Article
Chemistry, Analytical
Yuhong Luo, Wentao Wang, Yi Zeng, Shuangqing Wang, Xudong Guo, Rui Hu, Guoqiang Yang
Summary: A bioluminescent probe NQO1-Luc, equipped with a targeting group for NQO1, has been developed. It exhibits high selectivity and sensitivity towards NQO1 activity, releasing a bright bioluminescence emission. This probe offers a promising tool for investigating NQO1 related biological processes, including tumors.
Article
Plant Sciences
Setsuko Komatsu, Hisateru Yamaguchi, Keisuke Hitachi, Kunihiro Tsuchida, Shafiq Ur Rehman, Toshihisa Ohno
Summary: Plant-derived smoke solution improves wheat growth and enhances tolerance against flooding stress by regulating photosynthesis, glycolysis, and amino-acid metabolism.
Article
Plant Sciences
Ildiko Jocsak, Henrik Gyalog, Richard Hoffmann, Katalin Somfalvi-Toth
Summary: This study aimed to evaluate the heat stress alleviation capability of differentially applied biostimulant treatments on wheat seedlings. The results showed that biostimulant pretreatment can increase antioxidant capacity, decrease biophoton release and lipid oxidation, thus alleviating the harmful effects of heat stress on wheat seedlings. Biophoton emission was proven to be a suitable method for detecting and imaging heat stress effects on wheat seedlings.
Article
Cell Biology
Agnieszka Zmyslowska, Miljan Kuljanin, Beata Malachowska, Marcin Stanczak, Dominika Michalek, Aneta Wlodarczyk, Dagmara Grot, Joanna Taha, Bartlomiej Pawlik, Magdalena Lebiedzinska-Arciszewska, Hanna Nieznanska, Mariusz R. Wieckowski, Piotr Rieske, Joseph D. Mancias, Maciej Borowiec, Wojciech Mlynarski, Wojciech Fendler
Summary: The study evaluated protein levels and gene transcription changes in a human WFS cell model under experimental ER stress. Proteomic analysis revealed differences in specific signal pathways and down-regulation of respiratory chain subunits in NSC WFS cells, with up-regulation of proteins related to Krebs cycle and glycolysis. Pathway enrichment analysis showed significant down-regulation of mitochondrial protein import machinery and OXPHOS in mice hippocampi samples with WFS1 deficiency.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Environmental Sciences
Yan-ping Zhao, Jin-li Cui, Li-ping Fang, Ya-li An, Shu-chai Gan, Peng-ran Guo, Jiang-han Chen
Summary: This study investigated the degradation and transformation mechanisms of ROX in paddy soil, finding that ROX degrades more rapidly in flooded soils compared to non-flooded soils. The transformation products of ROX in flooded soils inhibited soil enzyme activities but this effect disappeared over time due to the sorption of transformed As products to amorphous Fe oxides.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biology
Giusy Tassone, Arian Kola, Daniela Valensin, Cecilia Pozzi
Summary: Alzheimer's disease is a neurodegenerative disorder affecting millions of people worldwide, with no effective treatments currently available. Research using proteomics and redox proteomics has identified potential drug targets in altered proteins and pathways, particularly in mitochondrial proteins related to metabolism, ATP generation, oxidative stress, and apoptosis. Despite the lack of effective drugs, compounds targeting mitochondria have shown promising results in research.
Article
Plant Sciences
Johanna Schwarze, James C. Carolan, Gavin S. Stewart, Paul F. McCabe, Joanna Kacprzyk
Summary: This study used Arabidopsis thaliana cell suspension culture to investigate the regulation of programmed cell death (PCD) induced by heat stress. The results revealed the changes in protein abundance and localization in both mitochondria and cytosol during the early stages of PCD.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Cell Biology
Matthew J. Jennings, Denisa Hathazi, Chi D. L. Nguyen, Benjamin Munro, Ute Munchberg, Robert Ahrends, Annette Schenck, Ilse Eidhof, Erik Freier, Matthis Synofzik, Rita Horvath, Andreas Roos
Summary: Study identified lipid accumulation and increased sensitivity to cholesterol stress in cells of patients with DNAJC3 mutations, leading to activation of unfolded protein response. Additionally, alterations in mitochondrial morphology and function were observed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi-ling Liu, Hai-lei Zheng
Summary: Acanthus ilicifolius showed better tolerance to tidal flooding stress with intact morphological structure, more efficient carbon and energy utilization, and a higher proportion of up-regulated proteins associated with carbon and energy metabolism. Acanthus mollis, on the other hand, could not survive long in flooding conditions, displaying disrupted cell structures, less efficient carbon and energy utilization, and a higher percentage of down-regulated proteins related to carbon and energy metabolism. Energy provision and flux balance played a crucial role in the flooding tolerance of both Acanthus ilicifolius and Acanthus mollis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Laura Lucena del Amo, Elena Duran-Gonzalez, Jorge A. Ramirez-Tejero, Antonio Martinez-Lara, David Cotan
