Review
Endocrinology & Metabolism
Ifigeneia Kassotaki, Georgios Valsamakis, George Mastorakos, Dimitris K. Grammatopoulos
Summary: Early life is a critical period with significant vulnerability to external influences that can impact development and health, especially fetal exposure to prenatal stress which can affect brain development and neurodevelopment of offspring. Increased stress hormones have been associated with alterations in fetal brain structure, while epigenetic changes may lead to long-term modifications of the stress regulatory system in offspring and increased susceptibility to psychosomatic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Wen Huang, Jin Zhou, Juanjuan Guo, Wen Hu, Guanghui Chen, Bin Li, Yajie Wen, Yimin Jiang, Kaili Fu, Huichang Bi, Yuanzhen Zhang, Hui Wang
Summary: Prenatal dexamethasone exposure can have lasting adverse effects on bile acid metabolism in offspring by affecting placental BA transporters and inducing imbalanced fetal-placental-maternal BA circulation, leading to increased levels of primary BAs in fetal serum.
Article
Biochemistry & Molecular Biology
Martin Steinbuechel, Johannes Menne, Rita Schroeter, Ute Neugebauer, Eberhard Schlatter, Giuliano Ciarimboli
Summary: Endogenous and exogenous positively charged organic substances are transported across cell membranes by organic cation transporters and multidrug and toxin extrusion proteins. High glucose concentrations can stimulate the activity and expression of organic cation transporters, potentially affecting the uptake of anti-diabetic drugs and renal tubular secretion of organic cations in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Freya Lyssy, Jacqueline Guettler, Beatrice A. Brugger, Christina Stern, Desir ee Forstner, Olivia Nonn, Cornelius Fischer, Florian Herse, Stefan Wernitznig, Birgit Hirschmugl, Christian Wadsack, Martin Gauster
Summary: This study investigates the localization and expression profile of S1PR1-S1PR3 in the human placenta. It reveals that S1PR2 is the predominant S1PR in the first trimester, while S1PR1 and S1PR3 increase towards term. S1PR1 is mainly found in endothelial cells, while S1PR2 and S1PR3 are predominantly located in villous trophoblasts. The study also shows that platelet-derived factors can down-regulate S1PR2 expression in trophoblasts.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Oncology
Elizabeth R. Hayden, Mingqing Chen, Kyle Z. Pasquariello, Alice A. Gibson, James J. Petti, Shichen Shen, Jun Qu, Su Sien Ong, Taosheng Chen, Yan Jin, Muhammad Erfan Uddin, Kevin M. Huang, Aviv Paz, Alex Sparreboom, Shuiying Hu, Jason A. Sprowl
Summary: OATP1B1 is a major drug uptake transporter in the liver, and its activity can be significantly inhibited by various TKIs. The inhibition of OATP1B1 by TKIs can lead to reduced phosphorylation levels, affecting its transport function and pharmacokinetics of substrates like rosuvastatin. Identified Src kinase LYN as a potential regulator of OATP1B1 activity, highly sensitive to inhibition by clinically relevant concentrations of TKIs.
CLINICAL CANCER RESEARCH
(2021)
Review
Obstetrics & Gynecology
Nikita P. Joshi, Aditi R. Mane, Akriti S. Sahay, Deepali P. Sundrani, Sadhana R. Joshi, Chittaranjan S. Yajnik
Summary: Maternal nutrient availability and transport through the placenta are essential for fetal development, particularly the transfer of glucose which is crucial for fetal growth and development. Glucose transport across the placenta is influenced by maternal glucose concentrations and mediated by glucose transporter family proteins. Alterations in these transporters can impact fetal growth and body composition, potentially leading to future metabolic risks for the baby.
REPRODUCTIVE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shotaro Michinaga, Ayaka Nagata, Ryosuke Ogami, Yasuhiro Ogawa, Shigeru Hishinuma
Summary: This study aimed to explore how H1 receptor-mediated ERK phosphorylation is regulated by Gq proteins and arrestins. The results showed that the Gq protein pathway mainly regulates early phosphorylation reaction, while the arrestin pathway mainly regulates late phosphorylation reaction.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kamelia Mirdamadi, Jacinda Kwok, Ori Nevo, Howard Berger, Micheline Piquette-Miller
Summary: Th-17 cytokines have an impact on the expression and activity of placental transporters, potentially affecting fetal exposure to endogenous and exogenous substances.
