Article
Biochemistry & Molecular Biology
Ishfaq Ahmad Sheikh, Mohd Amin Beg, Taha Abo-Almagd Abdel-Meguid Hamoda, Hammam Mahmoud Siraj Mandourah, Erdogan Memili
Summary: Polybrominated diphenyl ethers (PBDEs) are widely used fire-retardant chemicals in consumer products and have the potential to bioaccumulate in the environment, including wildlife and humans, leading to adverse health effects such as neurodevelopmental deficits and reproductive dysfunction. In this study, the structural interactions of four PBDEs with the thyroid hormone receptor (TR alpha) were investigated. The results showed that all four PBDEs bound tightly to TR alpha and disrupted the thyroid signaling, which could have implications in reproductive function and infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Xiaomei Huang, Muwei Huang, Yanqiu Zuo, Zhongsheng Yi, Hongyan Liu
Summary: Hydroxy polybrominated diphenyl ethers (OHPBDEs) interact with thyroid proteins mainly through computational simulation and molecular dynamics, leading to changes in the protein's structure and stability. The observed stronger binding ability of OHPBDEs with thyroxine-binding globulin (TBG) than with transthyretin (TTR) demonstrates the potential impact on endocrine function.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Public, Environmental & Occupational Health
Ming-Jun Hu, Jin-Liang Zhu, Qian Zhang, Jia-Liu He, Wan-Jun Yang, Zhen-Yu Zhu, Jia-Hu Hao, Fen Huang
Summary: Exposure to PBDEs and metals among rural adult residents along the Yangtze River in China may influence thyroid function, with some PBDE congeners and metals showing associations with thyroid hormones. However, there was no statistically significant association observed between PBDEs, metals, and thyroid-stimulating hormone. Bayesian Kernel Machine Regression analysis suggested similar trends in the relationship between PBDEs, metals mixtures, and thyroid hormones. Additional studies are needed to confirm these findings and identify potential mechanisms.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Surgery
Timothy M. Ullmann, Heng Liang, Hector Mora, Jacques Greenberg, Katherine D. Gray, Jessica Limberg, Dessislava Stefanova, Xin Zhu, Brendan Finnerty, Toni Beninato, Rasa Zarnegar, Irene Min, Thomas J. Fahey
Summary: The study investigated the effects of polybrominated diphenyl ethers (PBDEs) and tris(2-chloroethyl) phosphate (TCEP) on thyrocytes. PBDEs demonstrated genotoxicity but not cytotoxicity in follicular thyrocytes in vitro. These findings suggest that PBDEs may have carcinogenic potential in human thyroid cells.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Environmental Sciences
Fangwei Yang, Yiwen Cui, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie
Summary: Environmental and dietary pesticide exposures can disrupt thyroid hormone (THs) balance, with some diphenyl ether pesticides and their metabolites showing potential to interfere with THs synthesis, transport, binding, and metabolism related proteins. Specifically, fluoroglycofen (FOG) was found to have strong interactions with thyroid hormone receptor beta (TRβ), suggesting its potential to disturb THs nuclear receptor signaling. Benzene rings and hydrophobic groups might be important functional groups for disrupting TRβ.
Article
Environmental Sciences
Chi-fong Ko, Yi-Chen Yang, Jennifer Ia Wen Wen Liu, Yang-hsin Shih
Summary: This study focused on the thermal treatment of PBDE-contaminated soil, with the optimal conditions determined to be heating at 450 degrees Celsius for 30 minutes with a heating rate of 10 degrees Celsius per minute. Through this method, BDE-209 was successfully removed from the soil to below detection limits, indicating the feasibility of remediating PBDE-contaminated soil through thermal treatment.
Article
Multidisciplinary Sciences
Louise Ramhoj, Karen Mandrup, Ulla Hass, Terje Svingen, Marta Axelstad
Summary: Developmental exposure to DE-71 affects reproductive toxicity, potentially through anti-androgenic, anti-estrogenic, and perhaps estrogenic mechanisms, causing endocrine disrupting effects and raising concerns for potential long-term consequences on human reproductive health.
