Review
Reproductive Biology
Daniela Pereira Carvalho, Ariane Fontes Dias, Amanda Nancy Sferruzzi-Perri, Tania Maria Ortiga-Carvalho
Summary: Thyroid hormone transport, action, and metabolism in the placenta play important roles in controlling fetal growth both developmentally and in response to suboptimal maternal environments.
BIOLOGY OF REPRODUCTION
(2022)
Article
Medicine, Research & Experimental
Alaa Alkhalefah, Warwick B. Dunn, James W. Allwood, Kate L. Parry, Franchesca D. Houghton, Nick Ashton, Jocelyn D. Glazier
Summary: The study suggests that maternal intermittent fasting (IF) may have detrimental impacts on maternal physiology and fetal development, including effects on fetal weight and placental function.
Review
Biochemistry & Molecular Biology
Zhongli Chen, Marcel E. E. Meima, Robin P. P. Peeters, W. Edward Visser
Summary: Thyroid hormone transporters play a crucial role in fetal development and thyroid homeostasis during pregnancy. Understanding the mechanisms of different transporters in fetal tissues is essential for facilitating proper development and maintaining thyroid hormone balance. Further research using advanced human models is needed to fully comprehend their roles in thyroid hormone homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Zhongli Chen, A. S. Elise van der Sman, Stefan Groeneweg, Linda Johanna de Rooij, W. Edward Visser, Robin P. Peeters, Marcel E. Meima
Summary: Using pharmacological inhibitors, this study identified that MCT10 and LATs play a major role in T3 uptake in BeWo cells. T4 uptake appears to be independent of known TH transporters, suggesting the presence of alternative transporter(s) that are currently unknown.
Article
Developmental Biology
Arsenio Spinillo, Irene De Maggio, Beatrice Ruspini, Camilla Bellingeri, Chiara Cavagnoli, Serena Giannico, Anna Boschetti, Flavia Magri, Elisabetta Lovati, Fausta Beneventi
Summary: The study found that women with TPO Ab positivity and isolated hypothyroidism during pregnancy had placental pathologic features, with more prominent features in cases with TSH >= 2.5mU/L. These cases also had higher rates of FGR/SGA, placental pathological features suggesting decidual vasculopathy, and severe maternal vascular malperfusion. The increased risk of defective placentation and FGR associated with TPO Ab was independent of simultaneous presence of antinuclear antibodies (ANA) and TSH concentration.
Article
Environmental Sciences
Xuan Li, Tao Yu, Muxin Zhai, Yongyuan Wu, Baojing Zhao, Cancan Duan, Huiru Cheng, Han Li, Zhaolian Wei, Yuanyuan Yang, Zhen Yu
Summary: This study found that cadmium exposure reduces placental angiogenesis in preeclampsia by decreasing the expression of PLGF and VEGF and increasing the expression of sFlt1. Cadmium exposure also decreases the expression of thyroid hormone receptor alpha and Dio2. These results suggest that cadmium exposure impairs placental angiogenesis in preeclampsia by disturbing thyroid hormone receptor signaling.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Xiao Liang, Yin Wang, Lu Liu, Xi Zhang, Li Li, Rong Tang, Dapeng Li
Summary: This study investigated the effects of nitrite exposure on thyroid hormone levels and intestinal iodothyronine deiodinases activity in grass carp. The results showed that nitrite exposure altered thyroid hormone levels, morphology of thyroid follicles, and gene expressions related to thyroid hormone metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Endocrinology & Metabolism
Zhen Yu, Xinghao Feng, Zhongshan Lin, Xuan Li, Shiyue Su, Huiru Cheng, Yuanyuan Yang, Zhaolian Wei
Summary: This study found that cell proliferation was suppressed and apoptosis was increased in placental villi cytotrophoblasts of miscarriage. CD34+ vessel number and vascular endothelial growth factor (VEGF) protein abundance were decreased in miscarriage. In miscarriage group, the gene expression of Dio2, Dio3, TTR and THR alpha were downregulated. The protein abundances of TTR and THR alpha were also downregulated in miscarriage group. In JEG3 cells, the gene expression of PLGF was decreased and the expression of sFlt1 was increased in IOP treatment; The protein abundance of Dio2 was downregulated but the gene expression of Dio2 was unaffected in IOP treatment.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Engineering, Environmental
Jian Li, Ying Xu, Na Li, Rui Zuo, Yuanzheng Zhai, Haiyang Chen
Summary: Through integrated in vitro, in vivo, and in silico assays, the study investigated the thyroid hormone-disrupting effects and mechanisms of 8 typical organophosphate esters (OPEs). It was found that these chemicals competitively bound to the membrane thyroid hormone receptor (mTR) and some OPEs also interacted with the nuclear thyroid hormone receptor (nTR). Molecular docking simulation supported these findings. In addition, in vivo analyses using zebrafish embryo development demonstrated the thyroid hormone-disrupting effects of OPEs and their possible association with mTR.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Deyang Xu, Barbara Ann Halkier
Summary: Correction for the role of transporters at plasma membrane and tonoplast in plant specialized metabolism.
