Review
Neuroimaging
Junquan Liang, Qiaoyun Yu, Yuchen Liu, Yidan Qiu, Rundong Tang, Luda Yan, Peng Zhou
Summary: The shared and unique patterns of gray matter volume abnormalities in patients with major depressive and social anxiety disorder may be linked to the underlying neuropathogenesis of these mental illnesses and provide potential biomarkers.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Psychiatry
Junichi Takahashi, Yoji Hirano, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Noriko Kudo, Emiko Shishido, Kosuke Okazaki, Tomoko Shiino, Tomohiro Nakao, Kiyoto Kasai, Ryota Hashimoto, Toshiaki Onitsuka
Summary: The study suggests that detailed eye movement tests can assist in differentiating MDD from healthy controls, especially in older subjects.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
KangCheng Wang, YuFei Hu, ChaoGan Yan, MeiLing Li, YanJing Wu, Jiang Qiu, XingXing Zhu
Summary: This study investigated the brain morphology of depressed patients using voxel-based morphometry (VBM) and source-based morphometry (SBM) methods, and identified differences between first-episode and recurrent patients. These findings offer a promising multivariate approach for identifying potential neurobiological markers for depression.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: Using the DRePS method, common and specific alterations in local functional connectivity patterns were found in patients with BDD and MDD. Patients with both disorders showed decreased DRePS values in multiple brain regions, with MDD patients exhibiting specific decreases in the left caudate. Voxel signals in these regions also contributed to the classification of the two diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: This study characterized the common and specific alterations in the dynamic local functional connectivity pattern in patients with bipolar depressive disorder (BDD) and major depressive disorder (MDD) using a newly developed method called dynamic regional phase synchrony (DRePS). The findings provided new insight into the neural mechanism of BDD and MDD patients and could potentially inform the diagnosis and treatment of these disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Xipeng Long, Lei Li, Xiuli Wang, Yuan Cao, Baolin Wu, Neil Roberts, Qiyong Gong, Graham J. Kemp, Zhiyun Jia
Summary: This study conducted a comprehensive meta-analysis of gray matter volume alterations in adolescents with major depressive disorder and bipolar disorder. The findings suggest that distinct patterns of GMV alterations in these two populations could aid in differentiation and provide potential diagnostic biomarkers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yahui Liu, Jiajia Zhang, Meng Zhang, Xianrui Li, Kun Li, Bi Wang, Yongfeng Yang, Ruize Song, Yajing Si, Tianjun Ni, Xueke Wang, Yibo Geng, Qiaohua Chang, Haisan Zhang, Zhijun Zhang, Hongxing Zhang
Summary: This study found that patients with major depressive disorders have abnormalities in the frontal-limbic structures of the brain, specifically decreased gray matter volume in the right middle frontal and precentral gyri. Childhood trauma may be a contributing factor to these structural abnormalities and increased susceptibility to depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Anthony L. Vaccarino, Sandra E. Black, Susan Gilbert Evans, Benicio N. Frey, Mojib Javadi, Sidney H. Kennedy, Benjamin Lam, Raymond W. Lam, Bianca Lasalandra, Emily Martens, Mario Masellis, Roumen Milev, Sara Mitchell, Douglas P. Munoz, Alana Sparks, Richard H. Swartz, Brian Tan, Rudolf Uher, Kenneth R. Evans
Summary: The study used Rasch Measurement Theory to evaluate the measurement properties of the Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) in neurodegenerative disorders (ND) and major depressive disorder (MDD). The results showed that the QIDS-SR is suitable for assessing and screening depressive symptoms in persons with ND, but there are limitations in differentiating participants at certain severity levels.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Clinical
Thomas S. Blank, Bernhard M. Meyer, Marie-Kathrin Wieser, Ulrich Rabl, Paul Schoegl, Lukas Pezawas
Summary: This study found differences in brain structure and function between early-onset and adult-onset major depressive disorder patients. Early-onset patients showed abnormalities in the hippocampus and prefrontal cortex, which play a key role in emotion-regulation networks. Additionally, volumetric changes in early-onset patients were associated with insomnia symptoms. These results highlight the importance of adolescence as a pivotal developmental phase for major depressive disorder.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Yuqiong He, Qianting Yu, Tingyu Yang, Yaru Zhang, Kun Zhang, Xingyue Jin, Shuxian Wu, Xueping Gao, Chunxiang Huang, Xilong Cui, Xuerong Luo
