Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Vasantha Padmanabhan, Wenhui Song, Muraly Puttabyatappa
Summary: Exposure to endocrine-disrupting chemicals (EDCs) in the environment can disrupt the maternal-fetal environment and lead to adverse pregnancy outcomes. Research focuses on the effects of EDCs, the role of environmental and lifestyle factors, related mechanisms, and future research directions.
Article
Environmental Sciences
Zhiquan Liu, Huikang Lin, Yueyue Zheng, Yixuan Feng, Chaoli Shi, Ruoxin Zhu, Xingyao Shen, Yu Han, Hangjun Zhang, Yuchi Zhong
Summary: This study found that exposure to environmentally relevant concentrations of PFOA and PFOS had negative impacts on the immune system of black-spotted frogs. PFOS had a stronger effect on immune indicators compared to PFOA, and both chemicals activated the NF-Kappa B pathway, leading to immunotoxicity.
Article
Biochemistry & Molecular Biology
Anran Cai, Lutzen Portengen, Gokhan Ertaylan, Juliette Legler, Roel Vermeulen, Virissa Lenters, Sylvie Remy
Summary: This study investigated the molecular mechanisms underlying the association between metabolism-disrupting chemicals (MDCs) and birth weight. Through transcriptome analysis, several metabolism-related gene expressions associated with both an MDC and birth weight were identified, and pathways related to genetic information processing were found to be overlapping. This study provides valuable insights into the potential mechanisms of MDC-induced altered birth weight.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yuhao Wu, Junke Wang, Yuexin Wei, Jiadong Chen, Lian Kang, Chunlan Long, Shengde Wu, Lianju Shen, Guanghui Wei
Summary: Based on current evidence, maternal exposure to metals and phthalates may increase the risk for preterm birth.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Anish S. Kolan, Julianne M. Hall
Summary: Several studies have shown that endocrine disrupting chemicals (EDCs) can have harmful effects on various systems of the human body. This review summarizes the investigations into the impact of EDC exposure on reproductive systems, specifically preterm birth (PTB), and the efforts of international organizations to reduce the harmful effects of EDC exposure. The studies examined the association between EDCs and PTB, and although the findings differed, they collectively provide sufficient evidence of a possible link between EDC exposure and the risk of PTB. Therefore, international organizations such as the United Nations Environmental Programme (UNEP) and World Health Organization (WHO) should continue to regulate EDC exposure globally and monitor levels among individuals of reproductive age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yingyu Chen, Han Xiao, Asmagvl Namat, Juan Liu, Fengyu Ruan, Shunqing Xu, Ruizhen Li, Wei Xia
Summary: The study found that pregnant women exposed to a higher concentration of endocrine disrupting chemicals (EDCs) mixture in the first trimester may have an increased risk of preterm birth (PTB), with bisphenol A (BPA) being the most contributing factor among the detected EDCs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Pawel Radwan, Bartosz Wielgomas, Michal Radwan, Rafal Krasinski, Stella Bujak-Pietrek, Kinga Polanska, Anna Kilanowicz, Joanna Jurewicz
Summary: This study investigates the relationship between exposure to parabens and benzophenones, commonly found in cosmetics, and female reproductive health. It found that increased exposure to butyl paraben was associated with a significant decrease in MII oocyte count, while exposure to high levels of benzophenone-3 also decreased MII oocyte count. However, exposure to other parabens and benzophenone-3 were not related to any of the examined reproductive outcomes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
ZhiChao Dang
Summary: Both AMA and LAGDA are used to detect thyroid-mediated modality and adversity based on morphological changes during thyroid hormone-dependent metamorphosis. The EU Guidance recommends their use for investigating the effects of thyroid hormone system disrupting chemicals. However, there is debate over the necessity of using LAGDA as a follow-up to positive AMA results. This study analyzes the similarities, differences, and sensitivity of these two assays in detecting TDCs.
ENVIRONMENTAL POLLUTION
(2022)
Review
Endocrinology & Metabolism
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen
Summary: Endocrine disrupting chemicals, particularly antiandrogenic EDCs, may impact male reproductive health, especially when exposed during fetal development at the sensitive 'masculinization programming window'.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Summary: Research has shown a possible association between obesity and endocrine-disrupting chemicals, which can interfere with energy metabolism and adipose tissue structure regulation. Early exposure to these chemicals may induce epigenetic modifications, making individuals susceptible to obesity and other diseases.