Article
Environmental Sciences
Bingwei Yang, Yuting Wang, Changyu Fang, Erqun Song, Yang Song
Summary: Exposure to PBDEs metabolite PBDEQ induces ROS and mitochondrial dysfunction, promoting NLRP3 inflammasome activation through the TLRs-NF-kappa B signaling pathway. Additionally, bromine metabolism and K+ efflux are involved in the activation of this inflammatory response.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Limei Chen, Qitao Yin, Lu Xu, Minyu Hua, Zhen Zhang, Yuqian Xu, Wei Xia, Huizhong Qian, Jun Hong, Jun Jin
Summary: This study aims to analyze the concentrations of polybrominated diphenyl ethers (PBDEs) in a population of blood donors over a 4-year period and evaluate their temporal trends. The median concentrations of PBDEs showed a downward trend from 2013 to 2014 and then increased after 2014. There were no correlations between age and PBDE congener concentrations, while concentrations were generally lower in females than in males.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Qi Xu, Jian Li, Shang Cao, Guangcai Ma, Xianglong Zhao, Qiuyi Wang, Xiaoxuan Wei, Haiying Yu, Zhiguo Wang
Summary: In this study, 18 OH-PBDEs with neutral and anionic forms were selected to estimate their binding interactions with the ligand binding domain (LBD) of thyroid hormone receptor O (TRO) through molecular dynamics simulations. The results indicate that most OH-PBDEs have stronger binding affinities to TRO-LBD compared to their anionic counterparts, and the hydroxyl dissociation of ligands plays a major role in their binding. Additionally, 5 hydrophobic residues (Met313, Leu330, Ile276, Leu346, and Phe272) are identified to have important contributions to binding OH-PBDEs. These findings provide a solid theoretical basis for accurately assessing the thyroid hormone disrupting effects of these chemicals.
Article
Engineering, Environmental
Florence Portet-Koltalo, Nicolas Guibert, C. Morin, Florence De Mengin-Fondragon, Adele Frouard
Summary: The study utilized a unique method to assess the PBDE content in professional seating furnishing wastes and found that the total PBDE content did not exceed the tolerated threshold. Higher amounts of BDE-209 were identified in hard plastics, but in quantities less than 312 mg kg-1.
Article
Engineering, Environmental
Shaoyu Tang, Hua Yin, Xiaolong Yu, Shuona Chen, Guining Lu, Zhi Dang
Summary: Pseudomonas aeruginosa YH showed efficient degradation of BDE-47 and its intermediates, with transcriptome sequencing revealing significant gene regulation in response to BDE-47 exposure. Inhibition of multidrug efflux pump enhanced bacterial tolerance and degradation of BDE-47, while also accelerating its adsorption.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Jennifer Ia Wen Wen Liu, Yu-Jie Lin, Chi-Fong Ko, Jiann-yuan Ding, Yang-hsin Shih
Summary: A farm in Taoyuan, Taiwan has been contaminated with decabrominated diphenyl ether (BDE-209) for over 10 years, posing a hazardous risk to humans. The study investigates thermal treatment as a method to remove BDE-209 from soil. While heating to 450 degrees C for 30 minutes effectively removes BDE-209, it also reduces soil organic matter, damages microbial biomass, and affects revegetation. By using sugarcane bagasse as an amendment, soil fertility can be restored and bacterial composition improved, making it a promising method for sustainable remediation.
Article
Environmental Sciences
Qian Zhang, Mingjun Hu, Huabing Wu, Qingshan Niu, Xuelei Lu, Jialiu He, Fen Huang
Summary: The study found that exposure to PBDEs, As, and Hg may be associated with the development of thyroid cancer, with high levels of exposure to As and Hg being linked to an increased risk of thyroid cancer. There is a positive interaction effect between some PBDE congeners and Hg, while a negative interaction effect was observed between BDE-209 and Pb. Further prospective research with large samples is needed to confirm these findings.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Chenggang Gu, Zhihua Jin, Xiuli Fan, Qingqing Ti, Xinglun Yang, Cheng Sun, Xin Jiang
Summary: Polybrominated diphenyl ethers (PBDEs), widely distributed and harmful to human health and wildlife, require sustainable rehabilitation strategies. Although efficient bacteria have been isolated, understanding the external influences and mechanisms on biodegradation is lacking.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)