Article
Cell Biology
Emilia Przygrodzka, Corrine F. Monaco, Michele R. Plewes, Guojuan Li, Jennifer R. Wood, Andrea S. Cupp, John S. Davis
Summary: The study revealed that in bovine luteal cells, autophagy pathway activated by AMPK was increased during PGF2α-induced luteolysis, while the LH/PKA signaling pathway inhibited autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Anom Bowolaksono, Muhammad Fauzi, Ayu Mulia Sundari, Anantya Pustimbara, Retno Lestari, Abinawanto, Astari Dwiranti, Fadhillah
Summary: Our study indicates that LH prolongs the lifespan of the corpus luteum through an anti-apoptotic mechanism by increasing cell viability and suppressing the expression of apoptosis-related genes and proteins.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Agriculture, Dairy & Animal Science
Michael R. Goulet, Donnelly Hutchings, Jacob Donahue, Dean Elder, Paul C. W. Tsang
Summary: In this study, it was found that RhoA and thrombin induce the expression of CCN1 in steroidogenic luteal cells of the cow corpus hemorrhagicum through a specific signaling pathway. This provides important insights into the mechanism of luteal development and angiogenesis.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Emilia Przygrodzka, Xiaoying Hou, Pan Zhang, Michele R. Plewes, Rodrigo Franco, John S. Davis
Summary: Luteinizing hormone (LH) regulates ovulation and formation of the corpus luteum, while AMP-activated protein kinase (AMPK) exerts inhibitory effects on steroidogenesis in luteal cells by modulating the actions of PKA. AMPK regulates cholesterol availability for steroidogenesis by mediating phosphorylation of hormone-sensitive lipase (HSL), in contrast to the phosphorylation effects of LH/PKA on HSL.
Article
Agriculture, Dairy & Animal Science
Emilia Przygrodzka, Kamil Myszczynski, Jan Klos, Adam J. Ziecik
Summary: The study analyzed the effects of decreased oxygen concentration on the function and progesterone production of the corpus luteum in pigs, revealing that the luteal tissues of cyclic and pregnant gilts have similar sensitivity to reduced oxygen. Furthermore, transcription factors cJUN and CREB may play a role in regulating STAR expression during early pregnancy in gilts.
Article
Developmental Biology
Akshi Vashistha, H. Rahaman Khan, Medhamurthy Rudraiah
Summary: This study investigated the luteolytic actions of LH in rats during different stages of pregnancy, revealing that LH mediates luteolysis through multiple signaling pathways, with the cAMP/PKA/CREB pathway playing a key role. Additionally, a positive correlation between beta-arrestin 1 and 20α-HSD expression was found for the first time in this study, indicating its potential role in LH-mediated luteolysis.
Article
Agriculture, Dairy & Animal Science
Benjamin R. Crites, Sarah N. Carr, James C. Matthews, Phillip J. Bridges
Summary: Supplementing grazing cattle in selenium-deficient regions with an isomolar 1:1 mix of inorganic and organic selenium can increase early luteal phase progesterone levels, promoting embryonic development. The form of supplemental selenium affects the luteal transcriptome, regulating cholesterol biosynthesis and immune function in the corpus luteum.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Reproductive Biology
Megan A. Mezera, Wenli Li, Lihe Liu, Rina Meidan, Francisco Penagaricano, Milo C. Wiltbank
Summary: Research suggests that early subluteolytic PGF pulses impact the luteal transcriptome during natural luteolysis, though not by directly affecting steroidogenesis or inhibiting cellular function. Instead, these early pulses mainly alter pathways related to local steroid and glutathione metabolism.
BIOLOGY OF REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
Camilla H. K. Hughes, Megan A. Mezera, Milo C. Wiltbank, Joy L. Pate
Summary: This study combined two independent studies of global changes in the corpus luteum during early pregnancy to identify key regulators of luteal rescue, revealing 42 common transcripts that regulate functions such as inflammatory balance and matrix remodeling. Important regulators identified include interferon-stimulated genes, regulators of transforming growth factor-beta, and retinoic acid signaling pathways.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Reproductive Biology
Megan A. Mezera, Wenli Li, Milo C. Wiltbank
Summary: The study found significant alterations in expression of interferon-stimulated genes (ISGs) during early pregnancy, with immune/interferon signaling pathways being enriched. Most ISGs decreased during the second month of pregnancy, but some remained elevated even after cessation of IFNT secretion. Additionally, the study highlighted the importance of lack of PGF exposure in corpus luteum maintenance during early pregnancy, while the roles of diverse ISGs and other pathways activated during early pregnancy remain undefined.
BIOLOGY OF REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
Sang-Hee Lee, Seunghyung Lee
Summary: The study found that PGF2 alpha affects cell adhesion in bovine luteal theca cells by disrupting cytokeratin, vimentin, and desmoplakin proteins, as well as increasing ROCK protein levels, leading to decreased cell-cell adhesion during corpus luteum regression.
Article
Multidisciplinary Sciences
Angelika M. Kotlarczyk, Martyna Grzyb, Anna J. Korzekwa
Summary: In the ruminant uterus, steroid production mainly occurs during the reproductive season, especially during the estrous cycle, and continues during anestrus.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Granit Thaqi, Bajram Berisha, Michael W. Pfaffl
Summary: Adipokines play a crucial role in various biological processes, and their expression levels show significant differences during the estrous cycle and pregnancy in cows. This study aimed to investigate the local production of adipokines and their receptors in the bovine corpus luteum and their potential involvement in ovarian physiology. The findings suggest that adipokines are expressed and regulated differently during different phases of the cycle and during pregnancy, indicating their importance in corpus luteum function.
