Article
Biochemistry & Molecular Biology
Haodong Liu, Xiaojing Li, Penghui Li, Rihan Hai, Jiacheng Li, Qi Fan, Xing Wang, Yujie Chen, Xiaojuan Cao, Xiaoyu Zhang, Ruifeng Gao, Kun Wang, Chenguang Du
Summary: By conducting experiments on mice, it was discovered that VGlut2 neurons in the locus coeruleus play a significant role in weight regulation, while MC4R neurons in the paraventricular nucleus also contribute to weight management. Furthermore, LCVGlut2 neurons exhibit wide-ranging projections, receiving excitatory inputs from multiple brain nuclei. These findings have important implications for the treatment of obesity.
Article
Endocrinology & Metabolism
Uday Singh, Jingwei Jiang, Kenji Saito, Brandon A. Toth, Jacob E. Dickey, Samuel R. Rodeghiero, Yue Deng, Guorui Deng, Baojian Xue, Zhiyong Zhu, Leonid V. Zingman, Joel C. Geerling, Huxing Cui
Summary: The PVNMC4R+ neurons project broadly to brain regions involved in feeding, neuroendocrine, and autonomic control, while receiving monosynaptic input mainly from other hypothalamic nuclei and circumventricular organs. Activation of PVNMC4R+ neurons leads to suppression of feeding and physiological changes in cardiovascular and thermoregulatory functions, accompanied by acute transient hyperactivity and rest-like behavior.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jordan B. Wean, Bret N. Smith
Summary: The research suggests that FGF19 increases glutamate release in the DMV through enhancing the activity of AP and NTS neurons connected to the DMV in hyperglycemic mice. Additionally, FGF19 has an impact on intrinsic membrane properties in the NTS, but the effect on glutamate release is not solely dependent on this mechanism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Huiling Sun, Kai Meng, Lin Hou, Lijun Shang, Jianqun Yan
Summary: GLP-2 is a hormone secreted from the gut and brainstem that can suppress food intake by influencing the hypothalamus through the nucleus tractus solitarius. The GLP-2 system in the nucleus tractus solitarius exerts an inhibitory action on food intake, mediated by MC4-R.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Kei Tsukioka, Ko Yamanaka, Hidefumi Waki
Summary: This study elucidates the central mechanisms of cardiovascular regulation during high-intensity exercise, revealing that amygdala activation acts to limit maximum exercise performance and may implicate autonomic control modulating the hypothalamic paraventricular nucleus-nucleus tractus solitarius pathway.
Article
Neurosciences
Changlin Chen, Yichen Lin, Feng Cai, Jinsui Li, Haixun Li, Xiantao Li
Summary: Adenosine promotes sleep by inhibiting glutamatergic neurons in the paraventricular hypothalamic nucleus, which reduces their excitability.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Rui Wang, Dan Fang, Tingting Lin, Wenhui Liang, Hu Qiao
Summary: The recent study found that aldosterone can play a non-genomic regulatory role in rapid sodium intake by activating G protein-coupled estrogen receptor at the NTS level, and it exhibits obvious time and concentration-dependent regulation. However, the molecular mechanism of how aldosterone regulates sodium intake rapidly is still unclear.
NEUROSCIENCE LETTERS
(2023)
Article
Clinical Neurology
Bindu Parayil Sankaran, Saskia B. Wortman, Michel A. Willemsen, Shanti Balasubramaniam
Summary: A 7-year-old girl with rare genetic disease MEGD(H)EL presented with worsening respiratory issues and required mechanical ventilation, with MRI showing progression of known changes in the disease. Despite being ventilator dependent, she eventually succumbed to the effects of the disease.
Article
Biochemistry & Molecular Biology
Xia Wang, Ruijuan Guan, Xiaomei Zhao, Jun Chen, Danian Zhu, Linlin Shen, Nana Song
Summary: TASKs, specifically TASK1 and TASK3, in orexin neurons play a crucial role in regulating respiratory chemoreflex, with orexin neurons sensing extracellular pH changes and projecting to the NTS to modulate respiration. Blocking TASKs or OX1R can affect breathing response to acidosis in the LH.
