Article
Environmental Sciences
Nuria Guil-Oumrait, Damaskini Valvi, Raquel Garcia-Esteban, Monica Guxens, Jordi Sunyer, Maties Torrent, Maribel Casas, Martine Vrijheid
Summary: This study found that prenatal exposure to persistent organic pollutants may have lasting effects on child BMI into adolescence, and exposure to certain pollutants during pregnancy may be associated with major risk factors for adult CM syndrome.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Ana Lorena Lima Ferreira, Nathalia Freitas-Costa, Samary da Silva Rosa Freire, Amanda Caroline Cunha Figueiredo, Marina Padilha, Nadya Helena Alves-Santos, Gilberto Kac
Summary: This study aimed to investigate the association between maternal pre-pregnancy overweight/obesity and dietary intake during pregnancy and POP concentrations in human milk. The study found that maternal pre-pregnancy overweight/obesity and total lipid intake during pregnancy were associated with POP concentrations in human milk.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Alvina Leche, Eric Gismondi, Monica B. Martella, Joaquin L. Navarro
Summary: This study assessed persistent organic pollutants (POPs) for the first time in the Greater rhea from the Pampas grasslands of South America, revealing higher concentrations of POPs in populations living in intensive crop production areas, with PCBs being the most abundant pollutants. The study highlights the need for further research to evaluate the potential effects of POPs on the health of individuals and populations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Environmental
Vicente Mustieles, Francisco M. Perez-Carrascosa, Josefa Leon, Theis Lange, Jens-Peter Bonde, Celia Gomez-Pena, Francisco Artacho-Cordon, Rocio Barrios-Rodriguez, Rocio Olmedo-Requena, Jose Exposito, Jose J. Jimenez-Moleon, Juan P. Arrebola
Summary: The study found that there is a relationship between the oxidative microenvironment of adipose tissue and the concentration of persistent organic pollutants with cancer development. Certain enzymes were found to be associated with the risk of non-hormone-dependent cancer, and certain POPs were also positively associated with the risk of NHD cancer.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Seo Young Jang, Youngae Jung, Duk-Hee Lee, Geum-Sook Hwang
Summary: Persistent organic pollutants (POPs) accumulated in the body may be associated with the incidence of certain diseases. This study investigated the association between the concentration of POPs and circulating metabolites in human blood samples. The findings suggest that metabolites related to short-chain fatty acids and creatine can be useful risk indicators for estimating the effect of PCB exposure.
Article
Environmental Sciences
Louise Moura de Rezende, Ana Cristina Simoes Rosa, Sabrina da Silva Santos, Gina Torres Rego Monteiro
Summary: The objective of this study was to estimate the plasma levels of organochlorine pesticides and PCBs in hospitalized individuals in Petropolis, Brazil. Compared to data present in the literature, the concentration of POPs was lower, and individuals from 55 to 64 years of age and women presented a higher average concentration of organochlorine pesticides; men also presented a high concentration of PCBs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Francisco Miguel Perez-Carrascosa, Rocio Barrios-Rodriguez, Celia Gomez-Pena, Inmaculada Salcedo-Bellido, Maria Eugenia Velasco-Garcia, Jose Juan Jimenez-Moleon, Antonio Garcia-Ruiz, Jose Luis Navarro-Espigares, Pilar Requena, Carmen Munoz-Sanchez, Juan Pedro Arrebola
Summary: This study longitudinally explores the public healthcare costs associated with long-term exposure to a mixture of 8 persistent organic pollutants (POPs) in residents of two areas in Granada Province, Southern Spain. The results suggest that long-term exposure to these pollutants may increase healthcare costs and impact the efficiency of healthcare systems. However, further research is needed to determine whether interventions to reduce human exposure should be considered in healthcare policies, due to the limitations of the study.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Rosalinda C. Montone, Mariana B. Alonso, Marcos Cesar O. Santos, Paula Mendez-Fernandez, Satie Taniguchi, Ana Paula M. Barbosa, Renato M. Goncalves, Janeide de Assis Padilha, Carolina Bertozzi, Josilene da Silva, Juliana Marigo, Antonio Derley S. Pereira, Rafael A. Lourenco
Summary: This study analyzed the concentrations of persistent organic pollutants (POPs) in Franciscana dolphins from three regions in Brazil. The results showed that PCBs and DDTs were the predominant pollutants, with the highest PCB concentrations observed in highly urbanized and industrial areas. The sex and maturity of the dolphins had significant effects on the POPs concentrations. Although the concentrations of POPs are declining, PCB levels remain high and pose adverse health effects on the dolphins.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Richelle D. Bjorvang, Marie-Therese Vinnars, Nikos Papadogiannakis, Sebastian Gidlof, Linn Salto Mamsen, Daniel Mucs, Hannu Kiviranta, Panu Rantakokko, Paivi Ruokojarvi, Christian H. Lindh, Claus Yding Andersen, Pauliina Damdimopoulou
Summary: The study found that more chemicals were detected in fetal tissues compared to maternal serum and placenta, which may provide a misleading picture of actual fetal exposures.
