Article
Agriculture, Dairy & Animal Science
Dorota Anna Zieba, Malgorzata Szczesna, Katarzyna Kirsz, Weronika Biernat
Summary: This study investigated the relationships between leptin, growth hormone (GH), and suppressors of cytokine signaling-3 (SOCS-3) in sheep. The findings suggest that photoperiod plays an important role in regulating adaptive physiological processes in response to changing seasons. Leptin has a stronger influence on SOCS-3 expression during short days, and there is a strong association between leptin, GH, and SOCS-3.
Article
Multidisciplinary Sciences
Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Wakako Kawarazaki, Shigeyoshi Oba, Takeshi Marumo, Atsu Aiba, Toshiro Fujita
Summary: Rac1 plays a critical role in the postnatal development of renal papilla. Deficiency of Rac1 impairs the development of renal papilla and may be related to osmotic stress.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Laszlo Kovacs, Thiago Bruder-Nascimento, Lindsey Greene, Simone Kennard, Eric J. Belin de Chantemele
Summary: Individuals living with HIV have an increased risk for atherosclerosis-related cardiovascular disease, with the mechanism of HIV-associated vascular pathogenesis not fully understood. This study found that HIV-regulatory protein Tat may mediate HIV-induced endothelial dysfunction through Nox1-dependent mechanisms. Treatments with Tat resulted in decreased body weight, fat mass, and leptin levels, along with increased expression of Nox1 and NoxA1, leading to impaired endothelial function. The findings suggest potential targets such as the Nox1 and leptin system to improve vascular function in HIV infection-related CVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Caroline Hunsche, Oskarina Hernandez, Virginia Mela, M. Paz Viveros, Monica De la Fuente
Summary: The study found that blocking the neonatal leptin surge affects immune functions in rats, including anti-tumor NK activity and lymphocyte proliferation capacity. In addition, the chemotactic agents that induce lymphocyte proliferation and concentrations of certain cytokines released under mitogen-stimulated conditions were also altered.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Endocrinology & Metabolism
H. Zardooz, F. Sadeghirnahalli, F. Khodagholi
Summary: The study suggests that early life stress combined with psychological stress in young adulthood may increase insulin, insulin resistance, beta-cell dysfunction, and TNF-alpha levels. This combination of stressors may make the organism more susceptible to metabolic defects when exposed to psychological stress later in life.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Nutrition & Dietetics
Edoardo Pisa, Alberto Martire, Valentina Chiodi, Alice Traversa, Viviana Caputo, Jonas Hauser, Simone Macri
Summary: Research has shown that early exposure to breast milk lacking 3′SL can lead to decreased attention, spatial and working memory, as well as altered long-term potentiation in the hippocampal region in adulthood.
Article
Endocrinology & Metabolism
Yu Zhou, Min Gong, Yingfei Lu, Jianquan Chen, Rong Ju
Summary: The study showed that prenatal testosterone exposure led to obesity and glucose intolerance in aged female offspring, accompanied by decreased fasting serum insulin concentration, elevated serum triglyceride and testosterone concentrations, as well as affected glucose-stimulated insulin secretion in pancreatic beta cells.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Suyeon Han, Hyunsu Choi, Hyerim Park, Jwa-Jin Kim, Eu-Jin Lee, Young-Rok Ham, Ki-Rayng Na, Kang-Wook Lee, Yoon-Kyung Chang, Dae-Eun Choi
Summary: This study found that omega-3 polyunsaturated fatty acids (PUFAs) can attenuate kidney injury caused by unilateral ureteral obstruction (UUO) and exert their effects by enhancing autophagy.
Article
Medical Laboratory Technology
Ali C. M. Johnson, Richard A. Zager
Summary: Cardiorenal syndrome I (CRS-1) is a state of acute kidney injury in acute heart failure (AHF), induced by isoproterenol (Iso) in mouse model showed iron-mediated cortical abnormalities with oxidative stress and pro-inflammatory reactions, despite no lasting renal injury. Iso affects both hemodynamics and tubular cell toxicity, potentially contributing to a systemic inflammatory state through renal cytokine production.
TRANSLATIONAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Neda Mortaji, John E. Krzeczkowski, Khrista Boylan, Linda Booij, Maude Perreault, Ryan J. Van Lieshout
Summary: Optimal maternal nutrition during pregnancy has a positive association with child working memory, planning, and adaptability, especially in families experiencing barriers to providing stimulation and support to children in their home.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Neurosciences
Li Zhang, Zhaohong Qin, Fariba Sharmin, Wei Lin, Konrad M. Ricke, Michael A. Zasloff, Alexandre F. R. Stewart, Hsiao-Huei Chen
Summary: Inhibition of PTP1B can prevent neuronal loss and cognitive decline in a mouse model of Alzheimer's disease caused by mutations in beta-amyloid protein. While previous studies have focused on post-synaptic mechanisms, targeting PTP1B affects pre-synaptic mechanisms and impairs NMDAR-mediated synaptic plasticity, leading to cognitive deficits. A PTP1B-selective inhibitor could potentially be repurposed to treat Alzheimer's disease, as shown in preclinical studies.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biology
Ying Zhu, Yu Mei, Nimmi Baby, Huey Yee Teo, Zuhairah Binte Hanafi, Siti Nazihah Mohd Salleh, Sreedharan Sajikumar, Haiyan Liu
Summary: Hepatocellular carcinoma alters the gut microbiota and impairs cognitive functions by affecting synaptic tagging and capture (STC), a cellular mechanism for associative memory formation. This impairment is rescued after microbiota sterilization and induced by transplantation of microbiota from tumor-bearing mice. Mechanistic study reveals that HCC growth increases IL-1β levels in the serum and hippocampus, and depletion of IL-1β restores STC in tumor-bearing mice. These findings demonstrate the crucial role of gut microbiota in mediating tumor-induced cognitive impairment through IL-1β upregulation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yu-Lin Shih, Chin-Chuan Shih, Sun-Yi-Fan Chen, Jau-Yuan Chen
Summary: This study examines the relationship between serum leptin and renal function. The results show that serum leptin levels have a negative correlation with eGFR levels, suggesting that high serum leptin levels could be a novel marker for kidney failure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Chiara Divella, Alessandra Stasi, Rossana Franzin, Michele Rossini, Paola Pontrelli, Fabio Sallustio, Giuseppe Stefano Netti, Elena Ranieri, Luca Lacitignola, Francesco Staffieri, Alberto Maria Crovace, Giuseppe Lucarelli, Pasquale Ditonno, Michele Battaglia, Mohamed R. Daha, Peter van der Pol, Cees van Kooten, Giuseppe Grandaliano, Loreto Gesualdo, Giovanni Stallone, Giuseppe Castellano
Summary: Pentraxin family member PTX3 plays a crucial role in I/R injury and may be a potential therapeutic target for preventing complement-induced renal I/R injury.
Article
Nutrition & Dietetics
Yuki Nouchi, Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Miyuki Ikeya, Itsuki Kageyama, Takuya Wakasugi, Atsushi Teshigawara, Yuji Hattori, Yoshiki Tsuboi, Hiroaki Ishikawa, Koji Suzuki, Koji Ohashi
Summary: This study aimed to elucidate the molecular mechanism by which maternal high-fructose corn syrup (HFCS) intake increases circulating GC levels in rat offspring. By giving female Sprague Dawley rats HFCS solution, it was found that HFCS led to a decrease in activity of GC-metabolizing enzyme 11 beta-Hsd2 and an increase in renal miR-27a expression. These findings suggest that the elevation of circulating GC levels in offspring induced by maternal HFCS consumption may be explained by a decrease in 11 beta-Hsd2 activity via renal miR-27a expression.
Article
Endocrinology & Metabolism
Franziska Schmid, Christina Mayer, Maike Buettner-Herold, Stephan von Hoersten, Kerstin Amann, Christoph Daniel
Summary: Extrarenal DPP4 plays a significant role in renal transplant rejection, particularly in the recruitment of NK cells and early fibrosis. While the lack of extrarenal DPP4 did not affect the numbers of other immune cells, its effects on kidney transplantation were less pronounced than reported for systemic DPP4 inhibition.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Pediatrics
Jenny Voggel, Jasmine Mohr, Kai-Dietrich Nuesken, Jorg Doetsch, Eva Nuesken, Miguel A. Alejandre Alcazar
Summary: This review addresses the impact of perinatal circumstances on kidney health, highlighting the vulnerability of the kidney during the perinatal period to acute kidney injury (AKI) and chronic kidney disease (CKD). It provides a comprehensive overview of various insults during the perinatal period and discusses future preventive, therapeutic, and regenerative directions.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Maximilian Hessenauer, Ravikumar Vaghela, Carolin Korner, Stephan von Horsten, Christoph Pobel, Daniel Gage, Claudia Muller, Sahar Salehi, Raymund E. Horch, Andreas Arkudas
Summary: The development of an intravital microscopy model allows for better observation of intravascular events in the AV loop, enabling evaluation of leukocyte-endothelial cell interactions, vascularization, and tissue formation. This provides a deeper understanding of cellular and molecular processes in tissue engineering within the AV loop, supporting the advancement of novel therapeutic applications.
