Article
Neurosciences
Morgane M. Moss, Peter Zatka-Haas, Kenneth D. Harris, Matteo Carandini, Armin Lak
Summary: Research suggests that dopamine in the striatum plays a critical role in visual decision-making, encoding visual stimuli and rewarded actions in a lateralized fashion. Contrary to previous beliefs, dopamine signals in the DMS respond to contralateral stimuli and rewarded actions, facilitating associations between specific visual stimuli and actions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Subramaniam Jayanthi, Bruce Ladenheim, Patricia Sullivan, Michael T. McCoy, Irina N. Krasnova, David S. Goldstein, Jean Lud Cadet
Summary: Perturbations in striatal dopamine homeostasis may contribute to METH use disorder. Rats exposed to footshocks after long-term METH intake showed decreased intake when given a DA D1 receptor antagonist. Compulsive METH takers exhibited abnormal DA metabolism and decreased protein levels. These findings are consistent with studies on human METH users.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Wouter van Elzelingen, Jessica Goedhoop, Pascal Warnaar, Damiaan Denys, Tara Arbab, Ingo Willuhn
Summary: Dopamine signals in the striatum play a critical role in motivated behavior. The release and modulation of dopamine in different regions of the striatum vary, while prediction-error signals are limited to specific regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Stephanie Kullmann, Dominik Blum, Benjamin Assad Jaghutriz, Christoph Gassenmaier, Benjamin Bender, Hans-Ulrich Haering, Gerald Reischl, Hubert Preissl, Christian la Fougere, Andreas Fritsche, Matthias Reimold, Martin Heni
Summary: This study demonstrates that central administration of insulin can impact dopaminergic activity in the striatum, which in turn affects regional brain activity and connectivity. The interaction between insulin and dopamine and the regulation of whole-body metabolism through a complex network are further elucidated by our findings.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Siamak K. Sorooshyari, Nicholas Ouassil, Sarah J. Yang, Markita P. Landry
Summary: The emergence of new imaging tools has revolutionized our understanding of neurochemistry in brain development and cognition. In this study, near-infrared catecholamine nanosensors were used to image dopamine modulation in brain tissue slices. Machine learning techniques were applied to identify unique features of dopamine modulation related to stimulation strength and specific neuroanatomical regions. The results showed that machine learning could accurately distinguish dopamine release in different regions of the brain, which was not achievable with conventional statistical analysis. The study highlights the potential of machine learning as a powerful tool in differentiating neuroanatomical regions and detecting features not detectable by conventional statistical analysis.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Behavioral Sciences
John G. Howland, Rutsuko Ito, Christopher C. Lapish, Franz R. Villaruel
Summary: Emerging evidence suggests that the rodent medial prefrontal cortex (mPFC) plays a crucial role in adapting behavior to changing information. The mPFC subregions, such as the dorsal and ventral mPFC, have specific functions in regulating action control and translating affective signals. However, these subregions also interact and influence each other in the modulation of adaptive behavior.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Pei-Pei Liu, Chih-Chang Chao, Ruey-Ming Liao
Summary: SKF83959 disrupts operant behaviors in rats in a dose-dependent manner by reducing response numbers, showing distinct behavioral profiles in different tasks. Changes in CaMKII-CREB signaling in various regions of the brain are associated with the altered behavior induced by the drug.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Min Liu, Shouhong Mu, Weikai Han, Xu Tan, E. Liu, Zhaofang Hang, Shaowei Zhu, Qingwei Yue, Jinhao Sun
Summary: The study demonstrated that methamphetamine (MA) increases c-Fos expression and synaptic plasticity in the orbitofrontal cortex (OFC) and dorsal striatum (DS). MA activates projection neurons from the OFC to the DS and affects conditioned place preference (CPP) scores. The study also showed that DA release in the OFC is increased in the MA group, and D1R neurons in the OFC-DS pathway play a role in MA addiction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Margaret K. Tanner, Jazmyne K. P. Davis, Jennifer Jaime, Nicolette A. Moya, Alyssa A. Hohorst, Kelsey Bonar, Kelsey A. Abrams, Nashra Jamil, Rebecca Han, Troy J. Hubert, Nadja Brown, Esteban C. Loetz, Benjamin N. Greenwood
Summary: Exercise participation is low despite its clear benefits. This study investigates the neural substrates involved in the acquisition and maintenance of voluntary wheel running (VWR) in rats. The results show that the dorsomedial and dorsolateral striatum play critical roles in VWR in males, with the dorsomedial striatum being important for acquisition and the dorsolateral striatum supporting maintenance. However, in females, both striatal subregions are involved in VWR during both phases. This study highlights the sex-specific neural mechanisms underlying VWR and provides potential targets for promoting exercise.
PSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arif A. Hamid, Michael J. Frank, Christopher Moore
Summary: Evidence suggests that dopamine plays a role in shaping learning by encoding reward prediction errors, with tailored dynamics for striatal targets based on regional specialization. Dopamine activity shows wave-like spatiotemporal patterns in the dorsal striatum, propagating between subregions based on task demands.
Article
Psychiatry
Stuti Chhabra, Leonardo Nardi, Petra Leukel, Clemens J. Sommer, Michael J. Schmeisser
Summary: Autism spectrum disorder (ASD) is characterized by impaired social interaction and repetitive behavior, and is believed to be caused by a combination of environmental and genetic factors. The dopaminergic system and its impact on motor and reward-motivated behaviors play a role in ASD, and alterations in dopaminergic metabolism and neurotransmission have been observed in ASD mouse models. This study examines the distribution of dopamine receptors in different brain regions in three well-established ASD mouse models and provides insights into the potential mechanisms underlying ASD traits. The findings may also contribute to the development of targeted treatments for ASD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Erika Lucente, Bo Soederpalm, Mia Ericson, Louise Adermark
Summary: This study aimed to investigate the acute and sustained effects of nicotine on the female rat brain, focusing on changes in dopamine neurotransmission and synaptic plasticity. The findings showed that nicotine can decrease excitatory neurotransmission, enhance synaptic long-term depression, and induce behavioral sensitization and increased neurophysiological responsiveness. These effects may contribute to the establishment of persistent nicotine taking habits.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Toneisha Stubbs, Andrew Koemeter-Cox, James I. Bingman, Fangli Zhao, Anuradha Kalyanasundaram, Leslie A. Rowland, Muthu Periasamy, Calvin S. Carter, Val C. Sheffield, Candice C. Askwith, Kirk Mykytyn
Summary: A rod-shaped appendage called a primary cilium projects from most central neurons in the mammalian brain. Cilia are important for neuronal signaling and their dysfunction is associated with various neuropathologies. This study demonstrates that disrupting the localization of a specific ciliary GPCR, called dopamine receptor 1 (D-1), in neurons leads to obesity and reduced locomotor activity in male and female mice. Loss of a BBS protein or cilia on D-1-expressing neurons also reduces D-1-mediated signaling. These findings highlight the importance of neuronal cilia for proper GPCR signaling and shed light on the role of cilia in regulating weight and locomotor activity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Klara Danielsson, Oona Lagstrom, Mia Ericson, Bo Soderpalm, Louise Adermark
Summary: The study suggests that repeated amphetamine exposure leads to selective effects on dopamine signaling in striatal subregions, explaining why tolerance develops towards the drug's rewarding effects but not its psychosis inducing properties.
Article
Neurosciences
Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Yoshinori N. Ohnishi, Yukie Kawahara, Yuta Miyamoto, Takaichi Fukuda, Akinori Nishi
Summary: The striatum, the main structure of the basal ganglia, is subdivided into seven subregions with distinct roles in motor and emotional functions. Dopamine D1 receptor signaling is region-specifically regulated in the striatum, with aberrant activation in the IC associated with L-DOPA-induced dyskinesia. Future research focusing on D1 receptor signaling in the IC may lead to novel therapeutics for LID.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
C. Dirk Keene, Angela M. Wilson, Mitchell D. Kilgore, Lauren T. Bruner, Nadia O. Postupna, Martin Darvas
LABORATORY INVESTIGATION
(2019)
Article
Cell Biology
