Article
Fisheries
Yiyang Tang, Mengzhe Feng, Xianyu Zhu, Jinjing Long, Zejun Zhou, Shaojun Liu
Summary: Glucagon-like peptide 2 (GLP2) plays a role in regulating energy absorption and maintaining intestinal mucosal integrity in fish. This study investigated the function of GLP2 in the intestinal barrier and immune defense of a hybrid crucian carp. The results suggest that WR-GLP2 is involved in the intestinal mucosal barrier and immune defense against pathogen infection, through inducing the expression of antimicrobial molecules and alleviating intestinal apoptosis.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Yaqi Chang, Qiuhong Deng, Zhenyu Zhang, Hua Zhao, Jiayong Tang, Xiaoling Chen, Guangmang Liu, Gang Tian, Jingyi Cai, Gang Jia
Summary: GLP-2 alleviated LPS-induced intestinal barrier injury and inflammation in weaned piglets and IPEC-J2 cells through regulation of tight junction proteins and inflammatory cytokines, modulating the MLCK/pMLC signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Microbiology
Yuan Zeng, Yifan Wu, Qian Zhang, Xinhua Xiao
Summary: The gut microbiota and GLP-1 interact with each other, as gut microbiota metabolites stimulate GLP-1 secretion and affect its function and rhythm. The mechanism of action of GLP-1 on gut microbiota involves inflammatory response. Various interventions can affect the interaction between gut microbiota and GLP-1, which is of great significance for the treatment of metabolic diseases.
Article
Chemistry, Applied
Yajuan Bai, Yue Zhou, Xiang Li, Ruifen Zhang, Fei Huang, Bei Fan, Litao Tong, Fengzhong Wang, Mingwei Zhang
Summary: Longan pulp polysaccharide, known as LPIIa, is a bioactive compound that acts as a prebiotic and protects the intestinal barrier. This study found that LPIIa's molecular weight remained stable after gastrointestinal digestion and that 56.02% of it was consumed by gut microbiota during fecal fermentation. The intake of LPIIa increased the production of short-chain fatty acids and expression of G-protein-coupled receptor 41 in the colon, as well as improved the richness of beneficial bacteria in the colon content. Fecal fermented LPIIa showed better protection of the intestinal epithelial barrier compared to LPIIa alone.
Article
Endocrinology & Metabolism
Ying Wang, Haiyi Liu, Miaoyan Zheng, Yanhui Yang, Huizhu Ren, Yan Kong, Shanshan Wang, Jingyu Wang, Yingying Jiang, Juhong Yang, Chunyan Shan
Summary: Berberine may be beneficial in slowing down the progression from prediabetes to type 2 diabetes mellitus in ZDF rats by improving GLP-2 secretion, intestinal permeability, and gut microbiota structure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Microbiology
Jun Hu, Jianwei Chen, Xiaojian Xu, Qiliang Hou, Jing Ren, Xianghua Yan
Summary: This study compared the gut microbiome of seven different pig breeds and found significant differences between Congjiang miniature (CM) pigs and commercial Duroc x [Landrace x Yorkshire] (DLY) pigs. CM pigs had a stronger intestinal epithelial barrier function than DLY pigs. Fecal microbiota transplantation from CM and DLY pigs to germ-free (GF) mice confirmed the transfer of intestinal epithelial barrier characteristics, and identified Bacteroides fragilis and its metabolite 3-phenylpropionic acid as important contributors to the enhancement of the intestinal epithelial barrier.
Article
Biochemistry & Molecular Biology
Majid M. Syed-Abdul, Priska Stahel, Lili Tian, Changting Xiao, Avital Nahmias, Gary F. Lewis
Summary: In this study, the researchers investigated the site of action of glucagon-like peptide-2 (GLP-2) in mobilizing intestinal lipids. The results showed that GLP-2 acts via its receptor at a site distal to the Golgi, likely mobilizing extracellular intestinal lipids.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Endocrinology & Metabolism
Bruno Verges
Summary: Postprandial hyperlipidaemia, characterized by increased chylomicron production and delayed catabolism, is an important factor in the development of cardiovascular disease in individuals with type 2 diabetes. Insulin resistance and reduced GLP-1 secretion contribute to the pathophysiology of postprandial hyperlipidaemia. Multiple factors, including increased expression of microsomal triglyceride transfer protein and enhanced stability of apolipoprotein B-48, are involved in the overproduction of chylomicrons. These metabolic abnormalities can be influenced by glucose-lowering treatments, such as metformin, pioglitazone, alpha-glucosidase inhibitors, dipeptidyl peptidase 4 inhibitors, and GLP-1 agonists.
