Article
Surgery
Ra Ri Cha, Hee Jin Kim, Chang Min Lee, Jae Min Lee, Sang Soo Lee, Hyun Jin Cho, Chang Yoon Ha, Hyun Jin Kim, Ok-Jae Lee
Summary: Diagnostic iatrogenic colonic perforation is more frequent in older women, mostly occurring in the rectosigmoid region, and can be immediately detected. Endoscopic repair is more suitable for diagnostic perforations and smaller perforations.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Jieun Lee, Yoo Jin Lee, Jong Won Seo, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Jun Heo, Hyun Seok Lee, Joon Seop Lee, Byung Ik Jang, Kyeong Ok Kim, Kwang Bum Cho, Eun Young Kim, Dae Jin Kim, Yun Jin Chung
Summary: This prospective study aimed to assess the incidence of colonoscopy-related perforation and analyze clinical factors associated with poor outcomes. The incidence rate of colonoscopy-related perforation was 0.66/1000, with higher rates in therapeutic colonoscopy. Factors such as diagnostic colonoscopy, abdominal rebound tenderness, sigmoid colon location, delayed recognition, and abdominal tenderness were associated with poor clinical outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Katsumasa Kobayashi, Naoyoshi Nagata, Yohei Furumoto, Atsushi Yamauchi, Atsuo Yamada, Jun Omori, Takashi Ikeya, Taiki Aoyama, Naoyuki Tominaga, Yoshinori Sato, Takaaki Kishino, Naoki Ishii, Tsunaki Sawada, Masaki Murata, Akinari Takao, Kazuhiro Mizukami, Ken Kinjo, Shunji Fujimori, Takahiro Uotani, Minoru Fujita, Hiroki Sato, Sho Suzuki, Toshiaki Narasaka, Junnosuke Hayasaka, Mitsuru Kaise, Tomohiro Funabiki, Yuzuru Kinjo, Akira Mizuki, Shu Kiyotoki, Tatsuya Mikami, Ryosuke Gushima, Hiroyuki Fujii, Yuta Fuyuno, Naohiko Gunji, Yosuke Toya, Kazuyuki Narimatsu, Noriaki Manabe, Koji Nagaike, Tetsu Kinjo, Yorinobu Sumida, Sadahiro Funakoshi, Kana Kawagishi, Tamotsu Matsuhashi, Yuga Komaki, Kuniko Miki, Kazuhiro Watanabe, Naoki Kitano, Shu Kato, Shun Sakai, Eri Oshina, Tomohiro Mochida, Yukito Okura, Mana Matsuoka, Takahito Nozaka, Ayako Sato, Masato Yauchi, Taichi Matsumoto, Toru Asano
Summary: A multicenter long-term cohort study has shown that endoscopic band ligation (EBL) is an effective and safe treatment for colonic diverticular hemorrhage (CDH), with lower rebleeding rates, reduced need for interventional radiology, and shorter length of hospital stay.
Review
Biochemistry & Molecular Biology
Agnieszka Kulczynska-Przybik, Piotr Mroczko, Maciej Dulewicz, Barbara Mroczko
Summary: Reticulons play crucial roles in neuroanatomical plasticity, functional recovery, neurodegeneration, and neuroinflammation. They have potential clinical utility in understanding and treating neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marcin J. Suskiewicz, Evgeniia Prokhorova, Johannes G. M. Rack, Ivan Ahel
Summary: ADP-ribosylation is a widespread modification of biomolecules that regulates cellular functions. Recent studies have revealed its importance in human physiology and pathology, and its potential for therapy.
Review
Cell Biology
Daiqi Liu, Xuyao Han, Zhiwei Zhang, Gary Tse, Qingmiao Shao, Tong Liu
Summary: Heat shock proteins (HSPs) are protective proteins that play a role in cell stress response. They have been found to protect cells and organs, especially the cardiovascular system, against harmful conditions. Recent research has focused on the role of HSPs in the remodeling of atrial fibrillation (AF), a common arrhythmia that can be life-threatening.