NATURAL PRODUCT REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hannah E. J. Yong, Shiao-Yng Chan, Amlan Chakraborty, Gayathri Rajaraman, Sharon Ricardo, Mohamed Benharouga, Nadia Alfaidy, Frantisek Staud, Padma Murthi
Summary: This review focuses on the impact of viral infections on the placental barrier and the consequences for fetal growth and development. It specifically discusses how Zika, HIV, and SARS-CoV2 affect pregnant women and their offspring, laying the groundwork for developing therapeutics for emerging viruses.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Endocrinology & Metabolism
Anish D. Bagga, Brian P. Johnson, Qiang Zhang
Summary: In this study, a physiologically based kinetic (PBK) model of thyroid hormones (THs) was constructed to investigate the effects of TH binding proteins (THBPs) and endocrine-disrupting chemicals (EDCs). The model accurately describes the production, distribution, and metabolism of THs, and provides novel insights such as fast blood-tissue exchanges and the limitation of tissue influx in the presence of THBPs. Continuous exposure to THBP-binding EDCs does not alter steady-state TH levels, while intermittent exposure to TBG-binding EDCs can cause greater disruptions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Weibin Wang, Xingyun Su, Yongfeng Ding, Weina Fan, Weibin Zhou, Junwei Su, Zhendong Chen, Hong Zhao, Kaijin Xu, Qin Ni, Xiaowei Xu, Yunqing Qiu, Lisong Teng
Summary: Thyroid function abnormalities are common in COVID-19 patients, especially in severe cases. This might be partially explained by nonthyroidal illness syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Carla Moran, Nadia Schoenmakers, David Halsall, Susan Oddy, Greta Lyons, Sjoerd van den Berg, Mark Gurnell, Krishna Chatterjee
Summary: This article describes a diagnostic approach to discordant thyroid function tests, focusing on factors causing elevated free thyroxine and/or free triiodothyronine measurements with nonsuppressed TSH levels. A structured approach combining clinical assessment with additional laboratory investigations can establish a correct diagnosis, potentially preventing unnecessary investigation or inappropriate therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jun Choul Lee, Byong-Sop Song, Young Mi Kang, Yu-Ri Kim, Yea Eun Kang, Ju Hee Lee, Minho Shong, Hyon-Seung Yi
Summary: The study found a correlation between TSH concentration and muscle mass, muscle function related parameters in DTC patients undergoing TSH suppression therapy. Particularly, low TSH concentration was associated with decreased grip strength, especially in male patients under 70 years old.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Huili Jin, Tengfei Shan, Sisi Li, Xin Fan, Yan Zhao, Jie Li, Xiqin Tang, Richard Saffery, Chao Tong, Li Wen, Hongbo Qi, Mark D. Kilby, Philip N. Baker
Summary: Feeding patterns have an impact on early growth indices, with breastfeeding associated with higher body fat mass and smaller weight gain.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Neha Sharma, Oliver C. Watkins, Anne H. Y. Chu, W. Cutfield, Keith M. Godfrey, Hannah E. J. Yong, Shiao-Yng Chan
Summary: The incidence of preterm birth is increasing globally, and myo-inositol supplementation may have a positive impact on reducing this risk. However, the molecular mechanisms by which myo-inositol affects preterm labor remain unclear. This paper presents hypotheses on the role of uteroplacental myo-inositol in human parturition and explores potential molecular mechanisms through which myo-inositol may inhibit preterm labor onset.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Peripheral Vascular Disease
Jiujiang Liao, Yangxi Zheng, Mingyu Hu, Ping Xu, Li Lin, Xiyao Liu, Yue Wu, Biao Huang, Xuan Ye, Sisi Li, Ran Duan, Huijia Fu, Jiayu Huang, Li Wen, Yong Fu, Mark D. Kilby, Louise C. Kenny, Philip N. Baker, Hongbo Qi, Chao Tong
Summary: Incomplete spiral artery remodeling due to impaired extravillous trophoblast invasion is a key factor in malplacentation and the development of preeclampsia. Reduced sphingosine-1-phosphate levels and SPHK1 expression in preeclampsia-complicated pregnancies may contribute to defective placentation. Sphingosine-1-phosphate can promote trophoblast invasion through Hippo signaling-dependent YAP activation.