Article
Multidisciplinary Sciences
Yutao Liu, Bin Liu, Tingting Xu, Qian Wang, Wendi Li, Jialin Wu, Xiaoyu Zheng, Bin Liu, Ruiying Liu, Xingmei Liu, Xi Guo, Lu Feng, Lei Wang
Summary: The study identifies a fructose uptake system crucial for the growth of Vibrio cholerae in seawater, where fructose concentrations are low. This system may be important for the survival of pandemic V. cholerae in seawater.
NATURE COMMUNICATIONS
(2021)
Article
Developmental Biology
Kimberly O. O'Brien
Summary: The human placenta is a specialized organ responsible for housing and nourishing the fetus during pregnancy. Iron is an essential nutrient for successful pregnancy outcomes, but iron deficiency is common in pregnant women. Hormones produced by the mother, placenta, and fetus play important roles in iron homeostasis, but their functions vary in each compartment. Further research is needed to understand the partitioning of iron between these compartments.
Article
Biochemistry & Molecular Biology
Sanung Eom, Woog Jung, Jaeeun Lee, Hye Duck Yeom, Shinhui Lee, Chaelin Kim, Heui-Dong Park, Junho H. Lee
Summary: This study found that chanoclavine interacts with the 5-HT3A receptor to regulate IBS. Electrophysiological experiments demonstrated that chanoclavine can inhibit the activation of 5-HT3A receptor, potentially serving as a candidate for antiemetic drugs.
Article
Biochemistry & Molecular Biology
Hua-Long Zhu, Xue-Ting Shi, Xiao-Feng Xu, Guo-Xiang Zhou, Yong-Wei Xiong, Song-Jia Yi, Wei-Bo Liu, Li-Min Dai, Xue-Lin Cao, De-Xiang Xu, Hua Wang
Summary: Gestational exposure to environmental stress can lead to fetal growth restriction (FGR) with reduced levels of melatonin (MT) in the placenta. MT offers protective effects against FGR by inhibiting BNIP3-dependent mitophagy, potentially serving as a therapeutic agent against environmental stress-induced developmental toxicity.
Article
Biochemistry & Molecular Biology
Justin M. Watkins, Timothy J. Ross-Elliott, Xiaoyi Shan, Fei Lou, Bernd Dreyer, Meral Tunc-Ozdemir, Haiyan Jia, Jing Yang, Celio Cabral Oliveira, Luguang Wu, Yuri Trusov, Timothy D. Schwochert, Patrick Krysan, Alan M. Jones
Summary: In Arabidopsis thaliana, GPCRs are not necessary for G protein-coupled signaling, as the seven-transmembrane protein AtRGS1 modulates G protein signaling through ligand-dependent endocytosis, with the origin of endocytosis depending on ligand identity. Different trafficking origins and trajectories result in different cellular outcomes in this system.
Article
Multidisciplinary Sciences
Zhenxing Zhang, Xin Li, Fan Yang, Chao Chen, Ping Liu, Yi Ren, Pengkai Sun, Zixiong Wang, Yongping You, Yi-Xin Zeng, Xinjian Li
Summary: This study demonstrates that DHHC9-mediated GLUT1 palmitoylation at Cys207 is essential for plasma membrane localization of GLUT1 and for tumor growth in glioblastoma cells. The findings suggest a potential therapeutic target for targeting GLUT1 in cancer treatment.
NATURE COMMUNICATIONS
(2021)
Review
Plant Sciences
Simranjeet Singh, Vijay Kumar, Parul Parihar, Daljeet Singh Dhanjal, Rachana Singh, Praveen C. Ramamurthy, Ram Prasad, Joginder Singh
Summary: This article discusses the impact of stress caused by abiotic factors on plant growth and productivity, especially how drought conditions affect plants by disrupting water balance and ion homeostasis. Plants have evolved transportation systems to survive under drought stress, utilizing channels and transporters such as ABA, proteins, and carbohydrates.
PLANT CELL REPORTS
(2021)