Review
Environmental Sciences
S. Thanigaivel, Saranya Vinayagam, Lalitha Gnanasekaran, R. Suresh, Matias Soto-Moscoso, Wei-Hsin Chen
Summary: Emerging pollutants, including nanomaterials and microplastics, pose risks to aquatic ecosystems and human health. Microalgae-based mitigation techniques have shown promise in addressing these pollutants.
ENVIRONMENTAL RESEARCH
(2024)
Article
Biotechnology & Applied Microbiology
Jiayi He, ChenChen Liu, Mengzhe Du, Xiyi Zhou, Zhangli Hu, Anping Lei, Jiangxin Wang
Summary: The study investigated the metabolic response of Euglena to environmental stresses and the effects of different toxic chemicals on the content of its products. Through comprehensive metabolomics research, potential regulatory mechanisms and mechanisms behind the differential accumulation of metabolites were discovered.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marco Capezzone, Massimo Tosti Balducci, Eugenia Maria Morabito, Cosimo Durante, Paolo Piacentini, Liborio Torregrossa, Gabriele Materazzi, Giacomo Giubbolini, Virginia Mancini, Maja Rossi, Massimo Alessandri, Alessandra Cartocci
Summary: The incidence of thyroid cancer in Italy, particularly in the southern Tuscany region, is high and could be influenced by environmental heavy metal pollution. The study observed significantly higher incidence rates in Grosseto Province compared to other provinces, especially among male patients.
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Environmental Sciences
Yan Lv, Qun-De Zhang, Li-Ming Chang, Duo-Li Yang, Luqman Riaz, Cheng Li, Xiao-Hong Chen, Jian-Ping Jiang, Wei Zhu
Summary: Water pollution from lead poses significant threats to aquatic ecosystems and animals. This study investigated the effects of Pb(NO3)2 on tadpoles and water quality, and found that it impaired tadpole fitness and caused changes in metabolites and gut microbiota. The presence of anions, such as NO3-, influenced the outcomes. Gut microbiota plays an important role in mediating the effects of toxins on aquatic ecosystems.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Substance Abuse
P. Dilip Venugopal, Susana Addo Ntim, Reema Goel, Samantha M. Reilly, William Brenner, Shannon K. Hanna
Summary: Environmental hazards and ecotoxicity of e-cigarettes are often overlooked. This study provides a short-list of hazardous chemicals found in e-liquids, which should be considered for future environmental impact and risk assessments. The findings emphasize the importance of awareness and education in handling and disposing of e-liquids, and aim to inform strategies to prevent and reduce hazards from e-cigarettes.
Article
Environmental Sciences
Zhihua Qiao, Kailun Luo, Shanqi Zhou, Mengru Fu, Xuechun Shao, Kailin Gong, Cheng Peng, Wei Zhang
Summary: DBDPE and Cd are commonly found contaminants in e-waste, which can accumulate in the environment during e-waste dismantling. This study investigated their accumulation and phytotoxicity mechanisms using lettuce. The results showed that exposure to 1 mg/L Cd + DBDPE reduced Cd toxicity to lettuce, while exposure to 5 mg/L Cd + DBDPE increased Cd toxicity. Additionally, combined exposure affected amino acid metabolism, carbon metabolism, and ABC transport in lettuce.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Bailiang Liu, Chunyu Tang, Ying Zhao, Kui Cheng, Fan Yang
Summary: This experiment investigated the adsorption capacity of BC on heavy metals and its effects on soil microorganisms. The results showed that low-temperature BC protected bacteria while high-temperature BC inhibited bacterial growth and promoted heavy metal release.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Environmental Sciences
P. Snega Priya, P. Pratiksha Nandhini, Jesu Arockiaraj
Summary: This article explores the impact of environmental pollution on osteoporosis and analyzes the role of environmental factors in bone health. The article highlights the influence of environmental pollutants on the risk of osteoporosis and emphasizes the importance of understanding molecular mechanisms.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Abhilash Mavinakere Ramesh, Srikantaswamy Shivanna
Summary: The study focuses on the synthesis of MoO3/ZnO heterostructure using a hydrothermal route, which shows excellent photocatalytic degradation and biocompatibility, as well as the ability to remove heavy metals and inhibit bacterial growth. In animal experiments, MoO3/ZnO demonstrates significant bio-medication effects and contributes positively to environmental therapies.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Environmental Sciences
M. Foley, N. Askin, M. P. Belanger, C. Wittnich
Summary: The study found that winter flounder harvested from the western Atlantic region of Canada/USA are affected by heavy metal contamination, showing structural abnormalities and reduced weight for length. Comparing to data from 1980, the 2018 flounder had significantly reduced length and worsened weight with age.