Article
Multidisciplinary Sciences
Lili Long, Xinghua Tang
Summary: This study investigated the association between exposure to organochlorine pesticides and hearing loss in adults, finding a positive correlation between exposure to certain organochlorine pesticides and hearing loss.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Kerstin Kraetschmer, Rainer Malisch, Walter Vetter
Summary: The study analyzed levels of chlorinated paraffins in human milk samples from 53 countries, with CPs detected in all samples at concentrations of 23-700 ng/g lipid, accounting for 18-46% of total POPs. CP concentrations exceeded PCB concentrations in most countries, emphasizing the need for regulation and research on health effects related to CPs.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Environmental Sciences
Sophie E. Bresson, Scott Isom, Elizabeth T. Jensen, Sandra Huber, Youssef Oulhote, Joseph Rigdon, James Lovato, Angela D. Liese, Catherine Pihoker, Dana Dabelea, Shelley Ehrlich, Jerome Ruzzin
Summary: This study investigated the association between persistent organic pollutants (POPs) and type 1 diabetes (T1D) in youth. The results suggest that certain POPs may be associated with an increased risk of T1D and can negatively impact the function and viability of pancreatic beta-cells.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Water Resources
M. A. Novikov
Summary: Analysis of long-term observation data from 625 stations (2003-2018) in the Barents Sea revealed varying distribution of organochlorine pesticides and polychlorbiphenyls in bottom sediments, with the central depression and Kola Bay area showing the highest pollution levels and the Southeastern region the least contaminated. The central depression was identified as the main region of pollution deposition in the Barents Sea, with a significant amount of pollutants likely originating from accumulated old pollution due to melting of Arctic ice.
Article
Environmental Sciences
Phoebe J. Lewis, Anna Lashko, Andre Chiaradia, Graeme Allinson, Jeff Shimeta, Louise Emmerson
Summary: Reports on levels of persistent organic pollutants (POPs) in Antarctic seabirds based on blood are scarce. This paper fills a significant data gap in the Antarctic region by presenting levels of legacy POPs and novel brominated flame retardants in the blood of Antarctic seabird species. The results show that legacy POPs are still present in Antarctic wildlife despite long-term bans, and trace levels of new POPs were also detected.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
M. Chynel, C. Munschy, N. Bely, K. Heas-Moisan, C. Pollono, S. Jaquemet
Summary: The study found that bull sharks were more contaminated than tiger sharks, possibly due to their reliance on coastal habitats for feeding, while tiger sharks had lower contamination levels. The transfer of organic contaminants from mother to embryos differed between the two shark species, indicating that the mode of gestation in sharks may affect maternal transfer.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Oncology
Haleigh Cavalier, Leonardo Trasande, Miquel Porta
Summary: There is increasing attention on the causal relationship between pesticide exposure and cancer risk. Acute myeloid leukemia and colorectal cancer show the strongest evidence in existing studies. While some high-quality studies have been conducted, there are still gaps in the literature regarding the carcinogenic evidence for many pesticides. To advance research in this field, it is recommended to utilize new techniques and methods for more accurate exposure assessment, explore the effects of chemical mixtures, and conduct larger population-based cohort studies, particularly focusing on younger individuals during periods of susceptibility.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Engineering, Environmental
Marlene Agerstrand, Kenneth Arinaitwe, Thomas Backhaus, Ricardo O. Barra, Miriam L. Diamond, Joan O. Grimalt, Ksenia Groh, Faith Kandie, Perihan Binnur Kurt-Karakus, Robert J. Letcher, Rainer Lohmann, Rodrigo O. Meire, Temilola Oluseyi, Andreas Schaeffer, Mochamad Septiono, Gabriel Sigmund, Anna Soehl, Temitope O. Sogbanmu, Noriyuki Suzuki, Marta Venier, Penny Vlahos, Martin Scheringer
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Genetics & Heredity
Emilie Abby, Stefan C. C. Dentro, Michael W. J. Hall, Joanna C. C. Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W. W. Siebel, Moritz Gerstung, Benjamin A. A. Hall, Philip H. H. Jones
Summary: Notch1 mutations have opposite effects in normal and tumor cells of the mouse esophagus. Notch1 blockade reduces premalignant tumor growth and may be used as a prevention strategy for squamous esophageal cancer. NOTCH1 mutant clones are more common in normal human esophagus but less prevalent in esophageal cancers, suggesting that these mutations promote clonal expansion but hinder carcinogenesis. Further experiments confirmed the competitive advantage conferred by Notch1 mutations in mouse esophagus and the potential therapeutic effect of Notch1 blockade in preventing esophageal cancer.
