Article
Oncology
Jessica Amaru, Federica Barbieri, Marica Arvigo, Agnese Solari, Adriana Bajetto, Federica Nista, Claudia Campana, Gabriele Gaggero, Alessandro Prior, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Tullio Florio, Federico Gatto
Summary: The first-generation somatostatin receptor ligands (fg-SRLs), like octreotide, and the second-generation ligand, pasireotide, act mainly through SST2 in somatotroph tumor cells, and their combination does not show any additional benefits.
Review
Cell Biology
E. Vitali, S. Piccini, G. Trivellin, V Smiroldo, E. Lavezzi, A. Zerbi, G. Pepe, A. G. Lania
Summary: Pancreatic neuroendocrine tumors (Pan-NETs) are a heterogeneous group of neoplasms characterized by the expression of somatostatin receptors (SSTs), with SST2 being the main target for somatostatin analogs (SSAs). SSAs are effective in controlling hormone secretion, tumor proliferation, and other key processes through the binding to SST2. The interaction between SST2 and its associated proteins plays a crucial role in regulating signaling pathways and responsiveness to treatment in Pan-NETs.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Donatella Treppiedi, Giusy Marra, Genesio Di Muro, Rosa Catalano, Federica Mangili, Emanuela Esposito, Davide Calebiro, Maura Arosio, Erika Peverelli, Giovanna Mantovani
Summary: In pituitary tumor cells, SST2 and SST5 can form homo- and hetero-dimers, and FLNA plays a regulatory role in SST2/SST5 hetero-dimerization. Octreotide and pasireotide have different effects on the internalization and intracellular trafficking of SST2 and SST5.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Jian Zhao, Shimiao Wang, Stacy Markison, Sun Hee Kim, Sangdon Han, Mi Chen, Ana Karin Kusnetzow, Elizabeth Rico-Bautista, Michael Johns, Rosa Luo, R. Scott Struthers, Ajay Madan, Yunfei Zhu, Stephen F. Betz
Summary: The article describes the discovery of a novel class of SST2 agonists with excellent selectivity and pharmacodynamic activity, with compound 22 being the first non-peptide SST2 agonist to advance to human clinical trials.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Endocrinology & Metabolism
Ajay Madan, Stacy Markison, Stephen F. Betz, Alan Krasner, Rosa Luo, Theresa Jochelson, Jason Lickliter, R. Scott Struthers
Summary: This study evaluated the pharmacodynamics, pharmacokinetics, and safety of paltusotine, an orally bioavailable nonpeptide agonist for somatostatin receptor subtype 2 (SST2), for the treatment of acromegaly and neuroendocrine tumors. The results showed that paltusotine suppressed growth hormone (GH) and insulin-like growth factor 1 (IGF-1) release in a dose-dependent manner and had a safety profile similar to approved SST2 receptor ligands.
Article
Chemistry, Medicinal
Pascale Plas, Lorenzo Limana, Denis Carre, Amath Thiongane, Olivier Raguin, Rosalba Mansi, Florence Meyer-Losic, Stephane Lezmi
Summary: Limited experiments compared the treatment effects of repetitive cycles of radiolabelled somatostatin analogues, and found that [Lu-177]Lu-satoreotide tetraxetan showed superior binding properties, anti-tumour activity, and safety profile compared to [Lu-177]Lu-DOTA-TATE.
Article
Medicine, Research & Experimental
Francesca Mameli, Fabiana Ruggiero, Michelangelo Dini, Sara Marceglia, Marco Prenassi, Linda Borellini, Filippo Cogiamanian, Elena Pirola, Luigi Gianmaria Remore, Giorgio Fiore, Maria Rita Reitano, Natale Maiorana, Barbara Poletti, Marco Locatelli, Sergio Barbieri, Alberto Priori, Roberta Ferrucci
Summary: This study investigates the impact of deep brain stimulation on personality characteristics in Parkinson's disease patients and finds that despite improvements in motor function and quality of life, there is a significant increase in depressive traits.