Summary: Adolescents with major depression disorder (MDD) showed changes in microstate B and microstate D compared to healthy controls. These findings may enhance our understanding of dynamic EEG changes among adolescents with MDD and suggest alterations in brain development in this population.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Jing Jiang, Lei Li, Jinping Lin, Xinyu Hu, Youjin Zhao, John A. Sweeney, Qiyong Gong
Summary: Structural neuroimaging studies have found brain areas involved in the development of major depressive disorder (MDD). However, the results have been inconsistent due to variations in illness duration and effects of antidepressant treatment. This meta-analysis compared gray matter (GM) volumes in MDD patients with different medication status and illness duration, revealing potential effects of treatment and illness duration on brain structure. The analysis included 70 studies with a total of 3682 patients and 3469 controls, and identified decreased GM volume in frontal, temporal, and limbic regions of MDD patients. Drug effects were associated with larger GM volume in the right striatum and smaller GM volume in the right precuneus, while longer illness duration correlated with smaller GM volume in the right temporal gyrus. Similar GM decreases in the bilateral medial frontal cortex indicated a persistent alteration over the course of illness and treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Shaojia Lu, Jiamin Shao, Qian Feng, Congchong Wu, Zhe Fang, Lili Jia, Zheng Wang, Shaohua Hu, Yi Xu, Manli Huang
Summary: This study investigated the brain functional differences between individuals with and without anhedonia in major depressive disorder (MDD). The results showed that MDD patients with anhedonia exhibited increased functional connectivity in the bilateral superior frontal gyrus and decreased functional connectivity in the bilateral middle temporal gyrus and inferior parietal lobule compared to healthy controls. These findings suggest neurobiological differences between different subtypes of depression in MDD.
Article
Behavioral Sciences
Zuxing Wang, Zhili Zou, Jun Xiao, Peijia Wang, Yuanyuan Luo, Wenjiao Min, Ying He, Cui Yuan, Yihan Su, Chenghui Yang, Fan Chang, Hongru Zhu
Summary: Patients with remitted depression show abnormal brain activation, particularly in areas involved in cognitive function, emotion regulation, and perception. These alterations may be the primary or secondary neurophysiological mechanisms underlying major depressive disorder and could serve as potential neuroimaging targets for early screening.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Chunguo Zhang, Huan Jing, Haohao Yan, Xiaoling Li, Jiaquan Liang, Qinqin Zhang, Wenting Liang, Yangpan Ou, Can Peng, Yang Yu, Weibin Wu, Guojun Xie, Wenbin Guo
Summary: The study aimed to investigate the correlations between homotopic connectivity and clinical characteristics in patients with major depressive disorder (MDD). The results showed distinct differences in homotopic connectivity patterns between MDD patients and healthy controls, with abnormal connectivity in the insula and sensory-motor networks being potential neurobiological markers for MDD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Wooyoung Kang, Youbin Kang, Aram Kim, Hyeyoung Kim, Kyu-Man Han, Byung-Joo Ham
Summary: This study aimed to identify gray and white matter abnormalities in MDD patients who experienced childhood adversity. The results showed decreased gray matter in the left rectus and reduced white matter connectivity in various regions including the corpus callosum and superior longitudinal fasciculus. Childhood adversity was found to be negatively correlated with white matter connectivity. These findings suggest that MDD is associated with gray matter atrophy and white matter connectivity changes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Biqiu Tang, Wenjing Zhang, Jiang Liu, Shikuang Deng, Na Hu, Siyi Li, Youjin Zhao, Nian Liu, Jiaxin Zeng, Hengyi Cao, John A. Sweeney, Qiyong Gong, Shi Gu, Su Lui
Summary: Understanding how structural connectivity alterations affect dynamic function in schizophrenia patients, this study investigated the capacity of brain regions/networks to shift the system into easy-to-reach states. The results showed reduced controllability in default mode network, visual network, and subcortical regions, and increased controllability in somatomotor network. These alterations were also associated with impaired functional topology and increased temporal variability in dynamic functional connectivity.
