Article
Pharmacology & Pharmacy
Wei Yan, Parikshit Banerjee, Yannan Liu, Zhiqiang Mi, Changqing Bai, Haiyan Hu, Kenneth K. W. To, Hien T. T. Duong, Sharon S. Y. Leung
Summary: The study showed that incorporating phage into hydrogel had minimal impact on bacterial killing efficiency, acting as a phage depot to maintain higher phage titer at the infectious site for more effective treatment. The phage-loaded thermosensitive hydrogel is a simple and promising formulation for managing wound infections, demonstrating significant microbial suppression in ex vivo wound infection models.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Immunology
Michael J. McConnell, Antonio J. Martin-Galiano
Summary: This study utilized proteomic and computational data to identify a larger number of potentially immunogenic proteins in the Acinetobacter baumannii panproteome. The study found that certain antigens showed potential cross-reactivity with human proteins and were associated with different infection types. The integration of multi-omic data and knowledge of drug-resistant bacteria can aid in the development of effective multi-antigen vaccines against challenging infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Guido Granata, Fabrizio Taglietti, Francesco Schiavone, Nicola Petrosillo
Summary: This study assessed the efficacy and safety of a novel antibiotic, durlobactam, in the treatment of multidrug-resistant A. baumannii infections. Sixteen studies met the inclusion criteria, and it was found that durlobactam is effective when used in combination with sulbactam against A. baumannii. Further clinical trials are needed to confirm the potential of this combination therapy for treating infections caused by multidrug-resistant A. baumannii.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Deepa Dehari, Aiswarya Chaudhuri, Dulla Naveen Kumar, Rohit Patil, Mayank Gangwar, Sonam Rastogi, Dinesh Kumar, Gopal Nath, Ashish Kumar Agrawal
Summary: In this study, Acinetobacter baumannii (A. baumannii)-specific bacteriophages (BPAB & phi;1) were isolated and loaded into chitosan microparticles dispersed in a gel, showing therapeutic efficacy against MDR A. baumannii clinical strains. The isolated BPAB & phi;1 belonged to the Corticoviridae family with a burst size of 102.12 ± 2.65 PFUs per infected host cell. The developed formulation exhibited excellent antibiofilm eradication potential in vitro and effective wound healing after topical application.
Article
Immunology
Aminul Islam, Luis A. Actis, Timothy J. Wilson
Summary: This study reveals that natural antibodies (NAbs) enhance the host's immune response against A. baumannii infection, potentially leading to the development of effective therapies for human infections caused by antibiotic-resistant A. baumannii.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Chemistry, Medicinal
Keith D. Green, Nishad Thamban Chandrika, Loan Y. Vu, Allan H. Pang, Oleg V. Tsodikov, Sylvie Garneau-Tsodikova
Summary: The emergence of multidrug-resistant bacteria and the poor efficacy of available antibiotics have led to the urgent need for novel antibiotics. In this study, we synthesized a series of 46 aromatic hydrazides as potential treatments for A. baumannii infections. 34 compounds showed low-to sub-mu M inhibitory effects on A. baumannii growth and demonstrated high potency against multidrug-resistant clinical isolates, while being non-toxic to mammalian cells. These compounds have the potential to be developed into a selective anti-A. baumannii antibiotic.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Alicja Sloczynska, Matthew E. Wand, Stefan Tyski, Agnieszka E. Laudy
Summary: The study revealed the widespread presence of CHDL-type carbapenemases and insertion elements upstream of bla(CHDL) genes among Polish A. baumannii clinical isolates, contributing significantly to their carbapenem resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Infectious Diseases
Marin Kollef, Herve Dupont, David E. Greenberg, Pierluigi Viale, Roger Echols, Yoshinori Yamano, David P. Nicolau
