Oxidative DNA damage in disease-Insights gained from base excision repair glycosylase-deficient mouse models

Obesity and Cancer: A Gut Microbial Connection

(2014) N. Ohtani et al.   CANCER RESEARCH

Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

(2014) Luigia De Fazio   WORLD JOURNAL OF GASTROENTEROLOGY

Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1

(2013) Gabriele De Luca et al.   AGING CELL

DNA damage in normally and prematurely aged mice

(2013) Alexander Y. Maslov et al.   AGING CELL

Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress

(2013) Veslemøy Rolseth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of DNA repair in brain related disease pathology

(2013) Chandrika Canugovi et al.   DNA REPAIR

A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases

(2013) Anil K. Mantha et al.   MITOCHONDRION

Role of MUTYH in human cancer

(2013) Filomena Mazzei et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA

(2012) Steffen Loft et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells

(2012) Amilcar Reis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

(2012) Attila Bacsi et al.   DNA REPAIR

Regulation of DNA glycosylases and their role in limiting disease

(2012) Harini Sampath et al.   FREE RADICAL RESEARCH

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

(2012) David Berry et al.   ISME Journal

Prevention of Chronic Experimental Colitis Induced by Dextran Sulphate Sodium (DSS) in Mice Treated with FR91

(2012) Valter R. M. Lombardi et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

(2012) Zijing Sheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbial fingerprinting detects unique bacterial communities in the faecal microbiota of rats with experimentally-induced colitis

(2012) Ashis K. Samanta et al.   JOURNAL OF MICROBIOLOGY

Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage

(2012) Minmin Liu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

(2012) Harini Sampath et al.   PLoS One

Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice

(2012) C. Canugovi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal Adult Neurogenesis Is Maintained by Neil3-Dependent Repair of Oxidative DNA Lesions in Neural Progenitor Cells

(2012) Christine Elisabeth Regnell et al.   Cell Reports

DNA damage induces down-regulation of PEPCK and G6P gene expression through degradation of PGC-1α

(2011) Hyun-Ju Kim et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Obesity and Hepatosteatosis in Mice with Enhanced Oxidative DNA Damage Processing in Mitochondria

(2011) Haihong Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice

(2011) Harini Sampath et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

(2011) Sugako Oka et al.   CANCER SCIENCE

Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis

(2011) Ruth Halsne et al.   DNA REPAIR

Protection from Palmitate-Induced Mitochondrial DNA Damage Prevents from Mitochondrial Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Impaired Insulin Signaling in Rat L6 Skeletal Muscle Cells

(2011) Larysa V. Yuzefovych et al.   ENDOCRINOLOGY

8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice

(2011) Guoping Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome

(2011) Santi M. Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA Damage Level Determines Neural Stem Cell Differentiation Fate

(2011) W. Wang et al.   JOURNAL OF NEUROSCIENCE

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

(2011) Y. Sejersted et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ser 524 is a phosphorylation site in MUTYH and Ser 524 mutations alter 8-oxoguanine (OG): A mismatch recognition

(2010) Sucharita Kundu et al.   DNA REPAIR

Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine

(2010) Barbara van Loon et al.   DNA REPAIR

The Ser(326)Cys Polymorphism of 8-Oxoguanine Glycosylase 1 (OGG1) Is Associated with Type 2 Diabetes in Mexican Americans

(2010) Farook Thameem et al.   HUMAN HEREDITY

Evidence that OGG1 Glycosylase Protects Neurons against Oxidative DNA Damage and Cell Death under Ischemic Conditions

(2010) Dong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models

(2010) Aya M. Westbrook et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The Mutyh Base Excision Repair Gene Influences the Inflammatory Response in a Mouse Model of Ulcerative Colitis

(2010) Ida Casorelli et al.   PLoS One

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM

(2009) Makoto Daimon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of MUTYH and MSH2 in the Control of Oxidative DNA Damage, Genetic Instability, and Tumorigenesis

(2009) M. T. Russo et al.   CANCER RESEARCH

Expression and Polymorphisms of Gene 8-Oxoguanine Glycosylase 1 and the Level of Oxidative DNA Damage in Peripheral Blood Lymphocytes of Patients with Alzheimer's Disease

(2009) Jolanta Dorszewska et al.   DNA AND CELL BIOLOGY

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA

(2009) Michael K. Chan et al.   DNA REPAIR

Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance inEscherichia colimutant

(2009) Masashi Takao et al.   GENES TO CELLS

hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type

(2009) Toshiki Okasaka et al.   JOURNAL OF HUMAN GENETICS

Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits

(2009) Min Wu et al.   JOURNAL OF NEUROCHEMISTRY

Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice

(2009) Wing-Kin Syn et al.   LIVER INTERNATIONAL

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

Mitochondrial DNA, base excision repair and neurodegeneration

(2008) Nadja C. de Souza-Pinto et al.   DNA REPAIR

Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains

(2008) Veslemøy Rolseth et al.   DNA REPAIR

Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme

(2008) Amit K. Maiti et al.   DNA REPAIR

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

(2008) Sugako Oka et al.   EMBO JOURNAL

Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain

(2008) Changxing Shao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3

(2008) A R Dallosso et al.   GUT

Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism

(2008) Fabio Farinati et al.   INTERNATIONAL JOURNAL OF CANCER

Increased susceptibility of chronic ulcerative colitis‐induced carcinoma development in DNA repair enzymeOgg1deficient mice

(2008) Jie Liao et al.   MOLECULAR CARCINOGENESIS

DNA damage and ageing: new-age ideas for an age-old problem

(2008) George A. Garinis et al.   NATURE CELL BIOLOGY