Review
Environmental Sciences
Juana Sanchez-Alarcon, Mirta Milic, Lilia Patricia Bustamante-Montes, Keila Isaac-Olive, Rafael Valencia-Quintana, Ninfa Ramirez-Duran
Summary: The genotoxic potential of mercury and its derivatives remains controversial, with organic mercury compounds being more toxic than inorganic and elemental ones but all still posing a potential risk. There is not sufficient evidence for mercury to be classified as a human carcinogen. Studies have shown that inorganic mercury compounds such as mercury chloride and mercury nitrate, and organic compounds like methylmercury and thimerosal, are widely studied in populations with accidental, occupational, or iatrogenic exposure.
Article
Toxicology
Kenji Nakamura, Yuji Ishii, Shinji Takasu, Takehiko Nohmi, Makoto Shibutani, Kumiko Ogawa
Summary: This study clarified the role of chromosome aberrations (CAs) in chemical-induced carcinogenesis using a rat model with acetamide, a non-mutagenic hepatocarcinogen. Results showed that CAs induced by acetamide played a pivotal role in hepatocarcinogenesis in rats via micronucleus formation, highlighting the potential of chromosome rearrangements in chemical carcinogenesis.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Environmental Sciences
Juana Sanchez-Alarcon, Mirta Milic, Vilena Kasuba, Maria Guadalupe Tenorio-Arvide, Jose Mariano Rigoberto Montiel-Gonzalez, Stefano Bonassi, Rafael Valencia-Quintana
Summary: In agricultural activities, pest control is essential and chemical agents are the most effective method, but also represent a source of potential toxic compound exposure. Studies have shown increased DNA damage levels after exposure to pesticides, confirmed by cytogenetic biomarkers such as chromosomal aberrations, sister chromatid exchanges, micronuclei frequency, and other nuclear abnormalities.
Article
Genetics & Heredity
Joan-Ramon Daban
Summary: This study proposes that the bipolar pulling forces exerted by the mitotic spindle cause the sliding of chromosome layers and facilitate sister chromatid resolution. This hypothesis is supported by three favorable conditions.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Vaclav Bacovsky, Tomas Janicek, Roman Hobza
Summary: This study used hydroxyurea cell synchronization and 2D/3D microscopy to determine the position of sex chromosomes during the mitotic cell cycle and explored the upper limit for the expansion of the non-recombining region of sex chromosomes. The results showed that the velocity of large chromosomes is compensated by their distant positioning from the central interpolar axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Hayal Cobanoglu, Akin Cayir
Summary: The study found that tetrachlorvinphos resulted in different DNA damages in human peripheral lymphocytes, increased chromosomal instability level, indicating its genotoxic potential.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Iasmini Nicoli Galter, Ian Drumond Duarte, Maressa Malini, Francielen Barroso Aragao, Ian de Oliveira Martins, Livia Dorch Rocha, Maria Tereza Weitzel Dias Carneiro, Kamila Soares do Espirito Santo, Jose Augusto de Oliveira David, E. Silvia Tamie Matsumoto
Summary: The Itapemirim River in Brazil's state of Espirito Santo is considered a vital water resource, but continuous anthropogenic contamination is posing environmental threats. The study found that the water quality of the river is compromised, with genotoxic and mutagenic effects observed in various cells, indicating the need for action plans to restore its quality.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Andreja Juric, Irena Brcic Karaconji, Nevenka Kopjar
Summary: The study found that HGA in strawberry tree honey posed no significant cytotoxic threat to human peripheral blood lymphocytes in vitro, had a negligible potential for causing cytogenetic damage in treated cells, and efficiently counteracted the detrimental cytogenetic effects of the antineoplastic drug irinotecan. Further research is needed to explore the safety profile of HGA and its potential for developing new nutraceutical products.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Sugako Ogushi, Ahmed Rattani, Jonathan Godwin, Jean Metson, Lothar Schermelleh, Kim Nasmyth
Summary: Protection of near-centromeric REC8 cohesin and sister kinetochore co-orientation depend on spindle-chromosome complexes (SCCs) in meiosis I, while being lost in meiosis II, resulting in sister chromatid disjunction and production of haploid gametes. The catalytic activity of Separase is crucial for converting kinetochores to a bi-oriented state and deprotecting cohesin in meiosis I.Selective cleavage of REC8 near kinetochores is sufficient to disrupt co-orientation in univalent chromosomes, but may require resolution of chiasmata in bivalents.