Minh-Thanh T Nguyen, Shruti Vemaraju, Gowri Nayak, Yoshinobu Odaka, Ethan D. Buhr, Nuria Alonzo, Uyen Tran, Matthew Batie, Brian A. Upton, Martin Darvas, Zbynek Kozmik, Sujata Rao, Rashmi S. Hegde, P. Michael Iuvone, Russell N. Van Gelder, Richard A. Lang
NATURE CELL BIOLOGY
(2019)
Article
Neurosciences
Jonathan W. McKinley, Ziqing Shi, Ivana Kawikova, Matthew Hur, Ian J. Bamford, Suma Priya Sudarsana Devi, Annie Vahedipour, Martin Darvas, Nigel S. Bamford
Article
Neurosciences
Caitlin S. Latimer, Bridget T. Burke, Nicole F. Liachko, Heather N. Currey, Mitchell D. Kilgore, Laura E. Gibbons, Jonathan Henriksen, Martin Darvas, Kimiko Domoto-Reilly, Suman Jayadev, Tom J. Grabowski, Paul K. Crane, Eric B. Larson, Brian C. Kraemer, Thomas D. Bird, C. Dirk Keene
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2019)
Article
Chemistry, Analytical
Ming Huang, Martin Darvas, C. Dirk Keene, Yinsheng Wang
ANALYTICAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Emily E. Noble, Zhuo Wang, Clarissa M. Liu, Elizabeth A. Davis, Andrea N. Suarez, Lauren M. Stein, Linda Tsan, Sarah J. Terrill, Ted M. Hsu, A-Hyun Jung, Lauren M. Raycraft, Joel D. Hahn, Martin Darvas, Alyssa M. Cortella, Lindsey A. Schier, Alexander W. Johnson, Matthew R. Hayes, Daniel P. Holschneider, Scott E. Kanoski
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Sarah J. Benbow, Timothy J. Strovas, Martin Darvas, Aleen Saxton, Brian C. Kraemer
HUMAN MOLECULAR GENETICS
(2020)
Article
Multidisciplinary Sciences
Eun-Gyung Lee, Jessica Tulloch, Sunny Chen, Lesley Leong, Aleen D. Saxton, Brian Kraemer, Martin Darvas, C. Dirk Keene, Andrew Shutes-David, Kaitlin Todd, Steve Millard, Chang-En Yu
Editorial Material
Biochemistry & Molecular Biology
Yan Dou, Soroosh Fatemi, Martin Darvas, Michael Gale, Warren Ladiges
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2020)
Article
Neurosciences
Erik S. Carlson, Avery C. Hunker, Stefan G. Sandberg, Timothy M. Locke, Julianne M. Geller, Abigail G. Schindler, Steven A. Thomas, Martin Darvas, Paul E. M. Phillips, Larry S. Zweifel
Summary: The study reveals that cerebellar catecholamines play a role in cognitive behaviors, particularly in the lateral cerebellar nucleus (LCN). Norepinephrine is the major catecholamine in LCN, originating from locus coeruleus and a subset of Purkinje cells positive for TH staining. Deletion of TH in fibers innervating LCN results in impairments in sensorimotor integration, associative fear learning, response inhibition, and working memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Michael Wainberg, Tain Luquez, David M. Koelle, Ben Readhead, Christine Johnston, Martin Darvas, Cory C. Funk
Summary: Recent studies have reignited interest in the hypothesis that infectious agents, particularly herpesviruses, may contribute to Alzheimer's disease pathogenesis. These studies suggest that many key features of Alzheimer's disease, like amyloid beta production and neuroinflammation, may actually be protective responses to acute infection that become maladaptive in the case of chronic infection.
MOLECULAR PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Silvan R. Urfer, Martin Darvas, Kalman Czeibert, Sara Sandor, Daniel E. L. Promislow, Kate E. Creevy, Eniko Kubinyi, Matt Kaeberlein
Summary: The study found significant positive correlations between amyloid beta (Aβ42) levels in the companion dog brain and age, as well as with cognitive dysfunction scale scores. These results support the suitability of the companion dog as a model for Alzheimer's disease.
Article
Neurosciences
Yuhan Wang, Safa Bouabid, Martin Darvas, Fu-Ming Zhou
EXPERIMENTAL NEUROLOGY
(2020)
Article
Pathology
Silvan R. Urfer, Caitlin S. Latimer, Warren Ladiges, C. Dirk Keene, Sarah Benbow, Benjamin Harrison, Daniel E. L. Promislow, Matt Kaeberlein, Brian C. Kraemer, Adrienne Wang, Franco Guscetti, Martin Darvas
PATHOBIOLOGY OF AGING AND AGE-RELATED DISEASES
(2019)
Article
Pathology
Kavita Sharma, Martin Darvas, C. Dirk Keene, Laura J. Niedernhofer, Warren Ladiges
PATHOBIOLOGY OF AGING AND AGE-RELATED DISEASES
(2018)