry, Multidisciplinary
Yan-rou Bei, Shun-chi Zhang, Yu Song, Mao-lin Tang, Ke-lan Zhang, Min Jiang, Run-chao He, Shao-guo Wu, Xue-hui Liu, Li-mei Wu, Xiao-yan Dai, Yan-wei Hu
Summary: Atherosclerosis is a chronic inflammatory disease in which monocyte adhesion to endothelial cells plays a crucial role. This study shows that the novel gene EPSTI1 is significantly upregulated in atherosclerotic plaques and promotes monocyte adhesion to endothelial cells by increasing the expression of VCAM-1 and ICAM-1. The expression of EPSTI1 is regulated by LPS and is dependent on p65 nuclear translocation. These findings suggest that EPSTI1 may play a potential role in the development of atherosclerosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biotechnology & Applied Microbiology
Qian Zhang, Wei Zhang, Jing Liu, Haisen Yang, Yuxia Hu, Mengdi Zhang, Tuya Bai, Fuhou Chang
Summary: The study investigated the regulatory role of LPC on endothelial cell adhesion marker expression, suggesting that the LPC-G2A-ICAM-1/VCAM-1 pathway may contribute to atherogenic activity of oxLDL, with NF-kappa B antagonists potentially serving as effective therapeutic tools for cardiovascular diseases.
Article
Parasitology
Chintana Chirathaworn, Jira Chansaenroj, Watchadaporn Chaisuriyong, Somrat Lertmaharit, Yong Poovorawan
Summary: This study investigates the biomarkers of inflammation regulation in CHIKV infection-induced joint pain. The levels of sVCAM-1 were found to be significantly higher in patients with joint pain, while the levels of IL-1Ra and sVCAM-1 were not associated with age.
Article
Public, Environmental & Occupational Health
Swaantje Casjens, Savo Neumann, Katrin Ruehle, Lisa Gamrad-Streubel, Lisa-Marie Haase, Katharina K. Rudolph, Thomas Birk, Joerg Giesen, Volker Neumann, Dirk Pallapies, Juergen Buenger, Heiko U. Kaefferlein, Thomas Behrens, Thomas Bruening, Dirk Taeger
Summary: The study aimed to evaluate exposures to diesel engine exhaust (DEE) and polycyclic aromatic hydrocarbons (PAH) in a salt and potash mining population and the potential associations between these health hazards. The results showed that underground miners had the highest DEE exposures, followed by maintenance workers and facility workers. However, urinary concentrations of 1-hydroxypyrene (1-OHP) did not reflect these findings.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Sophie Meixensberger, Hanna Kuzior, Bernd L. Fiebich, Patrick Suess, Kimon Runge, Benjamin Berger, Kathrin Nickel, Dominik Denzel, Miriam A. Schiele, Maike Michel, Simon Maier, Karl Bechter, Katharina Domschke, Ludger Tebartz van Elst, Dominique Endres
Summary: The levels of sICAM-1 and sVCAM-1 in the CSF were higher in patients with schizophrenia spectrum disorder compared to those with depression, indicating endothelial dysfunction underlying BBB/BCSFB impairment. Additionally, a significant correlation of sVCAM-1 with CSF protein and AQ levels was observed in patients with schizophrenia spectrum disorders.
Article
Environmental Sciences
Harikrishna Prasad Mamidala, Dipnarayan Ganguly, Purvaja Ramachandran, Yudhistir Reddy, Arumughan Paneer Selvam, Gurmeet Singh, Kakolee Banerjee, Radhakrishnan Subhadra Robin, Ramesh Ramachandran
Summary: The distribution and sources of particulate organic carbon and nitrogen in mangroves ecosystems along the east and west coast of India were examined. The results showed that water quality in these mangrove waters is influenced by land-based contaminants and the concentration of particulate organic carbon is higher in the east coast.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tsung-Ju Wu, Sunny Li-Yun Chang, Chih-Yang Lin, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yi-Chin Fong, Chen-Ming Su, Chih-Hsin Tang
Summary: IL-17 increases monocyte adhesion in OA synovium by reducing miR-5701 expression and enhancing VCAM-1 production. These findings improve our understanding of IL-17's impact on OA progression and provide insights for the design of more effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Green & Sustainable Science & Technology
Mauricio A. Correa-Ochoa, Roxana Bedoya, Luisa M. Gomez, David Aguiar, Carlos A. Palacio-Tobon, Henry A. Colorado
Summary: The main goal of this research is to identify and analyze the achievements made so far in the characterization and measurement of the carbonaceous fraction in particulate matter, which contributes significantly to global pollution and the deterioration of public health.