DEVELOPMENTAL CELL
(2021)
Article
Plant Sciences
Ji-Hye Jang, Chang-Seob Seo, Hyekyung Ha, Su-Cheol Han, Mee-Young Lee, Hyeun-Kyoo Shin
Summary: Asiasari Radix et Rhizoma (ARE) is a traditional herbal medicine known for its pain-relieving properties, but recent studies suggest that it may have genotoxic effects, particularly evident in chromosomal aberration and Ames tests. Further research is needed to fully understand the potential risks associated with the use of this herbal medicine.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Esra Erikel, Deniz Yuzbasioglu, Fatma Unal
Summary: In this study, the genotoxic and modulatory effects of amygdalin were assessed using human peripheral lymphocytes. The results showed that amygdalin did not exhibit genotoxicity and cytotoxicity, but significantly reduced the frequencies of genomic damage induced by chemotherapy agents. This suggests that amygdalin has potential chemopreventive effects.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Toxicology
Avaneesh Kumar Pandey, Rajendra Kumar, Nusrat Shafiq, Ritika Kondel, Shanky Garg, Harish Negi, Sunil Kumar Arora, Neelam Varma, Samir Malhotra
Summary: The study evaluated the clastogenicity potential of nanoformulations of ethionamide and levofloxacin, showing relatively lower chromosomal damage in mice treated with nanoparticles compared to conventional formulations.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Review
Medicine, Legal
Niels Hadrup, Marie Frederiksen, Anoop K. Sharma
Summary: Boron is widely used as a flame retardant in insulation products, and high exposure may lead to unwanted health effects. It is mainly absorbed through the gastrointestinal tract after oral exposure, with intact skin serving as a barrier. Boron is primarily excreted via urine, and skin exposure can be fatal. Data on inhalation toxicity is limited, but skin exposure to boric acid has proven fatal in some cases.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Food Science & Technology
Miroslav Misik, Armen Nersesyan, Michael Kment, Benjamin Ernst, Tahereh Setayesh, Franziska Ferk, Klaus Holzmann, Georg Krupitza, Siegfried Knasmueller
Summary: The micronucleus (MN) test using Huh6 cells shows promising results with a sensitivity of 80% and a specificity of 94% for the detection of genotoxic carcinogens. The validity of MN tests with Huh6 is higher than that of other experimental models, which suggests a potential reduction in the use of laboratory rodents in genetic toxicology studies.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ece Akbas, Fatma Unal, Deniz Yuzbasioglu
Summary: This study investigated the genotoxicity of gadobutrol and gadoversetamide, two gadolinium-based contrast agents commonly used in magnetic resonance imaging. The results showed that both agents are likely to pose a genotoxic risk in human peripheral lymphocytes, with gadoversetamide demonstrating slightly stronger effects than gadobutrol. Further research is needed to determine the specific concentrations and treatment periods for the safe usage of these contrast agents.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Aleksandra Markovic, Jovana Tubic Vukajlovic, Darko Grujicic, Marina Radovic Jakovljevic, Milan Stankovic, Katarina Djordjevic, Ninoslav Djelic, Milena Radakovic, Olivera Milosevic-Djordjevic
Summary: The study found that extracts of methanol Teucrium arduini and Teucrium flavum have an antigenotoxic effect against MMC-induced chromosome and DNA damage in vitro. The extracts reduced micronucleus frequencies and genetic damage index in a dose-dependent manner, suggesting their potential medicinal relevance and therapeutic use.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Entomology
Zoran Stanimirovic, Uros Glavinic, Nemanja M. Jovanovic, Marko Ristanic, Dusanka Milojkovic-Opsenica, Jelena Mutic, Jevrosima Stevanovic
Summary: The cage and field experiments demonstrated that Li-cit is highly effective against Varroa destructor with minimal impact on bee survival. Li-cit showed significant varroacidal efficacy in the field experiment, with varying levels of lithium residues found in honey and wax samples from different time points.