MARINE POLLUTION BULLETIN
(2021)
Article
Environmental Sciences
Guanghui Xu, Xiaolong Lin, Yong Yu
Summary: Heavy metals in soil ecosystems pose a potential threat to soil biota. Micro-and nano-plastics (MNPs) can impact the accumulation of heavy metals in plants by altering soil microbial community and causing injury to plants. This study investigated the effects and mechanisms of MNPs on the uptake of Cu, Zn, Pb, and Cd in lettuce. The results showed that MNPs increased the uptake of heavy metals in lettuce by altering the relative abundance of key metal-activation bacteria in rhizospheric soil. The concentrations of heavy metals in nanoparticle treatments were significantly higher than that of microparticle treatments, particularly at higher nanoparticle concentration. Biomarkers and gene expression showed that high concentrations of nanoparticles caused more severe injuries to lettuce plants. Metabolomic analysis revealed that nanoparticles disturbed the metabolism of ATP-binding cassette transporter and plant hormone signal transduction in lettuce roots, leading to increased uptake of heavy metals by lettuce.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Aurang Zeb, Weitao Liu, Nouman Ali, Ruiying Shi, Yuhang Lian, Qi Wang, Jianling Wang, Jiantao Li, Zeqi Zheng, Jinzheng Liu, Miao Yu, Jianv Liu
Summary: This study investigated the effects of tire wear particles (TWPs) on the growth and metabolism of mung bean plants and soil. Despite the accumulation of heavy metals and polycyclic aromatic hydrocarbons (PAHs) in TWPs-treated soils, there was no significant impact on plant growth, indicating a degree of tolerance. However, TWPs exposure had significant effects on soil enzyme activities, plant metabolite profiles, and microbiota.
ENVIRONMENTAL POLLUTION
(2024)
Review
Environmental Sciences
Renu Yadav, Gagandeep Singh, Anita Rani Santal, Nater Pal Singh
Summary: Soil and water pollution, rapid industrialization, contaminated irrigation-water, increased waste-production and surge in agricultural land leads to the accumulation of Heavy Metals (HM) with time. HM contamination has raised concern over the past years and new remediation strategies are required to deal with it. Phytoremediation is of great significance in the removal, decomposition and detoxification of hazardous metals from HM-contaminated sites. There is a need for further research and biotechnological efforts to enhance the effectiveness of phytoremediation.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Review
Engineering, Environmental
Chenyuan Wu, Yuanqing Chao, Longfei Shu, Rongliang Qiu
Summary: Soil protists play crucial functional roles in terrestrial ecosystems, but their interaction with soil pollutants remains poorly understood. This review provides an overview of the current understanding of these interactions and identifies five research gaps. A better understanding of soil pollutant-protist interactions will contribute to the bioremediation and environmental applications of protists in soil.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
David C. Schroeder, Oliver Kracker, Tanja Froehr, Jerzy Gora, Michal Jewginski, Anke Niess, Iris Antes, Rafal Latajka, Antoine Marion, Norbert Sewald
FRONTIERS IN CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Katarzyna Haldys, Waldemar Goldeman, Michal Jewginski, Ewa Wolinska, Natalia Anger-Gora, Joanna Rossowska, Rafal Latajka
BIOORGANIC CHEMISTRY
(2020)
Article
Oncology
Ilona Dudka, Elin Thysell, Kristina Lundquist, Henrik Antti, Diego Iglesias-Gato, Amilcar Flores-Morales, Anders Bergh, Pernilla Wikstrom, Gerhard Grobner
Review
Biochemistry & Molecular Biology
Patrycja Ledwon, Fosca Errante, Anna Maria Papini, Paolo Rovero, Rafal Latajka
Summary: The cosmeceutical field, blending cosmetics and pharmaceuticals, is a highly investigated area where peptides are a group of interesting bioactive ingredients meeting industry requirements. Besides bioactivity, bioavailability and stability have become increasingly important factors when considering peptides as cosmeceutical ingredients. New methods are being developed to enhance peptides' skin-penetration and stability, as evidenced by scientific articles and patents in the cosmeceutical arena.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Medicinal
Katarzyna Haldys, Waldemar Goldeman, Natalia Anger-Gora, Joanna Rossowska, Rafal Latajka
Summary: A series of 12 monosubstituted acetophenone thiosemicarbazone derivatives were synthesized and tested for their inhibitory properties against tyrosinase activity, with compound 6 showing the highest effectiveness. All investigated compounds inhibited melanin production in B16F10 cells at the micromolar level. Molecular docking revealed interactions between the sulfur atom of the thiourea moiety and copper ions in the active site.