Review
Biochemistry & Molecular Biology
Rongshuang Huang, Ping Fu, Liang Ma
Summary: Chronic kidney disease (CKD) affects 10-14% of the global population, and kidney fibrosis is a hallmark manifestation of progressive CKD. However, there are currently no antifibrotic therapies available for CKD. Understanding the complex interplay between injured parenchyma and non-parenchymal cell lineages in the fibrotic niche, as well as the role of genetics and epigenetics, has shed light on the mechanisms of kidney fibrosis. Recent advancements in single-cell technology have helped answer key questions about profibrotic renal tubules, myofibroblast origins, immune cell involvement, and cell communication. Additionally, the reversible nature of epigenetic changes offers potential therapeutic strategies to halt or reverse kidney fibrosis. Developing biomarkers and antifibrotic treatments for CKD are also important areas of research.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Karin Hochrainer, Wei Yang
Summary: Stroke proteomics studies in both animal and human specimens are comprehensively reviewed in this article, with discussions on the limitations, challenges, and future perspectives in the field. The authors also provide a unique resource by presenting extensive lists of proteins identified as altered by stroke in proteomic studies, and perform post-analysis to reveal stroke-related cellular processes and pathways.
CIRCULATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Weilin Zeng, Yingqiu Song, Runze Wang, Rong He, Tianlu Wang
Summary: Neutrophil elastase (NE) is a major protease in neutrophils and plays multiple roles in inflammation, microbial killing, tumor growth regulation, and disease development. Sivelestat, a specific NE inhibitor, shows promise in clinical applications, particularly in the treatment of COVID-19. This review highlights the pathophysiological processes associated with NE and explores the potential clinical applications of sivelestat.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Biology
Karl N. Miller, Nirmalya Dasgupta, Tianhui Liu, Peter D. Adams, Maria Grazia Vizioli
Summary: Senescent cells, damaged cells that permanently exit the cell cycle, play important roles in chronic diseases through their proinflammatory secretory phenotype, which can be controlled through the formation of cytoplasmic chromatin fragments.
Review
Biochemistry & Molecular Biology
P. Cody He, Chuan He
Summary: m(6)A, the most prevalent mRNA modification, regulates gene expression by influencing mRNA metabolism in various physiological and pathophysiological processes. It plays a multifaceted role in mRNA decay, translation, and transcription, highlighting its crucial importance in post-transcriptional gene expression regulation.
Review
Neurosciences
Robin J. M. Franklin, Mikael Simons
Summary: Understanding the role of inflammation in remyelination is crucial for addressing the challenge of progressive multiple sclerosis.
Review
Gastroenterology & Hepatology
James Guoxian Huang, Pornthep Tanpowpong
Summary: There has been significant progress in paediatric gastroenterology, including diagnostic techniques and management strategies, in the last decade. However, there is limited literature on the utility and outcomes of paediatric GI endoscopy in the Asia-Pacific region. Understanding the diagnostic value of paediatric GI endoscopy is crucial, particularly for inflammatory bowel disease and eosinophilic GI disease. Contextualizing the diagnostic value within the region-specific prevalence of paediatric GI diseases is important. Advanced endoscopic techniques and state-of-the-art diagnostics and therapeutics are expected to play a bigger role in paediatric gastroenterology in the future. It is necessary for current and future paediatric endoscopists to adhere to minimum practice standards and stay updated with the evolving trends in endoscopy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Michael Hsiao, Ming-Shyan Huang, Chih-Jen Yang
Summary: In this review, the authors summarize the mechanisms of FAK-mediated signaling networks during tumor development and the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yufeng Deng, Luqi Hou, Dianyue Qin, Ting Huang, Tianzhu Yuan
Summary: The study analyzed the clinical data of esophageal perforation patients over the past 20 years, finding a decrease in mortality and complication rates over the last decade. Surgical and conservative treatments had overall immediate mortality rates of 10.01% and 6.49% respectively.
Article
Gastroenterology & Hepatology
Berbel L. M. Ykema, Lisanne S. Rigter, Manon C. W. Spaander, Leon M. G. Moons, Tanya M. Bisseling, Berthe M. P. Aleman, Evelien Dekker, Wieke H. M. Verbeek, Ernst J. Kuipers, Jan Paul de Boer, Pieternella J. Lugtenburg, Cecile P. M. Janus, Eefke J. Petersen, Judith M. Roesink, Richard W. M. van der Maazen, Gerrit A. Meijer, Michael Schaapveld, Flora E. van Leeuwen, Beatriz Carvalho, Petur Snaebjornsson, Monique E. van Leerdam
Summary: The study evaluated clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in Hodgkin's lymphoma (HL) survivors who had undergone abdominal radiotherapy and/or procarbazine treatment. Colorectal neoplasia in HL survivors differs from average-risk controls, with AN primarily classified based on polyp size (>=10 mm) and longer follow-up between HL diagnosis and colonoscopy associated with a higher prevalence of AN.
