Article
Biochemistry & Molecular Biology
Holger Loerchner, Juan M. Adrian-Segarra, Christian Waechter, Roxanne Wagner, Maria Elisa Goes, Nathalie Brachmann, Krishnamoorthy Sreenivasan, Astrid Wietelmann, Stefan Guenther, Nicolas Doll, Thomas Braun, Jochen Poeling
Summary: This study discovered that simultaneous and rapid activation of OSMR and LIFR after myocardial infarction (MI) can protect the functional and structural integrity of the infarcted heart, and this can be achieved by using engineered human-like OSM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
D. A. Diaz-Rizzolo, B. Kostov, R. Gomis, A. Siso-Almirall
Summary: Policies in sunny countries, such as those in the Mediterranean area, do not promote vitamin D supplementation despite the high prevalence of sub-optimal levels. A study in Catalonia found low 25(OH)D levels, with only a small percentage of the population getting tested. Measurements were primarily done in women over 45 years old, who were also prescribed the most vitamin D supplementation. Young people had few tests and were not prescribed supplementation, despite having sub-optimal levels.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Tengteng Gao, Xiaomin Liu, Shuo Xu, Xi Yu, Danni Zhang, Kexin Tan, Yi Zhou, Xumei Jia, Zhijun Zhang, Fengwang Ma, Chao Li
Summary: This study reveals the association between MdASMT9-mediated melatonin biosynthesis and nitrogen absorption in apple plants under N-deficiency conditions. Exogenous and endogenous melatonin treatment can improve the tolerance of apple plants to nitrogen deficiency by enhancing light harvesting and heat transfer capability and modulating amino acid metabolism. MdHY5 is involved in the melatonin-mediated promotion of MdNRT2.1 and MdNRT2.4 expression, ultimately enhancing nitrogen absorption.
Article
Pediatrics
Michael S. Wolf, Mioara D. Manole, Lee Ann New, Yaming Chen, Elif Soysal, Patrick M. Kochanek, Hulya Bayir, Robert S. B. Clark
Summary: Research shows that ascorbate-deficient juvenile ODS rats are resistant to neurodegeneration after asphyxial cardiac arrest, possibly due to the upregulation of the endogenous antioxidant GSH in the brain.
PEDIATRIC RESEARCH
(2022)
Retraction
Biochemistry & Molecular Biology
Tao Zhang, Yu-Chao Yin, Xiang Ji, Bo Zhang, Sheng Wu, Xiao-Zhe Wu, Hong Li, Ya-Dan Li, Ya-Ling Ma, Yu Wang, Hai-Tao Li, Bin Zhang, Di Wu
Summary: The study investigated the cardioprotective effects of AT1R knockdown in rats against sepsis-induced myocardial injury by inhibiting the MAPK signaling pathway. However, flaws and inconsistencies between the presented results and experimental methods led to the retraction of the article due to invalid conclusions.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Immunology
Keerthana Chithanathan, Monika Jurgenson, Mithu Guha, Ling Yan, Tamara Zarkovskaja, Martin Pook, Nathaniel Magilnick, Mark P. Boldin, Ana Rebane, Li Tian, Alexander Zharkovsky
Summary: This study investigated the effect of miR-146b deficiency on LPS-induced neuroinflammation. The results showed that miR-146b deficiency attenuates LPS-induced neuroinflammation, as evidenced by reduced sickness behavior, decreased inflammatory status of microglia, and loss of morphological signs of microglial activation. The upregulation of miR-146a in Mir146b-/- mice was found to be caused by overexpression of the miR-146a transcription inducer Irf7.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Cheng Kai Lu, Gang Liang
Summary: Iron deficiency enhances plant resistance to pathogens by inducing ethylene synthesis. The FIT-bHLH Ib module is responsible for activating the expression of ethylene synthesis-associated genes SAM1 and SAM2, thereby increasing resistance to Botrytis cinerea.