Article
Environmental Sciences
Elke Rouxel, Nathalie Costet, Christine Monfort, Karine Audouze, Lourdes Cirugeda, Eric Gaudreau, Joan O. Grimalt, Jesus Ibarluzea, Fabrice Laine, Sabrina Llop, Maria-Jose Lopez-Espinosa, Florence Rouget, Loreto Santa -Marina, Martine Vrijheid, Cecile Chevrier, Maribel Casas, Charline Warembourg
Summary: Several studies have shown that prenatal exposure to certain persistent organic pollutants (POPs) is associated with higher adiposity in childhood. This study aimed to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents. The findings suggest that prenatal exposure to POPs, especially organochlorine pesticides, is linked to unfavorable cardiometabolic health up to the age of 12.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Oncology
Miriam Marques, Sonia Corral, Maria Sanchez-Diaz, Natalia del Pozo, Jaime Martinez de Villarreal, Norbert Schweifer, Ivana Zagorac, Frank Hilberg, Francisco X. Real
Summary: Bladder cancer is a prevalent tumor that requires the development of novel therapies. Nintedanib, an angio-kinase inhibitor, has shown efficacy in combination with chemotherapy for locally advanced muscle-invasive bladder cancer. Our study investigated the mechanisms of action of nintedanib and identified potential markers and treatment strategies to overcome resistance.
MOLECULAR CANCER THERAPEUTICS
(2023)
Review
Oncology
Belen Caramelo, Sladjana Zagorac, Sonia Corral, Miriam Marques, Francisco X. Real
Summary: Bladder cancer is a highly prevalent tumor, especially among men. The tumor microenvironment, specifically the cancer-associated fibroblasts, play an important role in tumor development and progression. However, the role of cancer-associated fibroblasts in bladder cancer is not well understood.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Laura Medina-Perucha, Tomas Lopez-Jimenez, Constanza Jacques-Avino, Anna Sofie Holst, Carme Valls-Llobet, Jordina Munros-Feliu, Cristina Martinez-Bueno, Diana Pinzon-Sanabria, M. Mercedes Vicente-Hernandez, Anna Berenguera
Summary: This study aims to describe menstrual inequities and their associations with sociodemographic factors among women and people who menstruate in Spain. The findings suggest that menstrual inequities affect a significant number of women and individuals who menstruate in Spain, especially those from socioeconomically deprived backgrounds, vulnerable migrant populations, and non-binary and trans menstruators. These findings are important for informing future research and policymaking on menstrual inequity.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2023)
Article
Environmental Sciences
Jose Pumarega, Oriol Busca, Magda Gasull, Miquel Porta
Summary: This study aimed to raise awareness among the general public in the European Union about the presence of plastic residues in the human body and increase their support for plastic control legislation. Urine samples were collected from 69 volunteers from Spain, Portugal, Latvia, Slovenia, Belgium, and Bulgaria. The study found that phthalates and phenols were found in all samples, with higher concentrations in females. Most concentrations did not exceed reference values. The limitations of the study include the selection of volunteers and limited data on exposure factors.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Vasiliki Margari, David A. Hodell, Simon A. Parfitt, Nick M. Ashton, Joan O. Grimalt, Hyuna Kim, Kyung-Sook Yun, Philip L. Gibbard, Chris B. Stringer, Axel Timmermann, Polychronis C. Tzedakis
Summary: Through analyzing deep-sea sediment samples from the Portuguese margin, researchers found pronounced millennial-scale climate variability during the glacial period around 1.154 to 1.123 million years ago, including a terminal stadial cooling comparable to the most extreme events of the last 400,000 years. Climate simulations indicate a drastic decrease in suitability of early human habitats around the Mediterranean during the terminal stadial. These extreme conditions led to the depopulation of Europe, potentially lasting for several successive glacial-interglacial cycles.
