Review
Polymer Science
Kamla Pathak, Shashi Kiran Misra, Aayush Sehgal, Sukhbir Singh, Simona Bungau, Agnieszka Najda, Robert Gruszecki, Tapan Behl
Summary: Chitosan, a natural polymer, is extensively used for versatile drug delivery systems, with quaternized chitosan being preferred in pharmaceutical industries due to its superior properties. Quaternized chitosan has been widely applied in tissue engineering, wound healing, gene, and vaccine delivery.
Article
Engineering, Chemical
Anrong Zeng, Yangtao Wang, Dajun Li, Juedong Guo, Qiaowen Chen
Summary: This study investigated antibacterial blends of polycaprolactone, chitosan and quaternized chitosan, showing varying inhibition rates against Escherichia coli and Staphylococcus aureus at different blend ratios.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Juliana Domingues dos Santos Carvalho, Renata Santos Rabelo, Miriam Dupas Hubinger
Summary: The study investigated the thermal and rheological properties of methylcellulose and hydroxypropyl methylcellulose hydrogels with the addition of chitosan. The results indicated that the addition of chitosan allowed these polymers to form gels at lower temperatures, which could benefit the processing of oil carrier systems under milder thermal conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Giuseppantonio Maisetta, Anna Maria Piras, Vincenzo Motta, Simona Braccini, Diletta Mazzantini, Federica Chiellini, Ylenia Zambito, Semih Esin, Giovanna Batoni
Summary: The low-molecular-weight quaternized chitosan derivative QAL demonstrates antivirulence activity against Pseudomonas aeruginosa by inhibiting the production of virulence factors and reducing swarming motility. Additionally, QAL shows the ability to regulate QS-related genes and inhibit bacterial growth synergistically with tobramycin.
Article
Biochemistry & Molecular Biology
Tomasz Urbaniak, Gabriela S. Garcia-Briones, Alexander Zhigunov, Sviatoslav Hladysh, Edyta Adrian, Volodymyr Lobaz, Tereza Krunclova, Olga Janouskova, Ognen Pop-Georgievski, Dana Kubies
Summary: This study investigated layer-by-layer polyelectrolyte coatings with the ability to release heparin-binding proteins. The use of tannic acid as a physical crosslinker resulted in more stable films during assembly and increased protein release. The proteins released more when they were part of the heparin layers rather than as individual protein layers.
Article
Biochemistry & Molecular Biology
Jing Du, Yan Hong, Li Cheng, Zhengbiao Gu
Summary: The study found that complex coacervation occurred between CSA and HACC, with mass ratio and pH significantly influencing the complexation behavior. CSA/HACC complexes exhibited good pH and ionic strength stability, with electrostatic interactions, hydrogen bonding, and hydrophobic effects involved in the complexation process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Tinnakorn Phuangkaew, Nadda Booranabunyat, Suda Kiatkamjornwong, Panida Thanyasrisung, Voravee P. Hoven
Summary: Hydrophobized chitosan derivatives with hydrophilic positively charged groups were synthesized and assembled into nanoparticles, showing effective anti-biofilm activity against the dental caries pathogen.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Zheng Jin, Gaowei Hu, Kai Zhao
Summary: This study demonstrated that the synthesized M-N-2-HACC/N-CMCS nanoparticles showed high efficiency in mucosal delivery by utilizing the interaction with mucosal sites for drug release and delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Didem Demir, Sadin Ozdemir, Serpil Gonca, Nimet Bolgen
Summary: A novel cryogel scaffold loaded with styrax liquidus gum with antimicrobial and antioxidant properties was developed for potential tissue engineering applications. The styrax incorporated cryogels show promise for antimicrobial systems due to their chelating activity and high antioxidant, anti-biofilm, and antimicrobial properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fenghui Qiao, Zhiqi Jiang, Wen Fang, Jingzhi Sun, Qiaoling Hu
Summary: In this study, dual responsive nanoparticles were developed for drug delivery. The nanoparticles were able to release drug under the acidic tumor microenvironment and in the presence of mannitol. The nanoparticles were composed of chitosan, heparin, and poly(vinyl alcohol), and they exhibited dynamic covalent bonds and various functional groups for drug release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Zhongfei Gao, Changming Su, Chen Wang, Yulong Zhang, Chunhua Wang, Huanhuan Yan, Guige Hou