Article
Nutrition & Dietetics
Antonietta Canna, Elena Cantone, Anne Roefs, Sieske Franssen, Anna Prinster, Elia Formisano, Francesco Di Salle, Fabrizio Esposito
Summary: In this study, ultra-high field fMRI was used to investigate the neural signals in the Nucleus Tractus Solitarius (NTS) in response to different taste stimuli in the human brainstem. The results demonstrated a significant blood oxygen level-dependent (BOLD) response in the predicted location of the NTS for all basic taste stimuli. This study suggests the potential of using a similar experimental strategy to explore the central nervous system involvement in eating disorders.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Nilufer Sayar-Atasoy, Connor Laule, Iltan Aklan, Hyojin Kim, Yavuz Yavuz, Tayfun Ates, Ilknur Coban, Fulya Koksalar-Alkan, Jacob Rysted, Debbie Davis, Uday Singh, Muhammed Ikbal Alp, Bayram Yilmaz, Huxing Cui, Deniz Atasoy
Summary: This study investigates the role of norepinephrine in appetite regulation and identifies a novel ascending noradrenergic circuit that conveys hunger signals to the melanocortin pathway. The researchers found that norepinephrine levels in the paraventricular hypothalamic nucleus (PVN) increase with energy deficit signals and decrease with food access. They also discovered that the innervating catecholaminergic axon terminals from NTSTH-neurons target PVNMC4R-neurons and regulate appetite. These findings provide new insights into the mechanisms of appetite regulation.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Georgina K. C. Dowsett, Brian Y. H. Lam, John A. Tadross, Irene Cimino, Debra Rimmington, Anthony P. Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles S. H. Yeo
Summary: This study provides a detailed single-cell level characterization of cells in the AP and NTS expressing receptors for key anti-obesity drugs, revealing their gene expression profiles under different nutritional states. The research also identifies the transcriptional sensitivity of oligodendrocytes to overnight fasting and shows that roughly half of GIPR-expressing cells are oligodendrocytes.
MOLECULAR METABOLISM
(2021)
Article
Biochemical Research Methods
Jaesub Park, Sangyeon Lee, Kwansoo Kim, Jaegyun Jung, Doheon Lee
Summary: In this study, a computational approach called LAPINE is proposed for large-scale prediction of ADR-related proteins. The results show that LAPINE is capable of predicting ADR-related proteins with high reliability, providing insights into the mechanism of ADRs and aiding in prevention. The source code of LAPINE is available on GitHub and Figshare.
Article
Neurosciences
Qiuping Ye, Si Yuan, Lulu Yao, Yong Dai, Bing Deng, Jiahui Hu, Jiao Qiao, Hongmei Wen, Zulin Dou, Nenggui Xu
Summary: This study aims to investigate the effect of nucleus tractus solitarius (NTS) on post-stroke dysphagia (PSD) treated by electroacupuncture. The results showed that excitatory neurons in the NTS were involved in the treatment process of PSD by electroacupuncture. Furthermore, it was found that inhibiting the NTS reduced the EMG signal associated with swallowing response induced by M1 activation in PSD mice, which was rescued by electroacupuncture.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Julio C. Pascoaloti-Lima, Benedito H. Machado, Daniela Accorsi-Mendonca
Summary: Short-term sustained hypoxia (SH) causes changes in the respiratory pattern of Wistar-Hannover rats, possibly by reducing inhibitory modulation onto NTS-VLM neurons rather than other synaptic transmission alterations.
Article
Neurosciences
Csaba Fekete, Csaba Vastagh, Adam Denes, Erik Hrabovszky, Gabor Nyiri, Imre Kallo, Zsolt Liposits, Miklos Sarvari
Article
Medicine, Research & Experimental
Sungro Jo, Tatiana L. Fonseca, Barbara M. L. C. Bocco, Gustavo W. Fernandes, Elizabeth A. McAninch, Anaysa P. Bolin, Rodrigo R. Da Conceicao, Joao Pedro Werneck-de-Castro, Daniele L. Ignacio, Peter Egri, Dorottya Nemeth, Csaba Fekete, Maria Martha Bernardi, Victoria D. Leitch, Naila S. Mannan, Katharine F. Curry, Natalie C. Butterfield, J. H. Duncan Bassett, Graham R. Williams, Balazs Gereben, Miriam O. Ribeiro, Antonio C. Bianco
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Endocrinology & Metabolism
Edina Varga, Erzsebet Farkas, Gyorgyi Zseli, Andrea Kadar, Alexandra Venczel, Dora Kovari, Dorottya Nemeth, Zoltan Mate, Ferenc Erdelyi, Andras Horvath, Otto Szenci, Masahiko Watanabe, Ronald M. Lechan, Balazs Gereben, Csaba Fekete
Article
Anatomy & Morphology
