Article
Engineering, Environmental
Xueping Huang, Aiping Wang, Jian Luo, Yue Gao, Lei Guan, Peng Zhang, Feng Liu, Wei Mu, Beixing Li
Summary: This study prepared a series of LC-MCs with different particle sizes and evaluated their toxicity, revealing that the release and sedimentation behavior in water, as well as the toxicity to zebrafish, were all particle size-dependent. Exposure to micron-sized LC-MCs resulted in significantly lower fish mortality and malformations compared to nanosized LC-MCs, indicating the importance of regulating MC production in an appropriate size range for safe pesticide applications.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Shubhajit Saha, Kishore Dhara, Azubuike V. Chukwuka, Prasenjit Pal, Nimai Chandra Saha, Caterina Faggio
Summary: The acute toxicity of mercury to Clarias batrachus was studied using hematological and biochemical biomarkers at predetermined exposure concentrations. Significant differences were observed in hematological and biochemical variables between exposure groups, with exposed fish exhibiting decreased hemoglobin levels, hematocrit, and total erythrocyte count. The findings suggest toxicant-related anemia and immune-modulation and metabolic disruption. The overall health of mercury-exposed fish deteriorated approximately 3-fold compared to the control group. These observations indicate the potential for greater deleterious effects on less hardy aquatic biota under acute inorganic mercury exposure.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Environmental Sciences
Xiaoqing Xu, Yixin Yu, Min Ling, Irma Ares, Marta Martinez, Bernardo Lopez-Torres, Jorge-Enrique Maximiliano, Maria-Rosa Martinez-Larranaga, Xu Wang, Arturo Anadon, Maria-Aranzazu Martinez
Summary: This article reviews the oxidative and mitochondrial damage induced by lambda-cyhalothrin and the signaling pathways involved in this process, revealing a key mechanism of its toxicity - oxidative damage. The mechanism of antioxidants to alleviate the toxicity of lambda-cyhalothrin is also discussed.
ENVIRONMENTAL POLLUTION
(2023)
Article
Agronomy
Tomas Duque, Sumaiya Chowdhury, Marco Isaia, Stano Pekar, Kai Riess, Gregor Scherf, Ralf B. Schaefer, Martin H. Entling
Summary: This study highlights the high sensitivity of spiders to lambda-cyhalothrin, which can have unintended negative effects on pest suppression. Sensitivity is strongly related to phylogeny and climate, with spiders from boreal and polar climates being more sensitive. The observed differences in sensitivity between spider families and genera suggest that the functional composition of spider communities would change in areas affected by pesticide pollution. The variation in spider sensitivity emphasizes the need for multispecies investigations in pesticide risk assessment.
PEST MANAGEMENT SCIENCE
(2023)
Article
Chemistry, Applied
Ruiquan Hou, Jingtong Zhou, Zixia Song, Ning Zhang, Suqing Huang, Amir E. Kaziem, Chen Zhao, Zhixiang Zhang
Summary: In this study, pH-responsive LC@O-CMCS/PU nanoparticles were prepared by encapsulating ?-cyhalothrin (LC) with O-carboxymethyl chitosan (O-CMCS) to form LC/O-CMCS and then covering it with polyurethane (PU). LC@O-CMCS/PU showed good alkaline release properties and pesticide loading performance. It exhibited better leaf-surface adhesion and lower acute contact toxicity to Harmonia axyridis (H. axyridis) compared to commercial formulations containing emulsifiers. LC@O-CMCS/PU effectively reduced the toxicity of dew and has the potential to be used in pest control combining natural enemies and chemical pesticides.
CARBOHYDRATE POLYMERS
(2023)
Article
Entomology
Tomas Duque, Ralf B. Schaefer, Martin H. Entling
Summary: Spiders may be adversely affected by pesticides, and factors such as population origin and rearing conditions can influence their sensitivity to chemicals. Our study found that spiders from boreal climate are more sensitive to lambda-cyhalothrin compared to spiders from cool temperate climate. However, rearing and test temperature did not significantly affect spider chemical sensitivity.