JOURNAL OF APICULTURAL RESEARCH
(2022)
Article
Entomology
Robert Brodschneider, Johannes Schlagbauer, Iliyana Arakelyan, Alexis Ballis, Jan Brus, Valters Brusbardis, Luis Cadahia, Jean-Daniel Charriere, Robert Chlebo, Mary F. Coffey, Bram Cornelissen, Cristina Amaro da Costa, Ellen Danneels, Jiri Danihlik, Constantin Dobrescu, Garth Evans, Mariia Fedoriak, Ivan Forsythe, Ales Gregorc, Jes Johannesen, Lassi Kauko, Preben Kristiansen, Maritta Martikkala, Raquel Martin-Hernandez, Ewa Mazur, Franco Mutinelli, Solenn Patalano, Aivar Raudmets, Noa Simon Delso, Jevrosima Stevanovic, Aleksandar Uzunov, Flemming Vejsnaes, Anthony Williams, Alison Gray
Summary: This study surveyed beekeepers in 30 European countries and found significant variations in the methods used to control Varroa destructor, a parasitic mite in honey bee colonies. The most commonly used control methods include amitraz, oxalic acid, and formic acid. The study also identified three distinct clusters in Europe based on the control methods used.
JOURNAL OF PEST SCIENCE
(2023)
Article
Entomology
Uros Glavinic, Jovan Blagojevic, Marko Ristanic, Jevrosima Stevanovic, Nada Lakic, Milorad Mirilovic, Zoran Stanimirovic
Summary: This study investigated the effects of thymol on honey bees infected with Nosema ceranae. The results showed that thymol had positive effects on bee survival, immunity, antioxidative protection, and Nosema spore loads in infected bees. However, thymol caused health disorders when applied to Nosema-free bees, indicating the need for cautious and controlled use of thymol.
Article
Entomology
Alison Gray, Adjlane Noureddine, Alireza Arab, Alexis Ballis, Valters Brusbardis, Adrian Bugeja Douglas, Luis Cadahia, Jean-Daniel Charriere, Robert Chlebo, Mary F. Coffey, Bram Cornelissen, Cristina Amaro da Costa, Ellen Danneels, Jiri Danihlik, Constantin Dobrescu, Garth Evans, Mariia Fedoriak, Ivan Forsythe, Ales Gregorc, Iliyana Ilieva Arakelyan, Jes Johannesen, Lassi Kauko, Preben Kristiansen, Maritta Martikkala, Raquel Martin-Hernandez, Ewa Mazur, Carlos Aurelio Medina-Flores, Franco Mutinelli, Eslam M. Omar, Solenn Patalano, Aivar Raudmets, Gilles San Martin, Victoria Soroker, Philip Stahlmann-Brown, Jevrosima Stevanovic, Aleksandar Uzunov, Flemming Vejsnaes, Anthony Williams, Robert Brodschneider
Summary: This article presents the managed honey bee colony loss rates across 37 countries during the winter of 2019/20. The study reveals an overall colony winter loss rate of 18.1%, higher than the previous year. The research also highlights that beekeepers with larger operations, migration practices, and a higher proportion of new queens experience lower loss rates.
