Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses

Prelude to rational scale-up of penicillin production: a scale-down study

(2014) Guan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Kinetic models in industrial biotechnology – Improving cell factory performance

(2014) Joachim Almquist et al.   METABOLIC ENGINEERING

Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum

(2014) Friedrich Käß et al.   Microbial Cell Factories

Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells

(2014) J. H. van Heerden et al.   SCIENCE

A coupled population balance model and CFD approach for the simulation of mixing issues in lab-scale and industrial bioreactors

(2013) Jérôme Morchain et al.   AICHE JOURNAL

Flux response of glycolysis and storage metabolism during rapid feast/famine conditions inPenicillium chrysogenumusing dynamic13C labeling

(2013) Lodewijk de Jonge et al.   Biotechnology Journal

Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

(2013) Alvin W. Nienow et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Dynamic process conditions in bioprocess development

(2013) Oliver Spadiut et al.   ENGINEERING IN LIFE SCIENCES

Two-compartment processing as a tool to boost recombinant protein production

(2013) Mohammadhadi Jazini et al.   ENGINEERING IN LIFE SCIENCES

A dynamic two phase flow model for a pilot scale sodium borohydride hydrogen generation reactor

(2013) T. Sousa et al.   INTERNATIONAL JOURNAL OF HYDROGEN ENERGY

Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut+ strain using a two-compartment scale-down system

(2013) Bettina Lorantfy et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Glycolytic strategy as a tradeoff between energy yield and protein cost

(2013) A. Flamholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling of biokinetic and population balance models to account for biological heterogeneity in bioreactors

(2012) Jérôme Morchain et al.   AICHE JOURNAL

A model for cellulase production from Trichoderma reesei in an airlift reactor

(2012) Rachid Bannari et al.   BIOTECHNOLOGY AND BIOENGINEERING

CFD modelling of two-phase stirred bioreaction systems by segregated solution of the Euler–Euler model

(2012) M. Elqotbi et al.   COMPUTERS & CHEMICAL ENGINEERING

A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production

(2012) Yiming Yang et al.   JOURNAL OF BIOTECHNOLOGY

Substrate cycles in Penicillium chrysogenum quantified by isotopic non-stationary flux analysis

(2012) Zheng Zhao et al.   Microbial Cell Factories

Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter

(2011) Xiang Zou et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Experimental methods and modeling techniques for description of cell population heterogeneity

(2011) R. Lencastre Fernandes et al.   BIOTECHNOLOGY ADVANCES

Simulation of dissolved CO2 gradients in a scale-down system: A metabolic and transcriptional study of recombinant Escherichia coli

(2011) Antonino Baez et al.   Biotechnology Journal

A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: Impact of oscillations on Bacillus subtilis fed-batch cultivations

(2011) Stefan Junne et al.   Biotechnology Journal

An industrial perspective on bioreactor scale-down: What we can learn from combined large-scale bioprocess and model fluid studies

(2011) Henk Noorman   Biotechnology Journal

Scale-down of penicillin production in Penicillium chrysogenum

(2011) Lodewijk P. de Jonge et al.   Biotechnology Journal

Investigations on hydrodynamics and mass transfer in gas–liquid stirred reactor using computational fluid dynamics

(2011) Panneerselvam Ranganathan et al.   CHEMICAL ENGINEERING SCIENCE

Multidimensional population balance model for the simulation of turbulent gas–liquid systems in stirred tank reactors

(2011) A. Buffo et al.   CHEMICAL ENGINEERING SCIENCE

CFD simulation of wood chip combustion on a grate using an Euler–Euler approach

(2011) D. Kurz et al.   COMBUSTION THEORY AND MODELLING

Scale-down simulators for metabolic analysis of large-scale bioprocesses

(2010) Peter Neubauer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Origin and analysis of microbial population heterogeneity in bioprocesses

(2010) Susann Müller et al.   CURRENT OPINION IN BIOTECHNOLOGY

Industrial systems biology

(2009) José Manuel Otero et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modelling of mass transfer in gas–liquid stirred tanks agitated by Rushton turbine and CD-6 impeller: A scale-up study

(2009) J. Gimbun et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

Local void fraction and bubble size distributions in cold-gassed and hot-sparged stirred reactors

(2009) Yuyun Bao et al.   CHEMICAL ENGINEERING SCIENCE

Development and application of a differential method for reliable metabolome analysis in Escherichia coli

(2008) Hilal Taymaz-Nikerel et al.   ANALYTICAL BIOCHEMISTRY

Determination of the cytosolic free NAD/NADH ratio inSaccharomyces cerevisiaeunder steady-state and highly dynamic conditions

(2008) André B. Canelas et al.   BIOTECHNOLOGY AND BIOENGINEERING

Three-dimensional mathematical modeling of dispersed two-phase flow using class method of population balance in bubble columns

(2008) Rachid Bannari et al.   COMPUTERS & CHEMICAL ENGINEERING

Dynamic13C-tracer study of storage carbohydrate pools in aerobic glucose-limitedSaccharomyces cerevisiaeconfirms a rapid steady-state turnover and fast mobilization during a modest stepup in the glucose uptake rate

(2008) Fredrick O. Aboka et al.   FEMS YEAST RESEARCH

Euler−Euler Modeling of Flow, Mass Transfer, and Chemical Reaction in a Bubble Column

(2008) Dongsheng Zhang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum

(2007) Uly Nasution et al.   METABOLIC ENGINEERING