Article
Endocrinology & Metabolism
Silvia Leon, Chrysanthi Fergani, Rajae Talbi, Caroline A. Maguire, Achi Gerutshang, Stephanie B. Seminara, Victor M. Navarro
Summary: Tachykinins play an important role in the neuroendocrine control of reproduction by stimulating Kiss1 neurons to control GnRH pulsatility. Knockout mice for Tac1 (NKA/SP) and Tac2 (NKB) genes are fertile, suggesting compensatory mechanisms among different tachykinin systems. Further research confirmed the fundamental role of tachykinins in puberty onset, LH pulsatility, and facilitation of the preovulatory LH surge.
NEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Yi-Fan Jiang, Pin-Huan Yu, Yovita Permata Budi, Chih-Hsien Chiu, Chi-Yu Fu
Summary: This study investigated the dynamics of mitochondria in mammalian ovaries during folliculogenesis and luteal formation. The results showed that mitochondrial networks shifted from branched structures in follicles to spherical and tubular mitochondria in large luteal cells. Additionally, mitochondrial diameter and volume increased from folliculogenesis to luteal formation, indicating mitochondrial enlargement as an event during these processes. Modulation of mitochondrial morphology and respiratory enzyme expressions may be related to tissue remodeling during luteal formation.
SCIENTIFIC REPORTS
(2021)
Article
Anatomy & Morphology
B. Berisha, D. Schams, D. Rodler, M. W. Pfaffl
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2016)
Article
Agriculture, Dairy & Animal Science
Bajram Berisha, Dieter Schams, Daniela Rodler, Fred Sinowatz, Michael W. Pfaffl
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2016)
Article
Agriculture, Dairy & Animal Science
B. Berisha, D. Schams, D. Rodler, F. Sinowatz, M. W. Pfaffl
REPRODUCTION IN DOMESTIC ANIMALS
(2017)
Article
Genetics & Heredity
Rreze M. Gecaj, Corina I. Schanzenbach, Benedikt Kirchner, Michael W. Pfaffl, Irmgard Riedmaier, Ry Y. Tweedie-Cullen, Bajram Berisha
FRONTIERS IN GENETICS
(2017)
Article
Biochemistry & Molecular Biology
Bajram Berisha, Dieter Schams, Daniela Rodler, Fred Sinowatz, Michael W. Pfaffl
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2018)
Article
Mycology
Arieta Camaj, Karsten Meyer, Bajram Berisha, Tahir Arbneshi, Arben Haziri
MYCOTOXIN RESEARCH
(2018)
Article
Agriculture, Dairy & Animal Science
H. Kliem, D. Rodler, S. E. Ulbrich, F. Sinowatz, B. Berisha, H. H. D. Meyer, D. Schams
REPRODUCTION IN DOMESTIC ANIMALS
(2013)
Article
Agriculture, Dairy & Animal Science
V. S. Chouhan, R. P. Panda, V. P. Yadav, V. Babitha, F. A. Khan, G. K. Das, M. Gupta, S. S. Dangi, G. Singh, S. Bag, G. T. Sharma, B. Berisha, D. Schams, M. Sarkar
REPRODUCTION IN DOMESTIC ANIMALS
(2013)
Article
Endocrinology & Metabolism
Bajram Berisha, Daniela Rodler, Dieter Schams, Fred Sinowatz, Michael W. Pfaffl
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Agriculture, Dairy & Animal Science
Bajram Berisha, Dieter Schams, Fred Sinowatz, Daniela Rodler, Michael W. Pfaffl
REPRODUCTION IN DOMESTIC ANIMALS
(2020)
Article
Anatomy & Morphology
Bajram Berisha, Granit Thaqi, Daniela Rodler, Dieter Schams, Fred Sinowatz, Michael W. Pfaffl
Summary: The study evaluated the expression patterns and concentration changes of certain prostaglandin family members during experimentally induced luteolysis in cows. The results showed that the expression of PTGS2 increased significantly after PGF application, while the tissue concentration of PGF increased immediately after injection and again during structural luteolysis. In contrast, PGE concentration decreased during structural luteolysis. The mRNA of the FP receptor decreased significantly at 2 hours and 12 hours after PGF, while the mRNA of the EP4 receptor increased immediately after PGF application.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2022)
Article
Food Science & Technology
Rreze M. Gecaj, Skender Muji, Flutura C. Ajazi, Bajram Berisha, Alltane Kryeziu, Muharem Ismaili
Summary: Food adulteration and fraudulent practices are a global concern, especially in Balkan countries like Kosovo. This study used ELISA and real-time PCR methods to detect undeclared pork meat in commercial beef and chicken products, with findings showing varying levels of pork contamination. ELISA and PCR with pork specific primers demonstrated high reproducibility, with the latter being the most cost-effective method for detecting pork adulteration.
CZECH JOURNAL OF FOOD SCIENCES
(2021)
Article
Veterinary Sciences
Bajram Berisha
Summary: The objective of this study was to examine the expression patterns of hypoxia-inducible factor-1alpha and vascular endothelial growth factor isoforms during periovulation in cows. The results showed that both genes exhibited significant changes in expression levels before and after ovulation, suggesting their important roles in follicle regulation and angiogenesis during early corpora lutea formation.
ACTA VETERINARIA EURASIA
(2022)
Article
Environmental Sciences
Arieta Camaj, Tahir Arbneshi, Bajram Berisha, Arben Haziri, Aferdita Camaj
BULGARIAN JOURNAL OF AGRICULTURAL SCIENCE
(2019)
Article
Environmental Sciences
Flutura C. Ajazi, Kemajl Kurteshi, Matthias A. Ehrmann, Rreze Gecaj, Muharrem Ismajli, Bajram Berisha, Idriz Vehapi
BULGARIAN JOURNAL OF AGRICULTURAL SCIENCE
(2018)