Article
Public, Environmental & Occupational Health
Chao Tong, Li Wen, Lan Wang, Xin Fan, Yan Zhao, Yamin Liu, Xing Wang, Shuai Huang, Junnan Li, Jie Li, Longqiong Wang, Jie Gan, Lian Yu, Lianlian Wang, Huisheng Ge, Chengjin He, Jiaxiao Yu, Tianjiao Liu, Xiyao Liu, Yang Yang, Xin Li, Huili Jin, Youwen Mei, Jing Tian, Pamela Leong, Mark D. Kilby, Hongbo Qi, Richard Saffery, Philip N. Baker
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Hematology
Vanja Karamatic Crew, Louise A. Tilley, Timothy J. Satchwell, Samah A. AlSubhi, Benjamin Jones, Frances A. Spring, Piers J. Walser, Catarina Martins Freire, Nicoletta Murciano, Maria Giustina Rotordam, Svenja J. Woestmann, Marwa Hamed, Reem Alradwan, Mouza AlKhrousey, Ian Skidmore, Sarah Lewis, Shimon Hussain, Jane Jackson, Tom Latham, Mark D. Kiloy, William Lester, Nadine Becker, Markus Rapedius, Ashley M. Toye, Nicole M. Thornton
Article
Cell Biology
Ping Xu, Yangxi Zheng, Jiujiang Liao, Mingyu Hu, Yike Yang, Baozhen Zhang, Mark D. Kilby, Huijia Fu, Yamin Liu, Fumei Zhang, Liling Xiong, Xiyao Liu, Huili Jin, Yue Wu, Jiayu Huang, Tingli Han, Li Wen, Rufei Gao, Yong Fu, Xiujun Fan, Hongbo Qi, Philip N. Baker, Chao Tong
Summary: Pre-eclampsia (PE) is a metabolic disorder of the placenta that is caused by defective invasion of trophoblasts. This study investigated the role of AMPK in PE development and found that AMPK activation exacerbates PE manifestations but reduces cell death in the placenta. AMPK activation promotes glucose metabolism and glycogen deposition, enhancing cell viability but compromising trophoblast invasion. In contrast, ablation of AMPK leads to decreased glycogen deposition and structural malformation in the placenta. These findings highlight the importance of balancing invasiveness and viability in trophoblasts for proper placental function.
CELL PROLIFERATION
(2023)
Article
Obstetrics & Gynecology
Isabelle Greatholder, Emma Tomlinson, Jack Wilkinson, Lucy E. Higgins, Mark D. Kilby, Alexander E. P. Heazell
Summary: This study aimed to explore the feasibility of an observational study to identify modifiable factors associated with adverse neonatal outcomes in twin pregnancies. The results showed that twin pregnancies have different frequencies of exposures compared to singleton pregnancies, highlighting the need for twin-specific studies to identify modifiable factors and develop preventative strategies for morbidity and mortality in twin pregnancies.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Shiao-Yng Chan, Sheila J. Barton, See Ling Loy, Hsin Fang Chang, Philip Titcombe, Jui-Tsung Wong, Marilou Ebreo, Judith Ong, Karen ML. Tan, Heidi Nield, Sarah El -Heis, Timothy Kenealy, Yap-Seng Chong, Philip N. Baker, Wayne S. Cutfield, Keith M. Godfrey
Summary: This study examined the impact of a combined myo-inositol, probiotics, and micronutrient nutritional supplement on time-to-natural-conception and clinical pregnancy rates. The results showed that there was no significant difference in time-to-natural-conception and clinical pregnancy rates within a year between women receiving the supplement and those in the control group. Overweight women had a longer time-to-conception, but the supplement may shorten their time-to-conception to that comparable to nonoverweight/nonobese women.