JOURNAL OF APPLIED ENTOMOLOGY
(2023)
Article
Environmental Sciences
Dip Mukherjee, Nuno G. C. Ferreira, Nimai Chandra Saha
Summary: 2,4,6-Trichlorophenol has negative effects on different physiological parameters of Clarias batrachus, even at low concentrations and short-term exposure. This study highlights the importance of continued research on the impact of this compound.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Ecology
Z. Naeem, A. Zuberi, M. Ali, A. D. Naeem, M. Naeem
Summary: This study investigated the effects of ammonia exposure on the growth and hematological parameters of Clarias batrachus. The results showed that ammonia exposure led to a decrease in growth and several hematological parameters, while other parameters increased.
APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Shubhajit Saha, Azubuike Chukwuka, Dip Mukherjee, Lipika Patnaik, Susri Nayak, Kishore Dhara, Nimai Chandra Saha, Caterina Faggio
Summary: This study examined the impact of diazinon on Clarias batrachus, revealing a decrease in various physiological parameters with significant correlation to exposure concentration and duration. The findings suggest potential risks to the health of local fish populations in aquatic systems near agricultural areas.
APPLIED SCIENCES-BASEL
(2021)
Article
Environmental Sciences
Dip Mukherjee, Shubhajit Saha, Azubuike Chukwuka, Biswatosh Ghosh, Kishore Dhara, Nimai Chandra Saha, Prasenjit Pal, Caterina Faggio
Summary: The hydrophilic nature and persistent characteristics of neonicotinoids can lead to prolonged exposure for non-target organisms. In this study, the sublethal toxicity of the neonicotinoid Thiamethoxam (R) was investigated in the non-target freshwater fish species Clarias batrachus. The results showed that exposure to Thiamethoxam (R) affected the antioxidant enzyme responses, neurotransmission, and haematological and serum biochemistry of the fish, as well as causing histopathological alterations in the gill and liver tissues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Amina Settar, Hassina Khaldoun, Dalila Tarzaali, Nacima Djennane, Chahrazed Makhlouf, Ichrak Selmani, Oularbi Yasmine, Khaldoune Amel
Summary: Pesticides can cause harmful effects on the environment and human health, but preventive measures such as vitamin supplementation can be effective. This study investigated the toxic effects of a specific insecticide mixture on rabbit liver and the potential ameliorative effects of a vitamin mixture. The results showed that the insecticide caused weight loss, reduced food intake, altered biochemical parameters, and liver damage, while vitamin supplementation improved these conditions.
Article
Environmental Sciences
Suzhen Ye, Zhenya Tian, Weihua Ma, Xuyuan Gao, Hongsong Chen, Jingfang Yang, Chao Ma, Yan Zhang, Zhongshi Zhou
Summary: This study examined the response of bacteria in the midgut of the fruit fly Bactrocera tau to stress induced by the insecticides lambda-cyhalothrin and spinosad. The results showed that female B. tau were more resistant to the insecticides than males, and significant changes in the bacterial community structure and diversity were observed in both male and female flies after exposure to the insecticides. These findings provide a theoretical basis for understanding the relationship between midgut bacteria and insecticide resistance in B. tau.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Agronomy
Ivair Valmorbida, Brad S. Coates, Erin W. Hodgson, Molly Ryan, Matthew E. O'Neal
Summary: This study analyzed the relationship between vgsc gene mutations and fitness costs in soybean aphids. The results showed that there was no negative pleotropic effect associated with pyrethroid resistance in the tested clones, and discussed the potential impact on insecticide resistance management and integrated pest management plans.