Article
Medicine, Research & Experimental
Joice de Fatima Laureano Martins, Thaiany Goulart de Souza-Silva, Hudsara Aparecida de Almeida Paula, Viviane da Cruz Rafael, Sirlene Souza Rodrigues Sartori, Celia Lucia de Luces Fortes Ferreira
Summary: This study evaluated the potential effects of yacon-based product on glycemic profile and intestinal health in postmenopausal rats. The results showed that the product did not cause liver damage and gastrointestinal disorders, and it had beneficial effects on the morphology and function of the intestinal mucous of rats. It also had the potential to indirectly modulate glycemic and insulinemic profiles, weight gain, and body fat percentage.
Article
Pharmacology & Pharmacy
Anubhav Pratap-Singh, Yigong Guo, Alberto Baldelli, Anika Singh
Summary: Injectable peptides like insulin and GLP-1 are commonly used for diabetes treatment, but injection administration has disadvantages. Buccal and sublingual routes are valid alternatives due to their accessibility, but there are challenges in peptide selection, drug encapsulation, and delivery system design. Using hydrophobic polymers and neutral or positively charged nanoparticles can improve drug efficiency and efficacy in buccal delivery. Unidirectional films and tablets show higher bioavailability compared to sprays, mitigating the impact of saliva and enzymatic digestion.
Article
Microbiology
Yu Li, Wenjing Li, Zhiwei Zeng, Yu Han, Qinxi Chen, Xinyi Dong, Zepeng Wang, Saixiang Feng, Weisheng Cao
Summary: The therapeutic effect of MccY on S. Typhimurium-infected mice was studied and it was found that MccY significantly reduced mouse mortality, alleviated weight loss and diarrhea, and protected the integrity of the intestinal structure.
MICROBIOLOGY SPECTRUM
(2023)
Review
Microbiology
Nyan Abdalqadir, Khosrow Adeli
Summary: The intestine plays a crucial role in maintaining metabolic homeostasis, energy expenditure, and overall human health by sensing and responding to various signals, harboring a large population of microbes, and secreting a wide variety of hormones and molecules to regulate nutrition and physiology.
Article
Oncology
Noriko Tagawa, Honoka Ogura, Hikaru Miyawaki, Akihiro Asakawa, Ikuo Kato
Summary: This study found that peripheral administration of nesfatin-1 increased blood concentrations of GLP-1 and insulin, and decreased blood glucose concentrations in food-deprived mice. Furthermore, the study demonstrated that nesfatin-1 increased insulin concentrations by accelerating GLP-1 secretion. These findings suggest the potential therapeutic value of nesfatin-1 for GLP-1 release.
MOLECULAR MEDICINE REPORTS
(2023)
Review
Clinical Neurology
Hussein N. Yassine, Victoria Solomon, Angad Thakral, Nasim Sheikh-Bahaei, Helena C. Chui, Meredith N. Braskie, Lon. S. Schneider, Konrad Talbot
Summary: Medications for type 2 diabetes show potential for interventions in dementia syndromes by addressing the common energy failure in neurons. GLP-1 receptor agonists have protective effects on vascular, microglial, and neuronal functions, making them promising for dementia treatments. The development of these medications as dementia therapies requires a deeper understanding of regional changes in brain energy metabolism guided by novel imaging biomarkers.
ALZHEIMERS & DEMENTIA
(2022)
Article
Endocrinology & Metabolism
Khyati Girdhar, Marion Soto, Qian Huang, Lucie Orliaguet, Carly Cederquist, Bharathi Sundaresh, Jiang Hu, Maximilian Figura, Amol Raisingani, Emanuel E. Canfora, Ercument Dirice, Shiho Fujisaka, Gijs H. Goossens, Ellen E. Blaak, Rohit N. Kulkarni, C. Ronald Kahn, Emrah Altindis
Summary: Growing evidence suggests a significant link between gut microbiota, obesity, and metabolic syndrome. The study found that obesity led to changes in pancreatic function, such as increased pancreas weight and altered levels of certain peptides. The alterations in host proteins, particularly pancreatic enzymes, could be reversed by antibiotic treatment. These findings demonstrate that changes in gut microbiota may contribute to the development of obesity and diabetes.
