Review
Biology
Evanthia Bletsa, Evangelos Oikonomou, Kyriakos Dimitriadis, Panagiota K. Stampouloglou, Christos Fragoulis, Stavroula P. Lontou, Emmanouil Korakas, Eirini Beneki, Konstantinos Kalogeras, Vaia Lambadiari, Konstantinos Tsioufis, Manolis Vavouranakis, Gerasimos Siasos
Summary: LV remodeling is a dynamic process characterized by changes in ventricular size, shape, and wall thickness, and is considered a negative prognostic factor in heart failure patients. Hypertension, type 2 diabetes, and obesity are strongly associated with the development and progression of LV remodeling. Exercise training has been shown to have beneficial effects on cardiovascular prognosis and survival rates by improving functional capacity, muscle strength, and cardiac function in patients with coronary artery disease or heart failure.
Article
Cardiac & Cardiovascular Systems
Kazunori Omote, Hidemi Sorimachi, Masaru Obokata, Yogesh N. Reddy, Frederik H. Verbrugge, Massar Omar, Hilary M. DuBrock, Margaret M. Redfield, Barry A. Borlaug
Summary: This study aimed to characterize the pathophysiology of pulmonary vascular disease in left heart disease (PH-LHD) and found that PH-LHD patients displayed distinct features, such as poorer left atrial function and more severe right ventricular dysfunction at rest, as well as more severe impairments in cardiac output and oxygen delivery during exercise. Further study is required to identify innovative treatments for the pulmonary vasculature in PH-LHD.
EUROPEAN HEART JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xue-Ming Li, Li-Qing Peng, Rui Shi, Pei-Lun Han, Wei-Feng Yan, Zhi-Gang Yang
Summary: This study found that gender significantly affects left ventricular deformation in patients with essential hypertension, with women having higher LV GRS, GCS, and GLS compared to men. In hypertensive patients, LV GLS was significantly reduced, with hypertensive men showing more pronounced impairment in LV GRS, GCS, and GLS compared to women.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Medicine, General & Internal
Qing He, Yixia Lin, Ye Zhu, Lang Gao, Mengmeng Ji, Li Zhang, Mingxing Xie, Yuman Li
Summary: Right ventricular-pulmonary artery coupling refers to the relationship between RV contractility and RV afterload. RV-PA uncoupling leads to RV dysfunction and right heart failure. Accurate evaluation of RV-PA coupling is important for patient assessment, clinical decision making, risk stratification, and prognosis judgment in cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Sunder Neelakantan, Mohit Kumar, Emilio A. Mendiola, Haley Phelan, Vahid Serpooshan, Sakthivel Sadayappan, Reza Avazmohammadi
Summary: This study investigates the contractile behavior of the myocardium at multiple length scales in small animals. The results indicate that the contraction of the myocardium is dependent on transmural depth and relaxes faster in the direction with larger peak stresses.