Article
Environmental Sciences
Huanhuan Zhang, Yanqiu Li, Xiaoxin Zhang, Weiyi Chen, Qianhong Liang, Changchang Li, Luke D. Knibbs, Cunrui Huang, Qiong Wang
Summary: Maternal exposure to EDCs is associated with an increased probability of birth defects and congenital heart defects, while paternal exposure is mainly associated with an increased probability of low birth weight. These effects are more pronounced in mothers without multi-vitamins supplement and male babies.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Sherly Antony, Sham Antony, Sharrel Rebello, Sandhra George, Devika T. Biju, R. Reshmy, Aravind Madhavan, Parameswaran Binod, Ashok Pandey, Raveendran Sindhu, Mukesh Kumar Awasthi
Summary: Endocrine Disrupting Chemicals (EDCs) pose a serious threat to the health and future of humans and the ecosystem. This review provides an overview of various EDCs, their toxic effects, and both conventional and modern remediation methods. The use of sustainable approaches like bioremediation has shown positive impacts in controlling EDC pollution.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Viviana Ramirez, Yolanda Galvez-Ontiveros, Pablo Jose Gonzalez-Domenech, Miguel Angel Baca, Lourdes Rodrigo, Ana Rivas
Summary: The study aimed to review limited literature on the effects of postnatal exposure to EDC on child neurodevelopment and behavior. While some research suggests a relationship between postnatal EDC exposure and adverse neurobehavioral outcomes in children, the underlying mechanisms of action remain unclear.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Vineet Kumar Pal, Kurunthachalam Kannan
Summary: This study is the first to report VOCM concentrations in urine of pet dogs and cats, highlighting the need to identify sources and health implications of VOCs exposure in these animals.
ENVIRONMENTAL POLLUTION
(2023)
Article
Veterinary Sciences
Philibert Dougnon, Victorien Dougnon, Boris Legba, Kafayath Fabiyi, Arnaud Soha, Hornel Koudokpon, Kevin Sintondji, Esther Deguenon, Gildas Hounmanou, Carlos Quenum, Taeratou Aminou, Richard Lokossou, Innocent Togla, Cyrille Boko, Bruno Djossa, Francoise Assogba-komlan, Lamine Baba-moussa
Summary: This study assessed the presence of pathogenic bacteria in imported day-old chicks from Belgium to Benin. The results showed that Escherichia coli, Enterococcus spp., and coagulase-negative staphylococci were the most common bacteria identified. The Escherichia coli strains exhibited high resistance rates against ciprofloxacin and trimethoprim + sulfamethoxazole. Immediate detection of resistant bacteria in imported chicks is necessary to prevent their dissemination.
BMC VETERINARY RESEARCH
(2023)
Article
Environmental Sciences
Yumeng Shi, Shucong Chen, Mengqi Yan, Zhipeng Cheng, Leicheng Zhao, Yarui Liu, Bo Zhang, Hongkai Zhu, Tao Zhang, Kurunthachalam Kannan
Summary: Nitrogenous flame retardants (NFRs) have raised global concern due to their nephrotoxic effect, but the mechanism of exposure-induced kidney injury remains unknown. This study measured eight NFRs, four oxidative stress biomarkers (OSBs), and one kidney injury biomarker (NGAL) in urine samples collected from residents in e-waste disassembly and reference areas. Higher concentrations of NFRs and biomarkers were found in the urine of e-waste site residents, indicating that chronic exposure to NFRs can induce oxidative stress and kidney damage. Structure equation modeling revealed that oxidative stress mediated a significant portion of the effect of NFRs on NGAL in e-waste related people. Overall, this study suggests the long-term chronic exposure to NFRs can lead to oxidative stress and renal injury in humans, but the pathogenesis may be scenario-specific.