JOURNAL OF APICULTURAL RESEARCH
(2023)
Article
Physiology
Nemanja M. Jovanovic, Uros Glavinic, Marko Ristanic, Branislav Vejnovic, Jevrosima Stevanovic, Milivoje Cosic, Zoran Stanimirovic
Summary: The study found that lithium citrate has high efficacy against Varroa destructor and positive effects on honey bee virus loads and gene expression. Additionally, lithium citrate also has a reducing effect on oxidative stress parameters. The results demonstrate the advantages of lithium citrate treatment in controlling Varroa mites.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Entomology
Milan Rajkovic, Zoran Stanimirovic, Jevrosima Stevanovic, Marko Ristanic, Branislav Vejnovic, Michael Goblirsch, Uros Glavinic
Summary: Mushroom extracts, specifically from Agaricus bisporus, show potential in mitigating the negative effects of environmental stressors on honey bees through actions on their immune system, metabolism, and other physiological processes. This study evaluated the genotoxic and antigenotoxic properties of A. bisporus on honey bee cells and found that it did not induce DNA damage but showed promising antigenotoxic effects against H2O2-induced DNA damage.
JOURNAL OF APICULTURAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Nonno Hasegawa, Maeva A. Techer, Noureddine Adjlane, Muntasser Sabah al-Hissnawi, Karina Antunez, Alexis Beaurepaire, Krisztina Christmon, Helene Delatte, Usman H. Dukku, Nurit Eliash, Mogbel A. A. El-Niweiri, Olivier Esnault, Jay D. Evans, Nizar J. Haddad, Barbara Locke, Irene Munoz, Gregoire Noel, Delphine Panziera, John M. K. Roberts, Pilar De la Rua, Mohamed A. Shebl, Zoran Stanimirovic, David A. Rasmussen, Alexander S. Mikheyev
Summary: This study used phylogeographic analysis based on whole-genome data to reconstruct the origins and spread of deformed wing viruses (DWV) transmitted by the varroa mite. The results suggest that DWV-A likely originated in East Asia and spread in the mid-20th century, while DWV-B was acquired more recently from a source outside East Asia and appears to be absent from the original varroa host.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Entomology
Uros Glavinic, Milan Rajkovic, Marko Ristanic, Jevrosima Stevanovic, Branislav Vejnovic, Ninoslav Djelic, Zoran Stanimirovic
Summary: This study evaluated the genotoxic and antigenotoxic potential of thymol on honey bee cells. The results showed that thymol did not have an antigenotoxic effect, but had genotoxic effects at concentrations of 100 and 1000 mu g/mL. It is therefore recommended to use thymol with caution in beekeeping to avoid negative effects on honey bees.
Article
Parasitology
Milan Rajkovic, Uros Glavinic, Danica Bogunovic, Branislav Vejnovic, Darko Davitkov, Ninoslav Belic, Zoran Stanimirovic
Summary: This study aimed to investigate DNA damage caused by Dirofilaria immitis and evaluate the effects of antiparasitic treatment on DNA damage. The results showed that infection with D. immitis led to DNA damage in dogs, but treatment with ivermectin and doxycycline reduced DNA damage.
VETERINARY PARASITOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Nemanja M. Jovanovic, Uros Glavinic, Marko Ristanic, Branislav Vejnovic, Tamara Ilic, Jevrosima Stevanovic, Zoran Stanimirovic
Summary: The study aimed to investigate the effects of a plant-based supplement, B+, on honeybees. The results showed that the supplement improved bee survival, reduced the number of Nosema ceranae spores, and reduced oxidative stress in bees.
Article
Veterinary Sciences
Zoran Stanimirovic, Uros Glavinic, Marko Ristanic, Stefan Jelisic, Branislav Vejnovic, Mia Niketic, Jevrosima Stevanovic
Summary: The study evaluated the effect of a dietary supplement on the hygienic behavior of honey bees combating microsporidial and viral infections. The results showed that the supplement significantly increased hygienic behavior and had an anti-Nosema effect.
ACTA VETERINARIA-BEOGRAD
(2022)
