Article
Multidisciplinary Sciences
Erin J. Stephenson, Amanda S. Stayton, Aarti Sethuraman, Prahlad K. Rao, Charles Klazer Gomes, Molly C. Mulcahy, Liam McAllan, Michelle A. Puchowicz, Joseph F. Pierre, Dave Bridges, Joan C. Han
Summary: This study found that sucrose intake induces sexually dimorphic effects and influences the severity of fatty liver disease and the contribution of fatty acid synthesis to hepatic triglycerides in a sex-dependent manner. These findings demonstrate the role of sex in sucrose-induced fatty liver and highlight the importance of extrahepatic metabolism in the pathogenesis of diet-induced fatty liver and NAFLD.
NATURE COMMUNICATIONS
(2022)
Article
Reproductive Biology
Juan Carlos Gutierrez-Anez, Andrea Lucas-Hahn, Klaus-Gerd Hadeler, Patrick Aldag, Heiner Niemann
Summary: The study found that adding melatonin during in vitro culture can improve cumulus-oocyte competence and embryo development in prepubertal and adult dairy cattle, enhancing embryo quality.
Article
Neurosciences
Zhenzhen Yan, Xinran Cheng, Yuansong Li, Zexiong Su, Yiwei Zhou, Jie Liu
Summary: Sexual dimorphism in neurotransmitter release at the neuromuscular junctions (NMJs) of adult Caenorhabditis elegans has been observed. Adult males show enhanced neurotransmitter release and increased sensitivity to extracellular calcium concentration in their cholinergic synapses. Furthermore, male cholinergic synapses exhibit weaker synaptic depression but faster vesicle replenishment compared to hermaphrodites.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Erica. J. J. Stewart, Janice. A. A. Dye, Mette. C. C. Schladweiler, Pamela. M. M. Phillips, Katherine. L. L. McDaniel, Judy. H. H. Richards, Rachel. D. D. Grindstaff, William. T. T. Padgett, Makala. L. L. Moore, Donna Hill, Christopher. J. J. Gordon, Urmila. P. P. Kodavanti, Colette. N. N. Miller
Summary: This study found that early pregnancy exposure to ozone results in impaired metabolic flexibility in offspring, increasing the risk of obesity in males and hepatic dysfunction in females.
Article
Biochemistry & Molecular Biology
Matthew R. Bruce, Karen L. Jones, Anthony C. Vernon, Jill L. Silverman, Jacqueline N. Crawley, Jacob Ellegood, Jason P. Lerch, Judy Van de Water
Summary: The study suggests that maternal autoantibodies may play a significant role in immune responses leading to autism spectrum disorder, causing changes in offspring neurodevelopment and behavior. Findings indicate that offspring prenatally exposed to MAR-ASD autoantibodies exhibit increased brain volume, altered regional relationships, and gender-specific effects on social interaction and repetitive self-grooming behavior in adulthood.
MOLECULAR PSYCHIATRY
(2021)
Article
Gastroenterology & Hepatology
Sarra Smati, Arnaud Polizzi, Anne Fougerat, Sandrine Ellero-Simatos, Yuna Blum, Yannick Lippi, Marion Regnier, Alexia Laroyenne, Marine Huillet, Muhammad Arif, Cheng Zhang, Frederic Lasserre, Alain Marrot, Talal Al Saati, JingHong Wan, Caroline Sommer, Claire Naylies, Aurelie Batut, Celine Lukowicz, Tiffany Fougeray, Blandine Tramunt, Patricia Dubot, Lorraine Smith, Justine Bertrand-Michel, Nathalie Hennuyer, Jean-Philippe Pradere, Bart Staels, Remy Burcelin, Francoise Lenfant, Jean-Francois Arnal, Thierry Levade, Laurence Gamet-Payrastre, Sandrine Lagarrigue, Nicolas Loiseau, Sophie Lotersztajn, Catherine Postic, Walter Wahli, Christophe Bureau, Maeva Guillaume, Adil Mardinoglu, Alexandra Montagner, Pierre Gourdy, Herve Guillou
Summary: The study found that different diets induced more severe NAFLD in male mice, characterized by lipid accumulation and inflammation/fibrosis. Sex-biased hepatic gene signatures showed different responses to various dietary challenges, with Peroxisome proliferator-activated receptor alpha (PPAR alpha) playing a key role in gender-specific and NAFLD pathophysiology.
Article
Obstetrics & Gynecology
Maayan Hagbi Bal, Avi Harlev, Ruslan Sergienko, Eliahu Levitas, Iris Har-Vardi, Atif Zeadna, Aya Mark-Reich, Hadas Becker, Noa Ben-David, Lechaim Naggan, Tamar Wainstock
Summary: The study found an association between IVF treatment and offspring neoplasm risk, especially for offspring transferred as fresh embryos, at an earlier embryotic stage, or after harvesting three or more oocytes.