Summary: The bilayered nanofibrous membrane with good mechanical properties, antibacterial function, hydrophilicity, biocompatibility, and hemostasis is beneficial for wound healing. The outer layer provides mechanical support and antibacterial properties, while the inner layer promotes wound healing with hydrophilicity and biocompatibility. The membranes show excellent properties for wound dressing applications, accelerating wound healing and inhibiting scar formation.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Ke-Xin Huang, Ling-Yue Zhou, Jia-Qi Chen, Na Peng, Hong -Xiang Chen, Hua-Zhi Gu, Tao Zou
Summary: In recent years, there has been an increasing focus on natural polysaccharides due to their low cost, biocompatibility, and biodegradability. Quaternization is a modification method that enhances the solubility and antibacterial ability of natural polysaccharides. Water-soluble derivatives of cellulose, chitin, and chitosan have diverse applications in fields such as antibacterial products, drug delivery, wound healing, sewage treatment, and ion exchange membranes. By combining the inherent properties of these polysaccharides with quaternary ammonium groups, new products with multiple functions and properties can be obtained. This review summarizes the research progress in the applications of quaternized cellulose, chitin, and chitosan in the past five years and discusses the challenges and future perspectives in this promising field.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chaojie Xu, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Huahua Yu, Pengcheng Li
Summary: In this study, stable nanoparticles with good encapsulation efficiency and stability were successfully prepared using a novel method. The nanoparticles exhibited significant promotion of cytokine expression and showed favorable immune activity in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Bianca-Iustina Andreica, Alexandru Anisiei, Irina Rosca, Andreea-Isabela Sandu, Aurelian Sorin Pasca, Liliana Mititelu Tartau, Luminita Marin
Summary: Chitosan-based nanofibers have various applications in medicine and healthcare, and this study introduces binary quaternized chitosan/chitosan fibers. Their preparation involved electrospinning ternary chitosan/quaternized chitosan/poly(ethylene oxide) solutions and selectively removing poly(ethylene oxide). The fibers demonstrated reversible water vapor adsorption/desorption, similar swelling degrees to commercial wound dressings, good mechanical properties, and strong antimicrobial activity. Biocompatibility tests on human fibroblasts and rats indicated their safe use in contact with tissues. Overall, these bioactive materials have potential for tissue regeneration, wound healing, and drug delivery systems.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Ling Ding, Zhao Liu, Shen Song, Mohamed Aamer Abubaker, Lele Chen, Jipeng Shi, Zengjie Fan, Ji Zhang
Summary: HACC, synthesized by reacting chitosan with glycidyl trimethylammonium chloride, forms a non-Newtonian pseudoplastic fluid in solution, with thixotropy highly dependent on concentration changes. Dynamic viscoelasticity tests show that HACC exhibits both viscous behavior similar to a fluid and elastic properties of weak gel.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Alexander S. Gubarev, Alexey A. Lezov, Anna S. Senchukova, Petr S. Vlasov, Elena S. Serkova, Nina V. Kuchkina, Zinaida B. Shifrina, Nikolai V. Tsvetkov
Article
Polymer Science
Anna S. Senchukova, Mariya E. Mikhailova, Alexander S. Gubarev, Alexey A. Lezov, Elena Lebedeva, Ivan A. Makarov, Ivan M. Zorin, Nikolay Tsvetkov
POLYMER INTERNATIONAL
(2020)
Article
Polymer Science
Yulia A. Simonova, Maxim A. Topchiy, Marina P. Filatova, Natalia P. Yevlampieva, Mariya A. Slyusarenko, Galina N. Bondarenko, Andrey F. Asachenko, Mikhail S. Nechaev, Larisa M. Timofeeva
EUROPEAN POLYMER JOURNAL
(2020)
Article
Polymer Science
Boris M. Okrugin, Ralf P. Richter, Frans A. M. Leermakers, Igor M. Neelov, Ekaterina B. Zhulina, Oleg V. Borisov
Article
Polymer Science
Alexey Lezov, Alexander Gubarev, Tobias Kaiser, Willi Tobaschus, Nikolai Tsvetkov, Ivo Nischang, Ulrich S. Schubert, Holger Frey, Igor Perevyazko
Article
Polymer Science
A. A. Lezov, P. A. Fetin, A. S. Gubarev, A. A. Lezova, O. S. Vezo, A. S. Senchukova, M. E. Mikhailova, N. G. Mikusheva, I. M. Zorin, N. Tsvetkov
JOURNAL OF POLYMER RESEARCH
(2020)
Article
Polymer Science
Maria Slyusarenko, Nadezhda Nikiforova, Elena Sidina, Inga Nazarova, Vladimir Egorov, Yuri Garmay, Anastasiia Merdalimova, Natalia Yevlampieva, Dmitry Gorin, Anastasia Malek
Summary: The aim of the study was to explore a two-phase polymer system formed in human plasma for isolating exosome-enriched fraction of plasma extracellular nanovesicles (ENVs). The study systematically analyzed the optimal combination of polymer mixture parameters and characterized the isolated vesicles. This new method for plasma ENV isolation shows applicability for diagnostic purposes.