ACTA BIOMATERIALIA
(2023)
Article
Cardiac & Cardiovascular Systems
Nadira Hamid, Ulrich P. Jorde, Mark Reisman, Azeem Latib, D. Scott Lim, Susan M. Joseph, Alena Kurlianskaya, Oleg Polonetsky, Petr Neuzil, Vivek Reddy, Jason Foerst, Hemal Gada, Kendra J. Grubb, Guilherme Silva, Dean Kereiakes, Satya Shreenivas, Sean Pinney, Giedrius Davidavicius, Paul Sorajja, John P. Boehmer, Franz X. Kleber, Patrick Perier, Nicolas M. Van Mieghem, Nicolas Dumonteil, Martin B. Leon, Daniel Burkhoff
Summary: This study evaluated the effectiveness of the AccuCinch Transcatheter Left Ventricular Restoration system in patients with heart failure. The results showed that this technique can reduce left ventricular volume and improve patients' quality of life and exercise endurance.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Beatrice Santens, Frederik Helsen, Alexander Van De Bruaene, Pieter De Meester, Anne-Laure Budts, Els Troost, Philip Moons, Piet Claus, Filip Rega, Jan Bogaert, Werner Budts
Summary: Early recognition of adverse remodelling is crucial for patients with a systemic right ventricle (sRV). This study assessed prognostic markers for short-term clinical evolution in this population. Results showed that NT-proBNP was the best prognostic marker, and adverse remodelling was associated with cardiovascular events.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Engineering, Biomedical
Hong Shen Wong, Hadi Wiputra, Andreas Tulzer, Gerald Tulzer, Choon Hwai Yap
Summary: In cases of fetal aortic stenosis and evolving Hypoplastic Left Heart Syndrome (feHLHS), specific abnormalities and altered fluid dynamics are observed in the left ventricles (LV). The feHLHS LV shows narrowed and fast diastole mitral inflow, elevated energy losses, intraventricular pressure gradients, and vortex formation numbers, and poor blood turnover, indicating energy inefficiency of flow and additional burden on the LV.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Jussi Leinonen, Paivi Leinikka, Miikka Tarkia, Milla Lampinen, Avishag K. Emanuelov, Ronen Beeri, Esko Kankuri, Eero Mervaala
Summary: The left atrial appendage (LAA) of the adult heart contains progenitor cells and can be used as a regenerative transplant for myocardial infarction. Transplantation of LAA to mice with MI resulted in improved cardiac function and inhibition of deleterious remodeling. This method combines cell therapy and physical support.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Cristine J. Reitz, Marjan Tavassoli, Da Hye Kim, Saumya Shah, Robert Lakin, Allen C. T. Teng, Yu-Qing Zhou, Wenping Li, Sina Hadipour-Lakmehsari, Peter H. Backx, Andrew Emili, Gavin Y. Oudit, Uros Kuzmanov, Anthony O. Gramolini
Summary: The prognosis and treatment outcomes of heart failure patients heavily rely on disease etiology, which is complex and not fully understood. In this study, a combined proteomic and phosphoproteomic approach was used to examine cardiac tissue from patients with dilated cardiomyopathy (DCM) or ischemic cardiomyopathy (ICM). Unique global proteomic and phosphoproteomic profiles were identified, and a role for CTNNA3 phosphorylation in the pathophysiology of DCM was described.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
O. Caglar Yilmaz, Selcuk Ozkan
Summary: This study found a high prevalence of masked hypertension in patients with unexplained left ventricular hypertrophy (ULVH), highlighting the importance of screening with ambulatory blood pressure monitoring. Left ventricular mass index was significantly higher in masked hypertensive ULVH patients compared to normotensive ULVH and control subjects.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Review
Cardiac & Cardiovascular Systems
Katharina Schimmel, Kenzo Ichimura, Sushma Reddy, Francois Haddad, Edda Spiekerkoetter
Summary: Myocardial fibrosis is a process of extracellular matrix remodeling in response to cardiac stress. It can be classified into replacement fibrosis and reactive fibrosis. Reactive fibrosis develops over time in chronic pressure overload and affects the function of the left or right ventricle. Reactive fibrosis in the left ventricle is associated with the development and progression of heart failure, while reactive fibrosis in the right ventricle is common in conditions such as pulmonary arterial hypertension. Understanding the differences and common characteristics of extracellular matrix remodeling in the left and right ventricles under pressure overload is crucial for developing new approaches to treat heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Jessica Erin Haley, Christopher Davis