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAB) has been classified as a critical pathogen requiring urgent new antibiotic treatment options. Cefiderocol, the first approved siderophore cephalosporin, shows stable activity against carbapenem-resistant pathogens and has demonstrated clinical efficacy in treating CRAB infections. Combination therapy with other active antibiotics and monitoring for resistance development are recommended.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Marco Falcone, Giusy Tiseo, Alessandro Leonildi, Leonardo Della Sala, Alessandra Vecchione, Simona Barnini, Alessio Farcomeni, Francesco Menichetti
Summary: Cefiderocol appears to be a promising therapeutic option for carbapenem-resistant Acinetobacter baumannii (CRAB) infections, with a potential protective effect on 30-day mortality. However, further studies are needed to address the issue of microbiological failure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Joash Jun Keat Chu, Wee Han Poh, Nabilah Taqiah Binte Hasnuddin, En Yi Hew, Linh Chi Dam, Abbas El Sahili, Scott A. Rice, Boon Chong Goh
Summary: As antimicrobial resistance becomes a growing health threat, the need for novel therapeutic agents is urgent. This study identifies a lysin called Abp013 that exhibits significant lytic activity against drug-resistant strains of Acinetobacter baumannii. Abp013 is able to tolerate the presence of human serum and effectively kill bacterial cells within biofilms. These findings suggest that Abp013 holds promising potential as a novel therapeutic agent.
Article
Microbiology
Zhemin Zhang, Christopher E. Morgan, Robert A. Bonomo, Edward W. Yu
Summary: Acinetobacter baumannii, a highly antibiotic-resistant Gram-negative pathogen, is a significant global health threat. The presence of multidrug efflux pumps within the bacterium is a major cause of failure of drug-based treatments.
Article
Microbiology
Amir Nutman, Elizabeth Temkin, Liat Wullfhart, Vered Schechner, Mitchell J. Schwaber, Yehuda Carmeli
Summary: Acinetobacter baumannii (Ab) bloodstream infections (BSIs) are a major public health concern in Israel, with high mortality. This study provides insights into the incidence, antimicrobial resistance, and mortality of Ab-BSI in Israel from 2018 to 2019. The findings highlight the significant burden of Ab-BSI in both hospital and community settings, with antimicrobial resistance being a key factor contributing to higher mortality.
Article
Infectious Diseases
Diaa Alrahmany, Ahmed F. Omar, Gehan Harb, Wasim S. El Nekidy, Islam M. Ghazi
Summary: The study found that compared to combination therapy, monotherapy in patients with AB infections has lower mortality rates, shorter hospital stays, and fewer adverse events. Colistin monotherapy and certain Colistin combinations showed nearly equivalent mortality outcomes, while patients on combination therapy were more susceptible to adverse events.
Article
Multidisciplinary Sciences
Mei Liu, Adriana Hernandez-Morales, James Clark, Tram Le, Biswajit Biswas, Kimberly A. Bishop-Lilly, Matthew Henry, Javier Quinones, Logan J. Voegtly, Regina Z. Cer, Theron Hamilton, Robert T. Schooley, Scott Salka, Ry Young, Jason J. Gill
Summary: In this study, the successful treatment of a 68-year-old patient with a multidrug-resistant infection using lytic bacteriophages is reported. The genomes of the phages used for treatment and the A. baumannii strains before and during treatment were analyzed. The results showed the development of resistance to the phages during treatment. Complete genomic sequences of A. baumannii strains collected before and during treatment were generated, supporting a clonal relationship. In vitro experiments also provided insights into the in vivo environment.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Christopher E. Morgan, Zhemin Zhang, Robert A. Bonomo, Edward W. Yu
Summary: Antibiotic resistance is a serious global health threat, and in the Gram-negative bacteria Acinetobacter baumannii, the multidrug efflux pump (AdeJ) is a major resistance determinant. This study uses cryo-EM to reveal the structure of the novel tetracycline antibiotic TP-6076 bound to AdeJ and the ribosome, providing insights into their binding mechanisms.