Article
Biochemistry & Molecular Biology
Yuri Kohara, Shuta Ikai, Akihide Yoshihara, Koji Murao, Yasunori Sugiyama
Summary: Glucotoxicity, impaired insulin secretion, suppression of insulin gene expression, and apoptosis in pancreatic beta-cells caused by chronic hyperglycemia are key factors in the development of type 2 diabetes. Rare sugar d-allulose has been found to have antihyperglycemic and antihyperlipidemic effects. However, it is unclear how rare sugars, including d-allulose, directly affect pancreatic beta-cell function. This study shows that chronic exposure to certain ketohexoses can lead to reduced insulin gene expression, but d-allulose, d-sorbose, l-fructose, and l-tagatose do not affect pancreatic beta-cell function.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang, Li-Hua Yao
Summary: This study found that cordycepin, an extract from Cordyceps militaris, has a significant protective effect on glucotoxicity and lipotoxicity-induced damage in pancreatic islet cells. It improves cell viability, energy metabolism, and insulin synthesis and secretion. The mechanism may involve reducing ROS levels, increasing ATP content, causing membrane depolarization, balancing Ca2+ concentration, and inhibiting cell apoptosis through downregulation of the JNK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Toxicology
Jae Eun Park, Ji Sook Han
Summary: This study found that scopoletin can protect INS-1 pancreatic beta cells from apoptosis and oxidative stress caused by high glucose. It does so by reducing ROS, TBARS, and NO levels, increasing antioxidant enzyme activities, and influencing the apoptosis pathway. These findings suggest that scopoletin has the potential to be used as a pharmaceutical material to protect pancreatic beta cells.
TOXICOLOGY IN VITRO
(2023)
Review
Biochemistry & Molecular Biology
Lucie Oberhauser, Pierre Maechler
Summary: This review discusses the role of lipotoxicity and glucotoxicity in the pathophysiology of obesity-related type 2 diabetes, specifically in the loss of beta-cell function. It highlights the effects of free fatty acid metabolism and receptor-mediated signaling related to glucose-stimulated insulin secretion on beta-cell function. Chronic exposure to high glucose and free fatty acids contributes to beta-cell dysfunction, while the glycerolipid/free fatty acid cycle is considered a protective pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Simeng Bao, Hongzhi Zheng, Chengjie Chen, Yuhang Zhang, Lina Bao, Bei Yang, Yongyong Hou, Yanyan Chen, Qiang Zhang, Jingbo Pi, Jingqi Fu
Summary: The deficiency of Nfe2l1 in pancreatic beta cells significantly reduced STZ-induced damage and dysfunction, improving glucose tolerance and insulin secretion. This protective effect is partly due to the metabolic switch induced by Nfe2l1 deficiency to enhance glycolysis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Safia Costes, Gyslaine Bertrand, Magalie A. Ravier
Summary: Type 2 diabetes is characterized by chronic hyperglycemia due to functional beta-cell decline and reduced insulin sensitivity. The decrease in beta-cell mass in T2D is partly attributed to beta-cell apoptosis triggered by diabetogenic situations. This review discusses the molecular mechanisms involved in pancreatic beta-cell apoptosis in such situations and potential protective pathways by glucagon-like peptide-1-based therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Danhong Lin, Jingwen Yu, Leweihua Lin, Qianying Ou, Huibiao Quan
Summary: This study demonstrates that MRPS6 regulates glucose-stimulated insulin secretion (GSIS) and apoptosis in beta-cells by modulating the mitochondrial unfolded protein response (UPRmt). The findings contribute to our understanding of the molecular and cellular mechanisms of impaired glucose tolerance (IGT), prediabetes, and diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hsin-Yuan Chen, Yi-Fen Chiang, Kai-Lee Wang, Tsui-Chin Huang, Mohamed Ali, Tzong-Ming Shieh, Hsin-Yi Chang, Yong-Han Hong, Shih-Min Hsia
Summary: This study demonstrated that RHSL induced autophagy and alleviated STZ-induced ROS-mediated apoptosis in RIN-m5F cells.
Article
Biochemistry & Molecular Biology
Atenea A. Perez-Serna, Reinaldo S. Dos Santos, Cristina Ripoll, Angel Nadal, Decio L. Eizirik, Laura Marroqui
Summary: Diabetes is a chronic disease that affects glucose metabolism, either by autoimmune-driven beta-cell loss or by the progressive loss of beta-cell function. BCL-XL, an anti-apoptotic protein, plays a dual role in beta-cells, participating in cellular processes and fostering survival against pro-apoptotic insults. Overexpression of BCL-XL can partially protect beta-cells from cytokine- and palmitate-induced apoptosis, and the protection is more significant in human beta-cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Tatsuto Nakane, Suzuka Matsumoto, Satoshi Iida, Ayae Ido, Kensaku Fukunaga, Koji Murao, Yasunori Sugiyama
Summary: The study found that CPG16 inhibits the expression of the insulin gene by phosphorylating JDP2, thus blocking the upregulation of insulin promoter activity by JDP2.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xin Tong, Roland Stein
Summary: The accumulation of lipid droplets (LDs) in human pancreatic islets, mainly observed after 11 years of age, is essential for adult human islet beta-cell activity by preserving free fatty acid (FFA) homeostasis. Manipulating the levels of perilipin 2 (PLIN2), a key LD scaffold protein, can influence insulin secretion and beta-cell function in human islet cells. These findings suggest that LDs play a crucial role in maintaining beta-cell activity in adult human islets.