Summary: This study aims to explore the pathogenesis of fibromyalgia and the impact of nutritional intervention on it. The study recruits 200 female patients and analyzes their blood and stool samples. The results will contribute to the development of a comprehensive and reliable panel of diagnostic biomarkers and provide clues for the modulation of non-pharmacological therapies such as nutrition.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Setsuko Komatsu, Yoshie Tsutsui, Takashi Furuya, Hisateru Yamaguchi, Keisuke Hitachi, Kunihiro Tsuchida, Masahiko Tani
Summary: Research has shown that millimeter-wave irradiation can enhance the growth of wheat under flooding stress and promote recovery by regulating glycolysis, reactive-oxygen species scavenging, and cell organization. Additionally, millimeter-wave irradiation can improve tolerance against flooding in wheat by regulating auxin contents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Bicheng Yao, Jiamin Zhao, Siyang Ding, Marie-Claire Giel, Guoqiang Zhang, Dan Ding, Youhong Tang, Zhe H. Weng, Yuning Hong
Summary: A red-emissive probe TBPG was developed to measure the activity of beta-Glucosidase (beta-Glu). The probe exhibited fluorescence turn-on process upon hydrolysis in the presence of beta-Glu. The optimized detection conditions show excellent linearity, wide linear dynamic range, and low limit of detection.
Article
Horticulture
Musa Seymen
Summary: The study found that flooding stress significantly altered morpho-physiological and biochemical properties of spinach, reducing chlorophyll and protein content while increasing proline, hydrogen peroxide, and enzyme activity. Parameters such as leaf water content, membrane damage, and chlorophyll were identified as important indicators affected by flooding stress.
SCIENTIA HORTICULTURAE
(2021)
Article
Cell Biology
Miguel A. Gonzalez-Lozano, Joke Wortel, Rolinka J. van der Loo, Jan R. T. van Weering, August B. Smit, Ka Wan Li
Summary: The study dissected the molecular synaptic modulation mediated by mGluR5 using genetic and pharmacological mouse models, revealing a connection between mGluR5 and the modulation of synaptic mitochondrial function. This finding suggests a potential role of mGluR5 as a mediator between synaptic activity and mitochondrial function.
Article
Cardiac & Cardiovascular Systems
Yi-Han Lin, Maryann P. Platt, Ryan P. Gilley, David Brown, Peter H. Dube, Yanbao Yu, Norberto Gonzalez-Juarbe
Summary: This study found significant alterations in the cardiac proteome and phosphoproteome after pulmonary influenza infection, with viral particles persisting in the heart. Inhibition of necroptosis or prevention of mitochondrial damage may be potential therapeutic interventions to reduce cardiac damage during influenza infections.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Swapan Kumar Roy, Soo Jeong Kwon, Seong-Woo Cho, Abu Hena Mostafa Kamal, Sang-Woo Kim, Kabita Sarker, Myeong-Won Oh, Moon-Soon Lee, Keun-Yook Chung, Zhanguo Xin, Sun-Hee Woo
Article
Biochemical Research Methods
Abu Hena Mostafa Kamal, Setsuko Komatsu
JOURNAL OF PROTEOMICS
(2016)
Article
Biochemistry & Molecular Biology
Abu Hena Mostafa Kamal, Setsuko Komatsu
MOLECULAR BIOLOGY REPORTS
(2016)
Article
Multidisciplinary Sciences
Abu Hena M. Kamal, Michael B. Fessler, Saiful M. Chowdhury
Article
Multidisciplinary Sciences
Abu Hena M. Kamal, Jayanta K. Chakrabarty, S. M. Nashir Udden, Md. Hasan Zaki, Saiful M. Chowdhury
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Swapan Kumar Roy, Seong-Woo Cho, Soo Jeong Kwon, Abu Hena Mostafa Kamal, Sang-Woo Kim, Myeong-Won Oh, Moon-Soon Lee, Keun-Yook Chung, Zhanguo Xin, Sun-Hee Woo
Article
Zoology
Contessa A. Ricci, Abu Hena Mostafa Kamal, Jayanta Kishor Chakrabarty, Lauren E. Fuess, Whitney T. Mann, Lea R. Jinks, Vanessa Brinkhuis, Saiful M. Chowdhury, Laura D. Mydlarz
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2019)
Article
Biochemical Research Methods
Abu Hena Mostafa Kamal, Jim J. Aloor, Michael B. Fessler, Saiful M. Chowdhury
MOLECULAR & CELLULAR PROTEOMICS
(2019)
Article
Biology
Blair W. Perry, Audra L. Andrews, Abu Hena Mostafa Kamal, Daren C. Card, Drew R. Schield, Giulia I. M. Pasquesi, Mark W. Pellegrino, Stephen P. Mackessy, Saiful M. Chowdhury, Stephen M. Secor, Todd A. Castoe
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Ling Tao, Myrthala Moreno-Smith, Rodrigo Ibarra-Garcia-Padilla, Giorgio Milazzo, Nathan A. Drolet, Blanca E. Hernandez, Young S. Oh, Ivanshi Patel, Jean J. Kim, Barry Zorman, Tajhal Patel, Abu Hena Mostafa Kamal, Yanling Zhao, John Hicks, Sanjeev A. Vasudevan, Nagireddy Putluri, Cristian Coarfa, Pavel Sumazin, Giovanni Perini, Ronald J. Parchem, Rosa A. Uribe, Eveline Barbieri
Summary: This study shows that CHAF1A gain-of-function supports cell malignancy, blocks neuronal differentiation, and promotes NB oncogenesis. Mechanistically, CHAF1A upregulates polyamine metabolism, which blocks neuronal differentiation and promotes cell cycle progression.
