期刊
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
卷 53, 期 20, 页码 2374-2380出版社
WILEY
DOI: 10.1002/pola.27694
关键词
biodegradable; hyperbranched; step-growth polymerization; stimuli-sensitive polymer
资金
- National Natural Science Foundation of China [21374089/21404085]
- Doctorate Innovation Foundation of Northwestern Polytechnical University [CX201321]
- Program of New Century Excellent Talents of Ministry of Education of China [NCET-11-0817]
In this contribution, we present new reduction-cleavable hyperbranched disulfide bonds-containing poly(ester triazole)s with limited intramolecular cyclization, which can be synthesized by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) of A(2) monomer of dipropargyl 3,3-dithiobispropionate and B-3 monomer of tris(hydroxymethyl)ethane tri(4-azidobutanoate). The hyperbranched poly(ester triazole)s possess numerous terminal groups and weight-average molecular weight up to 20,400 g mol(-1) with a polydispersity index in the range 1.57-2.17. The CuAAC introduces rigid triazole units into the backbones of hyperbranched poly(ester triazole)s and reduces intramolecular cyclization, which is proved by topological analysis and H-1 NMR spectroscopy. The disulfide bonds on backbones endow the reduction-cleavable feature to the hyperbranched poly(ester triazole)s at the presence of dithiothreitol. It gives a novel and convenient methodology for the synthesis of reduction-responsive functional polymer with controlled topologies, and the reduction-cleavable hyperbranched poly(ester triazole)s with limited intramolecular cyclization are expected to possess potential in the application of stimuli-responsive anticancer drug nanocarriers. (c) 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 2374-2380
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