Article
Polymer Science
Anastasiia A. Elistratova, Ilya S. Kritchenkov, Alexey A. Lezov, Alexander S. Gubarev, Anastasia Solomatina, Daniel Kachkin, Nadezhda A. Shcherbina, Yu-Chan Liao, Yi-Chun Liu, Ya-Yun Yang, Nikolai Tsvetkov, Pavel S. Chelushkin, Pi-Tai Chou, Sergey P. Tunik
Summary: This study introduces block copolymer micelles loaded with a NIR phosphorescent iridium(III) complex for oxygen sensing applications, demonstrating their potential in PLIM oxygen sensing.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Vasily T. Lebedev, Gyula Torok, Yury Kulvelis, Olga Bolshkova, Natalia P. Yevlampieva, Marina A. Soroka, Eduard Fomin, Alexander Ya Vul, Seema Garg
Summary: The recent study focuses on the synthesis, structure, and physicochemical properties of complexes based on detonation nanodiamonds modified with metal-organic molecules, showing potential medical applications due to their magnetic and fluorescent properties.
Article
Chemistry, Analytical
Maria Slyusarenko, Sergey Shalaev, Alina Valitova, Lidia Zabegina, Nadezhda Nikiforova, Inga Nazarova, Polina Rudakovskaya, Maxim Vorobiev, Alexey Lezov, Larisa Filatova, Natalia Yevlampieva, Dmitry Gorin, Pavel Krzhivitsky, Anastasia Malek
Summary: A nanozyme-based technique using AuNPs aptasensors was developed to quantify plasma CD30 + SEVs, allowing for monitoring of classical Hodgkin lymphoma (cHL) activity. The method showed good performance in differentiating healthy donors and cHL patients, and a significant decrease in CD30 + SEVs was observed in the plasma of cHL patients after two cycles of chemotherapy.
Article
Polymer Science
Alexander S. Gubarev, Alexey A. Lezov, Nina G. Mikusheva, Igor Perevyazko, Anna S. Senchukova, Alexandra A. Lezova, Anna N. Podsevalnikova, Vyacheslav B. Rogozhin, Marcel Enke, Andreas Winter, Ulrich S. Schubert, Nikolai V. Tsvetkov
Summary: The study of metallopolymers is rapidly growing in polymer science, showing great potential for various applications. By conducting hydrodynamic studies and chemical structure analysis, researchers can explore the different properties of polymers containing various metal ions.
Article
Polymer Science
Anastasiia A. Elistratova, Alexander S. Gubarev, Alexey A. Lezov, Petr S. Vlasov, Anastasia Solomatina, Yu-Chan Liao, Pi-Tai Chou, Sergey P. Tunik, Pavel S. Chelushkin, Nikolai Tsvetkov
Summary: In this paper, a detailed hydrodynamic study of six commercial diblock copolymers was conducted. The study found that the block copolymers exhibited bimodal particle distributions in both organic solvent and water micellar dispersions. The micelles were stable and showed low critical micelle concentration values, with low toxicity towards cells.
Article
Materials Science, Paper & Wood
Alexander S. Gubarev, Olga V. Okatova, Galina F. Kolbina, Tatsiana A. Savitskaya, Dzmitry D. Hrynshpan, Georges M. Pavlov
Summary: An amphiphilic cellulose derivative named sodium salt of cellulose sulfoacetate was studied in a wide range of molecular masses using molecular hydrodynamics. The molecular masses were determined through sedimentation-diffusion analysis. The conformational characteristics of the chains, such as persistence length and hydrodynamic diameter, were established using the Multi-HYDFIT suite applied to the experimental data. The results showed that water-soluble cellulose derivatives form a community with similar equilibrium sizes of rigid chains in aqueous solutions.
Article
Polymer Science
Alexander S. S. Gubarev, Alexey A. A. Lezov, Anna N. N. Podsevalnikova, Nina G. G. Mikusheva, Petr A. A. Fetin, Ivan M. M. Zorin, Vladimir O. O. Aseyev, Ondrej Sedlacek, Richard Hoogenboom, Nikolai V. V. Tsvetkov
Summary: In this study, we investigated the hydrodynamic behavior of PMeOx, a hydrophilic polymer that has gained attention for use in pharmaceutical carriers. Our focus was to determine its characteristics under physiological conditions, which is important for understanding its potential use in pharmaceutical applications. Through our experiments, we found that PMeOx is a viable alternative to PEG, as it exhibits similar conformational parameters and behaves well in a phosphate-buffered saline solution at 37 degrees C.
Article
Polymer Science
Igor Perevyazko, Nina Mikusheva, Alexey Lezov, Alexander Gubarev, Marcel Enke, Andreas Winter, Ulrich S. Schubert, Nikolay Tsvetkov
Summary: This study focuses on the synthesis of poly(methacrylate)-based copolymers and their self-assembly behavior in dilute solutions through supramolecular/coordination interactions with metal ions. The conformational states and hydrodynamic characteristics of the metallo-supramolecular assemblies were determined using various analytical techniques.