Article
Clinical Neurology
Qianwen Lv, Haili Sun, Zhiyong Du, Xiaolu Jiao, Huahui Yu, Qiuju Sun, Fan Li, Yu Wang, Linyi Li, Chaowei Hu, Yanwen Qin
Summary: The study revealed a significant association between circulating VCAM-1 levels and the presence of CAD in Chinese adults with moderate to severe OSA, suggesting VCAM-1 as a potential novel biomarker for monitoring the development and progression of CAD in this population.
Article
Environmental Sciences
Hesham Hassan, James Schwab, Jie Zhang
Summary: Harmonizing the particulate carbon data from the CSN is challenging due to changes in samplers and analysis protocols. The study used field blanks, outlier filtering, and regression analysis to establish harmonization between urban sites. A comparison with IMPROVE network data showed consistent trends but small differences in EC concentrations.
AEROSOL AND AIR QUALITY RESEARCH
(2023)
Article
Environmental Sciences
Alexandra G. Ponette-Gonzalez, Dongmei Chen, Evan Elderbrock, Jenna E. Rindy, Tate E. Barrett, Brett W. Luce, Jun-Hak Lee, Yekang Ko, Kathleen C. Weathers
Summary: Urban tree canopies play an important role in absorbing atmospheric elemental carbon (EC). The deposition of EC on trees is influenced by urban form characteristics, meteorological factors, and topography. The study found that urban edge trees significantly contribute to dry EC deposition, while rainfall and wind-driven rain from pollution sources drive throughfall EC deposition.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Jennifer L. Garza, Jacqueline M. Ferguson, Alicia G. Dugan, Ragan E. Decker, Rick A. Laguerre, Adekemi O. Suleiman, Jennifer M. Cavallari
Summary: The organization of working hours has a significant impact on workers' health. This study found that low schedule control was associated with neck/shoulder musculoskeletal symptoms, while frequently working long hours was associated with leg/foot musculoskeletal symptoms. These working time characteristics should be considered in interventions to prevent musculoskeletal disorders and promote workers' health.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
John S. Evans, Leonora Rojas-Bracho, James K. Hammitt, Douglas W. Dockery
Summary: Retrofitting diesel vehicles in Mexico City with particulate filters and oxidation catalysts can significantly reduce emissions and improve public health, resulting in both economic and health benefits that outweigh the initial costs. This study highlights the importance of considering various interventions to control air pollution and protect public health, and emphasizes the need for further analysis and implementation of these measures.
Article
Oncology
Alicia G. Dugan, Ragan E. Decker, Sara Namazi, Jennifer M. Cavallari, Keith M. Bellizzi, Thomas O. Blank, Ellen A. Dornelas, Susan H. Tannenbaum, William S. Shaw, Helen Swede, Andrew L. Salner
Summary: This study explored the most valued types of support by breast cancer survivors during early survivorship, highlighting the importance of informational, emotional, instrumental, and quality of life support. Survivors expected more guidance related to work from healthcare providers, and there was a lack of emotional and instrumental support for some survivors.
JOURNAL OF CANCER SURVIVORSHIP
(2021)
Article
Public, Environmental & Occupational Health
Alicia G. Dugan, Sara Namazi, Jennifer M. Cavallari, Robert D. Rinker, Julius C. Preston, Vincent L. Steele, Martin G. Cherniack
Summary: This study collaborated with a correctional supervisors' union to develop a customized survey using CBPR methods and HWPP tools, identifying key themes related to supervisors' work and health. The findings provided insights into the root causes of health issues and opportunities for interventions addressing these causes.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jennifer M. Cavallari, Jennifer L. Garza, Jacqueline M. Ferguson, Rick A. Laguerre, Ragan E. Decker, Adekemi O. Suleiman, Alicia G. Dugan
Summary: The study found that working time characteristics were associated with work-related mental health issues such as burnout, and general mental health issues such as depressive symptoms. Work intensity was linked to burnout symptoms, while schedule control and predictability were associated with depressive symptoms.