Article
Biotechnology & Applied Microbiology
Aundrea K. Westfall, Blair W. Perry, Abu H. M. Kamal, Nicole R. Hales, Jarren C. Kay, Madhab Sapkota, Drew R. Schield, Mark W. Pellegrino, Stephen M. Secor, Saiful M. Chowdhury, Todd A. Castoe
Summary: This study explores the molecular control of extreme intestinal regeneration in snakes following long fasts. The researchers identify specific patterns of metabolic, stress response, and growth pathway activation that regulate the regenerative process, and identify key central regulatory molecules involved. The findings provide new insights into the understanding of regenerative capacities in vertebrates.
Article
Oncology
Yoko Fujita, Luis Nunez-Rubiano, Antonio Dono, Allison Bellman, Mauli Shah, Juan C. Rodriguez, Vasanta Putluri, Abu Hena Mostafa Kamal, Nagireddy Putluri, Roy F. Riascos, Jay-Jiguang Zhu, Yoshua Esquenazi, Leomar Y. Ballester
Summary: This study aimed to evaluate the potential of IDH1 p.R132H mutation and 2-hydroxyglutarate (2HG) in cerebrospinal fluid (CSF) as biomarkers for patients with IDH-mutant gliomas. The results showed that detection of IDH1 p.R132H mutation and increased D-2HG level in CSF may help identify IDH-mutant gliomas, and that D-2HG level and D/L-2HG ratio correlate with tumor volume in these patients.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karthik Reddy Kami Reddy, Danthasinghe Waduge Badrajee Piyarathna, Abu Hena Mostafa Kamal, Vasanta Putluri, Shiva Shankar Ravi, Roni J. Bollag, Martha K. Terris, Yair Lotan, Nagireddy Putluri
Summary: Bladder Cancer is the ninth most common cancer globally and the sixth most common cancer in the US. African Americans have a lower incidence of bladder cancer compared to European Americans, but a higher risk of cancer-related death. This study identifies ethnic-specific lipid alterations in bladder cancer, which may contribute to understanding the disparity in mortality.
Article
Oncology
Wangie Yu, Yunyun Chen, Nagireddy Putluri, Abdullah Osman, Cristian Coarfa, Vasanta Putluri, Abu H. M. Kamal, Jennifer Kay Asmussen, Panagiotis Katsonis, Jeffrey N. Myers, Stephen Y. Lai, Wuhao Lu, Clifford C. Stephan, Reid T. Powell, Faye M. Johnson, Heath D. Skinner, Jawad Kazi, Kazi Mokim Ahmed, Linghao Hu, Addison Threet, Matthew D. Meyer, James A. Bankson, Tony Wang, Jack Davis, Kirby R. Parker, Madison A. Harris, Mokryun L. Baek, Gloria V. Echeverria, Xiaoli Qi, Jin Wang, Andy I. Frederick, Alex J. Walsh, Olivier Lichtarge, Mitchell J. Frederick, Vlad C. Sandulache
Summary: We found that head and neck squamous cell carcinoma cells acquire cisplatin resistance through metabolic rewiring, including reduced KEAP1 gene activity, activation of the Nrf2 pathway, increased cell biomass and reducing equivalents, and enhanced glucose and glutamine metabolism. These metabolic changes result in reduced energy production and proliferation, leading to resistance to cisplatin.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
A. D. A. Shahinuzzaman, Abu Hena Mostafa Kamal, Jayanta K. Chakrabarty, Aurchie Rahman, Saiful M. Chowdhury
Summary: This study used HEK 293 cells to investigate the protein networks associated with TLR4. By performing co-immunoprecipitation and chemical cross-linking, the researchers identified MARCKSL1 and creatine kinase as potential proteins involved in statin-induced anti-inflammatory responses.