DIGESTIVE ENDOSCOPY
(2022)
Article
Public, Environmental & Occupational Health
Neil Gupta, Ana Mocumbi, Said H. Arwal, Yogesh Jain, Abraham M. Haileamlak, Solomon T. Memirie, Nancy C. Larco, Gene F. Kwan, Mary Amuyunzu-Nyamongo, Gladwell Gathecha, Fred Amegashie, Vincent Rakotoarison, Jones Masiye, Emily Wroe, Bhagawan Koirala, Biraj Karmacharya, Jeanine Condo, Jean Pierre Nyemazi, Santigie Sesay, Sarah Maogenzi, Mary Mayige, Gerald Mutungi, Isaac Ssinabulya, Ann R. Akiteng, Justice Mudavanhu, Sharon Kapambwe, David Watkins, Ole Norheim, Julie Makani, Gene Bukhman
Summary: This study found that in low-and lower-middle-income countries, the health sector priorities and interventions to prevent and manage noncommunicable diseases and injuries have primarily adopted elements of the World Health Organization Global Action Plan for NCDs 2013-2020. However, there have been limited efforts to prioritize among conditions and health-sector interventions for NCDIs based on local epidemiology and contextually relevant risk factors in these countries, or to consider the equitable distribution of health outcomes in interventions.
GLOBAL HEALTH-SCIENCE AND PRACTICE
(2021)
Article
Surgery
Mitchell L. S. Driessen, Leontien M. Sturms, Frank W. Bloemers, Henk Jan ten Duis, Michael J. R. Edwards, Dennis den Hartog, E. J. Kuipers, Peter A. Leenhouts, Martijn Poeze, Inger B. Schipper, Richard W. Spanjersberg, Klaus W. Wendt, Ralph J. de Wit, Stefan W. A. M. van Zutphen, Mariska A. C. de Jongh, Luke P. H. Leenen
Summary: The COVID-19 pandemic has had an adverse effect on the outcome of major trauma patients in the Netherlands. Fewer patients, especially those with less severe traumatic brain injuries, were admitted to the ICU during the peak period, resulting in increased mortality rates for this subgroup.
Article
Oncology
Josephina G. Kuiper, Myrthe P. P. Van Herk-Sukel, Valery E. P. P. Lemmens, Ernst J. Kuipers, Ron M. C. Herings
Summary: The NCR-PHARMO GP cohort, consisting of 135,868 cancer patients, provides rich data on primary care management of cancer, enabling large-scale observational cancer research in the primary care setting. Patient-level linkage allows for long-term follow-up with ongoing annual updates.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Oncology
S. A. Nieuwenburg, M. C. Mommersteeg, L. M. M. Wolters, A. J. van Vuuren, N. Erler, M. P. Peppelenbosch, G. M. Fuhler, M. J. Bruno, E. J. Kuipers, M. C. W. Spaander
Summary: This study found that FIT can be used with high accuracy and sensitivity for the diagnosis of H. pylori, and is considered the most convenient test method. Non-invasive Hp-FIT test shows great promise for combined upper and lower gastrointestinal (pre-) cancerous screening. Further research should explore the clinical implications, benefits, and cost-effectiveness of this approach.
Article
Gastroenterology & Hepatology
Suk Yee Lam, Michiel C. Mommersteeg, Bingting Yu, Linda Broer, Manon C. W. Spaander, Fabian Frost, Stefan Weiss, Henry Voelzke, Markus M. Lerch, Ben Schoettker, Yan Zhang, Hannah Stocker, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Alexis C. Wood, Stephen S. Rich, Jerome I. Rotter, Kent D. Taylor, Russell P. Tracy, Edmond K. Kabagambe, Marcis Leja, Janis Klovins, Raitis Peculis, Dace Rudzite, Liene Nikitina-Zake, Girts Skenders, Vita Rovite, Andre Uitterlinden, Ernst J. Kuipers, Gwenny M. Fuhler, Georg Homuth, Maikel P. Peppelenbosch
Summary: The association between anti-H pylori IgG titers and the TLR1/6/10 locus was not replicated across different populations, and the variation at this locus affected TLR1-mediated cytokine production and TLR1 surface expression on monocytes and neutrophils.