TISSUE ENGINEERING PART C-METHODS
(2021)
Article
Multidisciplinary Sciences
Kim Le Cann, Alec Foerster, Corinna Roesseler, Andelain Erickson, Petra Hautvast, Sebastian Giesselmann, Daniel Pensold, Ingo Kurth, Markus Rothermel, Virginia B. Mattis, Geraldine Zimmer-Bensch, Stephan von Hoersten, Bernd Denecke, Tim Clarner, Jannis Meents, Angelika Lampert
Summary: Huntington's disease (HD) is a neurodegenerative disorder caused by a genetic mutation, affecting specific neuronal populations in the brain. Differentiating hiPS cells into striatal neurons to model HD faces challenges in replicating previous protocols due to heterogeneity in neuronal populations and variability in Nav channels. The study highlights difficulties in generating accurate hiPS cell-derived MSNs for studying HD in vitro.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Anne-Christine Plank, Stefan Frey, Lukas Andreas Basedow, Jalal Solati, Fabio Canneva, Stephan von Hoersten, Oliver Kratz, Gunther H. Moll, Yulia Golub
Summary: Prenatal trauma exposure results in anxiety phenotype in mouse pups, characterized by elevated corticosterone levels and increased anxiety-like behavior. Adult PT mice showed increased Crhr1 mRNA levels and decreased Fkbp5 mRNA levels in the left dHPC, along with decreased methylation of the Crhr1 promoter and increased methylation of the Fkbp5 promoter. Interestingly, these changes were not observed in the embryonic dHPC of PT mice.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Christoph S. Clemen, Andreas Schmidt, Lilli Winter, Fabio Canneva, Ilka Wittig, Lore Becker, Roland Coras, Carolin Berwanger, Andreas Hofmann, Britta Eggers, Katrin Marcus, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Marcus Kruger, Stephan von Horsten, Ludwig Eichinger, Rolf Schroder
Summary: The study investigated N471D Washc5 knock-in and knock-out mice as models for SPG8. Knock-in mice exhibited mild clinical and laboratory abnormalities, but not a typical SPG8 phenotype. Knock-out mice showing normal WASHC5 levels could not be bred to homozygosity, suggesting essential role of WASHC5 in development.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Engineering, Biomedical
Ravikumar Vaghela, Andreas Arkudas, Daniel Gage, Carolin Korner, Stephan von Hoersten, Sahar Salehi, Raymund E. Horch, Maximilian Hessenauer
Summary: The AV loop model is a key technique in tissue engineering that addresses the problem of vascular support. This study used a novel intravital microscopy approach to observe the process of vascularization in hydrogels. GelMA proved to be a better matrix compared to fibrin in terms of microvessel formation and network maturation. This study provides a new tool for understanding important events in tissue regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Review
Cell Biology
Stefanie Obst, Josephine Herz, Miguel A. Alejandre Alcazar, Stefanie Endesfelder, Marius A. Moebius, Mario Ruediger, Ursula Felderhoff-Muser, Ivo Bendix
Summary: This article summarizes the recent findings on the mechanisms of hyperoxia-induced neonatal lung and brain injury, and discusses the potential common pathophysiological pathways connecting these two organ systems. The article also emphasizes the promises and needs of currently suggested therapies, including pharmacological and regenerative cell-based treatments.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Behavioral Sciences
Alexandra Bluhm, Sarah Schrempel, Sandra Moceri, Jens Stieler, Malte Feja, Stephan Schilling, Anja Schulze, Stephan von Hoersten, Maike Hartlage-Ruebsamen, Franziska Richter, Steffen Rossner
Summary: This study identifies a novel post-translational modification, pGlu79-αSyn, which promotes oligomer formation and neurotoxicity in synucleinopathies. MMP-3 and QC are implicated in the generation of pGlu79-αSyn in brains affected by αSyn pathology.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Ravikumar Vaghela, Andreas Arkudas, Daniel Gage, Carolin Koerner, Stephan von Hoersten, Sahar Salehi, Raymund E. Horch, Maximilian Hessenauer
Summary: Due to limitations in current in vivo experimental designs, our understanding of vascular development and its implications for large-scale tissue engineering is limited. Thus, this study aimed to develop unique in vivo imaging chambers for live visualization of cellular processes in the arteriovenous (AV) loop model in rats. Two different types of chambers were developed and filled with modified gelatin hydrogel. Intravital microscopy (IVM) using fluorescein isothiocyanate (FITC)-labeled dextran and rhodamine 6G dye allowed visualization of leukocyte trafficking and examination of microvascular development in the AV loop for up to 21 days. The combination of these IVM chambers provides a comprehensive understanding of vascular development in the AV loop tissue engineering model.
