Article
Endocrinology & Metabolism
Xiang Li, Kenan Wu, Qinzuo Dong, Hongxi Chen, Chunyan Li, Zeqin Ren, Fan Liu, Xianwu Yue, Chunlin Xia, Yuanfeng Wang, Yingjing Luo, Li Li, Rong Zhao, Zuhong Wang, Dongdong Qin
Summary: “The study demonstrated that OA could improve osteoporosis in ovariectomized rats and exerted an endocrine-modulating effect.”
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Denys Alva-Chavarria, Maribel Soto-Nunez, Edgar Flores-Soto, Ruth Jaimez
Summary: This study aimed to investigate the effects of raloxifene (Rx) and estradiol (E-2) on the hemostatic parameters in rats, including prothrombin time (PT), partial thromboplastin time (APTT), coagulation factors (VII, X, XI), and fibrinogen concentrations. The results showed that Rx increased PT and APTT, decreased factor VII, X, XI activities, and increased fibrinogen concentrations, while E-2 had different effects on these parameters. Overall, raloxifene exhibited a protective effect on hemostasis in rats.
Article
Environmental Sciences
Wenlan Yu, Xiaoyue Chang, Jianzhao Liao, Jinwen Quan, Siying Liu, Ting He, Gaolong Zhong, Jilei Huang, Zhonghua Liu, Zhaoxin Tang
Summary: Long-term ingestion of tribasic copper chloride may result in cognitive dysfunction and disrupt mitochondrial metabolism by inhibiting mitophagy.
ENVIRONMENTAL POLLUTION
(2023)
Article
Immunology
Bo Chen, Guangcheng Qin, Jingyu Xiao, Xiaoyuan Deng, Aolei Lin, Hongliang Liu
Summary: The transient neuroinflammation induced by surgery contributes to the development of PNDs in elderly rats through sustained downregulation and hypofunction of synaptic NR2A and NR2B subunits.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Pharmacology & Pharmacy
Frank Adu-Nti, Xu Gao, Jia-Min Wu, Jing Li, Javed Iqbal, Riaz Ahmad, Xin-Ming Ma
Summary: This study found that Osthole (OST) can improve ovariectomy-induced cognitive impairment, alleviate anxiety and depression-like behaviors, and reverse alterations in hippocampal protein levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Liping Zhou, Ka-Ying Wong, Christina Chui-Wa Poon, Wenxuan Yu, Huihui Xiao, Chi-On Chan, Daniel Kam-Wah Mok, Man-Sau Wong
Summary: The herbal medicine Rhizoma Drynariae (RD) exhibits estrogenic activities and interacts with the selective estrogen receptor modulator tamoxifen without altering its effects. This suggests that RD may be a relatively safe herbal remedy for bone protection.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jesse M. Lacasse, Vanessa Boulos, Caleigh Fisher, Sarran Hamilton, Megan Heron, Conall E. Mac Cionnaith, Vanessa Peronace, Noemie Tito, Wayne G. Brake
Summary: The study found that synthetic hormones contained in oral contraceptives can influence the cognitive strategies used by female animals during maze navigation.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Hui Wang, Lequan Song, Li Zhao, Haoyu Wang, Xinping Xu, Ji Dong, Jing Zhang, Binwei Yao, Xuelong Zhao, Ruiyun Peng
Summary: A study found that 1.5 GHz microwave radiation affects the spatial learning and memory abilities, hippocampal structure, and NMDAR signalling pathway proteins in rats. Microwave radiation has a dose-dependent effect on cognitive functions in humans and animals, such as learning and memory, attention, and orientation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hossein Azizian, Mohammad Khaksari, Gholamreza Asadikaram, Mansour Esmailidehaj, Nader Shahrokhi
Summary: In female diabetic rats, E2 alone and in combination with P4 improved cardiovascular function. E2 alone reduced blood glucose, food and water intake, while P4 decreased atherogenic and cardiac risk indices.