FERTILITY AND STERILITY
(2023)
Article
Biotechnology & Applied Microbiology
Xi Yuan, Jiayu Huang, Li Wen, Boris Novakovic, Mark D. Kilby, Chao Tong, Hongbo Qi, Richard Saffery, Philip N. Baker
Summary: Despite being genetically identical, monozygotic (MZ) twins can have discordant congenital heart disease (CHD) due to in utero environmental factors. This study identified epigenetic variations in cord blood of discordant MZ twins that are associated with CHD. The results revealed specific DNA methylation variations that are biomarkers and potential targets for intervention in CHD.
Article
Nutrition & Dietetics
Jun S. Lai, Marjorelee T. Colega, Keith M. Godfrey, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Yung Seng Lee, Johan G. Eriksson, Shiao-Yng Chan, Mary F. F. Chong
Summary: Adopting a healthy diet during and after pregnancy is important for women's cardiometabolic health. Changes in diet quality from pregnancy to 6 years postpregnancy were related to cardiometabolic markers 8 years postpregnancy in a study of 652 women. Improving or preventing a decline in diet quality postpregnancy may improve lipid profile and insulin resistance.
Article
Pediatrics
Li Wen, Huijia Fu, Richard Saffery, Chao Tong, Yamin Liu, Mark D. Kilby, Hongbo Qi, Philip N. Baker
Summary: This study measured the concentrations of adiponectin and leptin in the cord blood of monochorionic twins with selective intrauterine growth restriction (IUGR). The findings showed that cord blood adiponectin concentrations were negatively associated with IUGR, while cord blood leptin concentrations were significantly lower in IUGR twins. Furthermore, adiponectin was negatively associated with height increments in the first 6 months, and leptin was inversely associated with weight and height increments in the first 6 months, as well as weight and height at 6 and 24 months. These results indicate the influence of adiponectin and leptin in cord blood on IUGR and childhood growth trajectories.
Article
Nutrition & Dietetics
Jun S. Lai, Keith M. Godfrey, Choon Nam Ong, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Jerry K. Y. Chan, Shiao-Yng Chan, Mary F. -F. Chong
Summary: This study examined the associations between perinatal plasma carotenoids and E vitamers concentrations and glycemia, insulin resistance, and gestational and type 2 diabetes mellitus in GUSTO women. The findings suggest that higher concentrations of alpha- and beta-carotene and lutein may be beneficial for gestational fasting glycemia, while higher concentrations of vitamin E may increase gestational and post-pregnancy glycemia.
Article
Health Care Sciences & Services
V. Vien Lee, Smrithi Vijayakumar, Wei Ying Ng, Ni Yin Lau, Qiao Ying Leong, Delicia Shu Qin Ooi, Lin Lin Su, Yung Seng Lee, Shiao-Yng Chan, Agata Blasiak, Dean Ho
Summary: This study aimed to understand the needs and expectations of women before, during and after pregnancy for digital health interventions (DHIs) in order to inform and optimize future DHI developments. Through interviews and thematic analysis, personalization and localization of DHIs emerged as key concepts, with corresponding themes and subthemes identified.
NPJ DIGITAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Eamon Fitzgerald, Mojun Shen, Hannah Ee Juen Yong, Zihan Wang, Irina Pokhvisneva, Sachin Patel, Nicholas O'Toole, Shiao-Yng Chan, Yap Seng Chong, Helen Chen, Peter D. Gluckman, Jerry Chan, Patrick Kia Ming Lee, Michael J. Meaney
Summary: Pathological placental inflammation might increase the risk of future health problems. This study finds that genes associated with the homeostatic function of Hofbauer cells, a placenta-specific macrophage, are associated with protection against adult cardiovascular and depressive disorders.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Soo Min Han, Fang Huang, Jose G. B. Derraik, Mark H. Vickers, Surabhi Devaraj, Karine Redeuil, Esther Campos-Gimenez, Wei Wei Pang, Keith M. Godfrey, Shiao-Yng Chan, Sagar K. Thakkar, Wayne S. Cutfield
Summary: Maternal supplementation with vitamin D before and during pregnancy can increase the concentration of vitamin D in breast milk, but does not affect the concentration of B vitamins. The concentration of vitamin D3 in breast milk gradually increases during early lactation, while the concentrations of B vitamins have peaks at different time points.
CLINICAL NUTRITION
(2023)