Article
Neurosciences
Daria Chestnykh, Fabian Grassl, Canice Pfeifer, Jonas Duelk, Chiara Ebner, Mona Walters, Stephan von Hoersten, Johannes Kornhuber, Liubov S. S. Kalinichenko, Markus Heinrich, Christian P. Mueller
Summary: This study aimed to evaluate the impact of the newly developed DRD4 agonist APH199 on anxiety, anhedonia, alcohol reinforcement, and amphetamine-induced symptoms. The results showed that APH199 had minimal effects on behavior in mice, but caused significant psychotic-like responses in amphetamine-sensitized rats. These findings challenge the hypothesis of the therapeutic benefits of DRD4 agonists and highlight the need for further preclinical studies to ensure the safety of antipsychotics with DRD4 stimulating properties.
PSYCHOPHARMACOLOGY
(2023)
Review
Behavioral Sciences
Ivanna K. Timotius, Reinko F. Roelofs, Bar Richmond-Hacham, Lucas P. J. J. Noldus, Stephan Von Hoersten, Lior Bikovski
Summary: This study analyzed common gait parameters derived from 91 peer-reviewed experimental studies using CatWalk XT automated gait assessment tests in mice models of six disorders. The findings suggest that certain gait parameters serve as potential indicators of gait dysfunction across multiple disease models, while others are specific to particular models. This study is important for assisting users of CatWalk XT in similar or related research.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Pediatrics
Nina Ferrari, Nikola Schmidt, Inga Bae-Gartz, Christina Vohlen, Miguel A. Alejandre Alcazar, Konrad Brockmeier, Joerg Doetsch, Esther Mahabir, Christine Joisten
Summary: This pilot follow-up study investigated the long-term effects of a lifestyle intervention during pregnancy on children's motor performance and body composition up to 9 years of age. The study found that lifestyle intervention had an impact on children's cardiorespiratory endurance capacity and coordination, and maternal brain-derived neurotrophic factor (BDNF) levels were associated with running performance in children.
Article
Biochemistry & Molecular Biology
Judith Sommer, Hanna Ehnis, Tatjana Seitz, Julia Schneider, Andreas B. Wild, Sandra Moceri, Christa Buechler, Aline Bozec, Georg F. Weber, Susanne Merkel, Ruth Beckervordersandforth, Alexander Steinkasserer, Roland Schuele, Jonel Trebicka, Arndt Hartmann, Anja Bosserhoff, Stephan von Hoersten, Peter Dietrich, Claus Hellerbrand
Summary: This study finds that obesity leads to inflammation in visceral adipose tissue, with macrophages playing a significant role. FHL2 expression is enhanced in VAT of obese individuals, and it is involved in the interaction between macrophages and adipocytes, contributing to the development of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Dharmesh Hirani, Cristina M. Alvira, Soula Danopoulos, Carlos Milla, Michele Donato, Lu Tian, Jasmine Mohr, Katharina Dinger, Christina Vohlen, Jaco Selle, Silke Koningsbruggen-Rietschel, Verena Barbarino, Christian Pallasch, Stefan Rose-John, Margarete Odenthal, Gloria S. Pryhuber, Siavash Mansouri, Rajkumar Savai, Werner Seeger, Purvesh Khatri, Denise Al Alam, Joerg Doetsch, Miguel A. Alejandre Alcazar
Summary: This study identified a mechanism in which IL-6 activates macrophages, impairs ATII homeostasis, and disrupts elastic fiber formation, leading to inhibition of lung growth under hyperoxia conditions. Inhibiting IL-6 trans-signaling could promote lung growth.
EUROPEAN RESPIRATORY JOURNAL
(2022)