Article
Endocrinology & Metabolism
W. Vena, F. Carrone, A. Delbarba, O. Akpojiyovbi, L. C. Pezzaioli, P. Facondo, C. Cappelli, L. Leonardi, L. Balzarini, D. Farina, A. Pizzocaro, A. G. Lania, G. Mazziotti, A. Ferlin
Summary: This study evaluated the associations between body composition parameters, vertebral fractures, and trabecular bone score in adult males with Klinefelter syndrome. The results suggest that body composition may influence bone quality and the risk of vertebral fractures in individuals with Klinefelter syndrome.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Correction
Endocrinology & Metabolism
R. M. Ruggeri, E. Benevento, F. De Cicco, B. Fazzalari, E. Guadagno, I. Hasballa, M. G. Tarsitano, A. M. Isidori, A. Colao, A. Faggiano, I Aini, I Aini, M. Albertelli, Y. Alessi, B. Altieri, S. Antonini, L. Barrea, F. Birtolo, F. Campolo, G. Cannavale, C. Cantone, S. Carra, R. Centello, A. Cozzolino, S. Molfetta, V. Vito, G. Fanciulli, T. Feola, F. Ferrau, S. Gay, E. Giannetta, F. Grillo, E. Grossrubatscher, V Guarnotta, A. Salvia, A. Laffi, A. Lania, A. Liccardi, P. Malandrino, R. Mazzilli, E. Messina, N. Mikovic, R. Minotta, R. Modica, G. Muscogiuri, C. Pandozzi, G. Pugliese, G. Puliani, A. Ragni, M. Rubino, F. Russo, F. Sesti, L. Verde, A. Veresani, C. Vetrani, G. Vitale, V Zamponi, I Zanata
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
M. F. Birtolo, W. Vena, A. Pizzocaro, E. Lavezzi, A. Brunetti, S. Jaafar, N. Betella, A. C. Bossi, G. Mazziotti, A. G. Lania
Summary: This study investigated the relationship between serum testosterone levels and outcomes of COVID-19 in a large cohort of female patients. The results showed that high testosterone levels were associated with higher inflammatory markers and worse course of COVID-19, although this association disappeared after correcting for inflammatory parameters.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Alessandro Maria Berton, Nunzia Prencipe, Luca Bertero, Marco Baldi, Chiara Bima, Marina Corsico, Antonio Bianchi, Giovanna Mantovani, Francesco Ferrau, Paola Sartorato, Irene Gagliardi, Ezio Ghigo, Silvia Grottoli
Summary: This multicenter retrospective study aimed to identify the most relevant biomarkers specific for the Italian acromegaly population. The results showed that a low-grade SSTR2 expression was the most relevant predictor of resistance to first-generation somatostatin receptor ligands, followed by a SG/intermediate cytokeratin pattern and a T2-iso/hyperintense MRI signal.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Gianluca Franchellucci, Marta Andreozzi, Silvia Carrara, Luca De Luca, Francesco Auriemma, Danilo Paduano, Federica Calabrese, Antonio Facciorusso, Valeria Poletti, Alessandro Zerbi, Andrea Gerardo Lania, Alexia Francesca Bertuzzi, Paola Spaggiari, Vittorio Pedicini, Marcello Rodari, Pietro Fusaroli, Andrea Lisotti, Andrew Ofosu, Alessandro Repici, Benedetto Mangiavillano
Summary: Assessing the behavior of pancreatic neuroendocrine tumors (PNETs) remains a daily challenge for physicians. The definition of aggressiveness is crucial in determining the appropriate management strategy, ranging from observation to surgery. EUS has emerged as a valuable tool in diagnosing PNETs and has experienced rapid advancements in recent years, particularly in the assessment of aggressiveness using contrast-enhanced techniques. This review highlights the latest experiences and opportunities in evaluating PNET behavior with contact-enhanced EUS and contrast-enhanced harmonic EUS, with a focus on future applications and possibilities.
Article
Cardiac & Cardiovascular Systems
Sara Piccini, Giuseppe Favacchio, Cristina Panico, Emanuela Morenghi, Franco Folli, Gherardo Mazziotti, Andrea Gerardo Lania, Marco Mirani
Summary: A retrospective cohort study explored the determinants of cardiovascular protection in a real-world population of type 2 diabetes patients using GLP-1 RA treatment. The findings revealed that discontinuation of GLP-1 RA treatment increased the risk of cardiovascular events.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Giulia Del Sindaco, Jugurtha Berkenou, Angela Pagnano, Anya Rothenbuhler, Maura Arosio, Giovanna Mantovani, Agnes Linglart
Summary: This study analyzed a large cohort of 136 iPPSD/PHP patients, and found that 36% of patients experienced at least one neonatal complication, with the rate reaching 47% for iPPSD2/PHP1A patients. Neonatal complications were associated with earlier resistance to thyroid-stimulating hormone and the development of neurocognitive impairment and constipation later in life. Therefore, specific care and attention should be provided at birth for iPPSD/PHP, especially iPPSD2/PHP1A, newborns.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
L. Cianferotti, C. Cipriani, S. Corbetta, G. Corona, G. Defeudis, A. G. Lania, C. Messina, N. Napoli, G. Mazziotti
Summary: Endocrine diseases can lead to osteoporosis and fractures, but traditional bone density measurement methods may not accurately capture skeletal alterations caused by endocrine disorders. Therefore, it is important to use new techniques to assess bone quality for the diagnosis and prediction of skeletal fragility and fracture risk.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini, Margarita Kirienko, Luca di Tommaso, Cristiano Pini, Fabrizia Gelardi, Salvatore Ariano, Andrea Gerardo Lania, Gherardo Mazziotti, Giuseppe Mercante, Arturo Chiti
Summary: This study investigated the potential role of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) and found that PSMA expression and 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG) uptake on PET/CT can serve as complementary biomarkers for TC outcome prediction.