Article
Medicine, Research & Experimental
Carmen Tarifa, Selma A. Serra, Adela Herraiz-Martinez, Estefania Lozano-Velasco, Raul Benitez, Amelia Aranega, Diego Franco, Leif Hove-Madsen
Summary: This study aimed to investigate the relationship between Pitx2c expression and calcium release and electrical activity in atrial myocytes. By using confocal calcium imaging and patch-clamp techniques, it was found that Pitx2c deletion leads to calcium homeostasis imbalance and abnormal electrical activity, which resemble the abnormalities observed in right atrial myocytes from patients with AF.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Jingxuan Guo, Lizhi Long, Anle Chen, Xiaonan Dong, Zhipeng Liu, Limei Chen, Junying Wang, Lixing Yuan
Summary: This study identified the protein ZmNRAMP2, which plays a crucial role in root-to-shoot manganese translocation in maize plants. Mutants lacking the ZmNRAMP2 gene showed reduced manganese translocation and inhibited plant growth under manganese deficiency. In contrast, transgenic maize overexpressing ZmNRAMP2 exhibited enhanced manganese translocation and improved tolerance to manganese deficiency. This research provides a promising transgenic approach for developing crop cultivars with increased tolerance to low manganese conditions.
Article
Endocrinology & Metabolism
G. Akin Kagizmanli, D. Ozalp Kizilay, O. Besci, K. Yuksek Acinikli, S. Ozen, K. Demir, R. D. Goksen Simsek, E. Bober, S. Darcan, A. Abaci
Summary: This study evaluated the effects of combined AI and rhGH therapy for 1 year in adolescent males with GHD. The results showed that using AIs in addition to rhGH treatment can slow down bone age maturation in boys with GHD, and the therapy was found to be safe during the observation period.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Miguel Vazquez-Moreno, Daniel Locia-Morales, Adan Valladares-Salgado, Tanmay Sharma, Aleyda Perez-Herrera, Roxana Gonzalez-Dzib, Francisco Rodriguez-Ruiz, Niels Wacher-Rodarte, Miguel Cruz, David Meyre
Summary: The MC4R p.Ile269Asn mutation is associated with an increased risk of T2D in Mexican adults, even after adjusting for BMI. Mediation analysis showed that BMI accounts for 22.7% of the association between the mutation and T2D risk.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Qianqian Chen, Jifu Li, Guoxuan Liu, Xing Lu, Kang Chen, Jiang Tian, Cuiyue Liang
Summary: This study characterizes the function of the GmBBE-like43 gene in soybean's adaptation to aluminum and low phosphorus stresses. The gene is induced by phosphate starvation and aluminum stress, and its overexpression promotes root growth and oxidation. These findings suggest the importance of GmBBE-like43 in soybean's coordinated adaptation to aluminum toxicity and phosphorus starvation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Endocrinology & Metabolism
Gerhard Binder, Akie Nakamura, Roland Schweizer, Tsutomu Ogata, Maki Fukami, Keisuke Nagasaki
Summary: The study on the long-term treatment effects of aromatase inhibitor in boys with AEXS showed that early initiation of anastrozole treatment can promote adult height in these patients, suggesting a potential benefit of long-term inhibition of aromatase.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Tara Hyder, Christopher C. Marino, Sasha Ahmad, Azadeh Nasrazadani, Adam M. Brufsky
Summary: Aromatase inhibitors (AIs) are essential in the management of hormone receptor-positive (HR+) breast cancer, but their use is limited by the musculoskeletal adverse effects known as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS), which includes bone loss and arthralgias. The pathophysiology of AIMSS is not fully understood, but is proposed to be related to estrogen deprivation in the musculoskeletal and nervous systems.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Donghoon Kang, Hojeong Cha, Sung Eun Park, Jong-Hwa Ahn, Ji Kwon Park, Iyun Kwon, Ji Eun Park
Summary: This article reports a case of a patient with FVII deficiency who developed massive pulmonary embolism after childbirth. The patient was successfully treated with early application of extracorporeal membrane oxygenation, catheter-guided thrombectomy, and anticoagulants. There were no major sequelae over a 2-month follow-up.
