Article
Immunology
Syed Morshed, Rauf Latif, Terry F. Davies
Summary: This study found that non-neutral TSH receptor antibodies induce oxidative stress and apoptosis in thyroid cells through endocytosis. These results suggest that the oxidative stress reaction triggered by self-antibodies in patients with Graves' disease may be the main mechanism underlying inflammatory autoimmune reactions.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Endocrinology & Metabolism
Irene Campi, Guia Vannucchi, Ilaria Muller, Elisa Lazzaroni, Nicola Curro, Martina Dainese, Benedetta Montacchini, Danila Covelli, Claudio Guastella, Lorenzo Pignataro, Laura Fugazzola, Maura Arosio, Mario Salvi
Summary: This study compared the efficacy and safety of different doses of RTX in the treatment of active moderate-to-severe GO, suggesting that a single 500 mg dose regimen may be the optimal choice for most patients, as it can effectively improve the condition and enhance quality of life.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medical Laboratory Technology
Heleen I. Jansen, Heloise G. Gohy, Anita Boelen, Peter H. Bisschop, Jacquelien J. Hillebrand, Annemieke C. Heijboer
Summary: This study compared the performance of the Alinity, KRYPTOR, and Cobas immunoassays in measuring the concentration of TSH-receptor antibodies (TRAb) in blood samples of Graves' Disease patients. The results showed that the Alinity immunoassay yielded comparable results to KRYPTOR and Cobas, although slightly more negative results compared to Cobas were observed.
CLINICA CHIMICA ACTA
(2023)
Article
Immunology
Syed Morshed, Rauf Latif, Terry F. Davies
Summary: This study found that TSH or antioxidants can rescue thyroid cells from N-TSHR-mAb-induced apoptosis by enhancing autophagy. These results suggest that N-TSHR-mAb under low TSH conditions in Graves' disease patients may be detrimental to thyroid cell survival.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Endocrinology & Metabolism
A. Brancatella, L. Torregrossa, N. Viola, D. Sgro, M. Casula, F. Basolo, G. Materazzi, M. Marino, C. Marcocci, F. Santini, F. Latrofa
Summary: The purpose of this study is to correlate laboratory and ultrasound characteristics of Graves' disease with its pathological features. The results showed that thyroid volume was positively correlated with levels of thyroid hormones, autoantibodies, and lymphocytic infiltration, but not with follicular hyperplasia.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Terry F. Davies, Syed A. Morshed, Mihaly Mezei, Rauf Latif
Summary: TSH receptor antibodies play an important role in Graves' disease and Hashimoto's thyroiditis, and their measurement is useful for diagnosis and prognosis. However, it is not possible to accurately detect blocking TSH receptor antibodies in patients with Graves' disease due to potential interference from stimulating antibodies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Magdalena Stasiak, Katarzyna Zawadzka-Starczewska, Boguslaw Tymoniuk, Bartlomiej Stasiak, Andrzej Lewinski
Summary: The risk of GO is higher in patients with elevated TC and/or LDL cholesterol, and this risk is associated with specific HLA alleles. The study investigated the relationship between TC/LDL levels and the presence of GO-related HLA alleles in GD patients. The results showed a correlation between the high-risk HLA alleles (HLA-B*37:01 and C*03:02) and higher TC/LDL levels, as well as lower TC levels in alleles associated with non-GO GD (HLA-C*17:01 and B*08:01).
Article
Endocrinology & Metabolism
Mareile Stoehr, Michael Oeverhaus, Simon D. Lytton, Mareike Horstmann, Denise Zwanziger, Lars Moeller, Achim Stark, Dagmar Fuehrer-Sakel, Nikolaos Bechrakis, Utta Berchner-Pfannschmidt, J. Paul Banga, Svenja Philipp, Anja Eckstein
Summary: This study investigated the potential of new TRAb assays in predicting remission or relapse of hyperthyroidism in GD and GO patients. The findings suggest that the cell-based bioassay is the most sensitive method for predicting relapse, and repeated TRAb measurements can improve the accuracy of relapse prediction rates.