Yvette Ruska, Anett Szilvasy-Szabo, Dora Kovari, Andrea Kadar, Lilla Macsai, Richard Sinko, Erik Hrabovszky, Balazs Gereben, Csaba Fekete
Summary: The study shows the presence of GLP-1 receptor (GLP-1R) protein and mRNA in orexigenic neuropeptide Y (NPY) neurons in the ventromedial arcuate nucleus, along with the innervation of NPY neurons by inhibitory neurons containing GLP-1R. This suggests that GLP-1 signaling can influence NPY neurons both directly and indirectly, revealing a more complex mechanism of GLP-1's effects on energy homeostasis.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Endocrinology & Metabolism
Dora Kovari, Veronika Penksza, Anett Szilvasy-Szabo, Richard Sinko, Balazs Gereben, Ken Mackie, Csaba Fekete
Summary: Tanycytes regulate the hypothalamic-pituitary-thyroid axis by modulating local thyroid hormone availability and inhibiting TRH release. Decreased endocannabinoid release from tanycytes results in increased TSH synthesis, higher T4 levels, altered glucose homeostasis, and fat deposition.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Mate Durst, Katalin Konczol, Klementina Ocskay, Klaudia Sipos, Peter Varnai, Anett Szilvasy-Szabo, Csaba Fekete, Zsuzsanna E. Toth
Summary: Intrauterine growth retardation (IUGR) may increase the risk of developing non-obese type 2 diabetes. This study found that in a rat model of IUGR, adult rats showed altered response to the appetite-suppressing neuropeptide nesfatin-1 and impaired glucose metabolism. The results suggest that IUGR may lead to hypothalamic nesfatin-1 resistance, which may contribute to the development of non-obese type 2 diabetes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shengnan Liu, Siyi Shen, Ying Yan, Chao Sun, Zhiqiang Lu, Hua Feng, Yiruo Ma, Zhili Tang, Jing Yu, Yuting Wu, Balazs Gereben, Petra Mohacsik, Csaba Fekete, Xiaoyun Feng, Feixiang Yuan, Feifan Guo, Cheng Hu, Mengle Shao, Xin Gao, Lin Zhao, Yuying Li, Jingjing Jiang, Hao Ying
Summary: The active form of thyroid hormone, T3, promotes the proliferation of adipocyte progenitor cells in brown adipose tissue, leading to increased thermogenic capacity.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Daniel Kuti, Zsuzsanna Winkler, Krisztina Horvath, Balazs Juhasz, Anett Szilvasy-Szabo, Csaba Fekete, Szilamer Ferenczi, Krisztina J. Kovacs
Summary: There is a strong relationship between stress and metabolism, and understanding the details of the metabolic stress response is important for studying stress-related metabolic and psychopathologies.
Article
Endocrinology & Metabolism
Zoltan Peterfi, Anett Szilvasy-Szabo, Erzsebet Farkas, Yvette Ruska, Charles Pyke, Lotte Bjerre Knudsen, Csaba Fekete
Summary: GLP-1 not only directly stimulates POMC neurons, but also facilitates the presynaptic input of these cells by acting on presynaptically localized GLP-1R.
NEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Erzsebet Farkas, Edina Varga, Balazs Kovacs, Anett Szilvasy-Szabo, Antonieta Cote-Velez, Zoltan Peterfi, Magdalini Matziari, Monika Toth, Dora Zelena, Zsolt Mezriczky, Andrea Kadar, Dora Kovari, Masahiko Watanabe, Masanobu Kano, Ken Mackie, Balazs Rozsa, Yvette Ruska, Blanka Toth, Zoltan Mate, Ferenc Erdelyi, Gabor Szabo, Balazs Gereben, Ronald M. Lechan, Jean-Louis Charli, Patricia Joseph-Bravo, Csaba Fekete
Article
Medicine, Research & Experimental
Sanaz Gabery, Casper G. Salinas, Sarah J. Paulsen, Jonas Ahnfelt-Ronne, Tomas Alanentalo, Arian F. Baquero, Stephen T. Buckley, Erzsebet Farkas, Csaba Fekete, Klaus S. Frederiksen, Hans Christian C. Helms, Jacob F. Jeppesen, Linu M. John, Charles Pyke, Jane Nohr, Tess T. Lu, Joseph Polex-Wolf, Vincent Prevot, Kirsten Raun, Lotte Simonsen, Gao Sun, Anett Szilvasy-Szabo, Hanni Willenbrock, Anna Secher, Lotte Bjerre Knudsen
Article
Neurosciences
Imre Farkas, Flora Balint, Erzsebet Farkas, Csaba Vastagh, Csaba Fekete, Zsolt Liposits
Article
Endocrinology & Metabolism
Petra Mohacsik, Ferenc Erdelyi, Maria Baranyi, Balint Botz, Gabor Szabo, Monika Toth, Iren Haltrich, Zsuzsanna Helyes, Beata Sperlagh, Zsuzsa Toth, Richard Sinko, Ronald M. Lechan, Antonio C. Bianco, Csaba Fekete, Balazs Gereben
Article
Anatomy & Morphology
Zoltan Peterfi, Erzsebet Farkas, Kata Nagyunyomi-Senyi, Andrea Kadar, Szenci Otto, Andras Horvath, Tamas Fuzesi, Ronald M. Lechan, Csaba Fekete
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Anatomy & Morphology
Gyorgyi Zseli, Barbara Vida, Anett Szilvasy-Szabo, Monika Toth, Ronald M. Lechan, Csaba Fekete
BRAIN STRUCTURE & FUNCTION
(2018)