Article
Biochemistry & Molecular Biology
U. Varma, P. Koutsifeli, V. L. Benson, K. M. Mellor, L. M. D. Delbridge
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Multidisciplinary Sciences
Chanchal Chandramouli, Melissa E. Reichelt, Claire L. Curl, Upasna Varma, Laura A. Bienvenu, Parisa Koutsifeli, Antonia J. A. Raaijmakers, Miles J. De Blasio, Cheng Xue Qin, Alicia J. Jenkins, Rebecca H. Ritchie, Kimberley M. Mellor, Lea M. D. Delbridge
SCIENTIFIC REPORTS
(2018)
Article
Cardiac & Cardiovascular Systems
Claire L. Curl, Vennetia R. Danes, James R. Bell, Antonia J. A. Raaijmakers, Wendy T. K. Ip, Chanchal Chandramouli, Tristan W. Harding, Enzo R. Porrello, Jeffrey R. Erickson, Fadi J. Charchar, Andrew R. Kompa, Amanda J. Edgley, David J. Crossman, Christian Soeller, Kimberley M. Mellor, Jonathan M. Kalman, StephenB. Harrap, Lea M. D. Delbridge
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Multidisciplinary Sciences
Johannes V. Janssens, Brendan Ma, Margaret A. Brimble, Jennifer E. Van Eyk, Lea M. D. Delbridge, Kimberley M. Mellor
SCIENTIFIC REPORTS
(2018)
Review
Biochemistry & Molecular Biology
Lorna J. Daniels, Upasna Varma, Marco Annandale, Eleia Chan, Kimberley M. Mellor, Lea M. D. Delbridge
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Immunology
Jurre Y. Siegers, Boris Novakovic, Katina D. Hulme, Rebecca J. Marshall, Conor J. Bloxham, Walter G. Thomas, Mellissa E. Reichelt, Lonneke Leijten, Peter van Run, Karen Knox, Kamil A. Sokolowski, Brian W. C. Tse, Keng Yih Chew, Angelika N. Christ, Greg Howe, Timothy J. C. Bruxner, Mario Karolyi, Erich Pawelka, Rebecca M. Koch, Rosa Bellmann-Weiler, Francesco Burkert, Gunter Weiss, Romit J. Samanta, Peter J. M. Openshaw, Helle Bielefeldt-Ohmann, Debby van Riel, Kirsty R. Short
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Endocrinology & Metabolism
Lorna J. Daniels, Marco Annandale, Parisa Koutsifeli, Xun Li, Carol T. Bussey, Isabelle van Hout, Richard W. Bunton, Philip J. Davis, Sean Coffey, Rajesh Katare, Regis R. Lamberts, Lea M. D. Delbridge, Kimberley M. Mellor
Summary: This study indicates that elevated myocardial fructose and sorbitol levels in diabetic patients are associated with diastolic dysfunction. Experimental evidence suggests that fructose may promote the formation of cardiomyocyte cytosolic lipid inclusions, potentially contributing to lipotoxicity in the diabetic heart.
NUTRITION & DIABETES
(2021)
Article
Cardiac & Cardiovascular Systems
Meredith A. Redd, Sarah E. Scheuer, Natalie J. Saez, Yusuke Yoshikawa, Han Sheng Chiu, Ling Gao, Mark Hicks, Jeanette E. Villanueva, Yashutosh Joshi, Chun Yuen Chow, Gabriel Cuellar-Partida, Jason N. Peart, Louise E. See Hoe, Xiaoli Chen, Yuliangzi Sun, Jacky Y. Suen, Robert J. Hatch, Ben Rollo, Di Xia, Mubarak A. H. Alzubaidi, Snezana Maljevic, Gregory A. Quaife-Ryan, James E. Hudson, Enzo R. Porrello, Melanie Y. White, Stuart J. Cordwell, John F. Fraser, Steven Petrou, Melissa E. Reichelt, Walter G. Thomas, Glenn F. King, Peter S. Macdonald, Nathan J. Palpant
Summary: Ischemia-reperfusion injury (IRI) is a major risk factor in cardiovascular disease, and acid-sensing ion channel 1a (ASIC1a) is significantly associated with cardiac IRI. Genetic ablation of ASIC1a improves cardiomyocyte viability after acute IRI, and therapeutic blockade of ASIC1a shows cardioprotective effects equivalent to benchmark drugs.