Summary: Treatment for Hypoplastic Left Heart Syndrome (HLHS) and other single ventricle conditions often involves a series of surgical interventions, culminating in the Fontan procedure, which can result in abnormal circulatory physiology and limited exercise capacity. Various pharmacologic and nonpharmacologic interventions have been studied to enhance exercise capacity in Fontan patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Medicine, General & Internal
Vlad-Sabin Ivan, Roxana Buzas, Adina-Flavia Cutina Morgovan, Paul Ciubotaru, Melania Ardelean, Daniel Goje, Ilie Rosca Ciprian, Romulus Timar, Daniel Lighezan
Summary: The study examined the direct relationship between serum uric acid and ejection fraction in 303 heart failure patients, concluding that higher uric acid levels are associated with a lower ejection fraction of the left ventricle.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Argen Mamazhakypov, Lutz Hein, Achim Lother
Summary: Pulmonary hypertension is a devastating condition that causes severe damage to the cardiovascular system. Research has found that aldosterone and the mineralocorticoid receptor play a key role in the development of pulmonary hypertension. Pharmacological blockade of the mineralocorticoid receptor has been shown to reduce pulmonary hypertension and prevent right ventricular failure in experimental models. However, the effectiveness of using mineralocorticoid receptor antagonists in the treatment of pulmonary hypertension is controversial in clinical practice and further research is needed.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Murilo Esteves Nogueira, Ivo Vieira Sousa Neto, Daisy Motta-Santos, Ana Paula de Castro Cantuaria, Stella Maris de Freitas Lima, Taia Maria Berto Rezende, Hugo Alexandre de Paula Santana, Bernardo Assis Petriz, Rita de Cassia Marqueti, Jeeser Alves Almeida
Summary: This study shows that the combination of high-protein diet and resistance training has positive effects on cardiac tissue, reducing inflammatory parameters and enhancing molecular parameters.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Genetics & Heredity
Ariadne R. Lima, Barbara M. Ferreira, Chaofan Zhang, Angad Jolly, Haowei Du, Janson J. White, Moez Dawood, Tulio C. Lins, Marcela A. Chiabai, Ellen Beusekom, Mara S. Cordoba, Erica C. C. Caldas Rosa, Hulya Kayserili, Virginia Kimonis, Erica Wu, Cecilia Mellado, Vineet Aggarwal, Antonio Richieri-Costa, Decio Brunoni, Talyta M. Cano, Alexander A. L. Jorge, Chong A. Kim, Rachel Honjo, Debora R. Bertola, Raissa M. Dandalo-Girardi, Yavuz Bayram, Alper Gezdirici, Elif Yilmaz-Gulec, Evren Gumus, Gulay C. Yilmaz, Nobuhiko Okamoto, Hirofumi Ohashi, Zeynep Coban-Akdemir, Tadahiro Mitani, Shalini N. Jhangiani, Donna M. Muzny, Neysa A. P. Regattieri, Robert Pogue, Rinaldo W. Pereira, Paulo A. Otto, Richard A. Gibbs, Bassam R. Ali, Hans Bokhoven, Han G. Brunner, V. Reid Sutton, James R. Lupski, Angela M. Vianna-Morgante, Claudia M. B. Carvalho, Juliana F. Mazzeu
Summary: Robinow syndrome is a rare genetic disorder characterized by craniofacial dysmorphisms, disproportionate-limb short stature, and genital hypoplasia. It is caused by disturbances in the noncanonical WNT-pathway, with ROR2 gene variants being a common cause. This study identified multiple ROR2 variants in patients with autosomal recessive Robinow syndrome and characterized the phenotypic spectrum of the syndrome.
Article
Medicine, Research & Experimental
Ivo Vieira de Sousa Neto, Jonato Prestes, Guilherme Borges Pereira, Jeeser Alves Almeida, Graciele Vieira Ramos, Fabiane Hiratsuka Veiga de Souza, Paulo Eduardo Narcizo de Souza, Ramires Alsamir Tibana, Octavio Luiz Franco, Joao Luiz Quaglioti Durigan, Rodrigo Vanerson Passos Neves, Thiago dos Santos Rosa, Wagner Fontes, Rita de Cassia Marqueti
Summary: Paternal exercise has protective effects on adipose tissue remodeling and metabolic health of male rat offspring fed with high-fat diet, attenuating fibrosis and inflammatory profile, improving redox status, and positively affecting metabolic markers in the offspring's blood circulation.