ANNALS OF WORK EXPOSURES AND HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Lisa M. Rusch, Helen Swede, Alicia G. Dugan, Martin G. Cherniack, Janet Barnes-Farrell, Jennifer M. Cavallari
Summary: The study found that not engaging in leisure-time physical activity (LTPA) is associated with nonrestorative sleep (NRS) in high job demands, especially for workers with the lowest or highest physical demands in their jobs. Poor general health was associated with NRS at all levels of psychological demands, regardless of LTPA. LTPA may reduce NRS for workers with jobs at extreme levels of physical demands.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Despina Pampaka, Stefania I. Papatheodorou, Mohammad AlSeaidan, Rihab Al Wotayan, Rosalind J. Wright, Julie E. Buring, Douglas W. Dockery, Costas A. Christophi
Summary: This study found no significant association between antenatal depressive symptoms and adverse birth outcomes such as preterm birth, small for gestational age, or large for gestational age babies in Kuwait. Further research is needed to examine these associations due to the limited available evidence.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Environmental Sciences
Erin M. Bell, Sylvain De Guise, Jeffrey R. McCutcheon, Yu Lei, Milton Levin, Baikun Li, James F. Rusling, David A. Lawrence, Jennifer M. Cavallari, Caitlin O'Connell, Bethany Javidi, Xinyu Wang, Heejeong Ryu
Summary: This paper discusses scientific challenges related to PFAS, including rapid and low-cost detection, energy saving remediation, the role of T helper cells in immunotoxicity, and the biochemical and molecular effects of PFAS among community residents. Potential research directions are presented to improve the understanding of sensing, remediation, exposure to, and health effects of PFAS.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Public, Environmental & Occupational Health
Thomas R. Cunningham, Rebecca J. Guerin, Jacqueline Ferguson, Jennifer Cavallari
Summary: This paper reviews the literature and identifies that certain high-risk worker populations are more prone to fatigue due to factors such as irregular shifts, lack of fatigue management resources, and socioeconomic barriers. However, there is a lack of research specifically addressing working hours and fatigue in these populations. More research is needed to identify solutions and interventions for work-related fatigue in these high-risk worker groups.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2022)
Article
Engineering, Industrial
Jack T. Dennerlein, Jennifer M. Cavallari, Jeong Ho (Jay) Kim, Nicholas H. Green
Summary: The study evaluated the effects of an electro-magnetic active seat suspension on reducing whole body vibration exposure for long-haul truck drivers, and found that both active and passive seats led to a decrease in low back pain severity and disability scores. Additionally, while the active seat significantly reduced WBV exposures, the improvement in low back pain appeared to be influenced by multiple factors.
APPLIED ERGONOMICS
(2022)
Article
Statistics & Probability
Douglas W. Dockery
Summary: This paper provides a historical perspective on the coordinated developments of epidemiologic designs and statistical methods for air pollution health effects studies at the Harvard School of Public Health, which have led to significant improvement in air quality in the United States.
INTERNATIONAL STATISTICAL REVIEW
(2022)
Article
Public, Environmental & Occupational Health
Sara Namazi, Alicia G. Dugan, Jennifer M. Cavallari, Robert D. Rinker, Julius C. Preston, Vincent L. Steele, Mazen El Ghaziri, Martin G. Cherniack
Summary: A design team conducted a health assessment of correctional supervisors and identified sleep as a priority for intervention. By using a participatory approach, the team incorporated workers' experiences and root causes of poor sleep to develop relevant and acceptable solutions. The team identified root causes of poor sleep and proposed three solutions to address them: training on sleep hygiene, a sleep-tracking smartphone app, and a shared overtime policy.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Jennifer M. M. Cavallari, Jennifer L. L. Garza, Natalie R. R. Charamut, Cheyenne Szarka, Spencer D. D. Perry, Rick A. A. Laguerre, Lisa M. H. Sanetti, Alicia G. G. Dugan
Summary: During the COVID-19 pandemic, remote teaching led to increased work demands and limited resources for teachers, affecting their mental health. The study found that frequently working unexpectedly was associated with higher rates of depression and burnout symptoms. However, utilizing remote work resources was associated with lower rates of depressive symptoms.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Alicia G. Dugan, Rick A. Laguerre, Janet L. Barnes-Farrell, Jennifer M. Cavallari, Jennifer L. Garza, Lindsey A. Graham, Gretchen A. Petery, Nicholas Warren, Martin G. Cherniack
Summary: Aging workers in the manufacturing sector face a higher risk of workforce departure compared to other industries. Musculoskeletal health and perceived work ability are relevant to departure decisions, but studies rarely consider these constructs simultaneously, calling for more research in this area.
OCCUPATIONAL HEALTH SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Sara Namazi, Alicia G. Dugan, Richard H. Fortinsky, Mazen El Ghaziri, Janet L. Barnes-Farrell, Jonathan Noel, Jennifer M. Cavallari, William S. Shaw, Wayne A. Cole, Martin G. Cherniack
Summary: This study examined the impact of traumatic incident exposure at work on correctional supervisors' work-to-family conflict and depressive symptoms, finding that exposure to traumatic incidents can lead to greater depressive symptoms and work-to-family conflict. Additionally, social support was found to moderate this impact, suggesting the importance of interventions to address the adverse effects of traumatic incident exposure on correctional supervisors' family life and mental health.
OCCUPATIONAL HEALTH SCIENCE
(2021)