Article
Cell Biology
Zhen Wang, Hsiu-Wen Chan, Giovanna Gambarotta, Nicola J. Smith, Brooke W. Purdue, David J. Pennisi, Enzo R. Porrello, Shannon L. O'Brien, Melissa E. Reichelt, Walter G. Thomas, Tamara M. Paravicini
Summary: ErbB4 receptor mediates cardiomyocyte hypertrophy by activating neuregulin 1 (NRG1), while ErbB1 receptor does not directly induce hypertrophy. The four ErbB4 isoforms regulate NRG1-induced hypertrophic effect in cardiomyocytes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Jane E. Sinclair, Conor J. Bloxham, Han Chiu, Keng Yih Chew, Jake Russell, Yusuke Yoshikawa, Helle Bielefeldt-Ohmann, Lauren E. Steele, Katina D. Hulme, Nathalie Aj Verzele, Ellesandra C. Noye, Melanie Wu, Melissa E. Reichelt, Walter G. Thomas, Linda A. Gallo, Meredith A. Redd, Kirsty R. Short
Summary: The study found that compared to infected control mice, infected diabetic mice had increased levels of serum cardiac troponin I and creatine-kinase MB, left ventricular structural changes, and right ventricular functional alterations, showing experimental evidence that type 1 diabetes increases the risks of influenza-induced cardiovascular complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Physiology
Sophia L. Young, Lydia Ryan, Thomas P. Mullins, Melanie Flint, Sarah E. Steane, Sarah L. Walton, Helle Bielefeldt-Ohmann, David A. Carter, Melissa E. Reichelt, Linda A. Gallo
Summary: Selective SGLT2 inhibition reduces the risk of worsening heart failure and cardiovascular death in patients with existing heart failure, regardless of diabetic status. The study demonstrates the utility of dual SGLT1/2 inhibition in treating cardiac injury induced by pressure overload in normoglycemic mice, but its efficacy in high fat-fed mice with mild hyperglycemia and compromised renal morphology requires further study.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biology
Uda Y. Ho, Chun-Wei Allen Feng, Yvonne Y. Yeap, Amanda L. Bain, Zhe Wei, Belal Shohayeb, Melissa E. Reichelt, Hayden Homer, Kum Kum Khanna, Josephine Bowles, Dominic C. H. Ng
Summary: The loss of centriolar scaffold protein WDR62 in mouse testis leads to defects in spermatogenesis, including centriole underduplication in spermatocytes and delayed manchette removal in spermatids due to delayed Katanin p80 accumulation.
COMMUNICATIONS BIOLOGY
(2021)
Correction
Pharmacology & Pharmacy
Shannon L. O'Brien, Elizabeth K. M. Johnstone, Dominic Devost, Jacinta Conroy, Melissa E. Reichelt, Brooke W. Purdue, Mohammed A. Ayoub, Tatsuo Kawai, Asuka Inoue, Satoru Eguchi, Terence E. Hebert, Kevin D. G. Pfleger, Walter G. Thomas
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
David A. Eagles, Natalie J. Saez, Bankala Krishnarjuna, Julia J. Bradford, Yanni K. -Y. Chin, Hana Starobova, Alexander Mueller, Melissa E. Reichelt, Eivind A. B. Undheim, Raymond S. Norton, Walter G. Thomas, Irina Vetter, Glenn F. King, Samuel D. Robinson
Summary: This study discovered a peptide toxin, MIITX2-Mg1a, in the venom of the Australian giant red bull ant that mimics vertebrate epidermal growth factor. It acts as a potent agonist of the mammalian EGF receptor ErbB1, causing long-lasting hypersensitivity in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physiology
Emily S. Dorey, John P. Headrick, Tamara M. Paravicini, Mary E. Wlodek, Karen M. Moritz, Melissa E. Reichelt
Summary: The central question of this study is to explore the cardiovascular consequences of periconceptual ethanol on offspring throughout their lifespan. The main finding of the study is that periconceptional alcohol exposure has sex-specific effects on heart growth, with aging female offspring showing decreased cardiac output. This study highlights the importance of understanding the effects of alcohol exposure during pregnancy on cardiac development and function.
EXPERIMENTAL PHYSIOLOGY
(2023)