BIOMEDICAL JOURNAL
(2021)
Article
Engineering, Environmental
Shen Guo, Courtney R. A. Toth, Fei Luo, Xu Chen, Johnny Xiao, Elizabeth A. Edwards
Summary: The impact of oxygen on a strictly anaerobic, methanogenic benzene-degrading enrichment culture was investigated. The study found that oxygen had no measurable impact on benzene degradation rates, but caused drastic perturbation of the microbial community. It was also discovered that the anaerobic biotransformation of benzene is independent of oxygen and carried out by distinct microbial communities.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyung-Il Kim, Jae-Chul Lee, Dae Won Kim, Myoung Cheol Shin, Jun Hwi Cho, Ji Hyeon Ahn, Soon-Sung Lim, Il Jun Kang, Joon Ha Park, Moo-Ho Won, Tae-Kyeong Lee
Summary: In this study, the neuroprotective effect of oxcarbazepine (OXC) against ischemic injury induced by transient forebrain ischemia was investigated in gerbils. The results showed that post-ischemic treatment with OXC significantly attenuated hyperactivity and cognitive impairment, as well as increased TRPV1 expression in the CA1 region of the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Omar Hosea Cabrera, Nemanja Useinovic, Stefan Maksimovic, Michelle Near, Nidia Quillinan, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic
Summary: Anesthetics cause widespread neuroapoptosis and lasting cognitive impairments in the developing brains. This study shows that neonatal ketamine exposure interferes with normal neural circuit development and leads to lasting increase in excitatory synaptic transmission in the hippocampus.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Zohreh Zare, Sam Zarbakhsh, Mohsen Tehrani, Moslem Mohammadi
Summary: In this study, we investigated the detrimental effects of estrogen and insulin deficiencies on the hippocampus, specifically by examining apoptosis-induced neuronal damage and the cholinergic system in ovariectomized and/or diabetic rat hippocampus. We also explored the potential neuroprotective effects of treadmill exercise. Our findings suggest that both ovariectomy and diabetes lead to increased apoptosis-related protein levels and decreased survival of neurons in the hippocampus. Additionally, diabetic rats showed lower acetylcholinesterase (AChE) activity, indicating impairment in the cholinergic system. However, treadmill exercise attenuated apoptosis-induced neuropathology and restored AChE activity in diabetic rats. The neuroprotective effects of exercise were mediated by the inhibition of apoptosis. Notably, the exercise protocol used in this study did not have significant anti-apoptotic and neuroprotective effects in ovariectomized-diabetic rats.
Article
Toxicology
Wei Sun, Yang Yang, Xiao Chen, Yazi Mei, Xiaoliang Li, Lei An
Summary: The study found that prenatal exposure to cyanuric acid can cause cognitive and synaptic impairments due to the disruption of hippocampal mGluR1 signaling. These findings provide the first evidence for the deteriorated effects of cyanuric acid on synaptic depression and advanced cognitive performance.
TOXICOLOGY LETTERS
(2022)
Article
Behavioral Sciences
Alyssa F. DeLarge, Peter J. Winsauer
Summary: The psychoactive cannabinoid Delta(9)-THC found in marijuana was studied on memory in female rats. The THC dose-dependently decreased retention and increased errors and decreased response rate, with estradiol attenuation of THC-induced disruptions in OVX female rats.
HORMONES AND BEHAVIOR
(2021)
Article
Medicine, General & Internal
Candela Diaz-Canestro, Nicole R. Bonetti, Patricia Wuest, Vanasa Nageswaran, Luca Liberale, Juerg H. Beer, Fabrizio Montecucco, Thomas F. Luescher, Johannes Bohacek, Giovanni G. Camici
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Biochemical Research Methods
Mattia Privitera, Kim David Ferrari, Lukas M. von Ziegler, Oliver Sturman, Sian N. Duss, Amalia Floriou-Servou, Pierre-Luc Germain, Yannick Vermeiren, Matthias T. Wyss, Peter P. De Deyn, Bruno Weber, Johannes Bohacek
Article
Neurosciences
Oliver Sturman, Lukas von Ziegler, Christa Schlaeppi, Furkan Akyol, Mattia Privitera, Daria Slominski, Christina Grimm, Laetitia Thieren, Valerio Zerbi, Benjamin Grewe, Johannes Bohacek
NEUROPSYCHOPHARMACOLOGY
(2020)
Review
Neurosciences
Lukas von Ziegler, Oliver Sturman, Johannes Bohacek
Summary: Recent developments in behavioral analysis have unlocked vast potential, but challenges such as lack of standard experiments and large datasets still need to be addressed. Behavioral research labs lack access to the latest tools for data extraction and analysis, which require advanced computational skills.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Jeffrey S. Darling, Daniel W. Bayless, Lauren R. Dartez, Joshua J. Taylor, Arjun Mehrotra, William L. Smith, Jill M. Daniel
BEHAVIOURAL BRAIN RESEARCH
(2020)
Review
Neurosciences
Amalie Floriou-Servou, Lukas von Ziegler, Rebecca Waag, Christa Schlappi, Pierre-Luc Germain, Johannes Bohacek
Summary: Studying the stress response is crucial in neuroscience research, with a focus on understanding the complex molecular cascades triggered by acute stressors to predict healthy or maladaptive responses.
BIOLOGICAL PSYCHIATRY
(2021)
Review
Obstetrics & Gynecology
N. E. Baumgartner, J. M. Daniel
Summary: Research has shown a link between exposure to estradiol and enhanced memory through increasing ER alpha levels in the hippocampus, leading to improved cognitive function. Further studies implicate the importance of ER alpha in enhancing cognition, independent of the source of estrogen.