Article
Plant Sciences
YanZhi Zhang, Yan Zhang, Gulihaixia Halemahebai, Linai Tian, Huaiyang Dong, Gulimila Aisker
Summary: The study showed that urolithin A can protect pancreatic beta-cells from glycolipid-toxicity-induced apoptosis by inducing autophagy activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mohamed S. Abdel-Bakky, Abdulmajeed Alqasoumi, Waleed M. Altowayan, Elham Amin, Mostafa A. Darwish
Summary: This study discovered the critical role of ADAM10 and CXCL16 in the development of T1D, and the protective effect of resveratrol (RES) in preventing the deleterious effects caused by STZ. ADAM10 and CXCL16 may serve as potential therapeutic targets for T1D.
Article
Endocrinology & Metabolism
Katherine Veras, Camila Ferraz Lucena, Julia Goedcke, Fabiana S. Evangelista, Angelo Carpinelli, Carla Roberta de Oliveira Carvalho
Summary: This study evaluated the effects of moderated aerobic treadmill exercise training on pancreatic islet cell viability and function in mice consuming a high-fat and sucrose diet. The results showed that exercise training can slow down and prevent adverse metabolic effects associated with consuming a westernized diet.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Giuseppina Biondi, Nicola Marrano, Lucia Dipaola, Anna Borrelli, Martina Rella, Rossella D'Oria, Valentina A. Genchi, Cristina Caccioppoli, Immacolata Porreca, Angelo Cignarelli, Sebastio Perrini, Piero Marchetti, Leonardo Vincenti, Luigi Laviola, Francesco Giorgino, Annalisa Natalicchio
Summary: In this study, the role of p66(Shc) redox adaptor protein in pancreatic beta-cell insulin resistance under lipotoxic conditions and excess body fat was evaluated. The findings suggest that p66(Shc) protein mediates impaired beta-cell function and insulin resistance induced by saturated fatty acids and excess body fat.
Article
Genetics & Heredity
Jatuporn Sujjitjoon, Suwattanee Kooptiwut, Nalinee Chongjaroen, Namoiy Semprasert, Wanthanee Hanchang, Kanjana Chanprasert, Watip Tangjittipokin, Pa-thai Yenchitsomanus, Nattachet Plengvidhya
JOURNAL OF HUMAN GENETICS
(2016)
Article
Medicine, Research & Experimental
Aree Khamchan, Tatdao Paseephol, Wanthanee Hanchang
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Endocrinology & Metabolism
Suwattanee Kooptiwut, Wanthanee Hanchang, Namoiy Semprasert, Mutita Junking, Thawornchai Limjindaporn, Pa-thai Yenchitsomanus
JOURNAL OF ENDOCRINOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Suwattanee Kooptiwut, Pitchnischa Mahawong, Wanthanee Hanchang, Namoiy Semprasert, Suchada Kaewin, Thawornchai Limjindaporn, Pa-thai Yenchitsomanus
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2014)
Article
Medicine, Research & Experimental
Wanthanee Hanchang, Aree Khamchan, Navinee Wongmanee, Chananchida Seedadee
Article
Biochemistry & Molecular Biology
Wanthanee Hanchang, Navinee Wongmanee, Sasiwat Yoopum, Worarat Rojanaverawong
Summary: This study examined the protective effects of hesperidin on spleen damage caused by diabetes and its underlying mechanisms. The results showed that hesperidin improved spleen weight and histopathological alterations, reduced oxidative stress and inflammation, and prevented splenic cell apoptosis in diabetic rats. These findings suggest that hesperidin may be effective in preventing diabetic complications in the spleen.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Worarat Rojanaverawong, Navinee Wongmanee, Wanthanee Hanchang
Summary: This study aimed to evaluate the role of sacha inchi oil (SI) in alleviating hepatic insulin resistance and improving glucose metabolism in a rat model of type 2 diabetes. The results showed that SI treatment attenuated hyperglycemia and insulin resistance, improved hepatic histopathological alterations, and enhanced antioxidant defense in the diabetic rats. SI also decreased pro-inflammatory cytokine levels in the liver and enhanced hepatic insulin sensitivity. These findings suggest that SI has a potential role in improving glucose metabolism and hepatic insulin sensitivity in type 2 diabetes.
PREVENTIVE NUTRITION AND FOOD SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Sureena Pohsa, Wanthanee Hanchang, Nattapong Singpoonga, Peerasak Chaiprasart, Pornnarin Taepavarapruk
BIOMED RESEARCH INTERNATIONAL
(2020)