Article
Endocrinology & Metabolism
Mark J. Bolland, Alison Avenell, Andrew Grey
Summary: The prevalence of biochemical osteomalacia is very low, even in individuals with 25OHD levels below 25 nmol/L, with all cases of osteomalacia having 25OHD levels <= 18 nmol/L before supplementation.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
G. Mazziotti, E. Lavezzi, A. Brunetti, M. Mirani, G. Favacchio, A. Pizzocaro, M. T. Sandri, A. Di Pasquale, A. Voza, M. Ciccarelli, A. G. Lania
Summary: This study suggests that vitamin D deficiency, especially when combined with secondary hyperparathyroidism, may increase the risk of acute hypoxemic respiratory failure in COVID-19 patients and impact the need for ventilation during treatment.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Ryo Koda, Satoru Miyazaki, Noriaki Iino, Yo Sato, Kenichiro Hirano, Eiji Sunami, Shinichi Kosugi, Tsutomu Kanefuji, Akira Ogose, Ichiei Narita
Summary: In the case mentioned above, a 48-year-old woman with a long history of anorexia nervosa developed osteomalacia as a complication. In addition to poor nutritional intake and inadequate sun exposure, postoperative malabsorption and kidney phosphate loss contributed to the progression of the disease.
Article
Medical Laboratory Technology
Marilena Minieri, Bruno Daniele Leoni, Lorenza Bellincampi, Daniela Bajo, Alessia Agnoli, Anna Maria De Angelis, Massimo Pieri, Francesco Equitani, Vincenzo Rossi, Filippa Valente, Stefano Pignalosa, Alessandro Terrinoni, Sergio Bernardini
Summary: A new reference interval for iPTH was established by comparing data from a healthy population and patients, revealing a prevalent vitamin D insufficiency affecting the iPTH reference interval. Medical reports are recommended to include the iPTH range for vitamin D deficiency for diagnosis of primary hyperparathyroidism, and reporting an optimal vitamin D-based iPTH reference interval could be clinically relevant for treated patients.
CLINICA CHIMICA ACTA
(2021)
Article
Surgery
Laura E. Fischer, Fernando Moreno-Garcia, Rachel Tran, Allison Harmon, Cooper Little, Grayson Domingue, Kenneth Stewart, Fernando Mier Giraud, Rishi Thakral
Summary: The prevalence of secondary hyperparathyroidism (SHPT) is high in patients undergoing bariatric surgery, with a significant number of patients experiencing persistent SHPT for more than 1 year. The current vitamin D3 and calcium supplementation protocols may not effectively prevent SHPT in post-bariatric patients. Further studies are needed to develop effective treatment strategies to mitigate the adverse effects of bariatric surgery on bone metabolism.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Neurosciences
Suhalika S. Sahni, Shruti Kakkar, Ruchika Kumar, Jatinder S. Goraya
Summary: This study described a cohort of 26 children and adolescents with osteomalacic myopathy, most of whom presented with progressive walking difficulty and signs of rickets. Laboratory and radiographic findings were consistent with vitamin-D deficiency in all cases, and response to vitamin-D treatment was good.
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Medicine, General & Internal
Yuichiro Iwamoto, Fuminori Tatsumi, Kazunori Dan, Yukino Katakura, Masashi Shimoda, Tomohiko Kimura, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Summary: This case report describes a middle-aged male patient with bone pain and gait disturbance, who was diagnosed with vitamin D-deficient osteomalacia triggered by long-term social withdrawal and an unbalanced diet.
Review
Urology & Nephrology
Mario Cozzolino, Paola Minghetti, Pierluigi Navarra
Summary: A high percentage of chronic kidney disease patients have low vitamin D levels, which can lead to secondary hyperparathyroidism. Early intervention to restore vitamin D levels is recommended to prevent/delay secondary hyperparathyroidism. Controlling parathyroid hormone levels becomes a major focus of therapy for patients with intermediate-stage chronic kidney disease.