Article
Cell Biology
Zayna Chaker, Saba Aid, Hugues Berry, Martin Holzenberger
Meeting Abstract
Geriatrics & Gerontology
Zayna Chaker, Hugues Berry, Martin Holzenberger
EXPERIMENTAL GERONTOLOGY
(2015)
Article
Oncology
Jingjing Xie, Xiaoli Chen, Junke Zheng, Chunling Li, Satomi Stacy, Martin Holzenberger, Xuemei Hu, Cheng Cheng Zhang
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2015)
Article
Clinical Neurology
Cira Dansokho, Dylla Ait Ahmed, Saba Aid, Cecile Toly-Ndour, Thomas Chaigneau, Vanessa Calle, Nicolas Cagnard, Martin Holzenberger, Eliane Piaggio, Pierre Aucouturier, Guillaume Dorothee
Article
Endocrinology & Metabolism
C. Daniel De Magalhaes Filho, Laurent Kappeler, Joelle Dupont, Julien Solinc, Sonia Villapol, Cecile Denis, Marika Nosten-Bertrand, Jean-Marie Billard, Annick Blaise, Francois Tronche, Bruno Giros, Christiane Charriaut-Marlangue, Saba Aid, Yves Le Bouc, Martin Holzenberger
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Geriatrics & Gerontology
Zayna Chaker, Caroline George, Marija Petrovska, Jean-Baptiste Caron, Philippe Lacube, Isabelle Caille, Martin Holzenberger
NEUROBIOLOGY OF AGING
(2016)
Article
Endocrinology & Metabolism
Jean-Christophe Francois, Saba Aid, Zayna Chaker, Philippe Lacube, Jie Xu, Racha Fayad, Francine Cote, Patrick Even, Martin Holzenberger
Article
Dermatology
Mathieu Castela, Fabien Linay, Edwige Roy, Philippe Moguelet, Jie Xu, Martin Holzenberger, Kiarash Khosrotehrani, Selim Aractingi
EXPERIMENTAL DERMATOLOGY
(2017)
Meeting Abstract
Developmental Biology
Mona Christensen, Nicolas Di-Poi, Robert Asher, Martin Holzenberger, Jukka Jernvall
MECHANISMS OF DEVELOPMENT
(2017)
Article
Multidisciplinary Sciences
Rigo Cintron-Colon, Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Ruben Gonzalez-Rivera, Tiffany Lien, Tamas Bartfai, Saba Aid, Jean-Christophe Francois, Martin Holzenberger, Bruno Conti
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Oncology
Sangmi Ock, Jihyun Ahn, Seok Hong Lee, Hyun Min Kim, Hyun Kang, Young-Kook Kim, Hyun Kook, Woo Jin Park, Shin Kim, Shioko Kimura, Chan Kwon Jung, Minho Shong, Martin Holzenberger, E. Dale Abel, Tae Jin Lee, Bo Youn Cho, Ho-Shik Kim, Jaetaek Kim
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Cell Biology
Matilda Rehn, Anne Wenzel, Anne-Katrine Frank, Mikkel Bruhn Schuster, Sachin Pundhir, Nanna Jorgensen, Kristoffer Vitting-Seerup, Ying Ge, Johan Jendholm, Magali Michaut, Erwin M. Schoof, Tanja Lyholm Jensen, Nicolas Rapin, Russell T. Sapio, Kasper Langebjerg Andersen, Anders H. Lund, Michele Solimena, Martin Holzenberger, Dimitri G. Pestov, Bo Torben Porse
Summary: Ribosomopathies are a range of disorders that affect protein synthesis and primarily impact hematopoietic stem cells and erythroid development. This study demonstrates that the deletion of poly-pyrimidine-tract-binding protein 1 (PTBP1) in the hematopoietic compartment leads to a condition resembling ribosomopathy. The loss of PTBP1 results in reduced HSC self-renewal, erythroid differentiation, and protein synthesis, along with defects in splicing and ribosome biogenesis.
Article
Multidisciplinary Sciences
Maxim Katsenelson, Ilana Shapira, Eman Abbas, Kristina Jevdokimenko, Boaz Styr, Antonella Ruggiero, Saba Aid, Eugenio F. Fornasiero, Martin Holzenberger, Silvio O. Rizzoli, Inna Slutsky
Summary: This study reveals that insulin-like growth factor-1 receptor (IGF-1R) is a key regulator of firing rate homeostasis in central neural circuits. At the cellular level, IGF-1R interacts with the mitochondrial calcium uniporter complex (MCUc) and modulates the reliability of burst transfer, thereby affecting firing rate homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Sarah Malvaut, Simona Gribaudo, Delphine Hardy, Linda Suzanne David, Laura Daroles, Simon Labrecque, Marie-Anne Lebel-Cormier, Zayna Chaker, Daniel Cote, Paul De Koninck, Martin Holzenberger, Alain Trembleau, Isabelle Caille, Armen Saghatelyan
Article
Clinical Neurology
Caroline George, Geraldine Gontier, Philippe Lacube, Jean-Christophe Francois, Martin Holzenberger, Saba Aid