FERTILITY AND STERILITY
(2021)
Article
Multidisciplinary Sciences
Yan Zhu, Huai L. Feng, Man-Xi Jiang
Summary: The introduction of automated techniques for dish preparation in human fertility clinics or animal laboratories can significantly improve working efficiency and reduce the workload for embryologists. This study comparing manual and automated methods showed that the automated system reduced preparation time, increased efficiency and qualified rates without compromising medium osmolality stability. The findings suggest that automated dish preparation is a superior alternative to manual preparation, improving working efficiency and facilitating operational standardization.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Gang Liu, Yana Li, Tengjiao Zhang, Mushan Li, Sheng Li, Qing He, Shuxin Liu, Minglu Xu, Tinghui Xiao, Zhen Shao, Weiyang Shi, Weida Li
Summary: This study found sexually dimorphic transcriptomes in mouse beta cells, indicating sex-based differences in T2D susceptibility and pathogenesis. In a high-fat diet-induced T2D mouse model, sex-dependent T2D altered genes were identified, suggesting differences in the pathological mechanisms of T2D. Through islet transplantation experiments, it was shown that sex-mismatched islet transplants in diabetic mice led to impaired glucose tolerance, highlighting the importance of considering sex in T2D treatment.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Review
Endocrinology & Metabolism
Mohd Faizal Ahmad, Marjanu Hikmah Elias, Norazilah Mat Jin, Muhammad Azrai Abu, Saiful Effendi Syafruddin, Ani Amelia Zainuddin, Nao Suzuki, Abdul Kadir Abdul Karim
Summary: In vitro oocyte maturation (IVM) has been implemented worldwide, but it is not widely adopted in current in vitro fertilization (IVF) due to the lack of synchronization in protocols and definition criteria, resulting in difficulty in collecting proper outcome data and understanding the exact procedure. This review aims to consolidate the current clinical practice of IVM and explore its theoretical basis, as well as discuss potential future uses and the importance of collaboration among IVM centers for better clinical data collection and safety purposes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Veterinary Sciences
Ahmed Ezzat Ahmed, Ramya Ahmad Sindi, Nasra Ahmed Yousef, Hassan A. Hussein, Magdy R. Badr, Khalid M. Al Syaad, Fatimah A. Al-Saeed, Ahmed Saad A. Hassaneen, Mohamed Abdelrahman, Montaser Elsayed Ali
Summary: The study investigated the effects of adding epidermal growth factors (EGF) and/or b-Mercaptoethanol (bME) to the buffalo in vitro embryo production process. Results showed that supplementing EGF (20 ng/mL) to the TCM-199, IVF-TALP, or SOF media improved the growth and development of buffalo embryos. EGF (50 ng/mL) stimulated embryo production when added to the IVF-TALP or SOF media, but not the IVM medium. bME was less efficient, but could enhance embryo growth when added to the IVF-TALP media at a 50 mu M concentration.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Neurosciences
Ankit Sood, Pratik R. Chaudhari, Praachi Tiwari, Sneha Shah, Vidita A. Vaidya
Summary: Stress perception and response differ between sexes, which may contribute to sex differences in susceptibility to psychopathology. This study investigated the neuroimmune consequences of acute immobilization stress (AIS) and found sexually dimorphic effects in peripheral cytokines levels, with males showing a significant increase compared to females. However, no sexually dimorphic effects were observed in hippocampal cytokine and neuroinflammation-associated gene expression levels. The study highlights the importance of considering sex differences in the neuroimmune consequences of acute stress.
NEUROSCIENCE LETTERS
(2022)
Article
Endocrinology & Metabolism
Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds Jr, J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley
Summary: This study found that liver-specific deletion of CPT1a promotes sexually dimorphic steatotic liver disease (SLD) in mice, and new mechanisms by which females are protected from high-fat diet-induced liver injury were identified.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Amanda M. Rooney, Olufunmilayo O. Ayobami, Natalie H. Kelly, John C. Schimenti, F. Patrick Ross, Marjolein C. H. van der Meulen
Summary: Estrogen receptor-alpha (ER alpha) plays a crucial role in skeletal maintenance and adaptation to mechanical loading, with its effects depending on sex and age. Deletion of ER alpha in mature osteoblasts leads to reduced bone mass and increased mechanoadaptation in adult female mice, while the effects in male mice are minimal.
Article
Endocrinology & Metabolism
Jianing Niu, Qiurong Chang, Junting Xu, Jinli Li, Wenqiang Liu, Zhiqin Chen, Xianting Jiao, Yi Guo, Xiaoming Teng
Summary: This study aimed to identify the optimal oxidation-reduction level in the fertilization medium for IVF outcomes using the MiOXSYS system. It found that sORP values within the range of 228.7-235.3 mV were associated with better pregnancy outcomes and embryo quality.
FRONTIERS IN ENDOCRINOLOGY
(2023)