JOURNAL OF NEPHROLOGY
(2022)
Review
Endocrinology & Metabolism
Li-Xi Zhang, Ben Zhang, Xu-Yao Liu, Zi-Ming Wang, Peng Qi, Tong-Yue Zhang, Qiang Zhang
Summary: Secondary and tertiary hyperparathyroidism are common and complicated endocrine diseases, and their hyperactivity disorder can cause structural alterations in multiple organs and systems. The current treatment for these diseases remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
A. Song, H. Zhao, Y. Yang, S. Liu, M. Nie, O. Wang, X. Xing
Summary: This study aimed to evaluate the safety and efficacy of vitamin D supplementation in patients with PHPT. The results showed that vitamin D supplementation in PHPT patients with vitamin D deficiency significantly reduces PTH and ALP levels.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Enrique Soto-Pedre, Yeun Yi Lin, Jimena Soto-Hernaez, Paul J. Newey, Graham P. Leese
Summary: This study aimed to assess morbidity and mortality associated with primary hyperparathyroidism (PHPT). A large population-based retrospective study found that patients with PHPT had increased risk of death and various clinical diseases, including cardiovascular disease, cerebrovascular disease, diabetes, renal stones, and osteoporosis. These risks were independent of serum vitamin D concentration.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Hongquan Du, Aihua Jia, Mingyong Gu, Sen Li, Pei Zhang, Jie Bai
Summary: This article evaluated the impact of thyrotoxicosis on the occurrence and development of osteomalacia, suggesting that osteomalacia may be caused by the catabolism of vitamin D, deficiency of vitamin D, and disorders in calcium metabolism. It is recommended to diagnose osteomalacia by monitoring alkaline phosphatase, liver function, and clinical symptoms, and to treat it promptly to prevent fractures and deformities.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Nutrition & Dietetics
Nasser M. Al-Daghri, Sobhy Yakout, Shaun Sabico, Kaiser Wani, Syed Danish Hussain, Naji Aljohani, Suma Uday, Wolfgang Hoegler
Summary: Nutrition-acquired osteomalacia is prevalent in Arab adolescents, with a higher prevalence in girls compared to boys, which is likely associated with Arab traditional clothing and diet.
Article
Endocrinology & Metabolism
Ajay D. Rao, Istvan Bonyhay, Joel Dankwa, Maria Baimas-George, Lindsay Kneen, Sarah Ballatori, Roy Freeman, Gail K. Adler
Article
Medicine, Research & Experimental
Omar Bayomy, Ajay D. Rao, Rajesh Garg, Anand Vaidya, Alyssa R. Kotin, Beata Reiber, Stephanie Nijmeijer, Marcelo F. Di Carli, Michael Jerosch-Herold, Raymond Y. Kwong, Gail K. Adler
METABOLIC SYNDROME AND RELATED DISORDERS
(2017)
Article
Oncology
James Luke Godwin, Shuchie Jaggi, Imali Sirisena, Pankaj Sharda, Ajay D. Rao, Ranee Mehra, Colleen Veloski
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2017)
Article
Endocrinology & Metabolism
Elias S. Siraj, Carol Homko, Laura A. Wilson, Patrick May, Ajay D. Rao, Jorge Calles, Gianrico Farrugia, William L. Hasler, Kenneth L. Koch, Linda Nguyen, William J. Snape, Thomas L. Abell, Irene Sarosiek, Richard W. McCallum, Pankaj J. Pasricha, John Clarke, James Tonascia, Frank Hamilton, Henry P. Parkman
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Rajesh Garg, Ajay D. Rao, Maria Baimas-George, Shelley Hurwitz, Courtney Foster, Ravi V. Shah, Michael Jerosch-Herold, Raymond Y. Kwong, Marcelo F. Di Carli, Gail K. Adler
Article
Peripheral Vascular Disease
A. D. Rao, B. Sun, A. Saxena, P. N. Hopkins, X. Jeunemaitre, N. J. Brown, G. K. Adler, J. S. Williams
JOURNAL OF HUMAN HYPERTENSION
(2013)
Review
Endocrinology & Metabolism
Mahalakshmi Honasoge, Ajay D. Rao, Sudhaker D. Rao
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2014)
Article
Endocrinology & Metabolism
Andrea V. Haas, Bernard A. Rosner, Raymond Y. Kwong, Ajay D. Rao, Rajesh Garg, Marcelo F. Di Carli, Gail K. Adler
Editorial Material
Cardiac & Cardiovascular Systems
Ajay D. Rao, Cherie Lisa Vaz, Kevin Jon Williams
Review
Cell Biology
Vishnu K. Kumar, Atreju Lackey, Jonathan Snyder, Sunil Karhadkar, Ajay D. Rao, Antonio DiCarlo, Priscila Y. Sato
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Carolyn Y. Fang, Elizabeth A. Handorf, Ajay D. Rao, Philip T. Siu, Marilyn Tseng
Summary: The study found that social support moderates the association of acculturative stress with depressive symptoms among Chinese immigrant men, but not women. Future research should explore factors that can enhance resilience and mitigate acculturative stress effects on psychological well-being among Chinese immigrant women.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2021)
Meeting Abstract
Peripheral Vascular Disease
Ajay D. Rao, Zhao Huaqing, Ramachandran S. Vasan, E. Adlin
Meeting Abstract
Ophthalmology
Keval A. Ray, Danielle Verghese, Benjamin Bird, Martin Josef Schardt, Jose Calva-Moreno, Daniel Gritsyuk, Ajay Rao, Raul A. DeLa Cadena, William J. Foster
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Meeting Abstract
Endocrinology & Metabolism
Rajesh Garg, Ajay D. Rao, Gail Adler
Meeting Abstract
Endocrinology & Metabolism
Meredith McFarland, Qalb Khan, Rene J. Alvarez, Ajay D. Rao