PEST MANAGEMENT SCIENCE
(2022)
Article
Entomology
Kang Wang, Jun Ning Zhao, Jiao Yang Bai, Yun Zhu Shang, Si Qian Zhang, Yi Fan Hou, Mao Hua Chen, Zhao Jun Han
Summary: Pyrethroid insecticides have been widely used but pest resistance to them, particularly through target-site mechanisms like the VGSC M918L mutation, is a growing concern. This study found that the M918L mutation in Rhopalosiphum padi resulted in significant resistance to certain pyrethroids but also led to a fitness cost, including decreased longevity and fecundity. Additionally, the fitness cost was found to be correlated with the initial resistance allele frequency, showing the complex relationship between resistance and fitness in insect populations.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kingsley C. Kanu, Anthony C. Okoboshi, Adebayo A. Otitoloju
Summary: This study investigated the haematological and biochemical responses of juvenile C. gariepinus and O. niloticus to pesticide pulse exposure. The results showed significant effects on blood and biochemical parameters in both fish species after pulse and continuous exposure, indicating that brief exposure to high pesticide concentration was as hazardous as continuous exposure to low pesticide concentration.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biology
Sunil Kumar Jaiswal, Nikhat Jamal Siddiqi, Bechan Sharma
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2018)
Review
Chemistry, Medicinal
Nitika Singh, Abhishek Kumar, Vivek Kumar Gupta, Bechan Sharma
CHEMICAL RESEARCH IN TOXICOLOGY
(2018)
Review
Pharmacology & Pharmacy
Siva K. Korada, Nagendra S. Yarla, Vijayendra Mishra, Mohamed A. Daim, Bechan Sharma, G. M. Ashraf, R. Reggi, M. Palmery, Ilaria Peluso, Mohammad A. Kamal
CURRENT PHARMACEUTICAL DESIGN
(2018)
Article
Cell Biology
Vivek K. Gupta, Nikhat J. Siddiqi, Anil K. Ojha, Bechan Sharma
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Clinical Neurology
Amit Kumar, Tomoko Kitago
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2019)
Review
Clinical Neurology
Amit Kumar
CURRENT OPINION IN NEUROLOGY
(2019)
Review
Neurosciences
Orjon Rroji, Amit Kumar, Saravanan S. Karuppagounder, Rajiv R. Ratan
Summary: The laboratory has focused on understanding the transduction of physiological stress into transcriptional responses and has identified key epigenetic targets validated in in vivo studies. Their research highlights the importance of epigenetic proteins in mediating prodeath and prosurvival responses to ferroptosis, with pharmacological agents targeting these proteins showing beneficial effects in various disease models.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Marietta Zille, Juan A. Oses-Prieto, Sara R. Savage, Saravanan S. Karuppagounder, Yingxin Chen, Amit Kumar, John H. Morris, Karl A. Scheidt, Alma L. Burlingame, Rajiv R. Ratan
Summary: Ferroptosis is a form of regulated necrosis that occurs in traumatic brain injury, Huntington disease, and hemorrhagic stroke. It is activated by cystine deprivation, glutathione depletion, and hemolysis products. ERK1/2 activation is a key feature of ferroptosis, and the MEK inhibitor U0126 can inhibit this process. However, hemin-induced ferroptosis is ERK1/2-independent. This novel subtype of ferroptosis is relevant to bleeding in the brain and is dependent on 5-lipoxygenase, independent of ERK and transcription.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Amit Kumar, Manisha Vaish, Saravanan S. Karuppagounder, Irina Gazaryan, John W. Cave, Anatoly A. Starkov, Elizabeth T. Anderson, Sheng Zhang, John T. Pinto, Austin M. Rountree, Wang Wang, Ian R. Sweet, Rajiv R. Ratan
Summary: Antioxidant enzymes were not induced or increased in hypoxia, and their forced expression had varying effects on HIF1 alpha protein stability. Reduction in lipid peroxides or superoxide also did not influence HIF1 alpha protein stability. Mitochondria are suggested to contribute to hypoxic adaptation by consuming oxygen.
Article
Clinical Neurology
Nandini Kundu, Amit Kumar, Carlo Corona, Yingxin Chen, Sonia Seth, Saravanan S. Karuppagounder, Rajiv R. Ratan
Summary: Kundu et al. report that DMXAA, a compound, can activate STING, triggering interferon-associated gene expression in stroke. They show that STING activation has protective effects in stroke and suggest it as a potential therapeutic target. Tilorone, another compound, was also found to activate STING and protect against stroke.
BRAIN COMMUNICATIONS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Khushboo, B. Sharma
JOURNAL OF NEUROCHEMISTRY
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
A. Kumar, R. Singh, B. Sharma
JOURNAL OF NEUROCHEMISTRY
(2019)
Article
Neurosciences
Marietta Zille, Amit Kumar, Nandini Kundu, Megan W. Bourassa, Victor S. C. Wong, Dianna Willis, Saravanan S. Karuppagounder, Rajiv R. Ratan
Article
Toxicology
Sooad Saud Al-Otaibi, Maha Mohamad Arafah, Bechan Sharma, Abdullah Salih Alhomida, Nikhat Jamal Siddiqi
JOURNAL OF TOXICOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Nitika Singh, Bechan Sharma
FRONTIERS IN MOLECULAR BIOSCIENCES
(2018)