Article
Biochemistry & Molecular Biology
Eliane Santana Fernandes Alves, Bruno de Paula Oliveira de Santos, Leticia Valvassori Rodrigues, Carlos Daniel Pereira Freitas, Lucianna Helene Silva dos Santos, Simoni Campos Dias, Octavio Luiz Franco, Luciano Morais Liao, Mariana Torquato Quezado de Magalhaes
Summary: Synoeca-MP, a 14-residue peptide, exhibits antibacterial and antifungal activity. This study investigated the peptide's behavior and structure in membrane-like environments using CD spectroscopy, hydrogen-deuterium exchange, and molecular dynamics simulations. The peptide was found to adopt a partially α-helical conformation when bound to SDS micelles. These findings improve our understanding of the peptide's mode of action and provide insights for future clinical applications.
Review
Biochemistry & Molecular Biology
Cristiane dos Santos, Octavio Luiz Franco
Summary: Plants can synthesize peptides with antimicrobial properties, making them potential biofactories for antimicrobial peptides (AMPs). However, obtaining large-scale, diverse AMPs derived from plants is a significant challenge. This review summarizes the main findings from the past 5 years on plants used as biofactories for AMPs and provides insights into the prospects of using plant-based systems for recombinant AMP production for drug development and the availability of products in the market.
Review
Biochemical Research Methods
Samilla B. Rezende, Lucas R. Lima, Maria L. R. Macedo, Octavio L. Franco, Marlon H. Cardoso
Summary: Peptides and proteins play crucial roles in biological processes. Determining their three-dimensional structures using experimental and computational methods has greatly advanced structure prediction. Machine learning and deep learning approaches have further improved the accuracy of structure prediction. These methods have greatly assisted in answering key biological questions.
CURRENT BIOINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Ramar Perumal Samy, Stephen P. P. Mackessy, Alagarmalai Jeyasankar, Mano Ranjana Ponraj, Octavio Luiz Franco, Matthew A. A. Cooper, Matheswaran Kandasamy, Tapan Kumar Mohanta, Jebasingh Bhagavathsingh, Sakthivel Vaiyapuri
Summary: PaTx-II, an active component from the venom of the Mulga Snake, showed potent antimicrobial activity and promoted wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thuany Alencar-Silva, Ruben D. Diaz-Martin, Alessandra Zonari, Daniel Foyt, Mylieneth Guiang, Robert Pogue, Felipe Saldanha-Araujo, Simoni Campos Dias, Octavio Luiz Franco, Juliana Lott Carvalho
Summary: In this study, the IDR-1018 peptide was found to attenuate the cytotoxicity of synoeca-MP and promote skin cell proliferation and wound repair. The combination of these peptides exhibited good antimicrobial and pro-regenerative activity, suggesting the potential for new strategies in the treatment of skin lesions.
Review
Plant Sciences
Cristiane dos Santos, Octavio Luiz Franco
Summary: Throughout evolution, plants have developed a complex defense system against phytopathogens, which involves constitutive and induced factors combined as defense mechanisms. Plant defense relies on a signaling network connecting structural and biochemical defense and includes the accumulation of antimicrobial and pathogenesis-related (PR) proteins. These PR proteins play a key role in early defense events, reducing damage and mortality caused by pathogens. This review discusses defense response proteins, specifically PR proteins with enzymatic action, and the technological advancements in studying these enzymes for plant defense against phytopathogens.