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Sulleman Moreea, Harinder Dhaliwal, Dana C. Moffatt, Krish Ragunath, Terry Ponich, Alan N. Barkun, Ernst J. Kuipers, Robert Bailey, Fergal Donnellan, David Wagner, Keith Sanborn, James Lau
Summary: The study evaluated the safety and effectiveness of Hemospray as a monotherapy for active peptic ulcer bleeding. Results showed that Hemospray was successfully administered in nearly all patients, with a high rate of hemostasis achieved. Recurrent bleeding was observed in a small percentage of patients, but no adverse events were attributed to the use of Hemospray.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Endocrinology & Metabolism
Josephina G. Kuiper, Aline C. Fenneman, Anne H. van der Spek, Elena Rampanelli, Max Nieuwdorp, Myrthe P. P. Van Herk-Sukel, Valery E. P. P. Lemmens, Ernst J. Kuipers, Ron M. C. Herings, Eric Fliers
Summary: This study did not find a reduced risk of colorectal cancer in levothyroxine users. When stratified by tumour subsite, a borderline significant risk reduction of rectal cancer was found, indicating a need for further research.
ENDOCRINE CONNECTIONS
(2022)
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Article
Gastroenterology & Hepatology
Fanny E. R. Vuik, Stella A. Nieuwenburg, Sarah Moen, Eline H. Schreuders, Marinka D. Oudkerk Pool, Elisabeth F. P. Peterse, Cristiano Spada, Owen Epstein, Ignacio Fernandez-Urien, Albert Hofman, Ernst J. Kuipers, Manon C. W. Spaander
Summary: The study found that gastrointestinal lesions are very common in a largely asymptomatic Western population, with clinically relevant lesions found in 12% during CCE. These findings provide a reference frame for the prevalence rates of GI lesions in the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Josephina G. Kuiper, Myrthe P. P. Van Herk-Sukel, Valery E. P. P. Lemmens, Mathijs J. Kuiper, Ernst J. Kuipers, Ron M. C. Herings
Summary: This population-based case-control study found that colon and rectal cancer survivors have an increased risk of developing heart failure (HF). There are differences in risk factors for HF between colon cancer and rectal cancer patients. Physicians and general practitioners should be more aware of this potential increased risk in order to improve survival rates for these patients.
Article
Gastroenterology & Hepatology
Michiel C. Mommersteeg, Bing Ting Yu, Thierry P. P. van den Bosch, Johan H. von der Thusen, Ernst J. Kuipers, Michael Doukas, Maikel P. Peppelenbosch, Gwenny M. Fuhler
Summary: PD-L1 expression in gastric intestinal metaplasia (GIM) tissues is associated with PD-L1 positive G-cells. Gastric G-cells appear to be protected from H. pylori-induced immune destruction by expressing PD-L1. GIM itself does not express PD-L1 and is unlikely to evade immunosurveillance through PD-L1 expression.
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Han-Mo Chiu, David Lieberman, Ernst J. Kuipers, Matthew D. Rutter, Finlay Macrae, Khay-Guan Yeoh, Tiing Leong Ang, Vui Heng Chong, Sneha John, Jingnan Li, Kaichun Wu, Simon S. M. Ng, Govind K. Makharia, Murdani Abdullah, Nozomu Kobayashi, Masau Sekiguchi, Jeong-Sik Byeon, Hyun-Soo Kim, Susan Parry, Patricia Anne Cabral-Prodigalidad, Deng-Chyang Wu, Suparkij Khomvilai, Rashid N. Lui, Sunny Wong, Yu-Min Lin, E. Dekker
Summary: The Asia-Pacific Working Group on Colorectal Cancer Screening has updated their recommendations on screening methods, age for screening, and surveillance for individuals with a family history of CRC or advanced adenoma based on the most recent studies in the region.
Meeting Abstract
Gastroenterology & Hepatology
Pieter Wisse, Nicole S. Erler, S. Y. D. Boer, Gijsbert Den Hartog, M. Oudkerk Pool, Jochim S. Terhaar Sive Droste, C. Verveer, Gerrit Meijer, Iris Lansdorp-Vogelaar, Ernst J. Kuipers, Evelien Dekker, Manon Spaander
GASTROINTESTINAL ENDOSCOPY
(2022)