HORMONE AND METABOLIC RESEARCH
(2021)
Article
Endocrinology & Metabolism
Mareile Stoehr, Michael Oeverhaus, Simon D. Lytton, Mareike Horstmann, Denise Zwanziger, Lars Moeller, Achim Stark, Dagmar Fuehrer-Sakel, Nikolaos Bechrakis, Utta Berchner-Pfannschmidt, J. Paul Banga, Svenja Philipp, Anja Eckstein
Summary: This study aimed to investigate the use of serial measurements of TRAb to predict the course of Graves' Orbitopathy during the first 24 months from disease onset. It found that TRAb measurements provide added value to clinical activity and severity scores of GO during the 24-month follow-up and should be used especially in unclear decision-taking situations regarding therapy.
HORMONE AND METABOLIC RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Abhishek Sharma, Udayraj P. Nakade, Raut Akash, Virendra Pratap Yadav, Soumen Choudhury, Pooja Jaitley, Vipin Sharma, Satish Kumar Garg
Summary: This study reveals the differential involvement of calcium signaling pathways in PGF(2 alpha)-induced contractions in NP and pregnant buffaloes. The study suggests that the L-type Ca2+ channels play a role in both NP and pregnant uteri, while T-type Ca2+ channels seem to play a role only during pregnancy. Additionally, the enhanced functional involvement of Pyr3-sensitive TRPC3 channels and Rho-kinase pathways during NP may lead to increased sensitivity to PGF(2 alpha), while down-expression of TRPC3 and Rho-A proteins during pregnancy facilitate uterine quiescence.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuping Liu, Haiyan Yang, Xizhen Wu, Yaqi Kuang, Bixiu Ban, Ziyi Liang, Li Li, Zhenxing Huang, Decheng Lu, Yingfen Qin, Xinghuan Liang, Zuojie Luo
Summary: This study revealed that TSAb can induce abnormal activation of microglia, polarize to the M1 phenotype, and promote the inflammatory cascade reaction. TSHR plays a key role in NF-kappa B activation and proinflammatory cytokine release.
NEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tetsuya Tagami, Kenji Moriyama
Summary: This study identified neutral bioactivities of TBIIs in patients with autoimmune thyroid disease, which strongly inhibit TSH binding to TSH-R but do not exhibit TSAb or TSBAb activity. Differences in methods of detecting TRAb between TBII in vitro and bioassay may cause the discrepancy.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Multidisciplinary Sciences
Danielle L. L. Schmitt, Patricia Dranchak, Prakash Parajuli, Dvir Blivis, Ty Voss, Casey L. L. Kohnhorst, Minjoung Kyoung, James Inglese, Songon An
Summary: We have demonstrated that PFK1 can recruit other rate-determining enzymes in glucose metabolism to form glucosome assemblies in human cells. However, the mechanisms of assembly and disassembly of glucosomes and their functional role in glucose metabolism and cell biology remain unclear. Through high-throughput screening, we identified three compounds that inhibit cyclin-dependent kinase 2, ribosomal protein S6 kinase, and Aurora kinase A, respectively, and confirmed the active role of Aurora kinase A in glucosome formation. These protein kinases are known to be key signaling nodes in the cell cycle progression. Our study reveals a cell cycle-associated signaling network that regulates the formation of PFK1-mediated glucosome assembly in human cells.
Article
Medicine, General & Internal
Cigdem Tura Bahadir, Merve Yilmaz, Elif Kilickan
Summary: The FT3/FT4 ratio can help distinguish between GD and DT. In situations where RAIU/scintigraphy and TRAb studies are not available, the FT3/FT4 ratio is a viable diagnostic tool. Cut-off values with higher specificity can be more helpful in the differential diagnosis of GD.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Roxana-Elena Bohiltea, Bianca-Margareta Mihai, Elena Szini, Ileana-Alina Sucaliuc, Corin Badiu
Summary: This article reports a case of fetal and neonatal thyrotoxicosis in a healthy 37-year-old woman, which was managed successfully with proper treatment. The importance of monitoring fetal thyrotoxicosis signs and maternal TRAb concentration in guiding the course of a pregnancy associated with Graves' disease is emphasized.