Article
Environmental Sciences
Alison G. Paquette, Samantha Lapehn, Sophie Freije, James MacDonald, Theo Bammler, Drew B. Day, Christine T. Loftus, Kurunthachalam Kannan, W. Alex Mason, Nicole R. Bush, Kaja Z. LeWinn, Daniel A. Enquobahrie, Carmen Marsit, Sheela Sathyanarayana
Summary: This study provides the first human transcriptomic assessment of PAHs in the placenta and identifies associations between prenatal PAH exposure and placental gene expression, shedding light on the mechanisms by which PAHs may disrupt placental function.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Abigail Gaylord, Emily S. Barrett, Sheela Sathyanarayana, Shanna H. Swan, Ruby H. N. Nguyen, Nicole R. Bush, Kecia Carroll, Drew B. Day, Kurunthachalam Kannank, Leonardo Trasande
Summary: This study investigated the influence of prenatal exposure to the endocrine disrupting chemical bisphenol A on childhood atopic disease. The results showed that there were inverse associations between first trimester bisphenol A concentration and food allergy, while second trimester bisphenol A concentration was positively associated with food allergy. Additionally, prenatal exposure to bisphenol S was found to increase the risk of asthma among males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Wei Wang, Kurunthachalam Kannan
Summary: This study collected 72 single-use medical products of four categories from a hospital in New York State in 2015 and analyzed their migration of 10 phthalates in an ethanol/water mixture. The results showed that the leached phthalate concentration ranged from 0.04 to 54,600 μg, with DEHP being the major phthalate found in 99% of the samples. DEHP was also found in notable concentrations in products labeled as DEHP-free. The study calculated the direct exposure to phthalates from medical devices and first aid supplies, as well as dermal intake from creams/lotions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Henglin Zhang, You Wang, Huimin Zhu, Shaoyou Lu, Yu Wang, Jingchuan Xue, Tao Zhang, Kurunthachalam Kannan, Hongwen Sun
Summary: This study investigated the exposure of infants in South China to neonicotinoid insecticides (NEOs). The results showed that infants had detectable levels of NEOs in urine and blood samples, breast milk, infant formula, and tap water. The concentrations of specific NEOs varied in different samples, with dinotefuran and imidacloprid being the most abundant in urine, blood, breast milk, infant formula, and tap water. Older infants had higher NEO exposure than younger infants. Blood samples had higher concentrations of NEOs compared to urine samples, indicating that NEOs readily enter the bloodstream. Breast-fed infants had higher exposure levels than formula-fed infants. The study also found that external sources contributed to the majority of NEO exposure in infants.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Zhong-Min Li, Kurunthachalam Kannan
Summary: This study investigated the occurrence of synthetic chemicals including DPG, DTG, and TPG in indoor dust samples from 332 locations in 11 countries. DPG was detected in all dust samples, with varying concentrations among the countries. DPG accounted for over 87% of the total concentrations of the three compounds in all countries.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Zhong-Min Li, Kurunthachalam Kannan
Summary: A method using high-performance liquid chromatography-tandem mass spectrometry was developed for the quantification of Diphenylguanidine, 1,3-di-o-tolylguanidine, and 1,2,3-triphenylguanidine in human urine. The method had detection and quantification limits ranging from 0.002 to 0.02 ng/mL and 0.005 to 0.05 ng/mL, respectively. The method was applied to real human urine samples, revealing a detection frequency of 73% and a median concentration of 0.05 ng/mL for Diphenylguanidine in children's urine samples, and a detection frequency of 20% in adults' urine samples.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Alexandra Grippo, Kexin Zhu, Edwina H. Yeung, Erin M. Bell, Matthew R. Bonner, Lili Tian, Pauline Mendola, Lina Mu
Summary: This study examined the impact of indoor air pollution on early childhood neurodevelopment in the US population and found that unclean cooking fuel use and passive smoke exposure were associated with developmental delays in children.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Vishal Midya, Cecilia Sara Alcala, Elza Rechtman, Jill K. Gregory, Kurunthachalam Kannan, Irva Hertz-Picciotto, Susan L. Teitelbaum, Chris Gennings, Maria J. Rosa, Damaskini Valvi
Summary: A study investigates the interactions between environmental chemicals (ECs) and their association with autism spectrum disorder (ASD). By combining weighted quantile sum regression and machine learning methods, two potential interactions between specific ECs and ASD diagnosis are identified.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Mengqi Yan, Hongkai Zhu, Haining Luo, Tao Zhang, Hongwen Sun, Kurunthachalam Kannan
Summary: This study analyzed urine samples collected from 12 cities in mainland China to determine the concentrations of volatile organic compounds (VOCs) and oxidative stress biomarkers. The results showed that VOC exposure primarily came from cooking, solvents, and vehicle emissions. Regional variations in VOC concentrations were observed, with higher levels found in North and South China. The study also revealed a positive correlation between most VOCs and oxidative stress markers, suggesting potential health risks associated with VOC exposure.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Susanna D. Mitro, Rajeshwari Sundaram, Yan Qiao, Jessica L. Gleason, Edwina Yeung, Stefanie N. Hinkle, Pauline Mendola, James L. Mills, Sonia M. Grandi, Sunni L. Mumford, Enrique F. Schisterman, Cuilin Zhang, Katherine L. Grantz
Summary: Multifetal gestation is not associated with long-term maternal mortality, but may be associated with a lower risk of premature mortality.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
K. J. Polinski, S. L. Robinson, D. L. Putnick, R. Sundaram, A. Ghassabian, P. Joseph, V Gomez-Lobo, E. M. Bell, E. H. Yeung
Summary: Children born to mothers with PCOS did not show different cardiometabolic outcomes compared to children without exposure.
HUMAN REPRODUCTION
(2023)