Article
Public, Environmental & Occupational Health
Catuxa Maiz-Mazuela, Laura Medina-Perucha, Anna Berenguera, Tomas Lopez-Jimenez, Israel Rodriguez-Giralt, Pablo Cerezo Sepulveda, Constanza Jacques-Avino
Summary: During the COVID-19 lockdown in Spain, healthcare workers experienced work overload and worsened mental health. This study aims to explore the experiences of essential workers in Spain after the first year of the COVID-19 syndemic, considering work-life balance and reproductive work responsibilities.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2023)
Article
Obstetrics & Gynecology
Anna Sofie Holst, Constanza Jacques-Avino, Anna Berenguera, Cristina Martinez-Bueno, Jordina Munros-Feliu, Diana Pinzon-Sanabria, Carme Valls-Llobet, Tomas Lopez-Jimenez, Andrea Garcia-Egea, Maria Mercedes Vicente-Hernandez, Laura Medina-Perucha
Summary: This study explores the experiences of menstrual health and management among women and people who menstruate in the Barcelona area during the COVID-19 syndemic. Findings indicate that some participants experienced menstrual changes and barriers to access healthcare and menstrual products. However, menstrual management and self-care were easier during lockdown periods. The study highlights the need for further research and policy efforts to promote menstrual health and equity.
Article
Health Care Sciences & Services
Constanza Jacques-Avino, Laura Medina-Perucha, Yudy Young-Silva, Laura Granes, Tomas Lopez-Jimenez, Anna Berenguera
Summary: A qualitative research was conducted to explore the experiences related to health-oriented behaviours during lockdown in the Spanish population with a gender perspective. Among women, there was greater diversity in health behaviours, with difficult experiences related to COVID-19, living together and unpaid care work, as well as the importance of support networks standing out. Among men, different attitudes towards sport, self-care, and healthy eating were observed, along with a positive assessment of coexistence and organization in household chores. Both men and women faced emotional distress and difficulties in carrying out healthy activities due to work overload and economic problems.
Article
Public, Environmental & Occupational Health
Laura Medina-Perucha, Constanza Jacques-Avino, Tomas Lopez-Jimenez, Catuxa Maiz, Anna Berenguera
Summary: The purpose of this research is to explore care experiences during the first wave of COVID-19 lockdown in Spain. The study used self-photo-elicitation as a data collection method and analysed participants' photographs and texts. The findings indicate the importance of self-care, collective care, gendered care, and caring for non-human animals and the environment.
INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH AND WELL-BEING
(2023)
Article
Biochemical Research Methods
Jaime Martinez de Villarreal, Mark Kalisz, Gabriel Piedrafita, Osvaldo Grana-Castro, Dafni Chondronasiou, Manuel Serrano, Francisco X. Real
Summary: Transposable elements have played a major role in shaping mammalian genomes, but little is known about their cell-type-specific expression. A cost-efficient single-cell-resolution TE expression analytical approach is needed.
Article
Engineering, Environmental
Andreas Schaeffer, Ksenia J. Groh, Gabriel Sigmund, David Azoulay, Thomas Backhaus, Michael G. Bertram, Bethanie Carney Almroth, Ian T. Cousins, Alex T. Ford, Joan O. Grimalt, Yago Guida, Maria C. Hansson, Yunsun Jeong, Rainer Lohmann, David Michaels, Leonie Mueller, Jane Muncke, Gunilla Oberg, Marcos A. Orellana, Edmond Sanganyado, Ralf Bernhard Schaefer, Ishmail Sheriff, Ryan C. Sullivan, Noriyuki Suzuki, Laura N. Vandenberg, Marta Venier, Penny Vlahos, Martin Wagner, Fang Wang, Mengjiao Wang, Anna Soehl, Marlene Agerstrand, Miriam L. Diamond, Martin Scheringer
Summary: Pollution caused by chemicals and waste, along with climate change and biodiversity loss, poses a triple planetary crisis. In response, countries have established an intergovernmental science-policy panel to address chemicals, waste, and pollution prevention. Protecting this panel from conflicts of interest is crucial for its success.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)