MEDICINA-LITHUANIA
(2023)
Article
Biochemistry & Molecular Biology
Cintia E. Citterio, Balaji Veluswanny, Sarah J. Morgan, Valerie A. Galton, J. Paul Banga, Stephen Atkins, Yoshiaki Morishita, Susanne Neumann, Rauf Latif, Marvin C. Gershengorn, Terry J. Smith, Peter Arvan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Peng Liu, Yaoting Ji, Tony Yuen, Elizabeth Rendina-Ruedy, Victoria E. DeMambro, Samarth Dhawan, Wahid Abu-Amer, Sudeh Izadmehr, Bin Zhou, Andrew C. Shin, Rauf Latif, Priyanthan Thangeswaran, Animesh Gupta, Jianhua Li, Valeria Shnayder, Samuel T. Robinson, Yue Eric Yu, Xingjian Zhang, Feiran Yang, Ping Lu, Yu Zhou, Ling-Ling Zhu, Douglas J. Oberlin, Terry F. Davies, Michaela R. Reagan, Aaron Brown, T. Rajendra Kumar, Solomon Epstein, Jameel Iqbal, Narayan G. Avadhani, Maria I. New, Henrik Molina, Jan B. van Klinken, Edward X. Guo, Christoph Buettner, Shozeb Haider, Zhuan Bian, Li Sun, Clifford J. Rosen, Mone Zaidi
Editorial Material
Obstetrics & Gynecology
Peng Liu, Yaoting Ji, Tony Yuen, Elizabeth Rendina-Ruedy, Victoria E. DeMambro, Samarth Dhawan, Wahid Abu-Amer, Sudeh Izadmehr, Bin Zhou, Andrew C. Shin, Rauf Latif, Priyanthan Thangeswaran, Animesh Gupta, Jianhua Li, Valeria Shnayder, Samuel T. Robinson, Yue Eric Yu, Xingjian Zhang, Feiran Yang, Ping Lu, Yu Zhou, Ling-Ling Zhu, Douglas J. Oberlin, Terry F. Davies, Michaela R. Reagan, Aaron Brown, T. Rajendra Kumar, Solomon Epstein, Jameel Iqbal, Narayan G. Avadhani, Maria I. New, Henrik Molina, Jan B. van Klinken, Edward X. Guo, Christoph Buettner, Shozeb Haider, Zhuan Bian, Li Sun, Clifford J. Rosen, Mone Zaidi
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2017)
Article
Biochemistry & Molecular Biology
Syed A. Morshed, Risheng Ma, Rauf Latif, Terry F. Davies
Article
Biochemistry & Molecular Biology
Syed A. Morshed, Risheng Ma, Rauf Latif, Terry F. Davies
Article
Endocrinology & Metabolism
Simeng Sun, Sarawu tSummachiwakij, Ora Schneck, Syed A. Morshed, Risheng Ma, Rauf Latif, Terry F. Davies
FRONTIERS IN ENDOCRINOLOGY
(2019)
Editorial Material
Endocrinology & Metabolism
Terry F. Davies, Rauf Latif
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Syed A. Morshed, Risheng Ma, Rauf Latif, Terry F. Davies
Article
Endocrinology & Metabolism
Risheng Ma, Syed Morshed, Rauf Latif, Terry F. Davies
Article
Endocrinology & Metabolism
Mihaly Mezei, Ramkumarie Baliram, M. Rejwan Ali, Mone Zaidi, Terry F. Davies, Rauf Latif
Article
Medicine, General & Internal
Terry F. Davies, Stig Andersen, Rauf Latif, Yuji Nagayama, Giuseppe Barbesino, Maria Brito, Anja K. Eckstein, Alex Stagnaro-Green, George J. Kahaly
NATURE REVIEWS DISEASE PRIMERS
(2020)
Article
Endocrinology & Metabolism
Rauf Latif, Syed A. Morshed, Risheng Ma, Bengu Tokat, Mihaly Mezei, Terry F. Davies
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Risheng Ma, Rui Shi, Syed A. Morshed, Rauf Latif, Terry F. Davies
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Rauf Latif, Mihaly Mezei, Syed A. Morshed, Risheng Ma, Rachel Ehrlich, Terry F. Davies
Meeting Abstract
Biophysics
Mihaly Mezei, Ramkumarie Baliram, Rejwan M. Ali, Terry F. Davies, Rauf Latif
BIOPHYSICAL JOURNAL
(2017)