Article
Neurosciences
Xinyue Wan, Pengfei Zhang, Weina Wang, Xintong Wu, Qiaoyue Tan, Xiaorui Su, Simin Zhang, Xibiao Yang, Shuang Li, Hanbing Shao, Qiang Yue, Qiyong Gong
Summary: This study used rs-fMRI to investigate the temporal features of functional connectivity states and changes in connectivity strength in sleep-related hypermotor epilepsy (SHE). The results showed that SHE patients exhibited two dFC states, with state 1 characterized by stronger connections within networks and state 2 characterized by stronger connections between networks. SHE patients had increased fractional time and mean dwell time in state 2, as well as a higher number of state transitions. The NBS analysis revealed increased connectivity strength between networks in SHE patients. These findings suggest that the patterns of dFC may represent adaptive and protective mechanisms in the brain against epileptic seizures.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Chengmin Yang, Wenjing Zhang, Jiajun Liu, Li Yao, Jeffrey R. R. Bishop, Rebekka Lencer, Qiyong Gong, Zhipeng Yang, Su Lui
Summary: By introducing functional gradient, this study found that the functional connectivity of subcortical systems in schizophrenia patients was disrupted before treatment and normalized after treatment. The changes in gradient were associated with symptom improvement.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Jing Jiang, Lei Li, Jinping Lin, Xinyu Hu, Youjin Zhao, John A. Sweeney, Qiyong Gong
Summary: Structural neuroimaging studies have found brain areas involved in the development of major depressive disorder (MDD). However, the results have been inconsistent due to variations in illness duration and effects of antidepressant treatment. This meta-analysis compared gray matter (GM) volumes in MDD patients with different medication status and illness duration, revealing potential effects of treatment and illness duration on brain structure. The analysis included 70 studies with a total of 3682 patients and 3469 controls, and identified decreased GM volume in frontal, temporal, and limbic regions of MDD patients. Drug effects were associated with larger GM volume in the right striatum and smaller GM volume in the right precuneus, while longer illness duration correlated with smaller GM volume in the right temporal gyrus. Similar GM decreases in the bilateral medial frontal cortex indicated a persistent alteration over the course of illness and treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Psychiatry
Huibing Guo, Bin Feng, Yingqiao Ma, Xueyi Zhang, Huiyong Fan, Zaiquan Dong, Taolin Chen, Qiyong Gong
Summary: This study aims to integrate drawing indicators into the process of screening for or classifying mental disorders by conducting a systematic review and meta-analysis of the application of the HTP test. The results revealed that drawing characteristics can predict mental disorders, with the whole being the strongest predictor, followed by the house, tree, and person. Valid predictors can be categorized into four types: item absence, bizarre or twisted, excessive details, and small or simplified. These findings can promote the standardization of the HTP test and provide a theoretical reference for the screening and clinical diagnosis of mental disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Engineering, Biomedical
Xueyang Xiao, Hao Cai, Qiaorong Huang, Bing Wang, Xiaoming Wang, Qiang Luo, Yinggang Li, Hu Zhang, Qiyong Gong, Xuelei Ma, Zhongwei Gu, Kui Luo
Summary: In this study, a dual-modality contrast agent, Gd-DOTA-TPBP, was successfully synthesized using an amphiphilic block polymer as a carrier. The contrast agent exhibited high resolution and sensitivity, making it a promising tool for early-stage tumor diagnosis.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Changqiang Wu, Liang Du, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: Compared to traditional branched polymers, branched polymers with Gd(III) chelates as the internal skeleton show higher kinetic stability and better relaxivity enhancement for MRI contrast agents. Different poly-DOTA branched polymers were synthesized and the Gd(III) chelates displayed excellent stability and high T1 relaxivities. In vivo studies showed that P4-Gd had the best performance in terms of MRA effect, vascular stenosis detection, and longer observation window compared to Gd-DOTA. Overall, poly-DOTA branched polymers with Gd(III) chelates are promising candidates for MRI probes with improved relaxivity enhancement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiaoling Li, Zhenyu Duan, Xiaoting Chen, Dayi Pan, Qiang Luo, Lei Gu, Gang Xu, Yinggang Li, Hu Zhang, Qiyong Gong, Rongjun Chen, Zhongwei Gu, Kui Luo
Summary: Targeting the metabolic vulnerability of tumor cells is a promising anticancer strategy. Researchers have developed a nanomedicine called pOEG-b-D-SH@NP, which encapsulates maleimide-modified doxorubicin (Mal-DOX), to improve overall delivery efficiency and inhibit tumor metabolism through multiple pathways. The nanomedicine effectively depletes energy in colorectal cancer cells and shifts cell death from apoptosis to necroptosis. It also inhibits cellular oxidative phosphorylation and glycolysis, suppressing cancer growth in mouse models.
