Article
Physiology
Yaping Ma, Olubusayo Awe, Sally Radovick, Xiaofeng Yang, Sara Divall, Andrew Wolfe, Sheng Wu
Summary: The kisspeptin receptor plays an important role in the regulation of reproductive function. Deleting the kisspeptin receptor gene in pituitary gonadotropes led to lower follicle-stimulating hormone (FSH) levels in male mice without affecting testis function. Female mice with the deleted gene had normal reproductive function.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhenghui Liu, Mark Larsen, Zhenmin Lei, C. V. Rao, T. Rajendra Kumar
Summary: In the mouse testis, there are two distinct populations of Leydig cells that arise during development, fetal Leydig cells and adult Leydig cells. This study provides genetic evidence that fetal Leydig cells do not require LH-LHR signaling pathway, but a one-to-one LH ligand-LHR signaling pathway exists in vivo to regulate adult Leydig cell lineage and spermatogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lauren A. Logan, Erica A. Eugster
Summary: Girls with a pubertal LH-ICMA have higher baseline estradiol concentrations and more advanced breast development, while even girls with advanced development may have a prepubertal LH-ICMA. The LH-ICMA was pubertal in almost all boys with CPP in this study.
HORMONE RESEARCH IN PAEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Cezanne D. Kooij, Annelies M. C. Mavinkurve-Groothuis, Idske C. L. Kremer Hovinga, Leendert H. J. Looijenga, Tuula Rinne, Jacques C. Giltay, Laetitia M. O. de Kort, Aart J. Klijn, Ronald R. de Krijger, Annemarie A. Verrijn Stuart
Summary: This study reports the development of malignant testicular germ cell tumors in two young adult males with familial male-limited precocious puberty (FMPP) due to LHCGR pathogenic variants. The study also investigates the potential link between FMPP and testicular tumors. The results suggest that FMPP might increase the risk of developing testicular GCTs in early adulthood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Aylin Kilinc Ugurlu, Aysun Bideci, Ayse Murside Demirel, Gulnur Take Kaplanoglu, Duygu Dayanir, Ozlem Gulbahar, Tuba Saadet Deveci Bulut, Esra Doger, Mahmut Orhun Camurdan
Summary: This study aimed to investigate the effects of blue light exposure on puberty and testis tissue in male rats. The results showed that blue light exposure led to precocious puberty, suppressed spermatogenesis, and disrupted the integrity of the basement membrane in the testis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xin Yuan, Ruimin Chen, Ying Zhang, Xiaohong Yang, Xiangquan Lin
Summary: This study describes the clinical characteristics and long-term treatment with letrozole in a boy diagnosed with familial male-limited precocious puberty (FMPP). The boy's height approached his adult height after long-term treatment with letrozole, triptorelin, and spironolactone.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Leticia Manuel-Apolinar, Leticia Damasio-Santana, Eulalia Garrido-Magana, Aleida de Jesus Rivera-Hernandez
Summary: In girls with central precocious puberty (CPP) undergoing GnRH analogs treatment, leptin levels and higher leptin/adiponectin ratio (LAR) are associated with greater weight gain. This association is particularly evident in girls with BMI < 94th percentile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Bo Sun, Mingke Ni, Shanshan Tian, Wenting Guo, Shitian Cai, Mads T. Sondergaard, Yongxiang Chen, Yongxin Mu, John P. Estillore, Ruiwu Wang, Ju Chen, Michael T. Overgaard, Michael Fill, Josefina Ramos-Franco, Mette Nyegaard, Sui Rong Wayne Chen
Summary: ITPR1 is a critical intracellular calcium release channel that is involved in numerous cellular processes. While mutations in ITPR1 have been primarily associated with movement disorders, our study reveals the pathological consequences of ITPR1 gain of function (GOF) mutations, which enhance ITPR1 activity and increase the risk of testicular dysfunction.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
Shanhui Tao, Zhiang Yao, Huitao Li, Yiyan Wang, Xinyi Qiao, Yang Yu, Yang Li, Yangyang Ning, Ren-shan Ge, Shijun Li
Summary: This study demonstrates that exposure to 4-nonyl phenol compromises Leydig cell development through multiple mechanisms, including downregulation of key genes and proteins involved in Leydig cell steroidogenesis, induction of oxidative stress, and induction of apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Nutrition & Dietetics
Tingbei Bo, Jing Wen, Wenting Gao, Liqiu Tang, Min Liu, Dehua Wang
Summary: The study showed that HFD-induced precocious puberty increased risk-taking behavior and decreased memory in mice, with significant effects on TH and AVP in the hypothalamus. Although recovery on normal diet restored physiological indices, anxiety increased and memory was impaired in adult mice.
NUTRITION & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yunsoo Choe, Jong Ho Cha, Yun Jin Kim, Jinjoo Choi, Kyeongmi Lee, Nayoung Kim, Jae Yoon Na, Seung Yang
Summary: This study aimed to investigate the effect of rapid weight gain on the incidence of central precocious puberty (CPP) using nationwide population-based data. The study found that any rapid weight gain from birth to 3 years of age contributed to an increased risk of CPP in girls, but not in boys. Girls who experienced rapid weight gain during both infancy and toddlerhood had the highest risk of developing CPP.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Huihui Sun, Yi Qian, Naijun Wan, Lili Liu
Summary: During the COVID-19 pandemic, the differential diagnosis of idiopathic premature thelarche (IPT) and central precocious puberty (CPP) in girls aged 6 to 8 years was investigated. Predicted adult height (PAH) discrepancy was explored to guide appropriate diagnosis and treatment. Chinese girls with precocious puberty aged 6 to 8 years were recruited and divided into IPT and CPP groups. Clinical characteristics and differential diagnosis were analyzed, and risk factors for CPP were explored.
Article
Environmental Sciences
Fanli Sun, Xuying Wang, Pinzheng Zhang, Ziyun Chen, Zhiyi Guo, Xuan Shang
Summary: Exposure to silica nanoparticles (SiNPs) during puberty significantly damages the structure and function of the testis and epididymis by inducing oxidative stress, cell apoptosis, and an inflammatory response. These findings highlight the need for a more careful assessment of SiNPs before their application in juvenile supplies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hirofumi Ohga, Michiya Matsuyama
Summary: The study suggests that leptin may also directly facilitate GTH secretion in male chub mackerel.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
S. Palumbo, G. Cirillo, G. Sanchez, F. Aiello, A. Fachin, F. Baldo, M. C. Pellegrin, A. Cassio, M. Salerno, M. Maghnie, M. F. Faienza, M. Wasniewska, D. Fintini, C. Giacomozzi, S. Ciccone, E. Miraglia del Giudice, G. Tornese, A. Grandone
Summary: This study aimed to investigate the presence of Delta-like 1 homolog (DLK1) defects in a cohort of female and male patients with idiopathic central precocious puberty (CPP) who were negative for Makorin Ring Finger Protein 3 (MKRN3) defect. A novel heterozygous mutation in DLK1 was identified in a male proband, his sister, and their father, emphasizing the importance of genetic testing in males with CPP. The findings suggest the need for timely diagnosis and treatment for individuals with DLK1 defects, as illustrated by the short stature observed in the untreated father.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)