Article
Biochemistry & Molecular Biology
David Colameo, Marek Rajman, Michael Soutschek, Silvia Bicker, Lukas von Ziegler, Johannes Bohacek, Jochen Winterer, Pierre-Luc Germain, Christoph Dieterich, Gerhard Schratt
Summary: This study revealed different regulations between the somatic and process compartments of neurons during synaptic scaling. While crucial regulators of neuronal excitability were primarily downregulated in the somatic compartment, structural components of excitatory postsynapses were mainly downregulated in processes. This suggests that compartmentalized gene expression changes coexist with neuron-wide mechanisms during synaptic scaling to allow synaptic computation and homeostasis.
Article
Geriatrics & Gerontology
Nina E. Baumgartner, Katelyn L. Black, Shannon M. McQuillen, Jill M. Daniel
Summary: Both previous and continuous midlife estradiol treatment can increase levels of nuclear ER alpha in the hippocampus, impacting gene expression and protein levels related to estrogen effects on memory, indicating a long-lasting regulatory role of hippocampal ER alpha in memory.
NEUROBIOLOGY OF AGING
(2021)
Article
Multidisciplinary Sciences
Katharina Gapp, Guillermo E. Parada, Fridolin Gross, Alberto Corcoba, Jasmine Kaur, Evelyn Grau, Martin Hemberg, Johannes Bohacek, Eric A. Miska
Summary: Single traumatic events leading to exaggerated stress responses may contribute to the development of neuropsychiatric conditions. Studies suggest that acute paternal stress exposure can impact the RNA and metabolism of offspring. These effects may be transmitted from sperm to embryos, implicating a potential role in RNA-mediated inheritance of disease risk.
Article
Cell Biology
Christina Grimm, Stefan Fraessle, Celine Steger, Lukas von Ziegler, Oliver Sturman, Noam Shemesh, Daria Peleg-Raibstein, Denis Burdakov, Johannes Bohacek, Klaas Enno Stephan, Daniel Razansky, Nicole Wenderoth, Valerio Zerbi
Summary: Through optogenetic activation of D1R and D2R cells in the striatum, it was found that they evoke distinct activity within the basal ganglia-thalamocortical network and differentially engage cerebellar and prefrontal regions. Computational modeling confirmed that changes in D1R/D2R output drive functional relationships between these regions, suggesting an interconnected fronto-BG-cerebellar network modulated by these striatal cells.
Article
Neurosciences
Oliver Sturman, Lukas von Ziegler, Mattia Privitera, Rebecca Waag, Sian Duss, Yannick Vermeiren, Letizia Giovagnoli, Peter de Deyn, Johannes Bohacek
Summary: Chronic stress exposure in adolescence can lead to lasting changes in exploratory behavior and gene expression in the hippocampus in mice, but it does not alter the response to acute stress in adulthood and is unlikely to alter the function of the noradrenergic system.
NEUROBIOLOGY OF STRESS
(2021)
Article
Multidisciplinary Sciences
Lukas M. von Ziegler, Amalia Floriou-Servou, Rebecca Waag, Rebecca R. Das Gupta, Oliver Sturman, Katharina Gapp, Christina A. Maat, Tobias Kockmann, Han-Yu Lin, Sian N. Duss, Mattia Privitera, Laura Hinte, Ferdinand von Meyenn, Hanns U. Zeilhofer, Pierre-Luc Germain, Johannes Bohacek
Summary: This study investigates the molecular events in the mouse hippocampus induced by acute stress through the use of swim exposure. The results reveal the complexity and specificity of the acute stress response, highlighting changes in protein phosphorylation, gene transcription, and protein translation. These molecular events efficiently resolve within four hours after stress initiation.
NATURE COMMUNICATIONS
(2022)
Article
Computer Science, Artificial Intelligence
Markus Marks, Qiuhan Jin, Oliver Sturman, Lukas von Ziegler, Sepp Kollmorgen, Wolfger von der Behrens, Valerio Mante, Johannes Bohacek, Mehmet Fatih Yanik
Summary: This article introduces a tool for automated analysis of behavioral videos using deep neural networks. The tool can track and identify animal behavior, as well as classify individual and interacting animal behavior in complex environments. It can assist in studying behaviors related to brain function, the effects of pharmacological interventions, and genetic alterations.
NATURE MACHINE INTELLIGENCE
(2022)
Article
Obstetrics & Gynecology
Margaret A. Zimmerman, Benard O. Ogola, Mary M. Wilkinson, Bruna Visniauskas, Carmen De Miguel, Jill M. Daniel, Sarah H. Lindsey
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2020)