Article
Biochemistry & Molecular Biology
Michal Jewginski, Kinga Haremza, Jesus M. de los Santos, Zouhair Es Sbai, Bartosz Oszywa, Malgorzata Pawelczak, Francisco Palacios, Rafal Latajka
Summary: Phosphinate pseudopeptides are peptide analogs with metal-coordinating and enzyme inhibiting properties, making them ideal candidates for metal-related protease inhibitors. The addition of extra residues in the P2 position enhances the inhibitory effects towards specific enzymes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Ilona Dudka, Angelika Chachaj, Agata Sebastian, Wojciech Tanski, Hans Stenlund, Gerhard Grobner, Andrzej Szuba
Summary: In this pilot study, metabolic profiling of patients with rheumatoid arthritis starting therapy with biological disease-modifying antirheumatic drugs was conducted to evaluate metabolic changes associated with therapy success. The study identified potential metabolomics profiles as valuable prognostic indicators of treatment effectiveness, with promising biomarkers such as GlycA and GlycB for predicting response to bDMARD therapy.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Chemistry, Multidisciplinary
Agnieszka Staskiewicz, Patrycja Ledwon, Paolo Rovero, Anna Maria Papini, Rafal Latajka
Summary: Triazolyl-containing peptidomimetics play a crucial role in drug design by decreasing the susceptibility of molecules to enzymatic degradation. These compounds exhibit diverse biological properties and can be obtained through various synthetic strategies.
FRONTIERS IN CHEMISTRY
(2021)
Review
Chemistry, Physical
Patrycja Ledwon, Anna Maria Papini, Paolo Rovero, Rafal Latajka
Summary: Collagen fibres degradation involves a variety of enzymes, with fibrillar collagens like type I, II, and III being responsible for tissue structure and skin elasticity. Understanding the enzymes involved in collagen degradation, especially those degrading fibrillar collagen, can be valuable for future research and applications.
Article
Biochemistry & Molecular Biology
Michal Pawel Jewginski, Maciej Makowski, Malgorzata Pawelczak, Waldemar Goldeman, Alicja Trojanowska-Laskowska, Pawel Kafarski, Rafal Latajka
Summary: In this study, a new group of hybrid phosphonodehydropeptides composed of glycyl-(Z)-dehydrophenylalanine and structurally variable aminophosphonates were synthesized, and their activity towards cathepsin C was investigated. The results indicate that the inclusion of (Z)-dehydrophenylalanine residue induces ordered conformation. The investigated peptides act as weak or moderate inhibitors of cathepsin C.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Patrycja Ledwon, Waldemar Goldeman, Katarzyna Haldys, Michal Jewginski, Greta Calamai, Joanna Rossowska, Anna Maria Papini, Paolo Rovero, Rafal Latajka
Summary: The development of skin-care products, including cosmeceuticals containing proven active ingredients, such as peptides, is on the rise. However, the applicability of whitening agents in these products is often limited due to drawbacks like toxicity and lack of stability. In this study, thiosemicarbazone (TSC)-peptide conjugates were found to inhibit diphenolase activity, and were tested as tyrosinase and melanogenesis inhibitors in B16F0 cells. The results showed that TSC1-conjugates had a lower IC50 value than the widely used reference compound kojic acid, making them potential candidates for tyrosinase inhibition.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Physiology
Angelika Chachaj, Ilona Dudka, Malgorzata Jeziorek, Monika Sowicz, Agnieszka Adaszynska, Andrzej Szuba
Summary: This study aims to compare lymphoscintigraphy in women with lipedema and women with overweight/obesity. The results show that lymphatic alterations are present in both groups and are associated with weight and body composition parameters. Therefore, lymphoscintigraphy cannot distinguish between lipedema and overweight/obesity.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Angelika Chachaj, Rafal Matkowski, Gerhard Grobner, Andrzej Szuba, Ilona Dudka
Review
Chemistry, Multidisciplinary
Fosca Errante, Patrycja Ledwon, Rafal Latajka, Paolo Rovero, Anna Maria Papini
FRONTIERS IN CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Katarzyna Haldys, Rafal Latajka