Article
Plant Sciences
Daiane Gonzaga Ribeiro, Ana Carolina Mendes Bezerra, Ivonaldo Reis Santos, Priscila Grynberg, Wagner Fontes, Mariana de Souza Castro, Marcelo Valle de Sousa, Maria Eugenia Lisei-de-Sa, Maria Fatima Grossi-de-Sa, Octavio Luiz Franco, Angela Mehta
Summary: The co-occurrence of biotic and abiotic stresses severely affects crop performance and productivity in agricultural areas. The present study aimed to identify proteins involved in the resistance of cowpea to nematode and drought stresses. Proteomic analysis revealed key processes, such as hormonal signaling regulation, pathogenesis-related proteins production, and downregulation of photosynthetic activity.
Article
Chemistry, Multidisciplinary
Hadar Cohen, Naiem Ahmad Wani, Daniel Ben Hur, Ludovico Migliolo, Marlon H. Cardoso, Ziv Porat, Eyal Shimoni, Octavio Luiz Franco, Yechiel Shai
Summary: Antibiotic-resistant bacterial infections have increased sepsis and septic shock mortality worldwide and are now a global concern. Antimicrobial peptides (AMPs) show great potential for developing new antimicrobial agents and therapies for host response modulation. A new series of AMPs derived from pexiganan (MSI-78) have been synthesized, with positively charged amino acids at the ends and a hydrophobic core surrounded by positive charges simulating lipopolysaccharide (LPS). These peptides have been investigated for their antimicrobial activity and inhibition of LPS-induced cytokine release using various biochemical and biophysical methods. Two new AMPs, MSI-Seg-F2F and MSI-N7K, have shown promising results with neutralizing endotoxin activity while reducing toxicity and hemolytic activity. These designed peptides have the potential to eradicate bacterial infection and detoxify LPS, making them potentially useful for sepsis treatment.
Article
Chemistry, Medicinal
Ellynes Amancio Correia Nunes, Maria Claudia da Silva, Marlon Henrique Cardoso, Sergio Leandro Espindola Preza, Lucas Silva de Oliveira, Breno Emanuel Farias Frihling, Sebastien Olivier Charneau, Philippe Grellier, Octavio Luiz Franco, Ludovico Migliolo
Summary: This study found that synthetic polyalanine peptides Pa-MAP1.9 and Pa-MAP2 derived from polar fish can inhibit the growth of sleeping sickness pathogens, suggesting their potential as a treatment for sleeping sickness.
Article
Plant Sciences
Lucas Jose de Sousa, Ana Carolina Mendes Bezerra, Mariana Rocha Maximiano, Fabiano T. P. K. Tavora, Natalia Faustino Cury, Osmundo Brilhante de Oliveira Neto, Laurence Veronique Bindschedler, Octavio Luiz Franco, Luiz Eduardo Bassay Blum, Angela Mehta
Summary: This study compares the behavior of S-genes during the interaction of tomato with Xanthomonas euvesicatoria pv. perforans (Xep). It reveals that several putative host S-genes are positively modulated during bacterial infection. Additionally, using ASOs targeting the SlTFIIA γ gene significantly improves plant resistance against bacterial attack.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2023)
Review
Infectious Diseases
Ana Laura Pereira Lourenco, Thuanny Borba Rios, Allan Pires da Silva, Octavio Luiz Franco, Marcelo Henrique Soller Ramada
Summary: Antimicrobial peptides (AMPs) are a promising therapeutic approach against multi-drug resistant microorganisms, but their proteolytic susceptibility limits their market competitiveness. All-hydrocarbon stapling is an effective helix stabilization technique, but its toxicity poses limitations. This review explores recent studies on stapled AMPs for antimicrobial usage.
Review
Agriculture, Multidisciplinary
Mariana Rocha Maximiano, Octavio Luiz Franco
Summary: Modern agriculture faces challenges due to increasing food demand, climate change, and dietary pattern changes. Biotechnological advances, especially the CRISPR/Cas technology, have significant applications in editing the genomes of plant crops. This technology offers an alternative approach to developing plants resistant to biotic and abiotic stresses, contributing to more sustainable agricultural production.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)