Review
Biochemistry & Molecular Biology
Maria Francesca Birtolo, Simone Antonini, Andrea Saladino, Benedetta Zampetti, Elisabetta Lavezzi, Iacopo Chiodini, Gherardo Mazziotti, Andrea G. A. Lania, Renato Cozzi
Summary: Secondary Adrenal Insufficiency (SAI) is a condition characterized by low ACTH secretion due to hypothalamus or pituitary disease or injury. The evaluation of SAI is challenging due to non-specific symptoms, rarity, and pitfalls associated with laboratory tests. The gold standard test for assessing the HPA axis is the insulin tolerance test, but the ACTH stimulation test is safer and well-tolerated, although its diagnostic accuracy varies.
Article
Endocrinology & Metabolism
Morelli Valentina, Elli Francesca Marta, Frigerio Sofia, Vena Walter, Palmieri Serena, Lucca Camilla, Maffini Maria Antonia, Contarino Andrea, Bagnaresi Francesca, Mantovani Giovanna, Arosio Maura
Summary: This study aimed to evaluate the prevalence of ARMC5 genetic defects in patients with bilateral adrenal incidentaloma (BAI) and explore the possible genotype-phenotype correlations. The results showed that the prevalence of germline ARMC5 pathogenic variants was 18.8% in BAI patients with mild autonomous cortisol secretion (MACS+). Somatic ARMC5 pathogenic variants were also found in adrenal tissue of patients without germline ARMC5 variants, indicating their involvement in adrenal tumor development.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Hanna Ludar, Yael Levy-Shraga, Osnat Admoni, Hussein Majdoub, Kineret Mazor Aronovitch, Ilana Koren, Shoshana Rath, Ghadir Elias-assad, Shlomo Almashanu, Giovanna Mantovani, Orit Pinhas Hamiel, Yardena Tenenbaum-Rakover
Summary: This study retrospectively investigated all patients diagnosed with pseudohypoparathyroidism type IA (PHPIA) in two referral centers in Israel and found that 9 patients had genetically confirmed GNAS mutations. Long-term follow-up is warranted for newborns with a combination of congenital hypothyroidism, early-onset obesity, and minor dysmorphic features associated with PHPIA, as the complete clinical phenotype may develop a long time after initial presentation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Francesco Ferrau, Salvatore Giovinazzo, Ylenia Alessi, Antonino Catalano, Agostino Tessitore, Enrico Mormina, Federica Bellone, Giuseppe Giuffrida, Giuseppe Paola, Oana Ruxandra Cotta, Marta Ragonese, Francesca Granata, Andrea G. Lania, Gherardo Mazziotti, Salvatore Cannavo
Summary: This study found that patients with endogenous Cushing's syndrome have alterations in bone density and bone marrow fat that are associated with increased risk of vertebral fractures. Among these parameters, trabecular bone score and bone mineral density were found to be more accurate predictors of fracture risk.
Article
Endocrinology & Metabolism
Maria Francesca Birtolo, Simone Antonini, Andrea G. Lania, Gherardo Mazziotti
Summary: Skeletal fragility and vertebral fractures are common complications of growth hormone hypersecretion in acromegalic subjects. The coexistence of spine arthropathy further negatively impacts the quality of life for these patients. Managing these complications can be challenging even after controlling the disease biochemically. This article provides an analysis of the pathophysiological links between vertebral fractures and spine arthropathy in active and controlled acromegaly, as well as the diagnostic and therapeutic aspects of managing acromegalic osteo-arthropathy.