ADVANCED MATERIALS
(2023)
Article
Psychology, Clinical
Xueling Suo, Du Lei, Huaiqiang Sun, Wenbin Li, Kun Qin, Lingjiang Li, Graham J. Kemp, Song Wang, Qiyong Gong
Summary: Children and adolescents are more susceptible to developing PTSD than adults. This study investigates brain-wide microstructural abnormalities in pediatric PTSD, their relationship to age and sex, and their potential diagnostic value.
DEPRESSION AND ANXIETY
(2023)
Article
Clinical Neurology
Lei Wang, Qing Ma, Xiaoyi Sun, Zhilei Xu, Jiaying Zhang, Xuhong Liao, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia, Yihe Zhang
Summary: This study conducted frequency-resolved connectome analysis on a large sample of MDD patients and healthy controls, revealing significant frequency-dependent connectome alterations in MDD. These alterations mainly occur in the left parietal, temporal, precentral, and fusiform cortices, as well as bilateral precuneus. Additionally, the connectome alteration in the high frequency band (0.16-0.24 Hz) is significantly associated with illness duration.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Feifei Zhang, Hongsheng Xie, Song Wang, Fei Li, Qiyong Gong, Zhiyun Jia
Summary: This study found that the volume of the right orbitofrontal cortex was negatively correlated with exercise addiction. The function of the right orbitofrontal cortex played an indirect role in exercise addiction and affected it through its volume. The volume of the right orbitofrontal cortex mediated the relationship between ability motivation and exercise addiction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Oncology
Shuang Li, Xiaorui Su, Youquan Ning, Simin Zhang, Hanbing Shao, Xinyue Wan, Qiaoyue Tan, Xibiao Yang, Juan Peng, Qiyong Gong, Qiang Yue
Summary: This study aimed to develop and validate CT-based radiomics models to differentiate between parotid pleomorphic adenoma (PA) with and without complete capsule. The results showed that models based on radiomics features from the tumor and peritumor achieved higher AUCs compared to models based on features from the tumor alone. The best performing model was Linear discriminant analysis, achieving an AUC of 0.86 in cross-validation and 0.869 in the test set.
Review
Behavioral Sciences
Lei Li, Jing Jiang, Baolin Wu, Jinping Lin, Neil Roberts, John A. Sweeney, Qiyong Gong, Zhiyun Jia
Summary: Previous studies have found gray matter abnormalities in individuals with histories of childhood maltreatment. This study compared the effects in youth and adulthood and identified different patterns of gray matter changes. Adolescents closer to the maltreatment events showed more gray matter alterations in the developmental trajectory of brain structure.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neuroimaging
Yajuan Zhang, Chu-Chung Huang, Jiajia Zhao, Yuchen Liu, Mingrui Xia, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Ching-Po Lin, Chun-Yi Zac Lo
Summary: Through analysis of a large dataset, it has been found that there are abnormal functional connections between the brainstem nuclei and other brain regions in patients with major depressive disorder (MDD). These findings improve our understanding of the pathophysiology of depression and provide a theoretical foundation for the development of new pharmacotherapies.
NEUROIMAGE-CLINICAL
(2023)
Article
Materials Science, Biomaterials
Yuting Jiang, Haojie Gu, Zhongyuan Cai, Shengxiang Fu, Yingzi Cao, Lingling Jiang, Changqiang Wu, Wei Chen, Chunchao Xia, Su Lui, Bin Song, Qiyong Gong, Hua Ai
Summary: Researchers developed a facile method to synthesize poly(acrylic acid)-coated manganese oxide nanoparticles (MnO2/PAA NPs), which exhibited good biocompatibility and high longitudinal relaxivity. The MnO2/PAA NPs with a particle size of 4.9 nm showed higher longitudinal relaxivity. In vivo magnetic resonance angiography experiments demonstrated that MnO2/PAA NPs had better angiographic performance and rapid clearance compared to Gadovist (Gd-DO3A-Butrol).
BIOMATERIALS SCIENCE
(2023)
